Impacts of trichothecene mycotoxins on human colonic epithelial cells: molecular mechanisms and signaling pathways [0.03%]
单端孢霉烯族毒素对人结肠上皮细胞的影响：分子机制及信号通路研究
Shao-Ji Li,Chun-Min Yang,Shiyi Ou
Shao-Ji Li
Background: Trichothecenes are a family of structurally related mycotoxins typically found in cereal crops, thus threatening the health of human digestive tract. In colonic epithelial cells (CECs), trichothecenes inhibit ...
Peptide IRW upregulates ACE2 in spontaneously hypertensive rats via dopamine/D1R signaling pathway [0.03%]
多巴胺/d₁受体信号通路介导的肽段irw在自发性高血压大鼠中上调ace2的作用
Zihan Wang,Le Luo Guan,Jianping Wu
Zihan Wang
Introduction: The bioactive peptide IRW lowers blood pressure in spontaneously hypertensive rats (SHRs) by upregulating angiotensin-converting enzyme 2 (ACE2), but the underlying mechanisms remain unclear. ...
ZUP1 promotes DNA repair and immune evasion to drive olaparib resistance in triple-negative breast cancer [0.03%]
ZUP1通过促进DNA修复和免疫逃逸驱动三阴性乳腺癌对奥拉帕尼的耐药性
Shanshan Huang,Yu Qiu,Linyu Wu et al.
Shanshan Huang et al.
Introduction: Olaparib resistance limits its therapeutic efficacy in triple-negative breast cancer (TNBC). Exploring the mechanisms underlying olaparib resistance and developing combination strategies are of great clinica...
Lactoferrin alleviates non-alcoholic steatohepatitis via remodeling gut microbiota to regulate serotonin-related pathways [0.03%]
乳铁蛋白通过重塑肠道菌群来调节血清素相关通路从而缓解非酒精性脂肪肝病
Li Ding,Jia-Ying Xu,Li-Li Zhang et al.
Li Ding et al.
Introduction: Lactoferrin (LF), a multifunctional glycoprotein, has been implicated in the regulation of glucose and lipid metabolism. Objectives and meth...
Glycyrrhetinic acid augments lipid catabolism via immune-neural modulation in adipose tissue [0.03%]
甘草酸通过免疫-神经调节增强脂肪组织的脂质分解代谢
Wenjiao Jiang,Sasa Zhang,Xinyuan Sun et al.
Wenjiao Jiang et al.
Introduction: Glycyrrhetinic acid (GA) and its magnesium salt, magnesium isoglycyrrhizinate, exhibit promising anti-obesity effects through mechanisms that are not fully understood. ...
Single-nucleus RNA sequencing illuminates a functional analog of lymphoid organ in crustacean [0.03%]
单细胞RNA测序揭示甲壳类动物淋巴器官功能类似物
Mingzhe Sun,Shihao Li,Yuan Liu et al.
Mingzhe Sun et al.
Introduction: The evolution of lymphoid organs is a complex topic in the animal kingdom. A presumptive invertebrate lymphoid organ (Oka) was previously reported in shrimp based on its morphological and histological observ...
Gestational exposure to PM2.5 impaired cardiac development through ANGPTL4-mediated mitochondrial metabolic dysfunction [0.03%]
孕期暴露于PM₂.₅通过ANGPTL4介导的线粒体代谢障碍影响心脏发育
Jianong Lv,Ruiyang Ding,Chen Liang et al.
Jianong Lv et al.
Introduction: Increasing epidemiological studies suggested that maternal exposure to fine particulate matter (PM2.5) was associated with congenital heart defects (CHD) in fetuses, while the exact mechanisms were still unc...
SIRT3-activating, biodegradable poly-honokiol with high drug loading for thoracic aortic dissection therapy [0.03%]
用于胸主动脉夹层治疗的SIRT3激活型可生物降解高药载聚羟基香豆醛
Xi&#x;nan Qiao,Daquan Wang,Hanzhao Zhu et al.
Xi&#x;nan Qiao et al.
Introduction: Thoracic aortic dissection (TAD) is a life-threatening cardiovascular emergency with limited pharmacological treatment options. Objectives: ...
Photo-crosslinkable hydrogel with programmable dual time-phase drug release for accelerated healing of infected diabetic wounds [0.03%]
用于加速感染性糖尿病伤口愈合的可编程双时相药物释放的光交联水凝胶
Yufei Xue,Li Fan,Hui Liu et al.
Yufei Xue et al.
Chronic diabetic wounds remain a critical unmet challenge in clinical care, largely due to persistent bacterial infections and unresolved inflammation, leading to impaired healing. While photo-crosslinkable hydrogels offer localized therape...
The OsLHY-OsSCL30/OsDHT1 regulatory cascade coordinates heading date and plant height through Pre-mRNA splicing modulation in rice [0.03%]
OsLHY-OsSCL30/OsDHT1调控串珠通过Pre-mRNA剪接调控水稻抽穗期和株高
Yingying Lu,Yixian Guo,Rui Gao et al.
Yingying Lu et al.
Introduction: Heading date and plant height are critical agronomic traits in rice, governing climate adaptation and yield. Pre-mRNA splicing is a key post-transcriptional regulatory mechanism influencing plant development...