PROTAC derivatization of natural products for target identification and drug discovery: Design of evodiamine-based PROTACs as novel REXO4 degraders [0.03%]
基于天然产物的PROTAC衍生化在靶点鉴定与药物发现中的应用及吴茱萸碱类蛋白降解剂的设计与发展
Shuqiang Chen,Kaijian Bi,Huixin Liang et al.
Shuqiang Chen et al.
Introduction: Natural products (NPs) play a crucial role in the development of therapeutic drugs. However, it is still highly challenging to identify the targets of NPs. Besides, NPs usually exert their pharmacological ac...
P450Rdb: a manually curated database of reactions catalyzed by cytochrome P450 enzymes [0.03%]
P450Rdb：一种由人工整理的细胞色素P450酶催化反应的数据库
Yang Zhang,Xianrun Pan,Tianyu Shi et al.
Yang Zhang et al.
Introduction: Cytochrome P450 enzymes (P450s) are recognized as the most versatile catalysts worldwide, playing vital roles in numerous biological metabolism and biosynthesis processes across all kingdoms of life. Despite...
Ceria Nanozyme Coordination with Curcumin for Treatment of Sepsis-induced Cardiac Injury by Inhibiting Ferroptosis and Inflammation [0.03%]
四环素纳米酶与姜黄素配位治疗脓毒症诱导的心脏损伤的铁死亡和炎症抑制作用研究
Chenxiao Jiang,Qianzhi Shi,Jing Yang et al.
Chenxiao Jiang et al.
Introduction: Sepsis-induced cardiac injury is the leading cause of death in patients. Recent studies have reported that reactive oxygen species (ROS)-mediated ferroptosis and macrophage-induced inflammation are the two m...
Targeting YTHDF2 inhibits tumorigenesis of diffuse large B-cell lymphoma through ACER2-mediated ceramide catabolism [0.03%]
靶向YTHDF2通过ACER2介导的神经酰胺分解代谢抑制弥漫性大B细胞淋巴瘤的肿瘤发生
Xiaomin Chen,Tiange Lu,Mengfei Ding et al.
Xiaomin Chen et al.
Introduction: Epigenetic alterations play crucial roles in diffuse large B-cell lymphoma (DLBCL). Disturbances in lipid metabolism contribute to tumor progression. However, studies in epigenetics, especially its critical ...
4SQR-Code: A 4-state QR code generation model for increasing data storing capacity in the Digital Twin framework [0.03%]
4状态二维码生成模型：数字孪生框架下的一种提高数据存储容量的方法
Ababil Islam Udoy,Muhammad Aminur Rahaman,Md Jahidul Islam et al.
Ababil Islam Udoy et al.
Introduction: The usage of Quick Response (QR) Codes has become widely popular in recent years, primarily for immense electronic transactions and industry uses. The structural flexibility of QR Code architecture opens man...
Industrial Internet of Water Things architecture for data standarization based on blockchain and digital twin technology☆ [0.03%]
基于区块链和数字孪生技术的工业水资源标准化体系物联网架构研究
Mazin Abed Mohammed,Abdullah Lakhan,Karrar Hameed Abdulkareem et al.
Mazin Abed Mohammed et al.
Introduction: The Industrial Internet of Water Things (IIoWT) has recently emerged as a leading architecture for efficient water distribution in smart cities. Its primary purpose is to ensure high-quality drinking water f...
Fanglin Niu,Wenxuan Liu,Yuanyuan Ren et al.
Fanglin Niu et al.
Background: Diabetes Mellitus (DM), a chronic metabolic disease characterized by elevated blood glucose, is caused by various degrees of insulin resistance and dysfunctional insulin secretion, resulting in hyperglycemia. ...
Bio-inspired soft pneumatic actuator based on a kresling-like pattern with a rigid skeleton [0.03%]
一种基于克雷斯林图案的刚性骨架软气动执行器
Zhichuan Tang,Keshuai Yang,Hang Wang et al.
Zhichuan Tang et al.
Introduction: Biomimetic soft pneumatic actuators (SPA) with Kresling origami patterns have unique advantages over conventional rigid robots, owing to their adaptability and safety. ...
A first-in-class dimethyl 2-acetamido terephthalate inhibitor targeting Conyza canadensis SHMT1 with a novel herbicidal mode-of-action [0.03%]
一种针对Conyza canadensis SHMT1的新型除草作用机制的第一类二甲基2-乙酰胺对苯二甲酸抑制剂
Dingfeng Luo,Zhendong Bai,Haodong Bai et al.
Dingfeng Luo et al.
Introduction: Herbicide application is a highly efficiency method of weed control that boots agricultural output and assures food security. The development of novel herbicides focuses on improved bioactivity and new modes...
Leucine zipper protein 1 attenuates pressure overload-induced cardiac hypertrophy through inhibiting Stat3 signaling [0.03%]
亮氨酸拉链蛋白1通过抑制Stat3信号通路缓解压力超负荷诱导的心脏肥厚
Di Fan,Wan-Li Jiang,Zhi-Li Jin et al.
Di Fan et al.
Introduction: Cardiac hypertrophy is an important contributor of heart failure, and the mechanisms remain unclear. Leucine zipper protein 1 (LUZP1) is essential for the development and function of cardiovascular system; h...