The NLRP3 molecule influences the therapeutic effects of mesenchymal stem cells through Glut1-mediated energy metabolic reprogramming [0.03%]
NLRP3分子通过Glut1介导的代谢重组影响间充质干细胞的治疗效果
Jingrou Chen,Shujuan Xie,Dongbo Qiu et al.
Jingrou Chen et al.
Introduction: Numerous studies demonstrated that NLRP3 has been implicated in the pathogenesis of inflammatory bowel disease (IBD). Mesenchymal stem cells (MSCs) regulated the NLRP3 inflammasome, which has emerged as a no...
Genomic insights into the contribution of de novo lipogenesis to intramuscular fat deposition in chicken [0.03%]
基因组学视角下鸡肌肉内新脂肪合成的贡献分析
Huanxian Cui,Yongli Wang,Yuting Zhu et al.
Huanxian Cui et al.
Introduction: The proportion of animal based foods in daily diet of consumers is constantly increasing, with chicken being highly favored due to its high protein and low fat characteristics. The consumption of chicken aro...
Genetic linkage analysis of stable QTLs in Gossypium hirsutum RIL population revealed function of GhCesA4 in fiber development [0.03%]
基于Gossypium hirsutum近等基因系群体的稳定QTL遗传连锁分析及纤维发育中纤维素合酶Ⅳ(GhCesA4)功能研究
Ruìxián Liú,Xiànghuī Xiāo,Jǔwǔ Gōng et al.
Ruìxián Liú et al.
Introduction: Upland cotton is an important allotetrapolyploid crop providing natural fibers for textile industry. Under the present high-level breeding and production conditions, further simultaneous improvement of fiber...
Yong Zhou,Yang Jin,Tianyu Wu et al.
Yong Zhou et al.
Background: The reportedly high mutation rate of mitochondrial DNA (mtDNA) may be attributed to the absence of histone protection and complete repair mechanisms. Mitochondrial heteroplasmy refers to the coexistence of wil...
Biological potential and mechanisms of Tea's bioactive compounds: An Updated review [0.03%]
茶叶生物活性成分的生物学潜力及机制：综述更新
Qiaoxian Luo,Longbiao Luo,Jinmin Zhao et al.
Qiaoxian Luo et al.
Background: Tea (Camellia sinensis) has a rich history and is widely consumed across many countries, and is categorized into green tea, white tea, oolong tea, yellow tea, black tea, and dark tea based on the level of ferm...
Antibody-antibiotic conjugate targeted therapy for orthopedic implant-associated intracellular S. aureus infections [0.03%]
靶向疗法治疗骨科植入物相关细胞内金黄色葡萄球菌感染
Leilei Qin,Ning Hu,Yanhao Zhang et al.
Leilei Qin et al.
Introduction: Treating orthopedic implant-associated infections, especially those caused by Staphylococcus aureus (S. aureus), remains a significant challenge. S. aureus has the ability to invade host cells, enabling it t...
The male and female genomes of golden pompano (Trachinotus ovatus) provide insights into the sex chromosome evolution and rapid growth [0.03%]
金线鱼雌雄基因组的组装及性别分化研究
Honglin Luo,Yongde Zhang,Fuyan Liu et al.
Honglin Luo et al.
Introduction: Golden pompano (Trachinotus ovatus) is economically significant important for offshore cage aquaculture in China and Southeast Asian countries. Lack of high-quality genomic data and accurate gene annotations...
An interpretable artificial intelligence framework for designing synthetic lethality-based anti-cancer combination therapies [0.03%]
一种用于设计合成致死型抗癌症联合疗法的可解释人工智能框架
Jing Wang,Yuqi Wen,Yixin Zhang et al.
Jing Wang et al.
Introduction: Synthetic lethality (SL) provides an opportunity to leverage different genetic interactions when designing synergistic combination therapies. To further explore SL-based combination therapies for cancer trea...
CircMap4k2 reactivated by aneurysm plication alleviates residual cardiac remodeling after SVR by enhancing cardiomyocyte proliferation in post-MI mice [0.03%]
通过动脉瘤折叠重新激活的CircMap4k2通过增强心肌细胞增殖减轻MI后SVR小鼠残余心脏重塑
Junyu Yan,Chenzhi Ai,Qi Chen et al.
Junyu Yan et al.
Introduction: Surgical ventricular reconstruction (SVR) is an alternative therapeutic approach in patients with refractory heart failure (HF), but residual remodeling after SVR limits the improvement of HF. Recently, we r...
Machine learning approach reveals microbiome, metabolome, and lipidome profiles in type 1 diabetes [0.03%]
机器学习方法揭示1型糖尿病微生物组、代谢组和脂质体特征
Huiling Tan,Yu Shi,Tong Yue et al.
Huiling Tan et al.
Introduction: Type 1 diabetes (T1D) is a complex disorder influenced by genetic and environmental factors. The gut microbiome, the serum metabolome, and the serum lipidome have been identified as key environmental factors...