Small molecules reprogram reactive astrocytes into neuronal cells in the injured adult spinal cord [0.03%]
小分子可将受损脊髓中反应性星形胶质细胞重编程为神经元细胞
Zijian Tan,Shangyao Qin,Hong Liu et al.
Zijian Tan et al.
Introduction: Ectopic expression of transcription factor-mediated in vivo neuronal reprogramming provides promising strategy to compensate for neuronal loss, while its further clinical application may be hindered by deliv...
Bile acid and nonalcoholic steatohepatitis: Molecular insights and therapeutic targets [0.03%]
bile acid和非酒精性脂肪肝病：分子见解和治疗靶点
Zilu Cheng,Yixiong Chen,Bernd Schnabl et al.
Zilu Cheng et al.
Background: Nonalcoholic steatohepatitis (NASH) has been the second most common cause of liver transplantation in the United States. To date, NASH pathogenesis has not been fully elucidated but is multifactorial, involvin...
Xinyue Xu,Jia Wang,Yunlong Xia et al.
Xinyue Xu et al.
Background: Oral health is of fundamental importance to maintain systemic health in humans. Stem cell-based oral tissue regeneration is a promising strategy to achieve the recovery of impaired oral tissue. As a highly con...
Gut microbial GABAergic signaling improves stress-associated innate immunity to respiratory viral infection [0.03%]
肠道微生物的GABA能信号传导可提高应激相关呼吸道病毒感染的固有免疫反应
Yanan Gao,Zihao Liang,Bingyong Mao et al.
Yanan Gao et al.
Introduction: Epidemiological evidences reveal that populations with psychological stress have an increased likelihood of respiratory viral infection involving influenza A virus (IAV) and SARS-CoV-2. ...
Two aminopeptidase I homologs convergently contribute to pathobiology of fungal entomopathogen Beauveria bassiana via divergent physiology-dependent autophagy pathways for vacuolar targeting [0.03%]
两种同源的氨基肽酶I通过不同的自噬途径汇聚成虫真菌病原 Beauveria bassiana 的病理生物学
Jin-Li Ding,Kang Wei,Ming-Guang Feng et al.
Jin-Li Ding et al.
Introduction: In yeast, the cytoplasm-to-vacuole targeting (Cvt) pathway acts as a biosynthetic autophagy-related process, in which vacuolar targeting of hydrolase is mediated by the machineries involved in the selective ...
Effects of lifestyle and associated diseases on serum CC16 suggest complex interactions among metabolism, heart and lungs [0.03%]
生活方式及伴发疾病对血清CL16的影响提示代谢、心肺复杂的相互作用
Nathalie Rohmann,Paula Stürmer,Corinna Geisler et al.
Nathalie Rohmann et al.
Introduction: Clara cell 16-kDa protein (CC16) is an anti-inflammatory, immunomodulatory secreted pulmonary protein with reduced serum concentrations in obesity according to recent data. ...
Inhibition of oxidative stress-induced epithelial-mesenchymal transition in retinal pigment epithelial cells of age-related macular degeneration model by suppressing ERK activation [0.03%]
通过抑制ERK激活抑制氧化应激诱导的年龄相关性黄斑变模型视网膜色素上皮细胞间充质化转移
Ya-Chi Yang,Yueh Chien,Aliaksandr A Yarmishyn et al.
Ya-Chi Yang et al.
Introduction: Epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells is related to the pathogenesis of various retinopathies including age-related macular degeneration (AMD). Oxidative stress is...
The ubiquitin-like protein FAT10 in hepatocellular carcinoma cells limits the efficacy of anti-VEGF therapy [0.03%]
肝细胞癌中泛素样蛋白FAT10通过限制抗VEGF疗效促进肝细胞癌进展
Yumin Qiu,Ben Che,Wenming Zhang et al.
Yumin Qiu et al.
Introduction: The efficacy of anti-vascular endothelial growth factor (VEGF) therapy is limited. However, the key factors involved in limiting the efficacy of anti-VEGF therapy and the underlying mechanisms remain unclear...
HMGB1/STAT3/p65 axis drives microglial activation and autophagy exert a crucial role in chronic Stress-Induced major depressive disorder [0.03%]
HMGB1/STAT3/p65轴驱动的小胶质细胞活化及自噬在慢性应激诱导的重大抑郁症中发挥关键作用
Ke Xu,Mingyang Wang,Haiyang Wang et al.
Ke Xu et al.
Introduction: Neuroinflammation and autophagy are implicated in stress-related major depressive disorder (MDD), but the underlying molecular mechanisms remain largely unknown. ...
CRISPR/Cas9 based gene editing of Frizzled class receptor 6 (FZD6) reveals its role in depressive symptoms through disrupting Wnt/β-catenin signaling pathway [0.03%]
基于CRISPR / Cas9的基因编辑发现Frizzled类受体6（FZD6）通过破坏Wnt / β-链蛋白信号通路在抑郁症中的作用
Haijun Han,Mengxiang Xu,Ju Wang et al.
Haijun Han et al.
Introduction: As one of the common psychiatric diseases, depression poses serious threats to human health. Although many genes have been nominated for depression, few of them were investigated in details at the molecular ...