ANGPTL3 accelerates atherosclerotic progression via direct regulation of M1 macrophage activation in plaque [0.03%]
血管生成素样蛋白3通过直接调控斑块内M1型巨噬细胞活化促进动脉粥样硬化进展
Yuejie Zhang,Cen Yan,Yuan Dong et al.
Yuejie Zhang et al.
Introduction: The N-terminal domain of angiopoietin-like protein 3 (ANGPTL3) inhibits lipoprotein lipase activity. Its C-terminal fibrinogen-like (FBN) domain is a ligand of macrophage integrin αvβ3. ...
Organellophagy regulates cell death:A potential therapeutic target for inflammatory diseases [0.03%]
细胞器自噬调控细胞死亡：炎症疾病潜在的治疗靶点
Yu Duan,Ren-Qi Yao,Hua Ling et al.
Yu Duan et al.
Background: Dysregulated alterations in organelle structure and function have a significant connection with cell death, as well as the occurrence and development of inflammatory diseases. Maintaining cell viability and in...
Biogeography of intestinal mucus-associated microbiome: Depletion of genus Pseudomonas is associated with depressive-like behaviors in female cynomolgus macaques [0.03%]
肠道粘液相关微生物群的生物地理学：肠道假单胞菌属耗竭与雌性猕猴类似抑郁行为有关
Xunmin Tan,Jing Wu,Hanping Zhang et al.
Xunmin Tan et al.
Introduction: Depression is a debilitating and poorly understood mental disorder. There is an urgency to explore new potential biological mechanisms of depression and the gut microbiota is a promising research area. ...
Quercetin, a natural flavonoid, protects against hepatic ischemia-reperfusion injury via inhibiting Caspase-8/ASC dependent macrophage pyroptosis [0.03%]
天然黄酮类化合物檞皮素通过抑制巨噬细胞caspase-8/ASC依赖性焦亡保护肝脏缺血再灌注损伤
Jiacheng Lin,Fuyang Li,Junzhe Jiao et al.
Jiacheng Lin et al.
Introduction: Hepatic ischemia-reperfusion injury (IRI) is an inevitable adverse event following liver surgery, leading to liver damage and potential organ failure. Despite advancements, effective interventions for hepati...
Association of intestinal anti-inflammatory drug target genes with psychiatric Disorders: A Mendelian randomization study [0.03%]
肠道抗炎药物靶点基因与精神障碍的关联：一项孟德尔随机化研究
Guorui Zhao,Zhe Lu,Yundan Liao et al.
Guorui Zhao et al.
Introduction: Psychiatric disorders present a substantial global public health burden with limited drug options. The gut-brain axis connects inflammatory bowel diseases and psychiatric disorders, which often have comorbid...
Single-nucleus transcriptional and chromatin accessible profiles reveal critical cell types and molecular architecture underlying chicken sex determination [0.03%]
单细胞核转录组和染色质可及性揭示性别决定关键细胞类型及分子机制
Jianbo Li,Xiuan Zhang,Xiqiong Wang et al.
Jianbo Li et al.
Introduction: Understanding the sex determination mechanisms in birds has great significance for the biological sciences and production in the poultry industry. Sex determination in chickens is a complex process that invo...
Mesenchymal stem cell secretome for regenerative medicine: Where do we stand? [0.03%]
间充质干细胞分泌组在再生医学中的应用：我们目前处于什么水平？
Catarina M Trigo,Joana S Rodrigues,Sérgio P Camões et al.
Catarina M Trigo et al.
Background: Mesenchymal stem cell (MSC)-based therapies have yielded beneficial effects in a broad range of preclinical models and clinical trials for human diseases. In the context of MSC transplantation, it is widely re...
The hiPSC-derived corneal endothelial progenitor-like cell recovers the rabbit model of corneal endothelial dystrophy [0.03%]
基于hiPSC的角膜内皮前体样细胞修复兔角膜内皮营养不良模型研究
Yi-Jen Hsueh,Hung-Chi Chen,Yu-Yun Pan et al.
Yi-Jen Hsueh et al.
Introduction: Corneal endothelial dysfunction results in cornea opacity, damaging sightedness, and affecting quality of life. A corneal transplant is the current effective intervention. Due to the scarcity of donated corn...
Sodium citrate targeting Ca2+/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer [0.03%]
柠檬酸钠通过诱导卵巢癌细胞凋亡和铁死亡发挥抗肿瘤作用并靶向Ca2+/CAMKK2通路
Yulun Wu,Chaoran Jia,Wei Liu et al.
Yulun Wu et al.
Introduction: Ovarian cancer (OC) is known for its high mortality rate. Although sodium citrate has anti-tumor effects in various cancers, its effect and mechanism in OC remain unclear. ...
Crosstalk between endothelial cells and dermal papilla entails hair regeneration and angiogenesis during aging [0.03%]
内皮细胞与毛乳头细胞的相互作用在衰老期间促进头发再生和血管生成
Siyi Zhou,Zeming Li,Xinzhu Li et al.
Siyi Zhou et al.
Introduction: Tissues maintain their function through interaction with microenvironment. During aging, both hair follicles and blood vessels (BV) in skin undergo degenerative changes. However, it is elusive whether the ch...