Targeting benign prostate hyperplasia treatments: AR/TGF-β/NOX4 inhibition by apocynin suppresses inflammation and proliferation [0.03%]
抑制AR/TGF-β/NOX4通路的黄酮类化合物阿朴香豆素靶向治疗良性前列腺增生炎症及增殖
Bo-Ram Jin,Hyo-Jung Kim,Jung-Hyun Na et al.
Bo-Ram Jin et al.
Introduction: Apocynin (Apo), an NADPH oxidase (NOX) inhibitor, has been widely used to treat various inflammatory diseases. However, the therapeutic effects of Apo on benign prostatic hyperplasia (BPH), a multifactorial ...
Fusobacterium nucleatum outer membrane vesicles activate autophagy to promote oral cancer metastasis [0.03%]
核梭杆菌外膜囊泡通过激活自噬促进口腔癌转移
Gang Chen,Chunna Gao,Shan Jiang et al.
Gang Chen et al.
Introduction: Metastasis is an important cause of high mortality and lethality of oral cancer. Fusobacterium nucleatum (Fn) can promote tumour metastasis. Outer membrane vesicles (OMVs) are secreted by Fn. However, the ef...
Environmental viromes reveal global virosphere of deep-sea sediment RNA viruses [0.03%]
环境病毒组揭示深海沉积物RNA病毒的全球病毒圈
Xinyi Zhang,Haitao Wan,Min Jin et al.
Xinyi Zhang et al.
Introduction: Viruses are the most abundant and diverse life forms on the earth. Both DNA viruses and RNA viruses play important roles in marine ecosystems via regulating biogeochemical cycles. ...
A novel tree shrew model of lipopolysaccharide-induced acute respiratory distress syndrome [0.03%]
一种新颖的内毒素诱导树鼩急性肺损伤模型
Jun He,Yue Zhao,Zhenli Fu et al.
Jun He et al.
Introduction: Acute respiratory distress syndrome (ARDS) is a leading cause of respiratory failure, with substantial attributable morbidity and mortality. The small animal models that are currently used for ARDS do not fu...
Persistent activation of Nrf2 in a p62-dependent non-canonical manner aggravates lead-induced kidney injury by promoting apoptosis and inhibiting autophagy [0.03%]
Nrf2持续活化通过促进细胞凋亡和抑制自噬加重铅诱导的肾脏损伤：一种p62依赖的非经典方式
Cai-Yu Lian,Bing-Xin Chu,Wei-Hao Xia et al.
Cai-Yu Lian et al.
Introduction: Lead (Pb) is an environmental toxicant that poses severe health risks to humans and animals, especially renal disorders. Pb-induced nephrotoxicity has been attributed to oxidative stress, in which apoptosis ...
Targeted m6A demethylation of ITGA6 mRNA by a multisite dCasRx-m6A editor inhibits bladder cancer development [0.03%]
靶向ITGA6 mRNA上的m6A甲基化位点的dCasRx-m6A编辑器抑制膀胱癌发展
Xiaoling Ying,Yapeng Huang,Bixia Liu et al.
Xiaoling Ying et al.
Introduction: N6-methyladenosine (m6A) modification contributes to the pathogenesis and development of various cancers, including bladder cancer (BCa). In particular, integrin α6 (ITGA6) promotes BCa progression by coope...
Shuqi Wang,Zehan Pang,Huahao Fan et al.
Shuqi Wang et al.
Background: Enterovirus A71 (EV-A71) is capable of causing hand, foot and mouth disease (HFMD), which may lead to neurological sequelae and even death. As EV-A71 is resistant to environmental changes and mutates easily, t...
Live and pasteurized Akkermansia muciniphila decrease susceptibility to Salmonella Typhimurium infection in mice [0.03%]
活和巴氏消毒的Akkermansia muciniphila可降低小鼠感染伤寒沙门氏菌的易感性
Jiaxiu Liu,Hongli Liu,Huanhuan Liu et al.
Jiaxiu Liu et al.
Introduction: The gut microbiome is vital for providing resistance against colonized pathogenicbacteria. Recently, specific commensal species have become recognized as important mediators of host defense against microbial...
Gossypium purpurascens genome provides insight into the origin and domestication of upland cotton [0.03%]
紫棉基因组揭示了陆地棉的起源和驯化
Yu Cheng,Chujun Huang,Yan Hu et al.
Yu Cheng et al.
Introduction: Allotetraploid upland cotton (Gossypium hirsutum L.) is native to the Mesoamerican and Caribbean regions, had been improved in the southern United States by the mid-eighteenth century, was then dispersed wor...
Silver nitroprusside as an efficient chemodynamic therapeutic agent and a peroxynitrite nanogenerator for targeted cancer therapies [0.03%]
银亚硝基铁氰化合物作为高效的化动治疗剂和过氧亚硝酸盐纳米发生器用于靶向癌症治疗
Kanwal Asif,Muhammad Adeel,Md Mahbubur Rahman et al.
Kanwal Asif et al.
Introduction: Chemodynamic therapy (CDT) holds great promise in achieving cancer therapy through Fenton and Fenton-like reactions, which generate highly toxic reactive species. However, CDT is limited by the lower amount ...