Differences in alternative splicing and their potential underlying factors between animals and plants [0.03%]
动物和植物可变剪接的差异及其潜在影响因素分析
Yunfei Du,Lu Cao,Shuo Wang et al.
Yunfei Du et al.
Background: Alternative splicing (AS), a posttranscriptional process, contributes to the complexity of transcripts from a limited number of genes in a genome, and AS is considered a great source of genetic and phenotypic ...
HIF-1α inhibition by MO-2097, a novel chiral-free benzofuran targeting hnRNPA2B1 [0.03%]
一种新型光学纯苯并呋喃MO-2097通过靶向hnRNPA2B1抑制HIF-1α表达
Ho Jin Han,Aneesh Sivaraman,Minkyoung Kim et al.
Ho Jin Han et al.
Introduction: Hypoxia-inducible factor 1 (HIF-1) is a transcriptional activator mediating adaptive responses to hypoxia. It is up-regulated in the tumor microenvironment and recognized as an effective anticancer drug targ...
Activation of mitochondrial aldehyde dehydrogenase 2 promotes hair growth in human hair follicles [0.03%]
活化线粒体醛脱氢酶2可促进人体毛囊的生长
Seunghee Lee,Jungyoon Ohn,Bo Mi Kang et al.
Seunghee Lee et al.
Introduction: Hair loss is a common phenomenon associated with various environmental and genetic factors. Mitochondrial dysfunction-induced oxidative stress has been recognized as a crucial determinant of hair follicle (H...
Bo Qin,Dingsu Bao,Yang Liu et al.
Bo Qin et al.
Background: Due to the spatiotemporal complexity of the composition, structure, and cell population of the tendon-bone interface (TBI), it is difficult to achieve true healing. Recent research is increasingly focusing on ...
Teresa Matamá,Cristiana Costa,Bruno Fernandes et al.
Teresa Matamá et al.
Introduction: Natural hair curvature and colour are genetically determined human traits, that we intentionally change by applying thermal and chemical treatments to the fibre. Presently, those cosmetic methodologies act e...
T helper-1 activation via interleukin-16 is a key phenomenon in the acute phase of severe, first-episode major depressive disorder and suicidal behaviors [0.03%]
重症首次发作的重大抑郁障碍和自杀行为急性期的Th1活化通过白细胞介素-16是一个关键现象
Abbas F Almulla,Ali Abbas Abo Algon,Chavit Tunvirachaisakul et al.
Abbas F Almulla et al.
Background: Immune-inflammatory pathways in major depressive disorder are confined to the major dysmood disorder (MDMD) phenotype (Maes et al., 2022). No studies have addressed the immune profile of first episode MDMD (FE...
A hybridized mechano-electroporation technique for efficient immune cell engineering [0.03%]
一种高效的免疫细胞工程的混合机械-电穿孔技术
Dorsa Morshedi Rad,William P Hansen,Sareh Zhand et al.
Dorsa Morshedi Rad et al.
Immune cell engineering, which involves genetic modification of T cells, natural killer cells, and macrophages, is shifting the paradigm in immunotherapy for treating hematologic malignancies. These modified cells can be viewed as living dr...
Molecular underpinnings underlying behaviors changes in the brain of juvenile common carp (Cyrinus carpio) in response to warming [0.03%]
青鱼(Cyrinus carpio)大脑中适应升温引起行为变化的分子机制研究
Yuanli Zhao,Ming Duan,Xing Lin et al.
Yuanli Zhao et al.
Introduction: Global warming is increasing interest in how aquatic animals can adjust their physiological performance and cope with temperature changes. Therefore, understanding the behavioral changes and molecular underp...
Unlocking the secrets of aging: Epigenetic reader BRD4 as the target to combatting aging-related diseases [0.03%]
破解衰老之谜：表观遗传阅读蛋白BRD4或可成为抗衰药物靶点
Jiaxing Sun,Yu Gui,Shenghua Zhou et al.
Jiaxing Sun et al.
Background: Aging, a complex and profound journey, leads us through a labyrinth of physiological and pathological transformations, rendering us increasingly susceptible to aging-related diseases. Emerging investigations h...
Fetal hypoxia expose caused autophagy in ovary granulosa cells via PI3K/Akt/FoxO1 pathway and mitigated by melatonin subheading [0.03%]
胎儿低氧暴露通过PI3K/Akt/FoxO1途径诱导卵巢颗粒细胞自噬并用褪黑素缓解
Luyao Zhang,Kexiong Liu,Zhiqiang Liu et al.
Luyao Zhang et al.
Introduction: Fetal hypoxia has long-term effects on postnatal reproductive functions and the mitochondrial impairments of ovarian granulosa cells may be one of the causes. Melatonin applied to mitigate mitochondrial dysf...