Hair Growth Promoting Effect of Dicerocaryum senecioides Phytochemicals [0.03%]
毛发增生促进作用的Dicerocaryum senecioides植物化学成分研究
H Rambwawasvika,P Dzomba,L Gwatidzo
H Rambwawasvika
Phytochemicals from Dicerocaryum senecioides were studied for hair rejuvenation activity using BalB/c mice. Solvent extractions and thin layer chromatography (TLC) were used to extract and isolate the phytochemicals respectively. Phytochemi...
Caffeates and Caffeamides: Synthetic Methodologies and Their Antioxidant Properties [0.03%]
咖啡酸及咖啡酰胺的合成方法及其抗氧化性能研究
Merly de Armas-Ricard,Enrique Ruiz-Reyes,Oney Ramírez-Rodríguez
Merly de Armas-Ricard
Polyphenols are secondary metabolites of plants and include a variety of chemical structures, from simple molecules such as phenolic acids to condensed tannins and highly polymerized compounds. Caffeic acid (3,4-dihydroxycinnamic acid) is o...
Evaluation of the Molecular State of Piperine in Cyclodextrin Complexes by Near-Infrared Spectroscopy and Solid-State Fluorescence Measurements [0.03%]
近红外光谱及固态荧光测量评价β-环糊精包合物中胡椒碱的分子状态
Toshinari Ezawa,Yutaka Inoue,Isamu Murata et al.
Toshinari Ezawa et al.
The purpose of this study was to evaluate the physicochemical properties of piperine (PP) in ground mixtures (GMs) of PP with α-, β-, or γ-cyclodextrin (CD) under conditions of humidity, heat, and humidity-heat. In solid-state fluorescen...
Synthesis and Evaluation of Baylis-Hillman Reaction Derived Imidazole and Triazole Cinnamates as Antifungal Agents [0.03%]
作为抗真菌剂的巴利斯-希尔曼反应衍生物咪唑和三唑肉桂酸酯的合成与评价
Grady L Nelson,Michael J Williams,Shirisha Jonnalagadda et al.
Grady L Nelson et al.
Allylic acetates derived from Baylis-Hillman reaction undergo efficient nucleophilic isomerization with imidazoles and triazoles to provide imidazolylmethyl and triazolylmethyl cinnamates stereoselectively. Antifungal evaluation of these de...
Carrie L Lomelino,Jacob T Andring,Robert McKenna
Carrie L Lomelino
X-ray and neutron crystallography are powerful techniques utilized to study the structures of biomolecules. Visualization of enzymes in complex with substrate/product and the capture of intermediate states can be related to activity to faci...
Phytochemical Study and Evaluation of the Cytotoxic Properties of Methanolic Extract from Baccharis obtusifolia [0.03%]
Baccharis obtusifolia甲醇提取物的植物化学研究及其 cytotoxic 属性评估
Juan Carlos Romero-Benavides,Gina C Ortega-Torres,Javier Villacis et al.
Juan Carlos Romero-Benavides et al.
Some species of the Baccharis genus have been shown to possess important biomedical properties, including cytotoxic activity. In this study, we examined the cytotoxic effect of methanol extract from Baccharis obtusifolia (Asteraceae) in can...
Applications of Click Chemistry in the Development of HIV Protease Inhibitors [0.03%]
点击化学在HIV蛋白酶抑制剂开发中的应用
Mukesh M Mudgal,Nagaraju Birudukota,Mayur A Doke
Mukesh M Mudgal
Acquired Immunodeficiency Syndrome (AIDS) has been devastating for millions of people around the world. Inhibition of the human immunodeficiency virus (HIV) protease is among the most important approaches for the therapeutic intervention in...
Biophysical, Biochemical, and Cell Based Approaches Used to Decipher the Role of Carbonic Anhydrases in Cancer and to Evaluate the Potency of Targeted Inhibitors [0.03%]
用于解密癌细胞中碳酸酐酶的作用及评估靶向抑制剂效力的生物物理生化和细胞基础方法
Mam Y Mboge,Anusha Kota,Robert McKenna et al.
Mam Y Mboge et al.
Carbonic anhydrases (CAs) are thought to be important for regulating pH in the tumor microenvironment. A few of the CA isoforms are upregulated in cancer cells, with only limited expression in normal cells. For these reasons, there is inter...
Synthesis, Anti-Inflammatory Activity, and In Silico Study of Novel Diclofenac and Isatin Conjugates [0.03%]
新型双氯芬酸和异丁索共轭物的合成、抗炎活性及计算机辅助药物设计研究
Musab Mohamed Ibrahim,Tilal Elsaman,Mosab Yahya Al-Nour
Musab Mohamed Ibrahim
The design, synthesis, and development of novel non-steroidal anti-inflammatory drugs (NSAIDs) with better activity and lower side effects are respectable area of research. Novel Diclofenac Schiff's bases (M1, M2, M4, M7, and M8) were desig...
Correlation between Virtual Screening Performance and Binding Site Descriptors of Protein Targets [0.03%]
基于蛋白质靶点结合位点描述符的虚拟筛选效能相关性研究
Jamal Shamsara
Jamal Shamsara
Rescoring is a simple approach that theoretically could improve the original docking results. In this study AutoDock Vina was used as a docked engine and three other scoring functions besides the original scoring function, Vina, as well as ...