Silk_40K SNP array facilitates the genomic prediction of complex traits in silkworm (Bombyx mori) [0.03%]
一种家蚕(Bombyx mori)40K重测序芯片用于复杂性状的基因组选择研究
Chunlin Li,Xiaoling Tong,Rui Gao et al.
Chunlin Li et al.
Introduction: It is highly attractive to use silkworms producing natural fibres with excellent properties and insect-based nutrients on a large scale. Traits related to these often have complex genetic bases. Genomic sele...
Graphene mesosponge: a novel material for the sequestration of azo dyes in water [0.03%]
石墨烯介观海绵：水中偶氮染料封存新型材料
Amrita Jain,Chandni Kumar,Peter Škorňa et al.
Amrita Jain et al.
Azo dyes are synthetic organic compounds widely used in industries such as textiles, printing, and pharmaceuticals. Due to their chemical stability and extensive usage, they are significant environmental pollutants, especially in wastewater...
A medium throughput approach for single cell copy number variation sequencing towards efficient application in clinics [0.03%]
一种单细胞拷贝数变异测序中通量方法的建立及其在临床应用中的可行性研究
Guanchuan Lin,Caiming Chen,Mengchang Xu et al.
Guanchuan Lin et al.
Introduction: Single-cell copy number variation sequencing (scCNV-seq) is pivotal for genomic analysis. However, existing methods rely on whole-genome preamplification, suffering from high cost and biased CNV calling. The...
Neddylation: from regulatory mechanisms to clinical implications in cancer [0.03%]
Neddylation在癌症中的调控机制及临床意义
Ming Zhang,Peng Qiu,Yunxiang Feng et al.
Ming Zhang et al.
Background: Neddylation is a critical post-translational modification that is frequently hyperactivated in various human cancers. By modifying key substrates such as Cullins and non-Cullin proteins, this pathway plas a ce...
SPINK1-Driven cellular heterogeneity and interaction Networks in intrahepatic cholangiocarcinoma revealed by integrated multi-omics analysis [0.03%]
整合多组学分析揭示的肝内胆管癌中由SPINK1驱动的细胞异质性和互作网络
Xiaoxiang Rong,Jiayun Guan,Chanqi Ye et al.
Xiaoxiang Rong et al.
Introduction: Intrahepatic cholangiocarcinoma (ICC) is a highly heterogeneous and aggressive malignancy with poor prognosis and limited treatment options. The lack of precise molecular classification and incomplete unders...
Unraveling competitive protein interactions: A critical step toward improved production and therapeutics [0.03%]
解开竞争性蛋白质相互作用的谜团：提高生产和治疗效果的关键步骤
Yuan Tian,Xiao-Yue Zhang,Mehtab Muhammad Aslam et al.
Yuan Tian et al.
Competitive protein binding plays a pivotal role in regulating biological processes by influencing how proteins interact with shared ligands or binding sites. Despite its importance, this mechanism often receives limited attention in broade...
Menggui Zeng,Bingxue Jin,Lingfeng Liu
Menggui Zeng
Introduction: With the rapid proliferation of image information, the challenges associated with image storage and transmission have become increasingly prominent. Image compression a crucial strategy to address these issu...
Loss of Slc39a5 in α-cells impairs glucose metabolism by chronically increasing glucagon [0.03%]
SLC39A5缺失通过增加胰高血糖素而损害α细胞中的葡萄糖代谢
Wenli Chen,Weiyi Cui,Yan Xu et al.
Wenli Chen et al.
Introduction: Glucagon is a critical regulator of glucose homeostasis by regulating liver glycogenolysis and gluconeogenesis. Hyperglucagonemia has been observed in patients with type 2 diabetes mellitus (T2DM). However, ...
Wogonin, a bioactive flavonoid from Scutellaria baicalensis, alleviates alcoholic pancreatitis via AMPK-mediated TFEB activation [0.03%]
从黄芩中提取的生物活性黄酮化合物-染料木素通过AMPK介导的TFEB活化缓解酒精性胰腺炎
Zhen Qin,Xiaohong Sun,Jingmin Zeng et al.
Zhen Qin et al.
Introduction: Transcription factor EB (TFEB) deficiency contributes to insufficient autophagic degradation, resulting in zymogen granule (ZG) accumulation and subsequent premature activation, which underlies the pathogene...
Depression remodels tumor microenvironment to drive tumor progression: Bio-behavioural signalling pathways and clinical interventions [0.03%]
抑郁症重塑肿瘤微环境以促进肿瘤进展：生物行为信号通路与临床干预措施
Mengkai Ge,Wenjin Zhang,Wenlong Zhang et al.
Mengkai Ge et al.
Background: Depression, chronic stress, fear, and anxiety have been implicated as major risk factors in tumor growth, invasion, and metastasis. These psychological conditions stimulate the secretion of neurotransmitters a...