Ultraviolet radiation and the slug transcription factor induce proinflammatory and immunomodulatory mediator expression in melanocytes [0.03%]
紫外线和软骨素转录因子诱导黑素细胞表达促炎症和免疫调节介质
Stephanie H Shirley,Elizabeth A Grimm,Donna F Kusewitt
Stephanie H Shirley
Despite extensive investigation, the precise contribution of the ultraviolet radiation (UVR) component of sunlight to melanoma etiology remains unclear. UVR induces keratinocytes to secrete proinflammatory and immunomodulatory mediators tha...
Histological, immunohistological, and clinical features of merkel cell carcinoma in correlation to merkel cell polyomavirus status [0.03%]
Merkel细胞多瘤病毒相关Merkel细胞癌的临床病理和免疫组化特征分析
T Jaeger,J Ring,C Andres
T Jaeger
Merkel cell carcinoma is a rare, but highly malignant tumor of the skin with high rates of metastasis and poor survival. Its incidence rate rises and is currently about 0.6/100000/year. Clinical differential diagnoses include basal cell car...
Is there truly no benefit with sunscreen use and Basal cell carcinoma? A critical review of the literature and the application of new sunscreen labeling rules to real-world sunscreen practices [0.03%]
防晒霜的使用与基底细胞癌真的没有益处吗？文献批判性回顾及新的防晒霜标签规则在现实世界中的应用
Cameron Chesnut,Jenny Kim
Cameron Chesnut
Basal cell carcinoma (BCC) is the most common human malignancy. Both epidemiological and direct evidence have established ultraviolet (UV) exposure from the sun as the most important risk factor for BCC development. There has only been one ...
Paolo A Ascierto,John M Kirkwood,Francesco M Marincola et al.
Paolo A Ascierto et al.
Epidemiological profile of patients with cutaneous melanoma in a region of southern Brazil [0.03%]
巴西南部地区皮肤黑色素瘤患者的流行病学特征
Marcelo Moreno,Ricardo Ludwig Schmitt,Maria Gabriela Lang et al.
Marcelo Moreno et al.
Cutaneous melanoma (CM) is responsible for 75% of deaths from malignant skin cancer. The incidence of CM in the southern region of Brazil, particularly in the western region of Santa Catarina, is possibly higher than estimated. In this stud...
K C Masoumi,Gina Shaw-Hallgren,Ramin Massoumi
K C Masoumi
Ubiquitin and ubiquitin-related proteins posttranslationally modify substrates, and thereby alter the functions of their targets. The ubiquitination process is involved in various physiological responses, and dysregulation of components of ...
Daniela Gonsalves Shapiro,Wolfram E Samlowski
Daniela Gonsalves Shapiro
Disseminated metastatic disease, including brain metastases, is commonly encountered in malignant melanoma. The classical treatment approach for melanoma brain metastases has been neurosurgical resection followed by whole brain radiotherapy...
Adjuvant therapy: melanoma [0.03%]
黑色素瘤的辅助治疗
Diwakar Davar,Ahmad Tarhini,John M Kirkwood
Diwakar Davar
With an incidence that is increasing at 2-5% per year, cutaneous melanoma is an international scourge that disproportionately targets young individuals. Despite much research, the treatment of advanced disease is still quite challenging. Im...
Pre-treatment deep curettage can significantly reduce tumour thickness in thick Basal cell carcinoma while maintaining a favourable cosmetic outcome when used in combination with topical photodynamic therapy [0.03%]
刮除术联合外用光动力疗法治疗厚基底细胞癌可明显减少肿瘤厚度并维持美容效果
Eidi Christensen,Cato Mørk,Olav Andreas Foss
Eidi Christensen
Topical photodynamic therapy (PDT) has limitations in the treatment of thick skin tumours. The aim of the study was to evaluate the effect of pre-PDT deep curettage on tumour thickness in thick (≥2 mm) basal cell carcinoma (BCC). Additiona...
Victor D Martinez,Daiana D Becker-Santos,Emily A Vucic et al.
Victor D Martinez et al.
Arsenic is a potent human carcinogen. Around one hundred million people worldwide have potentially been exposed to this metalloid at concentrations considered unsafe. Exposure occurs generally through drinking water from natural geological ...