The epidermal lipid-microbiome loop and immunity: Important players in atopic dermatitis [0.03%]
表皮脂质-微生物环与免疫性：在特应性皮炎中重要的参与者
Junchao Wu,Lisha Li,Tingrui Zhang et al.
Junchao Wu et al.
Background: The promotion of epidermal barrier dysfunction is attributed to abnormalities in the lipid-microbiome positive feedback loop which significantly influences the imbalance of the epithelial immune microenvironme...
Gut microbiome-derived bacterial extracellular vesicles in patients with solid tumours [0.03%]
实体瘤患者中源自肠道微生物组的细菌胞外囊泡
Surbhi Mishra,Mysore Vishakantegowda Tejesvi,Jenni Hekkala et al.
Surbhi Mishra et al.
Introduction: Gut microbiome-derived nanoparticles, known as bacterial extracellular vesicles (bEVs), have garnered interest as promising tools for studying the link between the gut microbiome and human health. The divers...
Unlocking melanoma Suppression: Insights from Plasma-Induced potent miRNAs through PI3K-AKT-ZEB1 axis [0.03%]
解锁黑色素瘤抑制：通过PI3K-AKT-ZEB1轴洞察等离子体诱导的有力miRNAs
Pradeep Bhartiya,Apurva Jaiswal,Manorma Negi et al.
Pradeep Bhartiya et al.
Introduction: Melanoma is a rare but highly malignant form of skin cancer. Although recent targeted and immune-based therapies have improved survival rates by 10-15%, effective melanoma treatment remains challenging. Ther...
Metformin blocks BIK1-mediated CPK28 phosphorylation and enhances plant immunity [0.03%]
二甲双胍阻断BIK1介导的CPK28磷酸化并增强植物免疫能力
Yazhou Bao,Qian Zhang,Hai Zhu et al.
Yazhou Bao et al.
Introduction: Metformin (MET), derived from Galega officinalis, stands as the primary first-line medication for the treatment of type 2 diabetes (T2D). Despite its well-documented benefits in mammalian cellular processes,...
NCAPD3 promotes diffuse large B-cell lymphoma progression through modulating SIRT1 expression in an H3K9 monomethylation-dependent manner [0.03%]
NCAPD3通过组蛋白H3赖氨酸9单甲基化依赖性调控SIRT1表达促进弥漫大B细胞淋巴瘤进展
Tiange Lu,Juan Yang,Yiqing Cai et al.
Tiange Lu et al.
Introduction: Condensin, a family of structural maintenance of chromosome complexes, has been shown to regulate chromosome compaction and segregation during mitosis. NCAPD3, a HEAT-repeat subunit of condensin II, plays a ...
Baicalein induces apoptosis by inhibiting the glutamine-mTOR metabolic pathway in lung cancer [0.03%]
黄芩素通过抑制谷氨酰胺-mtor代谢途径诱导肺癌细胞凋亡
Jingyang Li,Di Zhang,Shaohui Wang et al.
Jingyang Li et al.
Introduction: Baicalein, a bioactive component of Scutellaria baicalensis Georgi, has been shown to promote apoptosis in non-small cell lung cancer cells. However, previous studies have not determined if baicalein exerts ...
Moscatilin inhibits vascular calcification by activating IL13RA2-dependent inhibition of STAT3 and attenuating the WNT3/β-catenin signalling pathway [0.03%]
莫斯卡丁通过激活IL13RA2依赖性STAT3抑制和减弱WNT3 / β-连环蛋白信号通路来抑制血管钙化
Tingting Zhang,Mengmeng Zhu,Jialing Ma et al.
Tingting Zhang et al.
Introduction: Vascular calcification, a devastating vascular complication accompanying atherosclerotic cardiovascular disease and chronic kidney disease, increases the incidence of adverse cardiovascular events and compro...
5-HT7R enhances neuroimmune resilience and alleviates meningitis by promoting CCR5 ubiquitination [0.03%]
5-HT7R通过促进CCR5泛素化增强神经免疫韧性并缓解脑膜炎
Zhenfang Gao,Yang Gao,Yuxiang Li et al.
Zhenfang Gao et al.
Introduction: Excessive immune activation induces tissue damage during infection. Compared to external strategies to reconstruct immune homeostasis, host balancing ways remain largely unclear. ...
Machine learning and genetic algorithm-guided directed evolution for the development of antimicrobial peptides [0.03%]
机器学习和遗传算法指导的定向进化用于开发抗菌肽
Heqian Zhang,Yihan Wang,Yanran Zhu et al.
Heqian Zhang et al.
Introduction: Antimicrobial peptides (AMPs) are valuable alternatives to traditional antibiotics, possess a variety of potent biological activities and exhibit immunomodulatory effects that alleviate difficult-to-treat in...
Early-life tobacco smoke elevating later-life osteoporosis risk: Mediated by telomere length and interplayed with genetic predisposition [0.03%]
生命早期的烟草烟雾通过端粒长度影响生命后期骨质疏松风险并与遗传易感性相互作用
Dongsheng Di,Haolong Zhou,Zhangbo Cui et al.
Dongsheng Di et al.
Introduction: The growing prevalence of osteoporosis (OP) in an aging global population presents a significant public health concern. Tobacco smoke negatively affects bone turnover, leading to reduced bone mass and height...