The exoprotein Gbp of Fusobacterium nucleatum promotes THP-1 cell lipid deposition by binding to CypA and activating PI3K-AKT/MAPK/NF-κB pathways [0.03%]
牙龈卟啉单胞菌的外分泌蛋白Gbp通过与Cyp A结合激活PI3K-AKT/MAPK/NF-κB信号通路促进THP-1细胞脂质沉积
Song Shen,Tianyong Sun,Xiangjiu Ding et al.
Song Shen et al.
Introduction: Growing evidence has shown the correlation between periodontitis and atherosclerosis, while our knowledge on the pathogenesis of periodontitis-promoting atherosclerosis is far from sufficient. ...
The miR-7/EGFR axis controls the epithelial cell immunomodulation and regeneration and orchestrates the pathology in inflammatory bowel disease [0.03%]
miR-7/EGFR轴调控上皮细胞免疫调节和再生并主导炎症性肠病的病理过程
Juanjuan Zhao,Mengmeng Guo,Yaping Yan et al.
Juanjuan Zhao et al.
Introduction: The epithelial immunomodulation and regeneration are intrinsic critical events against inflammatory bowel disease (IBD). MiR-7 is well documented as a promising regulator in the development of various diseas...
Tumor-infiltrating mast cells stimulate ICOS+ regulatory T cells through an IL-33 and IL-2 axis to promote gastric cancer progression [0.03%]
肿瘤浸润的肥大细胞通过IL-33和IL-2轴刺激ICOS+调节性T细胞，从而促进胃癌进展
Yipin Lv,Wenqing Tian,Yongsheng Teng et al.
Yipin Lv et al.
Introduction: In solid tumors, regulatory T cell (Treg) and mast cell perform different roles depending on the microenvironment. Nevertheless, mast cell and Treg-mediated interactions in gastric cancer (GC) are unclear, a...
Dietary neoagarotetraose extends lifespan and impedes brain aging in mice via regulation of microbiota-gut-brain axis [0.03%]
新型膳食糖 neoagarotetraose 通过调控菌群-肠-脑轴延缓小鼠寿命和脑衰老
Tao Li,Shaoqing Yang,Xiaoyan Liu et al.
Tao Li et al.
Introduction: Dietary oligosaccharides can impact the gut microbiota and confer tremendous health benefits. Objectives: The aim of this...
Suppression of hepatocellular carcinoma by Ulva lactuca ulvan via gut microbiota and metabolite interactions [0.03%]
海藻糖通过肠道微生物群和代谢物相互作用抑制肝细胞癌
Yinghui Qiu,Jingxiang Xu,Wei Liao et al.
Yinghui Qiu et al.
Introduction: Ulva lactuca polysaccharide (ULP) is green algae extract with numerous biological activities, including anticoagulant, anti-inflammatory, and antiviral effects. However, the inhibitory ability of ULP in the ...
Environmental viromes reveal the global distribution signatures of deep-sea DNA viruses [0.03%]
环境病毒组揭示深海DNA病毒的全球分布特征
Tianliang He,Min Jin,Pei Cui et al.
Tianliang He et al.
Introduction: Viruses are abundant and ecologically significant in marine ecosystems. However, the virome of deep-sea sediments is not extensively investigated. ...
Disturbances of purine and lipid metabolism in the microbiota-gut-brain axis in male adolescent nonhuman primates with depressive-like behaviors [0.03%]
抑郁样行为的青春期非人灵长类动物肠道微生物-肠-脑轴中嘌呤和脂质代谢紊乱
Teng Teng,Gerard Clarke,Jing Wu et al.
Teng Teng et al.
Introduction: Major depressive disorder (MDD) in adolescents is a widespread and growing global public health concern with unique characteristics and pathophysiological mechanisms that are distinct from MDD in adults. ...
Potential nutritional strategies to prevent and reverse sarcopenia in aging process: Role of fish oil-derived ω-3 polyunsaturated fatty acids, wheat oligopeptide and their combined intervention [0.03%]
潜在的营养策略可预防和逆转衰老过程中的肌肉减少症：鱼油衍生的ω-3多不饱和脂肪酸、小麦寡肽及其联合干预的作用
Da Pan,Ligang Yang,Xian Yang et al.
Da Pan et al.
Introduction: Nutritional support is potentially considered an essential step to prevent muscle loss and enhance physical function in older adults. Object...
ENOX2 inhibition enhances infiltration of effector memory T-cell and mediates response to chemotherapy in immune-quiescent nasopharyngeal carcinoma [0.03%]
ENOX2抑制可增强效应记忆T细胞浸润并介导免疫静息型鼻咽癌对化疗的应答
Ngar-Woon Kam,Olivier Laczka,Xiang Li et al.
Ngar-Woon Kam et al.
Introduction: The immunosuppressive tumor microenvironment is a major barrier for chemotherapy. Different chemosensitization approaches to reinstate immunological surveillance for cancers that are immune quiescent at the ...
Effect of anisotropy on deformation and crack formation under the brittle removal of 6H-SiC during SPDT process [0.03%]
各向异性对SPDT过程中6H-SiC脆性去除变形及裂纹形成的影响
Binbin Meng,Chen Li
Binbin Meng
Introduction: Monocrystal SiC is representative of the third generation semiconductor materials, the efficient process technology of 6H-SiC wafer have always been a hot topic. Developing a SPDT processing method based on ...