A hybridized mechano-electroporation technique for efficient immune cell engineering [0.03%]
一种高效的免疫细胞工程的混合机械-电穿孔技术
Dorsa Morshedi Rad,William P Hansen,Sareh Zhand et al.
Dorsa Morshedi Rad et al.
Immune cell engineering, which involves genetic modification of T cells, natural killer cells, and macrophages, is shifting the paradigm in immunotherapy for treating hematologic malignancies. These modified cells can be viewed as living dr...
Molecular underpinnings underlying behaviors changes in the brain of juvenile common carp (Cyrinus carpio) in response to warming [0.03%]
青鱼(Cyrinus carpio)大脑中适应升温引起行为变化的分子机制研究
Yuanli Zhao,Ming Duan,Xing Lin et al.
Yuanli Zhao et al.
Introduction: Global warming is increasing interest in how aquatic animals can adjust their physiological performance and cope with temperature changes. Therefore, understanding the behavioral changes and molecular underp...
Unlocking the secrets of aging: Epigenetic reader BRD4 as the target to combatting aging-related diseases [0.03%]
破解衰老之谜：表观遗传阅读蛋白BRD4或可成为抗衰药物靶点
Jiaxing Sun,Yu Gui,Shenghua Zhou et al.
Jiaxing Sun et al.
Background: Aging, a complex and profound journey, leads us through a labyrinth of physiological and pathological transformations, rendering us increasingly susceptible to aging-related diseases. Emerging investigations h...
Fetal hypoxia expose caused autophagy in ovary granulosa cells via PI3K/Akt/FoxO1 pathway and mitigated by melatonin subheading [0.03%]
胎儿低氧暴露通过PI3K/Akt/FoxO1途径诱导卵巢颗粒细胞自噬并用褪黑素缓解
Luyao Zhang,Kexiong Liu,Zhiqiang Liu et al.
Luyao Zhang et al.
Introduction: Fetal hypoxia has long-term effects on postnatal reproductive functions and the mitochondrial impairments of ovarian granulosa cells may be one of the causes. Melatonin applied to mitigate mitochondrial dysf...
Digital techniques and trends for seed phenotyping using optical sensors [0.03%]
基于光学传感器的作物种子表型鉴定技术及趋势研究进展
Fei Liu,Rui Yang,Rongqin Chen et al.
Fei Liu et al.
Background: The breeding of high-quality, high-yield, and disease-resistant varieties is closely related to food security. The investigation of breeding results relies on the evaluation of seed phenotype, which is a key s...
Clinical development and informatics analysis of natural and semi-synthetic flavonoid drugs: A critical review [0.03%]
天然及半合成黄酮类药物的临床开发和信息学分析：批判性综述
Kuo Xu,Xia Ren,Jintao Wang et al.
Kuo Xu et al.
Background: Flavonoids are one of the most important metabolites with vast structural diversity and a plethora of potential pharmacological applications, which have drawn considerable attention in the laboratory. Neverthe...
Natural aporphine alkaloids: A comprehensive review of phytochemistry, pharmacokinetics, anticancer activities, and clinical application [0.03%]
植物原阿朴菲生物碱的植物化学、药代动力学、抗肿瘤活性及临床应用综合述评
Jing Sun,Xingtian Zhan,Weimin Wang et al.
Jing Sun et al.
Background: Cancer is the most common cause of death and is still a serious public health problem. Alkaloids, a class of bioactive compounds widely diffused in plants, especially Chinese herbs, are used as functional ingr...
Discovery of new quaternized norharmane dimers as potential anti-MRSA agents [0.03%]
一类新的四甲基化二氢异博美满生物碱的发现及其抗MRSA活性研究
Jiang-Kun Dai,Wen-Jia Dan,Yi-Dan Cao et al.
Jiang-Kun Dai et al.
Introduction: Methicillin-resistant Staphylococcus aureus (MRSA)-caused infections greatly threaten public health. The discovery of natural-product-based anti-MRSA agents for treating infectious diseases has become one of...
ASIC1/RIP1 accelerates atherosclerosis via disrupting lipophagy [0.03%]
ASIC1/ RIP1通过干扰脂噬促进动脉粥样硬化的发展
Yuan-Mei Wang,Huang Tang,Ya-Jie Tang et al.
Yuan-Mei Wang et al.
Introduction: Atherosclerosis, a major contributor to cardiovascular disease, remains a significant health concern worldwide. While previous research has shown that acid-sensing ion channel 1 (ASIC1) impedes macrophage ch...
Maximizing crustaceans (shrimp, crab, and lobster) by-products value for optimum valorization practices: A comparative review of their active ingredients, extraction, bioprocesses and applications [0.03%]
最大化甲壳素副产品的价值：关于其活性成分、提取方法、生物过程和应用的综述式研究（以虾、蟹和龙虾为例）
Zuying Zhang,Zhenmin Ma,Lili Song et al.
Zuying Zhang et al.
Background: The processing of the three major crustaceans (shrimp, lobster, and crab) is associated with inevitable by-products, high waste disposal costs, environmental and human health issues, loss of multiple biomateri...