Challenges and advances in the management of inflammation in atherosclerosis [0.03%]
动脉粥样硬化炎症管理面临的挑战与进展
Yiming Xing,Xianhe Lin
Yiming Xing
Introduction: Atherosclerosis, traditionally considered a lipid-related disease, is now understood as a chronic inflammatory condition with significant global health implications. ...
Targeting the STAT3/IL-36G signaling pathway can be a promising approach to treat rosacea [0.03%]
靶向STAT3/IL-36G信号通路有望成为治疗玫瑰痤疮的新方法
Xin Meng,Yun Zhong,Xuyuan Kuang et al.
Xin Meng et al.
Background: Rosacea is an inflammatory skin disorder characterized by the release of inflammatory mediators from keratinocytes, which are thought to play a crucial role in its pathogenesis. Despite an incidence of approxi...
Zipan Lyu,Yau-Tuen Chan,Yuanjun Lu et al.
Zipan Lyu et al.
Introduction: Adipogenesis, the process of white adipose tissue expansion, plays a critical role in the development of obesity. Osteoprotegerin (OPG), known for its role in bone metabolism regulation, emerges as a potenti...
Kynurenine acts as a signaling molecule to attenuate pulmonary fibrosis by enhancing the AHR-PTEN axis [0.03%]
犬尿酸通过增强AHR-PTEN轴作为信号分子来缓解肺纤维化
Yi Wang,Guo-Rao Wu,Huihui Yue et al.
Yi Wang et al.
Introduction: Pulmonary fibrosis (PF) is a fatal fibrotic lung disease without any options to halt disease progression. Feasible evidence suggests that aberrant metabolism of amino acids may play a role in the pathoetiolo...
Nanoparticle-mediated celastrol ER targeting delivery amplify immunogenic cell death in melanoma [0.03%]
纳米颗粒介导的雷斯坦醇ER靶向递送可增强黑色素瘤的免疫原性细胞死亡
Fengling Wang,Wenjing Lai,Dandan Xie et al.
Fengling Wang et al.
Introduction: Chemoimmunotherapy, which benefits from the combination of chemotherapy and immunotherapy, has emerged as a promising strategy in cancer treatment. However, effectively inducing a robust immune response rema...
Associations between specific dietary patterns, gut microbiome composition, and incident subthreshold depression in Chinese young adults [0.03%]
特定饮食模式、肠道菌群构成与中国年轻人亚临床抑郁的发病之间的关联
Xiumin Jiang,Xiaotong Wang,Meng Zhang et al.
Xiumin Jiang et al.
Introduction: The interplay between influential factors and the incidence of subthreshold depression (SD) in young adults remains poorly understood. Objec...
Hippo-YAP/TAZ-ROS signaling axis regulates metaflammation induced by SelenoM deficiency in high-fat diet-derived obesity [0.03%]
硒缺乏通过 hippo-YAP/TAZ-ROS 信号轴诱发高脂饮食引起的代谢性炎症
Jingzeng Cai,Jiaqiang Huang,Di Li et al.
Jingzeng Cai et al.
Introduction: Metabolic inflammation (metaflammation) in obesity is primarily initiated by proinflammatory macrophage infiltration into adipose tissue. SelenoM contributes to the modulation of antioxidative stress and inf...
Muhammad Mahtab Aslam Khan Khakwani,Xin-Ying Ji,Saadullah Khattak et al.
Muhammad Mahtab Aslam Khan Khakwani et al.
Background: Nuclear pore complexes (NPCs) are the architectures entrenched in nuclear envelop of a cell that regulate the nucleo-cytoplasmic transportation of materials, such as proteins and RNAs for proper functioning of...
Pyroptosis: A spoiler of peaceful coexistence between cells in degenerative bone and joint diseases [0.03%]
焦亡：退变性骨关节疾病细胞和平共存的破坏者
Zhichao Li,Wenxiang Cheng,Kuanhui Gao et al.
Zhichao Li et al.
Background: As people age, degenerative bone and joint diseases (DBJDs) become more prevalent. When middle-aged and elderly people are diagnosed with one or more disorders such as osteoporosis (OP), osteoarthritis (OA), a...
Tumor microenvironment as niche constructed by cancer stem cells: Breaking the ecosystem to combat cancer [0.03%]
肿瘤微环境作为由癌症干细胞构建的生态位：打破生态系统以对抗癌症
Hao Zhong,Shiyue Zhou,Shuangshuang Yin et al.
Hao Zhong et al.
Background: Cancer stem cells (CSCs) are a distinct subpopulation of cancer cells with the capacity to constantly self-renew and differentiate, and they are the main driver in the progression of cancer resistance and rela...