LncRNA HCP5 remodels G6PD dual post-translational modification to mediate metabolic adaptations driving osimertinib resistance in lung adenocarcinoma [0.03%]
长链非编码RNA HCP5 通过重塑G6PD双重翻译后修饰介导代谢适应以诱导肺腺癌对奥希替尼耐药性
Wei Xu,Xi Chen,Qianqian Zhang et al.
Wei Xu et al.
Introduction: Osimertinib represents the standard treatment for EGFR-mutant lung adenocarcinoma (LUAD); however, acquired resistance limits its clinical efficacy. Elucidating the underlying mechanisms of resistance is cru...
PCSK9 promotes prostate cancer via facilitating intratumoral cholesterol accumulation and enhancing immunosuppressive tumor microenvironment [0.03%]
PCSK9通过促进瘤内胆固醇积累和增强免疫抑制性肿瘤微环境来促进前列腺癌发展
Yan Gu,Fengxiang Wei,Ying Dong et al.
Yan Gu et al.
Introduction: Cholesterol plays critical roles in prostate cancer (PCa) proliferation, immune evasion, and androgen signaling. PCSK9 regulates cholesterol metabolism. Its role in PCa remains unclear. ...
LPCAT3 deficiency Drives phospholipid remodeling and mitochondrial oxidative dysfunction to accelerate MASH-HCC development [0.03%]
LPCAT3缺陷通过磷脂重塑和线粒体氧化损伤加速MASH-HCC的发展
Gaoxuan Shao,Chenhao Ye,Chenceng Sun et al.
Gaoxuan Shao et al.
Introduction: Metabolic dysfunction-associated steatohepatitis (MASH) represents a severe subtype of metabolic dysfunction-associated fatty liver disease (MAFLD), characterized by hepatic steatosis, chronic inflammation, ...
Brain-heart interaction: direct and indirect circuits in health and diseases [0.03%]
脑-心交互作用：健康与疾病中的直接和间接环路
Yi Wang,Lele Liu,Tianai Zhang et al.
Yi Wang et al.
Background: Epidemiological data indicate a significant global increase in both comorbidity and mutually induced rates between cardiovascular and neurological diseases. Among these, cardiovascular and cerebrovascular dise...
Antidiabetic drug effects on gastrointestinal health: convergent evidence from a longitudinal cohort and Mendelian randomization study [0.03%]
抗糖尿病药物对胃肠道健康的影响：纵向队列和孟德尔随机化研究的证据收敛性
Xinxuan Li,Jie Chen,Lijuan Wang et al.
Xinxuan Li et al.
Introduction: The global prevalence of diabetes continues to rise, and long-term use of anti-diabetic drugs has thus become a cornerstone of clinical management for most patients. ...
Umbilical cord-derived mesenchymal stem cells restore renal homeostasis in Alport Syndrome: Mechanistic insights and clinical translation [0.03%]
胎盘来源的间充质干细胞通过恢复Alport综合征的肾内稳态实现临床转化：机制见解及临床应用研究
Li Huang,Che Zhang,Zegan Liu et al.
Li Huang et al.
Introduction: X-linked Alport syndrome (AS) is a progressive hereditary nephropathy caused by mutations in the COL4A5 gene, leading to end-stage renal disease in young adults. Current treatments are palliative with limite...
Genetic identification of the FcδR complex: TRβV12-4 as the IgD-binding domain targeted for immunotherapy in rheumatoid arthritis [0.03%]
FcδR复合体的基因鉴定：系统性红斑狼疮和类风湿关节炎治疗靶标TRβV12-4是IgD结合区
Xiaoxi Hu,Chenchen Han,Dongliang Huang et al.
Xiaoxi Hu et al.
Introduction: Rheumatoid arthritis (RA) is a chronic autoimmune disease that drives progressive joint destruction and functional disability. Current therapies are often limited by inadequate efficacy and risks of broad im...
Landscape of volatile organic compounds for differential diagnosis, pathological typing, and severity prediction in lung cancer: a large population-based prospective study [0.03%]
基于人群的肺癌大规模前瞻性研究中挥发性有机化合物标志物的差异诊断、病理分型及预后价值探索
Run Xiang,Peihong Hu,Mingxin Liu et al.
Run Xiang et al.
Background: In this study, we have developed the largest sample size model to achieve non-invasive, convenient and low-cost lung cancer diagnosis and discrimination using Volatile organic compounds (VOCs) analysis. ...
GL-V9 disrupts the mitochondrial homeostasis and triggers the integrated stress response by promoting the binding of cytosolic MDM2 with NDUFS1 in colorectal cancer [0.03%]
GL-V9通过促进胞质MDM2与NDUFS1结合在结直肠癌中破坏线粒体稳态并触发综合应激反应
Yibo Zhang,Chen Xun,Chenxiao Shi et al.
Yibo Zhang et al.
Introduction: The oncogenic role of mouse double minute 2 (MDM2) is primarily attributed to its regulation of p53-dependent signaling cascades. The colorectal cancer (CRC) remains in the top five most prevalent and lethal...
Plasma proteomic architecture of educational attainment associated with morbidity and mortality [0.03%]
教育成就与患病和死亡相关的血浆蛋白质组学架构研究
Zhenguo Wu,Dachuan Guo,Yijia Wan et al.
Zhenguo Wu et al.
Introduction: Higher educational attainment is robustly linked to lower morbidity and mortality, yet the underlying biological mechanisms remain elusive. ...