Hybridization-based discovery of novel quinazoline-2-indolinone derivatives as potent and selective PI3Kα inhibitors [0.03%]
基于杂化的新型喹唑啉-2-吲哚酮衍生物的发现作为有效的选择性PI3Kα抑制剂
Changqun Liu,Yuening Cao,Yi Zuo et al.
Changqun Liu et al.
Introduction: Phosphatidylinositol 3-kinases (PI3Ks) overexpression can elicit cellular homeostatic dysregulation, which further contributes to tumorigenesis, with PI3Kα emerging as the most prevalent mutant isoform kina...
Achieving healthy aging through gut microbiota-directed dietary intervention: Focusing on microbial biomarkers and host mechanisms [0.03%]
通过肠道微生物群导向的饮食干预实现健康老龄化：关注微生物生物标志物和宿主机制
Yue Xiao,Yingxuan Feng,Jianxin Zhao et al.
Yue Xiao et al.
Background: Population aging has become a primary global public health issue, and the prevention of age-associated diseases and prolonging healthy life expectancies are of particular importance. Gut microbiota has emerged...
The epidermal lipid-microbiome loop and immunity: Important players in atopic dermatitis [0.03%]
表皮脂质-微生物环与免疫性：在特应性皮炎中重要的参与者
Junchao Wu,Lisha Li,Tingrui Zhang et al.
Junchao Wu et al.
Background: The promotion of epidermal barrier dysfunction is attributed to abnormalities in the lipid-microbiome positive feedback loop which significantly influences the imbalance of the epithelial immune microenvironme...
Gut microbiome-derived bacterial extracellular vesicles in patients with solid tumours [0.03%]
实体瘤患者中源自肠道微生物组的细菌胞外囊泡
Surbhi Mishra,Mysore Vishakantegowda Tejesvi,Jenni Hekkala et al.
Surbhi Mishra et al.
Introduction: Gut microbiome-derived nanoparticles, known as bacterial extracellular vesicles (bEVs), have garnered interest as promising tools for studying the link between the gut microbiome and human health. The divers...
Unlocking melanoma Suppression: Insights from Plasma-Induced potent miRNAs through PI3K-AKT-ZEB1 axis [0.03%]
解锁黑色素瘤抑制：通过PI3K-AKT-ZEB1轴洞察等离子体诱导的有力miRNAs
Pradeep Bhartiya,Apurva Jaiswal,Manorma Negi et al.
Pradeep Bhartiya et al.
Introduction: Melanoma is a rare but highly malignant form of skin cancer. Although recent targeted and immune-based therapies have improved survival rates by 10-15%, effective melanoma treatment remains challenging. Ther...
Metformin blocks BIK1-mediated CPK28 phosphorylation and enhances plant immunity [0.03%]
二甲双胍阻断BIK1介导的CPK28磷酸化并增强植物免疫能力
Yazhou Bao,Qian Zhang,Hai Zhu et al.
Yazhou Bao et al.
Introduction: Metformin (MET), derived from Galega officinalis, stands as the primary first-line medication for the treatment of type 2 diabetes (T2D). Despite its well-documented benefits in mammalian cellular processes,...
NCAPD3 promotes diffuse large B-cell lymphoma progression through modulating SIRT1 expression in an H3K9 monomethylation-dependent manner [0.03%]
NCAPD3通过组蛋白H3赖氨酸9单甲基化依赖性调控SIRT1表达促进弥漫大B细胞淋巴瘤进展
Tiange Lu,Juan Yang,Yiqing Cai et al.
Tiange Lu et al.
Introduction: Condensin, a family of structural maintenance of chromosome complexes, has been shown to regulate chromosome compaction and segregation during mitosis. NCAPD3, a HEAT-repeat subunit of condensin II, plays a ...
Baicalein induces apoptosis by inhibiting the glutamine-mTOR metabolic pathway in lung cancer [0.03%]
黄芩素通过抑制谷氨酰胺-mtor代谢途径诱导肺癌细胞凋亡
Jingyang Li,Di Zhang,Shaohui Wang et al.
Jingyang Li et al.
Introduction: Baicalein, a bioactive component of Scutellaria baicalensis Georgi, has been shown to promote apoptosis in non-small cell lung cancer cells. However, previous studies have not determined if baicalein exerts ...
Moscatilin inhibits vascular calcification by activating IL13RA2-dependent inhibition of STAT3 and attenuating the WNT3/β-catenin signalling pathway [0.03%]
莫斯卡丁通过激活IL13RA2依赖性STAT3抑制和减弱WNT3 / β-连环蛋白信号通路来抑制血管钙化
Tingting Zhang,Mengmeng Zhu,Jialing Ma et al.
Tingting Zhang et al.
Introduction: Vascular calcification, a devastating vascular complication accompanying atherosclerotic cardiovascular disease and chronic kidney disease, increases the incidence of adverse cardiovascular events and compro...
5-HT7R enhances neuroimmune resilience and alleviates meningitis by promoting CCR5 ubiquitination [0.03%]
5-HT7R通过促进CCR5泛素化增强神经免疫韧性并缓解脑膜炎
Zhenfang Gao,Yang Gao,Yuxiang Li et al.
Zhenfang Gao et al.
Introduction: Excessive immune activation induces tissue damage during infection. Compared to external strategies to reconstruct immune homeostasis, host balancing ways remain largely unclear. ...