BRAF in Melanoma: Pathogenesis, Diagnosis, Inhibition, and Resistance [0.03%]
黑色素瘤中的BRAF基因：发病机制、诊断、抑制和耐药性问题
Ryan J Sullivan,Keith T Flaherty
Ryan J Sullivan
Since the initial discovery that a subset of patients with cutaneous melanoma harbor BRAF mutations, substantial research has been focused on determining the pathologic consequences of BRAF mutations, optimizing diagnostic techniques to ide...
Ulcerative granular cell tumor: a clinicopathological and immunohistochemical study [0.03%]
溃疡性颗粒细胞瘤的临床病理和免疫组化研究
Mohamed El-Khalawany,Al-Sadat Mosbeh,Fatma Abd-Al Salam et al.
Mohamed El-Khalawany et al.
Granular cell tumor (GCT) is uncommonly presented with cutaneous ulcer. We examined the clinicopathological and immunohistochemical features of this ulcerative form in fourteen cases that may raise the awareness of this variant. The study i...
Molecular Network Associated with MITF in Skin Melanoma Development and Progression [0.03%]
与MITF相关的皮肤黑色素瘤发生发展分子网络研究进展
Ichiro Yajima,Mayuko Y Kumasaka,Nguyen Dinh Thang et al.
Ichiro Yajima et al.
Various environmental and genetic factors affect the development and progression of skin cancers including melanoma. Melanoma development is initially triggered by environmental factors including ultraviolet (UV) light, and then genetic/epi...
Dianne E Godar
Dianne E Godar
The incidence of cutaneous malignant melanoma (CMM) has been increasing at a steady rate in fair-skinned populations around the world for decades. Scientists are not certain why CMM has been steadily increasing, but strong, intermittent UVB...
Prognostic parameters for the primary care of melanoma patients: what is really risky in melanoma? [0.03%]
黑色素瘤患者初级诊疗的预后因素：什么因素是黑色素瘤真正的高危因素？
Daniela Göppner,Martin Leverkus
Daniela Göppner
Due to intensified research in recent years, the understanding of the molecular mechanisms involved in the development of melanoma has dramatically improved. The discovery of specific, causal mutations such as BRAF or KIT oncogenes not only...
Quentin Godechal,Bernard Gallez
Quentin Godechal
The incidence of malignant melanoma, the most dangerous form of skin cancer, is rising each year. However, some aspects of the tumor initiation and development are still unclear, and the current method of diagnosis, based on the visual aspe...
Lynne Robertson,Maxwell B Sauder
Lynne Robertson
Background. Darier's disease (DD), also known as Keratosis Follicularis or Darier-White disease, is a rare disorder of keratinization. DD can present as a generalized autosomal dominant condition as well as a localized or segmental postzygo...
Case Reports
Journal of skin cancer. 2012:2012:839561. DOI:10.1155/2012/839561 2012
Treatment of locally advanced melanoma by isolated limb infusion with cytotoxic drugs [0.03%]
化疗药物选择性灌注治疗肢端黑色素瘤患者的临床研究
Hidde M Kroon
Hidde M Kroon
Since its introduction in the late 1950s, isolated limb perfusion (ILP) has been the preferred treatment option for locally advanced melanoma and sarcoma confined to a limb. This treatment results in high response rates with a satisfying du...
Nichole R Dean,Larissa Sweeny,J Scott Magnuson et al.
Nichole R Dean et al.
Recurrent, advanced stage cutaneous squamous cell carcinoma (cSCC) is uncommon with limited publications on patient outcomes. A retrospective study including patients who underwent surgical resection for recurrent, advanced stage cSCC of th...
Incidental cutaneous reaction patterns: epidermolytic hyperkeratosis, acantholytic dyskeratosis, and hailey-hailey-like acantholysis: a potential marker of premalignant skin change [0.03%]
偶然性皮肤反应模式：表皮松解性过度角化、棘层松解性异常角化和Hailey-Hailey样棘层松解：癌前皮肤改变的潜在标志
Erich M Gaertner
Erich M Gaertner
Focal acantholytic dyskeratosis (FAD), epidermolytic hyperkeratosis (EHK), and Hailey-Hailey-like acantholysis (HH) represent unique histology reaction patterns, which can be associated with defined phenotypic and genotypic alterations. Inc...