Antiviral activity and mechanism of purine morpholine nucleoside analogues incorporating a sulfonamide fragment [0.03%]
含磺酰胺片段的嘌呤吗啉核苷类似物的抗病毒活性及作用机制研究
Yuyuan Yang,Runjiang Song,Shaobo Wang et al.
Yuyuan Yang et al.
Introduction: Pepper mild mottle virus (PMMoV) poses an enormous threat to pepper production because of its high infectivity and soil persistence. Commercially available antiviral agents, ningnanmycin and ribavirin, have ...
Single-cell and spatial transcriptome profiling identifies cellular heterogeneity and immunosuppressive tumor microenvironment in inflammatory breast cancer [0.03%]
单细胞及空间转录组分析揭示炎性乳腺癌的异质性和免疫抑制微环境
Xueni Sun,Jing Xia,Haiyang Jiang et al.
Xueni Sun et al.
Introduction: Inflammatory breast cancer (IBC) is a highly aggressive subtype of breast cancer associated with a poor prognosis. A better understanding of IBC's pathological and molecular basis is crucial for developing p...
Enhancement of NK cell activity via DNA-sensing inhibition by Poxin transgene [0.03%]
通过正痘病毒基因Poxin抑制DNA感知来增强NK细胞活性
Ling-Zu Kong,Seok-Min Kim,Soo Yun Lee et al.
Ling-Zu Kong et al.
Introduction: Natural Killer (NK) cell therapy has shown strong potential for cancer treatment; however, NK cell efficacy is limited by their short lifespan and suppression within the tumor microenvironment. One factor co...
Nano-priming with selenium nanoparticles reprograms seed germination, antioxidant defense, and phenylpropanoid metabolism to enhance Fusarium graminearum resistance in maize seedlings [0.03%]
硒纳米颗粒介导的种子纳米启动子重编程谷物发芽、抗氧化防御和苯丙烷代谢以提高玉蜀黍属植物幼苗的抗病性
Qinyong Dong,Tingjie Huang,Chunran Zhou et al.
Qinyong Dong et al.
Introduction: Fusarium graminearum (F. graminearum) threatens maize through stem rot and deoxynivalenol (DON) contamination. Conventional approaches like chemical seed coatings are constrained by limited long-term efficac...
Basophilic exosomes promote SLE development via exacerbating B cell activation through the lncRNA ENST00000537616/miR-330-5p/KRAS axis [0.03%]
basophil-derived exosomal lncRNA ENST00000537616通过miR-330-5p/KRAS轴促进B细胞活化从而加剧系统性红斑狼疮的发展
Jiaxuan Chen,Shuxian Chen,Kangyuan Shen et al.
Jiaxuan Chen et al.
Introduction: Uncontrolled B-cell activation in systemic lupus erythematosus (SLE) induces autoantibody production and inflammation and causes tissue damage. Basophils have been shown to promote B cell activation in SLE; ...
S100B induces angiogenesis via the clathrin/FOXO1/β-catenin signaling pathway and contributes to Bevacizumab resistance in epithelial ovarian cancer [0.03%]
S100B通过网格蛋白/FOXO1/β-连环蛋白信号通路诱导血管生成并导致贝伐单抗耐药在卵巢上皮癌中的作用
Haoya Xu,Wenzhi Li,Huiran Yue et al.
Haoya Xu et al.
Introduction: Bevacizumab (BEV), the most common antiangiogenic agent for treating ovarian cancer, prolongs progression-free survival (PFS) but does not significantly improve overall survival (OS). Improving the limited c...
Prenatal supplementation with the gut-derived tryptophan metabolite indole-3-propionic acid alleviates colitis susceptibility in maternal immune-activated offspring mice [0.03%]
母体免疫激活后代小鼠肠道衍生色氨酸代谢产物丁酸异丙酯的产前补充剂可减轻结肠炎易感性
Ying He,Chen Ding,Bo Zhang et al.
Ying He et al.
Introduction: Maternal immune activation (MIA) impairs gut immune function in offspring, with maternal microbiota and their metabolites influencing intestinal development. Indole-3-propionic acid (IPA), a microbial metabo...
Parasympathetic pathway in melatonin regulation exogenous melatonin alleviates abnormal glucose metabolism in the breast muscle under long-term light exposure through the parasympathetic pathway [0.03%]
褪黑素调节副交感神经通路外源性褪黑素通过副交感神经通路缓解长期光照下胸部肌肉异常糖代谢
Miao Yu,Mengjie Xu,Guangju Wang et al.
Miao Yu et al.
Introduction: Human beings and animals have been exposed to long-term artificial lighting environments to induce glucose metabolism disorder. Melatonin (MT) is involved in the regulation of glucolipid metabolism, and can ...
Ciliary IFT88 inhibits intervertebral disc degeneration under excessive mechanical stress by regulating endplate cartilage calcification [0.03%]
纤毛IFT88通过调节终板软骨钙化抑制机械应力过载诱发的椎间盘退变
Zhi-Rui Dong,Jing Wang,Yu-Kai Huang et al.
Zhi-Rui Dong et al.
Introduction: Endplate cartilage is crucial for nutrient transport to intervertebral disc (IVD), and its calcification due to abnormal mechanical stress significantly contributes to intervertebral disc degeneration (IDD)....
Genomic landscape of paired primary and peritoneal metastatic lesions in gastric cancer highlights evolutionary dynamics and mutational drivers [0.03%]
配对胃癌原发灶和腹膜转移灶的基因组景观揭示了进化动力学和突变驱动因素
Song Li,Weiwei Zhang,Qian Yang et al.
Song Li et al.
Introduction: Peritoneal metastasis is a prevalent form of gastric cancer spread, often resulting in poor outcomes. Due to the lack of clinical recommendation for surgery, current omics studies are limited to analyzing su...