Cardiomyopathies: classification, clinical characterization, and functional phenotypes [0.03%]
心肌病：分类、临床特征和功能表型
Danuta Szczesna-Cordary,Sachio Morimoto,Aldrin V Gomes et al.
Danuta Szczesna-Cordary et al.
The role of the cullin-5 e3 ubiquitin ligase in the regulation of insulin receptor substrate-1 [0.03%]
Cul-5泛素连接酶在胰岛素受体底物-1调节中的作用
Christine Zhiwen Hu,Jaswinder K Sethi,Thilo Hagen
Christine Zhiwen Hu
Background. SOCS proteins are known to negatively regulate insulin signaling by inhibiting insulin receptor substrate-1 (IRS1). IRS1 has been reported to be a substrate for ubiquitin-dependent proteasomal degradation. Given that SOCS protei...
Dmitry Karpov,Michael H Glickman,Shoshana Bar-Nun et al.
Dmitry Karpov et al.
Eun-Kyoung Yim Breuer,Mandi M Murph,Rolf J Craven
Eun-Kyoung Yim Breuer
A critical appraisal of quantitative studies of protein degradation in the framework of cellular proteostasis [0.03%]
细胞稳态背景下蛋白质降解定量研究的批判性评价
Beatriz Alvarez-Castelao,Carmen Ruiz-Rivas,José G Castaño
Beatriz Alvarez-Castelao
Protein homeostasis, proteostasis, is essential to understand cell function. Protein degradation is a crucial component of the proteostatic mechanisms of the cell. Experiments on protein degradation are nowadays present in many investigatio...
Oxygen versus Reactive Oxygen in the Regulation of HIF-1α: The Balance Tips [0.03%]
氧与活性氧在HIF-1α调节中的平衡偏向性：哪种信号通路占优势？
Thilo Hagen
Thilo Hagen
Hypoxia inducible factor (HIF) is known as the master regulator of the cellular response to hypoxia and is of pivotal importance during development as well as in human disease, particularly in cancer. It is composed of a constitutively expr...
The Ubiquitin-Proteasome System in Huntington's Disease: Are Proteasomes Impaired, Initiators of Disease, or Coming to the Rescue? [0.03%]
泛素-蛋白酶体系统在亨廷顿舞蹈病中的作用：蛋白酶体是功能受损、致病因素还是来解救的？
Sabine Schipper-Krom,Katrin Juenemann,Eric A J Reits
Sabine Schipper-Krom
Huntington's disease is a progressive neurodegenerative disease, caused by a polyglutamine expansion in the huntingtin protein. A prominent hallmark of the disease is the presence of intracellular aggregates initiated by N-terminal huntingt...
Potential role of peptidylarginine deiminase enzymes and protein citrullination in cancer pathogenesis [0.03%]
肽基精氨酸脱亚胺酶和蛋白质瓜氨酸化在癌症发病机制中的潜在作用
Sunish Mohanan,Brian D Cherrington,Sachi Horibata et al.
Sunish Mohanan et al.
The peptidylarginine deiminases (PADs) are a family of posttranslational modification enzymes that catalyze the conversion of positively charged protein-bound arginine and methylarginine residues to the uncharged, nonstandard amino acid cit...
Cardiomyopathy-Related Mutations in Cardiac Troponin C, L29Q and G159D, Have Divergent Effects on Rat Cardiac Myofiber Contractile Dynamics [0.03%]
心肌病相关的两种心脏troponin C突变体L29Q和G159D对大鼠心肌纤维收缩动力学产生不同的影响
Sampath K Gollapudi,Murali Chandra
Sampath K Gollapudi
Previous studies of cardiomyopathy-related mutations in cardiac troponin C (cTnC)-L29Q and G159D-have shown diverse findings. The link between such mutant effects and their divergent impact on cardiac phenotypes has remained elusive due to ...
Divalent Metal Ion Transport across Large Biological Ion Channels and Their Effect on Conductance and Selectivity [0.03%]
二价金属离子穿过大生物通道蛋白及其对电导率和选择透过性的影响
Elena García-Giménez,Antonio Alcaraz,Vicente M Aguilella
Elena García-Giménez
Electrophysiological characterization of large protein channels, usually displaying multi-ionic transport and weak ion selectivity, is commonly performed at physiological conditions (moderate gradients of KCl solutions at decimolar concentr...