E3 ubiquitin ligase RNF128 attenuates colitis and colorectal tumorigenesis by triggering the degradation of IL-6 receptors [0.03%]
E3连接酶RNF128通过促进白细胞介素6受体的降解来抑制结肠炎和结直肠肿瘤发生
Tian-Sheng He,Kuntai Cai,Weiling Lai et al.
Tian-Sheng He et al.
Introduction: Intestinal immune dysregulation is strongly linked to the occurrence and formation of tumors. RING finger protein 128 (RNF128) has been identified to play distinct immunoregulatory functions in innate and ad...
The role of SPI1/VSIG4/THBS1 on glioblastoma progression through modulation of the PI3K/AKT pathway [0.03%]
SPI1/VSIG4/THBS1通过调节PI3K/AKT途径在胶质母细胞瘤进展中的作用
Jie Shen,Lihui Zhou,Ke Ye et al.
Jie Shen et al.
Introduction: Glioblastoma multiforme (GBM) poses a significant challenge in terms of treatment due to its high malignancy, necessitating the identification of additional molecular targets. VSIG4, an oncogenic gene partic...
Macrophage exosomes mediate palmitic acid-induced metainflammation by transferring miR-3064-5p to target IκBα and activate NF-κB signaling [0.03%]
巨噬细胞源外泌体通过递送miR-3064-5p靶向IκBα激活NF-κB信号介导棕榈酸诱导的meta炎症反应
Huiyu Luo,Jiexian Wang,Fengjuan Lin et al.
Huiyu Luo et al.
Introduction: High palmitic acid (PA) levels trigger metainflammation, facilitating the onset and progression of chronic metabolic diseases. Recently, exosomes were identified as new inflammation mediators. However, the m...
Host-virus coevolution drives soil microbial function succession along a millennium land reclamation chronosequence [0.03%]
宿主-病毒的共生进化驱动千年垦荒年代土壤微生物功能演替
Wenbing Li,Yiling Wang,Kankan Zhao et al.
Wenbing Li et al.
Introduction: Gene exchange between viruses and hosts plays an important role in driving virus-host coevolution, enabling adaptation of both viruses and hosts to environmental changes. However, the mechanisms and function...
RNA modification gene WDR4 facilitates tumor progression and immunotherapy resistance in breast cancer [0.03%]
乳腺癌中RNA修饰基因WDR4促进肿瘤进展和免疫治疗抵抗
Yongzhou Luo,Wenwen Tian,Da Kang et al.
Yongzhou Luo et al.
Introduction: Growing interest toward RNA modification in cancer has inspired the exploration of gene sets related to multiple RNA modifications. However, a comprehensive elucidation of the clinical value of various RNA m...
The mechanism by which oriented polypropylene packaging alleviates postharvest 'Black Spot' in radish root (Raphanus sativus) [0.03%]
定向聚丙烯包装袋对减轻萝卜肉质根贮藏后黑斑病的影响机制
Zixin Lin,Bihong Feng,Shibei Fang et al.
Zixin Lin et al.
Introduction: The postharvest physiological disorder known as 'black spot' in radish roots (Raphanus sativus) poses a significant challenge to quality maintenance during storage, particularly under summer conditions. The ...
WTAP/YTHDF1-mediated m6A modification amplifies IFN-γ-induced immunosuppressive properties of human MSCs [0.03%]
WTAP/YTHDF1介导的mRNA m6A修饰增强人脐带间充质干细胞免疫抑制功能
Quan Chen,Luoquan Ao,Qing Zhao et al.
Quan Chen et al.
Introduction: The immunosuppressive capacity of mesenchymal stem cells (MSCs) is dependent on the "license" of several pro-inflammatory factors to express immunosuppressive molecular profiles, which determines the therape...
Developing a multi-modular assembled prime editing (mPE) system improved precise multi-base insertion efficiency in dicots [0.03%]
一种用于双子叶植物多碱基精准插入的多模块组装式prime编辑系统(mPE)的研究与发展
Pengjun Lu,Erwei Zuo,Jianbin Yan
Pengjun Lu
Introduction: The Prime Editing (PE) system is a precise and versatile genome editing tool with great potential in plant breeding and plant synthetic biology. However, low PE efficiency severely restricts its application,...
Transcriptomic profiling of gastrointestinal tracts in dairy cattle during lactation reveals molecular adaptations for milk synthesis [0.03%]
泌乳期间对奶牛胃肠 tract的转录组分析揭示了牛奶合成的分子适应性
Yahui Gao,George E Liu,Li Ma et al.
Yahui Gao et al.
During lactation, dairy cattle's digestive tract requires significant adaptations to meet the increased nutrient demands for milk production. As we attempt to improve milk-related traits through selective pressure, it is crucial to understa...
WWP2 deletion aggravates acute kidney injury by targeting CDC20/autophagy axis [0.03%]
WWP2缺失通过靶向CDC20/自噬轴加重急性肾损伤
Ran You,Yanwei Li,Yuteng Jiang et al.
Ran You et al.
Introduction: Acute kidney injury (AKI) is associated with high morbidity and mortality rates. The molecular mechanisms underlying AKI are currently being extensively investigated. WWP2 is an E3 ligase that regulates cell...