Comprehensive insights into potential roles of purinergic P2 receptors on diseases: Signaling pathways involved and potential therapeutics [0.03%]
全面了解嘌呤能P2受体在疾病中的潜在作用：涉及的信号通路和潜在治疗手段
Yanshuo Guo,Tianqi Mao,Yafei Fang et al.
Yanshuo Guo et al.
Background: Purinergic P2 receptors, which can be divided into ionotropic P2X receptors and metabotropic P2Y receptors, mediate cellular signal transduction of purine or pyrimidine nucleoside triphosphates and diphosphate...
Exercise-Induced Reduction of IGF1R Sumoylation Attenuates Neuroinflammation in APP/PS1 Transgenic Mice [0.03%]
运动通过减少APP / PS1转基因小鼠中IGF1R的SUMO化来减轻神经炎症
Yisheng Chen,Xiaofeng Chen,Zhiwen Luo et al.
Yisheng Chen et al.
Introduction: Alzheimer's Disease (AD), a progressive neurodegenerative disorder, is marked by cognitive deterioration and heightened neuroinflammation. The influence of Insulin-like Growth Factor 1 Receptor (IGF1R) and i...
Erianin serves as an NFATc1 inhibitor to prevent breast cancer-induced osteoclastogenesis and bone destruction [0.03%]
埃里安因作为NFATc1抑制剂预防乳腺癌诱发的破骨细胞生成及骨破坏作用
Jiehuang Zheng,Weili He,Yan Chen et al.
Jiehuang Zheng et al.
Introduction: Breast cancer-related bone metastasis can lead to skeletal-related events (SREs), which decrease patient quality of life. Inhibition of osteoclastogenesis is a key treatment for SREs; however, the availabili...
PPARs in atherosclerosis: The spatial and temporal features from mechanism to druggable targets [0.03%]
核受体PPARs在动脉粥样硬化中的时空特征从机制到药物靶点
Yi Zheng,Mingyan Shao,Yanfei Zheng et al.
Yi Zheng et al.
Background: Atherosclerosis is a chronic and complex disease caused by lipid disorder, inflammation, and other factors. It is closely related to cardiovascular diseases, the chief cause of death globally. Peroxisome proli...
Sympathetic innervation induces exosomal miR-125 transfer from osteoarthritic chondrocytes, disrupting subchondral bone homeostasis and aggravating cartilage damage in aging mice [0.03%]
交感神经介导的软骨细胞来源外泌体miR-125转移至软骨下骨破骨前体细胞，加重小鼠年龄相关性骨关节炎病理进展
Zhiyuan Guan,Yanbin Liu,Liying Luo et al.
Zhiyuan Guan et al.
Introduction: Osteoarthritis (OA) is a progressive disease that poses a significant threat to human health, particularly in aging individuals: Although sympathetic activation has been implicated in bone metabolism, its ro...
Decoding and reconstructing disease relations between dry eye and depression: a multimodal investigation comprising meta-analysis, genetic pathways and Mendelian randomization [0.03%]
干眼与抑郁症之间疾病关联的解码和重建：包含meta分析、遗传途径和孟德尔随机化的多模式调查
Kao-Jung Chang,Hsin-Yu Wu,Pin-Hsuan Chiang et al.
Kao-Jung Chang et al.
Introduction: The clinical presentations of dry eye disease (DED) and depression (DEP) often comanifest. However, the robustness and the mechanisms underlying this association were undetermined. ...
Ribociclib leverages phosphodiesterase 4 inhibition in the treatment of neutrophilic inflammation and acute respiratory distress syndrome [0.03%]
核糖酸 cyclin D 拮抗剂通过抑制磷酸二酯酶 4 治疗中性粒细胞炎症和急性呼吸窘迫综合征
Po-Jen Chen,Shun-Hua Chen,Yu-Li Chen et al.
Po-Jen Chen et al.
Introduction: Overwhelming neutrophil activation and oxidative stress significantly contribute to acute respiratory distress syndrome (ARDS) pathogenesis. However, the potential of repurposing ribociclib, a cyclin-depende...
Multiplexed PLGA scaffolds with nitric oxide-releasing zinc oxide and melatonin-modulated extracellular vesicles for severe chronic kidney disease [0.03%]
负载释放一氧化氮的锌 oxide 和褪黑素调节的外泌体的 PLGA 多重化支架用于严重慢性肾脏病
Won-Kyu Rhim,Jiwon Woo,Jun Yong Kim et al.
Won-Kyu Rhim et al.
Introduction: With prevalence of chronic kidney disease (CKD) in worldwide, the strategies to recover renal function via tissue regeneration could provide alternatives to kidney replacement therapies. However, due to rela...
Long-term and short-term cardiovascular disease mortality among patients of 21 non-metastatic cancers [0.03%]
21种无转移癌症患者的长期和短期心血管病死亡率
Tianwang Guan,Olivia Monteiro,Dongting Chen et al.
Tianwang Guan et al.
Introduction: Previous studies on cardiovascular disease (CVD) death risk in cancer patients mostly focused on overall cancer, age subgroups and single cancers. ...
Rapid discrimination and ratio quantification of mixed antibiotics in aqueous solution through integrative analysis of SERS spectra via CNN combined with NN-EN model [0.03%]
基于CNN结合NN-EN模型的拉曼光谱整合分析鉴别并定量水溶液中的抗生素混合物
Quan Yuan,Lin-Fei Yao,Jia-Wei Tang et al.
Quan Yuan et al.
Introduction: Abusing antibiotic residues in the natural environment has become a severe public health and ecological environmental problem. The side effects of its biochemical and physiological consequences are severe. T...