DeepB3P: A transformer-based model for identifying blood-brain barrier penetrating peptides with data augmentation using feedback GAN [0.03%]
基于Transformer的DeepB3P模型：使用反馈GAN数据增强的方法识别穿透血脑屏障的多肽
Qiang Tang,Wei Chen
Qiang Tang
Introduction: The blood-brain barrier (BBB) serves as a critical structural barrier and impedes the entry of most neurotherapeutic drugs into the brain. This poses substantial challenges for central nervous system (CNS) d...
Development of modern Chinese medicine guided by molecular compatibility theory [0.03%]
基于分子配伍理论的现代中药研发新模式
Lifeng Luo,Jieru Zhou,Xiaonan Liu et al.
Lifeng Luo et al.
Background: Traditional Chinese Medicine (TCM) has gained global attention, particularly after Professor Youyou Tu was awarded the Nobel Prize for her discovery of artemisinin as a treatment for malaria. However, the theo...
Pharmacological inhibition of Septins with Forchlorfenuron attenuates thrombus formation in experimental thrombotic mice models with modulating multiple signaling pathways in platelets [0.03%]
Septin药理学抑制剂Forchlorfenuron通过调节多种信号通路减轻实验性血栓模型中小鼠的血栓形成
Zhen Hao,Minghui Yan,Reyisha Tuerhong et al.
Zhen Hao et al.
Introduction: The Septin family of cytoskeletal proteins is abundant in platelets. When these proteins are functionally blocked using the compound forchlorfenuron (FCF), it hampers the normal activation processes of purif...
Loss of Nup155 promotes high fructose-driven podocyte senescence by inhibiting INO80 mRNA nuclear export [0.03%]
Nup155丢失通过抑制INO80 mRNA核输出促进高果糖驱动的足细胞衰老
Li Chen,Tangdi Xu,Zixuan Wang et al.
Li Chen et al.
Introduction: Podocyte senescence causes podocyte loss and glomerulopathy. Excessive fructose intake is a risk factor for podocyte injury. However, whether high fructose promotes podocyte senescence remains unknown. ...
ST6GALNAC1-mediated sialylation in uterine endometrial epithelium facilitates the epithelium-embryo attachment [0.03%]
ST6GALNAC1介导的子宫内膜上皮岩藻糖基化促进上皮-胚胎黏附
Xinyue Dong,Hao Wang,Jinxuan Cai et al.
Xinyue Dong et al.
Introduction: Embryo implantation requires synergistic interaction between the embryo and the receptive endometrium. Glycoproteins and glycan-binding proteins are involved in endometrium-embryo attachment. Sialyl Tn (sTn)...
Impacts of parental genomic divergence in non-syntenic regions on cotton heterosis [0.03%]
亲本非同源区间基因组差异对棉花杂种优势的影响
Chujun Huang,Yu Cheng,Yan Hu et al.
Chujun Huang et al.
Introduction: Heterosis has revolutionized crop breeding, enhancing global agricultural production. However, the mechanisms underlying heterosis remain obscure. Xiangzamian 2# (XZM2), a super hybrid upland cotton (Gossypi...
Short-chain fatty acid butyrate against TMAO activating endoplasmic-reticulum stress and PERK/IRE1-axis with reducing atrial arrhythmia [0.03%]
短链脂肪酸丁酸通过激活内质网应激和PERK/IRE1轴来对抗TMAO并减少心房颤动
Tzu-Yu Cheng,Ting-Wei Lee,Shao-Jung Li et al.
Tzu-Yu Cheng et al.
Introduction: The accumulation of microbiota-derived trimethylamine N-oxide (TMAO) in the atrium is linked to the development and progression of atrial arrhythmia. Butyrate, a major short-chain fatty acid, plays a crucial...
Histone deacetylases facilitate Th17-cell differentiation and pathogenicity in autoimmune uveitis via CDK6/ID2 axis [0.03%]
组蛋白去乙酰化酶通过CDK6/ID2轴促进自身免疫性虹膜炎中Th17细胞的分化和致病性
Chun Zhang,Xiuxing Liu,Chenyang Gu et al.
Chun Zhang et al.
Introduction: Autoimmune uveitis (AU) is a prevalent ocular autoimmune disease leading to significant visual impairment. However, underlying pathogenesis of AU required to develop more efficient therapy remain unclear. ...
Deciphering the dynamic expression network of fiber elongation and the functional role of the GhTUB5 gene for fiber length in cotton based on an introgression population of upland cotton [0.03%]
基于陆地棉导入群体解析纤维伸长动态表达网络及GhTUB5基因的增长效用
Jianjiang Ma,Liupeng Yang,Yuanyue Dang et al.
Jianjiang Ma et al.
Introduction: Interspecific introgression between Gossypium hirsutum and G. barbadense allows breeding cotton with outstanding fiber length (FL). However, the dynamic gene regulatory network of FL-related genes has not be...
GDF11 protects against mitochondrial-dysfunction-dependent NLRP3 inflammasome activation to attenuate osteoarthritis [0.03%]
GDF11通过保护线粒体功能依赖的NLRP3炎性小体活化来缓解骨关节炎
Pengfei Zhang,Haoxin Zhai,Shuai Zhang et al.
Pengfei Zhang et al.
Introduction: Osteoarthritis (OA) is a highly prevalent degenerative disease worldwide, and tumor necrosis factor (TNF-α) is closely associated with its development. Growth differentiation factor 11 (GDF11) has demonstra...