An miR156-regulated nucleobase-ascorbate transporter 2 confers cadmium tolerance via enhanced anti-oxidative capacity in barley [0.03%]
一个由miR156调节的核苷酸抗坏血酸转运蛋白2通过增强抗氧化能力提高大麦的镉耐受性
Nian-Hong Wang,Xue-Yi Zhou,Shou-Heng Shi et al.
Nian-Hong Wang et al.
Introduction: Cadmium (Cd) is one of the most detrimental heavy metal pollutants, seriously affecting crop production and human health. Nucleobase-ascorbic acid transporters (NAT) are widely present in many living organis...
Fluorescence-enabled evaluation of nasal tract deposition and coverage of pharmaceutical formulations in a silicone nasal cast using an innovative spray device [0.03%]
一种创新喷雾装置在硅鼻模中评估药物制剂的鼻腔沉积和覆盖的荧光方法
Davide D&#x;Angelo,Stefan Kooij,Frank Verhoeven et al.
Davide D&#x;Angelo et al.
Introduction: The characterisation of nasal formulations is a critical point. However, there are still no recommendations or guidelines in terms of standard approaches for evaluating the formulation's nasal deposition and...
Lung specific homing of diphenyleneiodonium chloride improves pulmonary fibrosis by inhibiting macrophage M2 metabolic program [0.03%]
二苯基碘鎓氯化物的肺特异性定位可通过抑制巨噬细胞M2代谢程序来改善肺纤维化
Huirui Wang,Yinghui Gao,Li Wang et al.
Huirui Wang et al.
Introduction: Pulmonary fibrosis (PF) is a fatal disease with a variable and unpredictable course. Effective clinical treatment for PF remains a challenge due to low drug accumulation in lungs and imbalanced polarization ...
CBS-H2S axis preserves the intestinal barrier function by inhibiting COX-2 through sulfhydrating human antigen R in colitis [0.03%]
CBS-H2S轴通过硫化人抗原R抑制COX-2来维持结肠炎肠道屏障功能
Shihao Guo,Zhihao Huang,Jing Zhu et al.
Shihao Guo et al.
Introduction: Lipopolysaccharide (LPS) causes lesions of the epithelial barrier, which allows translocation of pathogens from the intestinal lumen to the host's circulation. Hydrogen sulfide (H2S) regulates multiple physi...
Soluble Trem2 is a negative regulator of erythrophagocytosis after intracerebral hemorrhage in a CD36 receptor recycling manner [0.03%]
可溶性 TREM2 通过清道夫受体 CD36 内吞循环机制抑制脑出血后红细胞吞噬作用
Hang Zhou,Jianru Li,Libin Hu et al.
Hang Zhou et al.
Introduction: Microglia and macrophages participate in hematoma clearance after intracerebral hemorrhage (ICH), thereby facilitating tissue restoration and neurological recovery. Triggering receptor expressed on myeloid c...
GPX2 is a potential therapeutic target to induce cell apoptosis in lenvatinib against hepatocellular carcinoma [0.03%]
GPX2可能是LEN治疗肝癌细胞凋亡的潜在靶点
Wenliang Tan,Kelin Zhang,Xinming Chen et al.
Wenliang Tan et al.
Introduction: Lenvatinib has recently become available as the first-line therapy for advanced hepatocellular carcinoma (HCC), but its molecular mechanism in HCC remains largely unknown. ...
Consistency and reproducibility of large panel next-generation sequencing: Multi-laboratory assessment of somatic mutation detection on reference materials with mismatch repair and proofreading deficiency [0.03%]
具错配修复和校对缺陷的参考材料中体细胞突变检测的多实验室评估：大规模 panels 的下一代测序的一致性和可重复性评估
Duo Wang,Yuanfeng Zhang,Rui Li et al.
Duo Wang et al.
Introduction: Clinical precision oncology increasingly relies on accurate genome-wide profiling using large panel next generation sequencing; however, difficulties in accurate and consistent detection of somatic mutation ...
Integrated immunogenomic analysis of single-cell and bulk tissue transcriptome profiling unravels a macrophage activation paradigm associated with immunologically and clinically distinct behaviors in ovarian cancer [0.03%]
整合免疫组学分析单细胞和批量组织转录组揭示了卵巢癌中与免疫学及临床表现不同的行为相关的巨噬细胞激活模式
Congcong Yan,Ke Li,Fanling Meng et al.
Congcong Yan et al.
Introduction: Increasing evidence demonstrates that the activation states and diverse spectrum of macrophage subtypes display dynamic heterogeneity in the tumor microenvironment, which plays a critical role in a variety o...
Newly identified axon types of the facial nerve unveil supplemental neural pathways in the innervation of the face [0.03%]
newly identified facial nerve轴突类型揭示了面部神经支配的额外神经通路
Vlad Tereshenko,Udo Maierhofer,Dominik C Dotzauer et al.
Vlad Tereshenko et al.
Introduction: Neuromuscular control of the facial expressions is provided exclusively via the facial nerve. Facial muscles are amongst the most finely tuned effectors in the human motor system, which coordinate facial exp...
Continental scale deciphering of microbiome networks untangles the phyllosphere homeostasis in tea plant [0.03%]
泛大陆尺度的解译微生物组网络可揭示茶叶植株叶片圈的稳态机制
Ping Xu,Erinne Stirling,Hengtong Xie et al.
Ping Xu et al.
Introduction: Assembly and co-occurrence of the host co-evolved microbiota are essential ecological and evolutionary processes, which is not only crucial for managing individual plant fitness but also ecological function....