Preparation of human astrocytes with potent therapeutic functions from human pluripotent stem cells using ventral midbrain patterning [0.03%]
利用中脑腹侧分化的方案从人多能干细胞高效诱导具有治疗潜能的星形胶质细胞
Ye Rim Nam,Minji Kang,Minji Kim et al.
Ye Rim Nam et al.
Introduction: Astrocytes are glial-type cells that protect neurons from toxic insults and support neuronal functions and metabolism in a healthy brain. Leveraging these physiological functions, transplantation of astrocyt...
Extracellular vesicles derived from Lactobacillus johnsonii promote gut barrier homeostasis by enhancing M2 macrophage polarization [0.03%]
乳酸菌约翰逊氏菌来源的细胞外囊泡通过增强M2型巨噬细胞极化促进肠道屏障稳态
Shiyu Tao,Jinping Fan,Jingjing Li et al.
Shiyu Tao et al.
Introduction: Diarrheic disease is a common intestinal health problem worldwide, causing great suffering to humans and animals. Precise manipulation strategies based on probiotics to combat diarrheic diseases have not bee...
The efferocytosis process in aging: Supporting evidence, mechanisms, and therapeutic prospects for age-related diseases [0.03%]
衰老过程中效应细胞吞噬作用的证据、机制及在治疗年龄相关性疾病中的前景
Meng Zhang,Jin Wei,Yu Sun et al.
Meng Zhang et al.
Background: Aging is characterized by an ongoing struggle between the buildup of damage caused by a combination of external and internal factors. Aging has different effects on phagocytes, including impaired efferocytosis...
Efficient chemo-immunotherapy leveraging minimalist electrostatic complex nanoparticle as "in situ" vaccine integrated tumor ICD and immunoagonist [0.03%]
高效的化疗免疫疗法利用极简静电复合纳米颗粒作为“原位”疫苗集成肿瘤ICD和免疫激动剂
Yunfei Han,Mingxia Jiang,Yanju Sun et al.
Yunfei Han et al.
Introduction: Immunotherapy has unprecedentedly opened up a series of neoteric tactics for cancer treatment. As a burgeoning approach, chemo-immunotherapy has innovatively expanded the accomplishments of conventional chem...
The role of extracellular vesicles in non-alcoholic steatohepatitis: Emerging mechanisms, potential therapeutics and biomarkers [0.03%]
细胞外囊泡在非酒精性脂肪性肝炎中的作用：不断出现的机制、潜在治疗和生物标志物
Qianrong Wang,Xiangning Tang,Yu Wang et al.
Qianrong Wang et al.
Non-alcoholic steatohepatitis (NASH), an emerging global healthcare problem, has become the leading cause of liver transplantation in recent decades. No effective therapies in the clinic have been proven due to the incomplete understanding ...
Nuclear transport of phosphorylated LanCL2 promotes invadopodia formation and tumor progression of glioblastoma by activating STAT3/Cortactin signaling [0.03%]
磷酸化LanCL2的核转运通过激活STAT3/Cortactin信号促进胶质母细胞瘤的侵袭伪足形成和肿瘤进展
Hua-Fu Zhao,Yun-Sheng Liu,Jing Wang et al.
Hua-Fu Zhao et al.
Introduction: Our previous study showed that the abscisic acid receptor lanthionine synthetase C-like 2 (LanCL2) is a significant prognostic factor for overall survival in young glioblastoma patients. However, the role of...
Sonic hedgehog restrains the ubiquitin-dependent degradation of SP1 to inhibit neuronal/glial senescence associated phenotypes in chemotherapy-induced peripheral neuropathy via the TRIM25-CXCL13 axis [0.03%]
Sonic hedgehog通过TRIM25-CXCL13轴抑制化疗诱导的周围神经病变中的神经元/胶质细胞衰老相关表型，方法是限制SP1的泛素依赖性降解
Ying Zou,Shu Wu,Qian Hu et al.
Ying Zou et al.
Introduction: Chemotherapy-induced peripheral neuropathy (CIPN) is a common complication that affects an increasing number of cancer survivors. However, the current treatment options for CIPN are limited. Paclitaxel (PTX)...
Polyphenols synergistic drugs to ameliorate non-alcoholic fatty liver disease via signal pathway and gut microbiota: A review [0.03%]
多酚类协同药物通过信号通路和肠道微生物群改善非酒精性脂肪肝病的综述
Hongcai Li,Jingjing Liang,Mengzhen Han et al.
Hongcai Li et al.
Background: Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease with an increasing incidence worldwide. Single drug therapy may have toxic side effects and disrupt gut microbiota balance. Polypheno...
Hybridization-based discovery of novel quinazoline-2-indolinone derivatives as potent and selective PI3Kα inhibitors [0.03%]
基于杂化的新型喹唑啉-2-吲哚酮衍生物的发现作为有效的选择性PI3Kα抑制剂
Changqun Liu,Yuening Cao,Yi Zuo et al.
Changqun Liu et al.
Introduction: Phosphatidylinositol 3-kinases (PI3Ks) overexpression can elicit cellular homeostatic dysregulation, which further contributes to tumorigenesis, with PI3Kα emerging as the most prevalent mutant isoform kina...
Achieving healthy aging through gut microbiota-directed dietary intervention: Focusing on microbial biomarkers and host mechanisms [0.03%]
通过肠道微生物群导向的饮食干预实现健康老龄化：关注微生物生物标志物和宿主机制
Yue Xiao,Yingxuan Feng,Jianxin Zhao et al.
Yue Xiao et al.
Background: Population aging has become a primary global public health issue, and the prevention of age-associated diseases and prolonging healthy life expectancies are of particular importance. Gut microbiota has emerged...