Disturbance of bile acids profile aggravates the diarrhea induced by capecitabine through inhibiting the Wnt/β-catenin pathway [0.03%]
扰乱胆汁酸谱型通过抑制Wnt/β-catenin信号通路加重卡培他滨诱导的腹泻
Zhipeng Wang,Zhijun Liu,Lili Cui et al.
Zhipeng Wang et al.
Introduction: Diarrhea is the primary dose-limiting side effect of capecitabine(Cap) hindering its clinical application, but the mechanism is unclear. Clarifying this mechanism may enhance the patient compliance and impro...
Cadmium targeting transcription factor EB to inhibit autophagy-lysosome function contributes to acute kidney injury [0.03%]
镉通过靶向转录因子EB抑制自噬-溶酶体功能从而导致急性肾损伤
Peng-Fei Dong,Tian-Bin Liu,Kai Chen et al.
Peng-Fei Dong et al.
Introduction: Environmental and occupational exposure to cadmium (Cd) has been shown to cause acute kidney injury (AKI). Previous studies have demonstrated that autophagy inhibition and lysosomal dysfunction are important...
An updated review and recent advancements in carbon-based bioactive coatings for dental implant applications [0.03%]
基于碳的生物活性涂层在牙科种植体应用中的最新进展及综述更新
Nazrah Maher,Anum Mahmood,Muhammad Amber Fareed et al.
Nazrah Maher et al.
Background: Surface coating of dental implants with a bioactive biomaterial is one of the distinguished approaches to improve the osseointegration potential, antibacterial properties, durability, and clinical success rate...
Neopterin mediates sleep deprivation-induced microglial activation resulting in neuronal damage by affecting YY1/HDAC1/TOP1/IL-6 signaling [0.03%]
神经pterin通过影响YY1/HADC1/TOP1/IL-6信号通路介导睡眠剥夺诱导的小胶质细胞活化导致的神经元损伤
Xuan Li,Ziyu Kong,Ke Cai et al.
Xuan Li et al.
Introduction: Sleep deprivation (SD) is a common disorder in modern society. Hippocampus is an important region of the brain for learning, memory, and emotions. Dysfunction of hippocampus can lead to severe learning and m...
Nicotinamide riboside alleviates ionizing radiation-induced intestinal senescence by alleviating oxidative damage and regulating intestinal metabolism [0.03%]
烟酰胺核糖通过减轻氧化损伤和调节肠道代谢缓解电离辐射诱导的肠道衰老
Tongpeng Yue,Yinping Dong,Qidong Huo et al.
Tongpeng Yue et al.
Introduction: The intestine, frequently subjected to pelvic or abdominal radiotherapy, is particularly vulnerable to delayed effects of acute radiation exposure (DEARE) owing to its high radiation sensitivity. Radiation-i...
Hyperibone J exerts antidepressant effects by targeting ADK to inhibit microglial P2X7R/TLR4-mediated neuroinflammation [0.03%]
超强骨J通过靶向ADK抑制微胶质细胞P2X7R / TLR4介导的神经炎症发挥抗抑郁作用
Ting Li,Yawei Li,Jinhu Chen et al.
Ting Li et al.
Introduction: The antidepressant properties of Hypericum species are known. Hyperibone J, a principal component found in the flowers of Hypericum bellum, exhibited in vitro anti-inflammatory effects. However, the antidepr...
Elevation of p53 sensitizes obese kidney to adriamycin-induced aberrant lipid homeostasis via repressing HNF4α-mediated FGF21 sensitivity [0.03%]
p53上调通过抑制HNF4α介导的FGF21敏感性使肥胖肾脏易发生阿霉素诱导的脂质稳态异常
Jiahao Li,Yufeng Tang,Guangping Lu et al.
Jiahao Li et al.
Introduction: Lipid metabolism disorders have been confirmed to be closely related to kidney injury caused by adriamycin (ADR) and obesity, respectively. However, it has not been explored whether lipid metabolism disorder...
Tumor necrosis factor-α-treated human adipose-derived stem cells enhance inherent radiation tolerance and alleviate in vivo radiation-induced capsular contracture [0.03%]
肿瘤坏死因子-α处理的人脂肪来源干细胞可提高放射耐受性并减轻体内放射诱导的包囊挛缩病情Severity分级
Chanutchamon Sutthiwanjampa,Seung Hyun Kang,Mi Kyung Kim et al.
Chanutchamon Sutthiwanjampa et al.
Introduction: Post-mastectomy radiotherapy plays a crucial role in breast cancer treatment but can lead to an inflammatory response causing soft tissue damage, particularly radiation-induced capsular contracture (RICC), i...
Auts2 enhances neurogenesis and promotes expansion of the cerebral cortex [0.03%]
Auts2促进神经发生并促进脑皮层的扩张
Cédric Boucherie,Maisa Alkailani,Yves Jossin et al.
Cédric Boucherie et al.
Introduction: The AUTS2 gene is associated with various neurodevelopmental and psychiatric disorders and has been suggested to play a role in acquiring human-specific traits. Functional analyses of Auts2 knockout mice hav...
Charged polystyrene microplastics inhibit uptake and transformation of 14C-triclosan in hydroponics-cabbage system [0.03%]
带电的聚苯乙烯微塑料抑制水培白菜系统的14C-三氯生的吸收和转化
Enguang Nie,Yandao Chen,Shengwei Xu et al.
Enguang Nie et al.
Introduction: Since the outbreak of COVID-19, microplastics (MPs) and triclosan in pharmaceuticals and personal care products (PPCPs) are markedly rising. MPs and triclosan are co-present in the environment, but their int...