Modulation of warm temperature-sensitive growth using a phytochrome B dark reversion variant, phyB[G515E], in Arabidopsis and rice [0.03%]
利用拟南芥PHYB[G515E]暗回复突变体和水稻PHYB转基因系调节植物高温敏感生长响应
Jin Jeon,Md Mizanor Rahman,Hee Wook Yang et al.
Jin Jeon et al.
Introduction: Ambient temperature-induced hypocotyl elongation in Arabidopsis seedlings is sensed by the epidermis-localized phytochrome B (phyB) and transduced into auxin biosynthesis via a basic helix-loop-helix transcr...
Chamber Attention Network (CAN): Towards interpretable diagnosis of pulmonary artery hypertension using echocardiography [0.03%]
心超诊断肺动脉高压的解释性方法—— Chamber Attention Network(CAN)
Dezhi Sun,Yangyi Hu,Yunming Li et al.
Dezhi Sun et al.
Introduction: Accurate identification of pulmonary arterial hypertension (PAH) in primary care and rural areas can be a challenging task. However, recent advancements in computer vision offer the potential for automated s...
Qian Yan,Shasha Liu,Yang Sun et al.
Qian Yan et al.
Background: Pulmonary hypertension (PH) represents a progressive condition characterized by the remodeling of pulmonary arteries, ultimately culminating in right heart failure and increased mortality rates. Substantial ev...
Depleting LCAT Aggravates Atherosclerosis in LDLR-deficient Hamster with Reduced LDL-Cholesterol Level [0.03%]
LCAT活性下降通过降低LDL-C水平加重LDLR缺乏的叙利亚仓鼠的动脉粥样硬化病变发展程度
Xiao Lin,Wei Zhang,Chun Yang et al.
Xiao Lin et al.
Introduction: Lecithin cholesterol acyltransferase (LCAT) plays a crucial role in acyl-esterifying cholesterol in plasma, which is essential for reverse cholesterol transport (RCT). Previous studies indicated that its act...
PROTAC derivatization of natural products for target identification and drug discovery: Design of evodiamine-based PROTACs as novel REXO4 degraders [0.03%]
基于天然产物的PROTAC衍生化在靶点鉴定与药物发现中的应用及吴茱萸碱类蛋白降解剂的设计与发展
Shuqiang Chen,Kaijian Bi,Huixin Liang et al.
Shuqiang Chen et al.
Introduction: Natural products (NPs) play a crucial role in the development of therapeutic drugs. However, it is still highly challenging to identify the targets of NPs. Besides, NPs usually exert their pharmacological ac...
P450Rdb: a manually curated database of reactions catalyzed by cytochrome P450 enzymes [0.03%]
P450Rdb：一种由人工整理的细胞色素P450酶催化反应的数据库
Yang Zhang,Xianrun Pan,Tianyu Shi et al.
Yang Zhang et al.
Introduction: Cytochrome P450 enzymes (P450s) are recognized as the most versatile catalysts worldwide, playing vital roles in numerous biological metabolism and biosynthesis processes across all kingdoms of life. Despite...
Ceria Nanozyme Coordination with Curcumin for Treatment of Sepsis-induced Cardiac Injury by Inhibiting Ferroptosis and Inflammation [0.03%]
四环素纳米酶与姜黄素配位治疗脓毒症诱导的心脏损伤的铁死亡和炎症抑制作用研究
Chenxiao Jiang,Qianzhi Shi,Jing Yang et al.
Chenxiao Jiang et al.
Introduction: Sepsis-induced cardiac injury is the leading cause of death in patients. Recent studies have reported that reactive oxygen species (ROS)-mediated ferroptosis and macrophage-induced inflammation are the two m...
Targeting YTHDF2 inhibits tumorigenesis of diffuse large B-cell lymphoma through ACER2-mediated ceramide catabolism [0.03%]
靶向YTHDF2通过ACER2介导的神经酰胺分解代谢抑制弥漫性大B细胞淋巴瘤的肿瘤发生
Xiaomin Chen,Tiange Lu,Mengfei Ding et al.
Xiaomin Chen et al.
Introduction: Epigenetic alterations play crucial roles in diffuse large B-cell lymphoma (DLBCL). Disturbances in lipid metabolism contribute to tumor progression. However, studies in epigenetics, especially its critical ...
4SQR-Code: A 4-state QR code generation model for increasing data storing capacity in the Digital Twin framework [0.03%]
4状态二维码生成模型：数字孪生框架下的一种提高数据存储容量的方法
Ababil Islam Udoy,Muhammad Aminur Rahaman,Md Jahidul Islam et al.
Ababil Islam Udoy et al.
Introduction: The usage of Quick Response (QR) Codes has become widely popular in recent years, primarily for immense electronic transactions and industry uses. The structural flexibility of QR Code architecture opens man...
Industrial Internet of Water Things architecture for data standarization based on blockchain and digital twin technology☆ [0.03%]
基于区块链和数字孪生技术的工业水资源标准化体系物联网架构研究
Mazin Abed Mohammed,Abdullah Lakhan,Karrar Hameed Abdulkareem et al.
Mazin Abed Mohammed et al.
Introduction: The Industrial Internet of Water Things (IIoWT) has recently emerged as a leading architecture for efficient water distribution in smart cities. Its primary purpose is to ensure high-quality drinking water f...