Enteric fungi protect against intestinal ischemia-reperfusion injury via inhibiting the SAA1-GSDMD pathway [0.03%]
肠真菌通过抑制SAA1-GSDMD途径防御肠道缺血再灌注损伤
Yihui Chen,Ben Han,Xu Guan et al.
Yihui Chen et al.
Introduction: Prophylactic antifungal therapy has been widely used for critical patients, but it has failed to improve patient prognosis and has become a hot topic. This may be related to disruption of fungal homeostasis,...
Calcium influx: An essential process by which α-Synuclein regulates morphology of erythrocytes [0.03%]
钙离子内流：通过该过程，α-突触核蛋白调控红细胞形态变化
Ying Yang,Min Shi,Xiaodan Liu et al.
Ying Yang et al.
Introduction: Morphological abnormalities of erythrocytes/red blood cells (RBCs), e.g., increased acanthocytes, in Parkinson's disease (PD) have been reported previously, although the underlying mechanisms remain to be ch...
Evolocumab prevents atrial fibrillation in rheumatoid arthritis rats through restraint of PCSK9 induced atrial remodeling [0.03%]
依折麦布通过抑制PCSK9诱导的心房重构预防类风湿性关节炎大鼠心房颤动发生
Xuejie Han,Yunlong Gao,Meijiao He et al.
Xuejie Han et al.
Introduction: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is implicated in the pathogenesis and progression of autoimmune disease. Patients with rheumatoid arthritis (RA) are at high risk of developing atrial fi...
AI-2 quorum sensing controlled delivery of cytolysin-A by tryptophan auxotrophic low-endotoxic Salmonella and its anticancer effects in CT26 mice with colon cancer [0.03%]
组氨酸营养缺陷的低内毒血症沙门菌通过AI-2群体感应控制释放细胞溶素A及其在CT26结肠癌小鼠中的抗肿瘤作用
Ram Prasad Aganja,Chandran Sivasankar,John Hwa Lee
Ram Prasad Aganja
Introduction: The limitations of conventional cancer therapies necessitate target-oriented, highly invasive, and safe treatment approaches. Hence, the intrinsic anti-tumor activity of Salmonella can offer better options t...
ALKBH5 induces fibroblast-to-myofibroblast transformation during hypoxia to protect against cardiac rupture after myocardial infarction [0.03%]
缺氧时ALKBH5诱导成纤维细胞向肌成纤维细胞转化以预防心梗后心脏破裂
Kun Yang,Yongchao Zhao,Jingjing Hu et al.
Kun Yang et al.
Introduction: N6-methyladenosine (m6A) methylation produces a marked effect on cardiovascular diseases. The m6A demethylase AlkB homolog 5 (ALKBH5), as an m6A "eraser", is responsible for decreased m6A modification. Howev...
Integrative gene duplication and genome-wide analysis as an approach to facilitate wheat reverse genetics: An example in the TaCIPK family [0.03%]
整合基因重复和全基因组分析在促进小麦反向遗传学研究中的作用——TaCIPK家族为例
Ya&#x;nan Wu,Jialu Feng,Qian Zhang et al.
Ya&#x;nan Wu et al.
Introduction: Reverse genetic studies conducted in the plant with a complex or polyploidy genome enriched with large gene families (like wheat) often meet challenges in identifying the key candidate genes related to impor...
β-Elemene induced ferroptosis via TFEB-mediated GPX4 degradation in EGFR wide-type non-small cell lung cancer [0.03%]
β-艾叶烯通过TFEB介导的GPX4降解诱导EGFR野生型非小细胞肺癌铁死亡
Li-Ping Zhao,Hao-Jie Wang,Die Hu et al.
Li-Ping Zhao et al.
Introduction: β-Elemene (β-ELE), derived from Curcuma wenyujin, has anticancer effect on non-small cell lung cancer (NSCLC). However, the potential target and detail mechanism were still not clear. TFEB is the master re...
Plasma glycoproteomics delivers high-specificity disease biomarkers by detecting site-specific glycosylation abnormalities [0.03%]
基于检测位点特异性糖基化异常发现疾病标志物的血浆糖蛋白组学研究
Hans J C T Wessels,Purva Kulkarni,Maurice van Dael et al.
Hans J C T Wessels et al.
Introduction: The human plasma glycoproteome holds enormous potential to identify personalized biomarkers for diagnostics. Glycoproteomics has matured into a technology for plasma N-glycoproteome analysis but further evol...
Irisin as an agent for protecting against osteoporosis: A review of the current mechanisms and pathways [0.03%]
Irisin抗骨质疏松作用机制研究进展
Xinli Hu,Zheng Wang,Wei Wang et al.
Xinli Hu et al.
Background: Osteoporosis is recognized as a skeletal disorder characterized by diminished bone tissue quality and density. Regular physical exercise is widely acknowledged to preserve and enhance bone health, but the deta...
Antifouling applications and fabrications of biomimetic micro-structured surfaces: A review [0.03%]
仿生微纳结构表面防污应用及制备方法综述性研究论文
Yuhan Liu,Xiaoyan He,Chengqing Yuan et al.
Yuhan Liu et al.
Background: Since the inception of the term "Biomimetics" in 1991, the concept of utilizing natural solutions or deriving inspiration from nature to address contemporary engineering challenges has gained significant atten...