An integrated in vitro human iPSCs-derived neuron and in vivo animal approach for preclinical screening of anti-seizure compounds [0.03%]
一种针对抗癫痫化合物临床前筛选的体内外综合方法：基于人诱导多能干细胞来源神经元的体内动物模型研究
Chunfang Zhao,Ben Rollo,Muhammad Shahid Javaid et al.
Chunfang Zhao et al.
Introduction: One-third of people with epilepsy continue to experience seizures despite treatment with existing anti-seizure medications (ASMs). The failure of modern ASMs to substantially improve epilepsy prognosis has b...
Core genes of biomineralization and cis-regulatory long non-coding RNA regulate shell growth in bivalves [0.03%]
双壳类动物贝壳生长的生物矿化核心基因和顺式调控长非编码RNA
Maoxiao Peng,João C R Cardoso,Gareth Pearson et al.
Maoxiao Peng et al.
Introduction: Bivalve molluscs are abundant in marine and freshwater systems and contribute essential ecosystem services. They are characterized by an exuberant diversity of biomineralized shells and typically have two sy...
A next-generation dynamic programming language Julia: Its features and applications in biological science [0.03%]
一种下一代动态编程语言Julia及其在生物科学中的应用和特点分析
Soumen Pal,Manojit Bhattacharya,Snehasish Dash et al.
Soumen Pal et al.
Background: The advent of Julia as a sophisticated and dynamic programming language in 2012 represented a significant milestone in computational programming, mathematical analysis, and statistical modeling. Having reached...
Tetramethylpyrazine nitrone exerts neuroprotection via activation of PGC-1α/Nrf2 pathway in Parkinson's disease models [0.03%]
四甲基吡嗪硝酮通过激活PGC-1α/Nrf2信号通路发挥帕金森病模型中的神经保护作用
Baojian Guo,Chengyou Zheng,Jie Cao et al.
Baojian Guo et al.
Introduction: Parkinson's disease (PD) is common neurodegenerative disease where oxidative stress and mitochondrial dysfunction play important roles in its progression. Tetramethylpyrazine nitrone (TBN), a potent free rad...
Differences in alternative splicing and their potential underlying factors between animals and plants [0.03%]
动物和植物可变剪接的差异及其潜在影响因素分析
Yunfei Du,Lu Cao,Shuo Wang et al.
Yunfei Du et al.
Background: Alternative splicing (AS), a posttranscriptional process, contributes to the complexity of transcripts from a limited number of genes in a genome, and AS is considered a great source of genetic and phenotypic ...
HIF-1α inhibition by MO-2097, a novel chiral-free benzofuran targeting hnRNPA2B1 [0.03%]
一种新型光学纯苯并呋喃MO-2097通过靶向hnRNPA2B1抑制HIF-1α表达
Ho Jin Han,Aneesh Sivaraman,Minkyoung Kim et al.
Ho Jin Han et al.
Introduction: Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator mediating adaptive responses to hypoxia. It is up-regulated in the tumor microenvironment and recognized as an effective anticancer drug targ...
Activation of mitochondrial aldehyde dehydrogenase 2 promotes hair growth in human hair follicles [0.03%]
活化线粒体醛脱氢酶2可促进人体毛囊的生长
Seunghee Lee,Jungyoon Ohn,Bo Mi Kang et al.
Seunghee Lee et al.
Introduction: Hair loss is a common phenomenon associated with various environmental and genetic factors. Mitochondrial dysfunction-induced oxidative stress has been recognized as a crucial determinant of hair follicle (H...
Bo Qin,Dingsu Bao,Yang Liu et al.
Bo Qin et al.
Background: Due to the spatiotemporal complexity of the composition, structure, and cell population of the tendon-bone interface (TBI), it is difficult to achieve true healing. Recent research is increasingly focusing on ...
Teresa Matamá,Cristiana Costa,Bruno Fernandes et al.
Teresa Matamá et al.
Introduction: Natural hair curvature and colour are genetically determined human traits, that we intentionally change by applying thermal and chemical treatments to the fibre. Presently, those cosmetic methodologies act e...
T helper-1 activation via interleukin-16 is a key phenomenon in the acute phase of severe, first-episode major depressive disorder and suicidal behaviors [0.03%]
重症首次发作的重大抑郁障碍和自杀行为急性期的Th1活化通过白细胞介素-16是一个关键现象
Abbas F Almulla,Ali Abbas Abo Algon,Chavit Tunvirachaisakul et al.
Abbas F Almulla et al.
Background: Immune-inflammatory pathways in major depressive disorder are confined to the major dysmood disorder (MDMD) phenotype (Maes et al., 2022). No studies have addressed the immune profile of first episode MDMD (FE...