Triad3A-Mediated K48-Linked ubiquitination and degradation of TLR9 impairs mitochondrial bioenergetics and exacerbates diabetic cardiomyopathy [0.03%]
TRiAD3A介导的TLR9泛素化降解通过损害线粒体生物能恶化糖尿病心肌病
Chunyan Kong,Zhen Guo,Fangyuan Liu et al.
Chunyan Kong et al.
Introduction: Targeted protein degradation represents a promising therapeutic approach, while diabetic cardiomyopathy (DCM) arises as a consequence of aberrant insulin secretion and impaired glucose and lipid metabolism i...
Intracellular Fusobacterium nucleatum infection increases METTL3-mediated m6A methylation to promote the metastasis of esophageal squamous cell carcinoma [0.03%]
胞内福赛拟杆菌感染通过增加METTL3介导的m6A甲基化促进食管鳞癌转移
Songhe Guo,Fangfang Chen,Linfang Li et al.
Songhe Guo et al.
Introduction: The tumor-associated microbiota plays a vital role in cancer development. Accumulating evidence shows that Fusobacterium nucleatum (Fn) participates in the progression of multiple tumor types. However, the u...
Harnessing the dental cells derived from human induced pluripotent stem cells for hard tissue engineering [0.03%]
利用人诱导多能干细胞来源的牙细胞进行硬组织工程化研究
Eun-Jung Kim,Ka-Hwa Kim,Hyun-Yi Kim et al.
Eun-Jung Kim et al.
Introduction: Most mineralized tissues in our body are present in bones and teeth. Human induced pluripotent stem cells (hiPSCs) are promising candidates for cell therapy to help regenerate bone defects and teeth loss. Th...
Liver metastases across cancer types sharing tumor environment immunotolerance can impede immune response therapy and immune monitoring [0.03%]
不同癌症类型的肝转移瘤共有的肿瘤环境免疫耐受可阻碍免疫治疗和免疫监测
Yuzhen Gao,Shipeng Chen,Hao Wang et al.
Yuzhen Gao et al.
Background: Hepatic immune tolerance might contribute to the development of therapeutic resistance to immunotherapy. However, addressing this issue is challenging since the efficacy of immunotherapy in the context of live...
Inducing the "re-development state" of periodontal ligament cells via tuning macrophage mediated immune microenvironment [0.03%]
通过调节巨噬细胞介导的免疫微环境诱导牙周韧带细胞“再发育状态”
Guanqi Liu,Linjun Zhang,Xuan Zhou et al.
Guanqi Liu et al.
Introduction: Periodontal regeneration, specifically the restoration of the cementum-periodontal ligament (PDL)-alveolar bone complex, remains a formidable challenge in the field of regenerative dentistry. In light of per...
Algal-bacterial consortium promotes carbon sink formation in saline environment [0.03%]
微藻-细菌联合作用促进盐碱地固碳Sink形成
Wenhui Gu,Songcui Wu,Xuehua Liu et al.
Wenhui Gu et al.
Introduction: The level of atmospheric CO2 has continuously been increasing and the resulting greenhouse effects are receiving attention globally. Carbon removal from the atmosphere occurs naturally in various ecosystems....
Targeting Desulfovibrio vulgaris flagellin-induced NAIP/NLRC4 inflammasome activation in macrophages attenuates ulcerative colitis [0.03%]
靶向定殖于肠道的硫酸盐还原菌Desulfovibrio vulgaris引起的NAIP/NLRC4炎性小体活化可减轻溃疡性结肠炎症状
Yaping An,Zihan Zhai,Xin Wang et al.
Yaping An et al.
Introduction: The perturbations of gut microbiota could interact with excessively activated immune responses and play key roles in the etiopathogenesis of ulcerative colitis (UC). Desulfovibrio, the most predominant sulfa...
Forsythiaside A alleviates acute lung injury by inhibiting inflammation and epithelial barrier damages in lung and colon through PPAR-γ/RXR-α complex [0.03%]
山梅花素A通过PPAR-γ/RXR-α复合体抑制肺和结肠上皮屏障损伤及炎症从而缓解急性肺损伤
Jing Wang,Xinyan Xue,Xingtao Zhao et al.
Jing Wang et al.
Introduction: Acute lung injury (ALI) is a lung disease characterized by inflammation and still requires further drug development. Forsythiaside A as the active compound of Forsythiae Fructus has the therapeutic potential...
Lipidomic analysis identifies long-chain acylcarnitine as a target for ischemic stroke [0.03%]
脂质组分析鉴定长链酰基肉碱为缺血性卒中的治疗靶点
Xin-Xin Huang,Lei Li,Run-Hao Jiang et al.
Xin-Xin Huang et al.
Introduction: Lipid metabolism dysfunction is widely involved in the pathological process of acute ischemic stroke (AIS). The coordination of lipid metabolism between neurons and astrocytes is of great significance. Howev...
Modifications of lipid pathways restrict SARS-CoV-2 propagation in human induced pluripotent stem cell-derived 3D airway organoids [0.03%]
对脂肪代谢途径的修饰限制了SARS-CoV-2在人诱导多能干细胞来源的类器官中增殖
Ping-Hsing Tsai,Jun-Ren Sun,Yueh Chien et al.
Ping-Hsing Tsai et al.
Background: Modifications of lipid metabolism were closely associated with the manifestations and prognosis of coronavirus disease of 2019 (COVID-19). Pre-existing metabolic conditions exacerbated the severity of severe a...