Nanoparticles for Targeted Delivery of Active Agents against Tumor Cells [0.03%]
用于靶向递送抗肿瘤细胞活性物质的纳米粒子
Rassoul Dinarvand,Paulo Cesar de Morais,Antony D&#x;Emanuele
Rassoul Dinarvand
Native and Complexed IGF-1: Biodistribution and Pharmacokinetics in Infantile Neuronal Ceroid Lipofuscinosis [0.03%]
婴儿神经 ceroid 活素的分布和药代动力学及复杂性
Tuulia Huhtala,Jussi Rytkönen,Anu Jalanko et al.
Tuulia Huhtala et al.
Infantile neuronal ceroid lipofuscinosis (INCL) is a severe neurodegenerative disorder of childhood characterized by selective death of cortical neurons. Insulin-like growth factor 1 (IGF-1) is important in embryonic development and is cons...
José M Morachis,Enas A Mahmoud,Jagadis Sankaranarayanan et al.
José M Morachis et al.
Effective gene delivery tools offer the possibility of addressing multiple diseases; current strategies rely on viruses or polyplexes. Encapsulation of DNA within nanoparticles is an attractive alternative method for gene delivery. We inves...
Translating nanotechnology from bench to pharmaceutical market: barriers, success, and promises [0.03%]
纳米技术从实验到医药市场的发展：障碍、成功和前景
Abhijit A Date,Rajesh R Patil,Riccardo Panicucci et al.
Abhijit A Date et al.
Reversible masking using low-molecular-weight neutral lipids to achieve optimal-targeted delivery [0.03%]
使用低分子量中性脂质实现可逆型屏蔽以达到最佳靶向递送效果
Nancy Smyth Templeton,Neil Senzer
Nancy Smyth Templeton
Intravenous injection of therapeutics is required to effectively treat or cure metastatic cancer, certain cardiovascular diseases, and other acquired or inherited diseases. Using this route of delivery allows potential uptake in all disease...
Poly(ethylene glycol)-Prodrug Conjugates: Concept, Design, and Applications [0.03%]
聚乙二醇-前药缀合物：概念、设计与应用
Shashwat S Banerjee,Naval Aher,Rajesh Patil et al.
Shashwat S Banerjee et al.
Poly(ethylene glycol) (PEG) is the most widely used polymer in delivering anticancer drugs clinically. PEGylation (i.e., the covalent attachment of PEG) of peptides proteins, drugs, and bioactives is known to enhance the aqueous solubility ...
Jun H Lee,Anjan Nan
Jun H Lee
Disseminated metastatic breast cancer needs aggressive treatment due to its reduced response to anticancer treatment and hence low survival and quality of life. Although in theory a combination drug therapy has advantages over single-agent ...
Development and evaluation of a novel pellet-based tablet system for potential colon delivery of budesonide [0.03%]
一种用于布地奈德结肠递送的新型颗粒基片剂系统的研究开发及评估
Jaleh Varshosaz,Jaber Emami,Naser Tavakoli et al.
Jaleh Varshosaz et al.
Budesonide, a potent glucocorticoid, is used for the treatment of inflammatory bowel diseases. Current available oral formulations of budesonide have low efficacy against ulcerative colitis because of the premature drug release in the upper...
Formulation Strategies, Characterization, and In Vitro Evaluation of Lecithin-Based Nanoparticles for siRNA Delivery [0.03%]
基于卵磷脂的siRNA递送纳米粒的制备、表征及体外评价研究
Sebastián Ezequiel Pérez,Yamila Gándola,Adriana Mónica Carlucci et al.
Sebastián Ezequiel Pérez et al.
The aim of the present work was to take advantage of lecithin's biocompatibility along with its physicochemical properties for the preparation of lecithin-based nanocarriers for small interfering RNA (siRNA) delivery. Water lecithin dispers...
A versatile polymer micelle drug delivery system for encapsulation and in vivo stabilization of hydrophobic anticancer drugs [0.03%]
一种用于疏水抗肿瘤药物包载及体内稳定的聚合物胶束给药系统
Jonathan Rios-Doria,Adam Carie,Tara Costich et al.
Jonathan Rios-Doria et al.
Chemotherapeutic drugs are widely used for the treatment of cancer; however, use of these drugs is often associated with patient toxicity and poor tumor delivery. Micellar drug carriers offer a promising approach for formulating and achievi...