Structural optimization and functional evaluation of cytisine for redox homeostasis regulation in lung cancer cells [0.03%]
用于肺癌细胞氧化还原稳态调节的番木鳖碱的结构优化及功能评价
Zhicui Qin,Zilu Xin,Xueli Zhang et al.
Zhicui Qin et al.
Introduction: Targeting redox homeostasis represents a promising strategy to selectively eliminate cancer cells through oxidative stress-mediated apoptosis. However, developing specific molecular entities capable of effec...
Lactylation at the metabolic-epigenetic interface in cardiovascular diseases: context-dependent mechanisms and translational roadmap [0.03%]
代谢表观遗传界面中乳酰化的心血管疾病研究：上下文依赖机制和转化路线图
Guilin Cheng,Yan Liu,Yangkun Xing et al.
Guilin Cheng et al.
Background: Lysine lactylation has redefined lactate's biological role from a metabolic byproduct to a signaling molecule. This post-translational modification directly couples cellular energetics with gene regulation, cr...
Escherichia coli expressing the kpsM gene exacerbates drug-induced liver injury through up-regulating α1,2-fucosyltransferase and disturbing the host taurine metabolism-from animal models and clinical studies [0.03%]
携带kpsM基因的大肠杆菌通过上调α-1,2岩藻糖基转移酶和干扰宿主牛磺酸代谢来加剧药物性肝损伤：从动物模型到临床研究
Wenkang Gao,Shengqi Yan,Li Zhang et al.
Wenkang Gao et al.
Background and aims: Drug-induced liver injury (DILI) is a leading cause of acute liver failure. Patients with DILI have disorders of the gut microbiota, yet little is known about the influence of gut microbes on this dis...
Ogt-mediated KDM6B O-GlcNAcylation regulates histone demethylation and alleviates osteoarthritis [0.03%]
OGT介导的KDM6B O-连接-N-乙酰葡萄糖胺化调节组蛋白去甲基化并缓解骨关节炎
Xiang Gao,Hang Liu,Jianming Guo et al.
Xiang Gao et al.
Objective: Osteoarthritis (OA) is a common orthopedic disease characterized by cartilage degeneration, osteophyte formation, and synovial hyperplasia. Although dysregulated O-GlcNAcylation has been implicated in various m...
Nrf2 deficiency in myeloid cells accelerates atherosclerosis by promoting the inflammatory response and impairing efferocytosis [0.03%]
髓系细胞Nrf2缺乏通过促进炎症反应和抑制吞噬作用加速动脉粥样硬化形成
Xiaoge Xu,Cuijie Liu,Jinshan Bo et al.
Xiaoge Xu et al.
Introduction: Atherosclerotic lesions are the fundamental pathologies of cardiovascular diseases. The exact role of the nuclear factor erythroid 2-related factor 2 (NRF2) in macrophages in atherosclerosis remains uncertai...
Ursolic acid reduces Aβ-driven aggression via Gab1-mediated autophagy and dorsal hippocampal circuit modulation in Alzheimer's disease [0.03%]
乌索lic酸通过Gab1介导的自噬和背侧海马环路调节减少阿尔茨海默病中Aβ驱动的攻击行为
Guilin Pi,Lijuan Zhang,Huiyang Lei et al.
Guilin Pi et al.
Introduction: Aggression is one of the most debilitating neuropsychiatric symptoms in Alzheimer's disease (AD), posing significant challenges for both patients and caregivers. However, the underlying mechanism remains unc...
Development and validation of dynamic clinical subphenotypes for acute pancreatitis using hematocrit and blood urea nitrogen trajectories in intensive care unit: a multicenter retrospective cohort study [0.03%]
采用血红蛋白和血液尿素氮轨迹在重症监护病房开发并验证急性胰腺炎临床亚型：一项基于多中心回顾性队列研究
Jianhua Wan,Maobin Kuang,Shixuan Xiong et al.
Jianhua Wan et al.
Background: Acute Pancreatitis (AP) is a common gastrointestinal emergency in which early fluid therapy is critical, yet optimal strategies remain debated. Although Hematocrit (HCT) and Blood Urea Nitrogen (BUN) are recom...
The serine Protease-Serine protease inhibitor regulatory network in inflammatory bowel Disease: From molecular mechanisms to novel therapeutic Horizons [0.03%]
炎性肠病中丝氨酸蛋白酶-丝氨酸蛋白酶抑制剂调控网络：从分子机制到新的治疗前景
Qinrong Li,Huilan Ye,Rirong Chen et al.
Qinrong Li et al.
Background: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract that presents a significant global health challenge. Although its exact etiology remains unclear, growing evide...
Tryptophan metabolism in tumor microenvironment and therapeutic implications [0.03%]
肿瘤微环境中色氨酸代谢与治疗意义
Junjie Wen,Junqing Jiang,Xianglong Ma et al.
Junjie Wen et al.
Background: Tryptophan (Trp) catabolism has been recognized as a key immunosuppressive axis in cancer. However, this largely centered on indoleamine-2,3-dioxygenase 1 (IDO1). The clinical failure of IDO1 inhibitors has ex...
Corrigendum to "Enhanced LRP8 expression induced by Helicobacter pylori drives gastric cancer progression by facilitating β-Catenin nuclear translocation". [J. Adv. Res. 69 (2025) 299-312] [0.03%]
“Helicobacter pylori诱导的LRP8表达增强通过促进β-catenin核转位促进胃癌进展”的勘误[J Advances Res, 69 (2025) 299-312 ]
Bin Liu,Ihtisham Bukhari,Fazhan Li et al.
Bin Liu et al.