Deciphering the dynamic expression network of fiber elongation and the functional role of the GhTUB5 gene for fiber length in cotton based on an introgression population of upland cotton [0.03%]
基于陆地棉导入群体解析纤维伸长动态表达网络及GhTUB5基因的增长效用
Jianjiang Ma,Liupeng Yang,Yuanyue Dang et al.
Jianjiang Ma et al.
Introduction: Interspecific introgression between Gossypium hirsutum and G. barbadense allows breeding cotton with outstanding fiber length (FL). However, the dynamic gene regulatory network of FL-related genes has not be...
GDF11 protects against mitochondrial-dysfunction-dependent NLRP3 inflammasome activation to attenuate osteoarthritis [0.03%]
GDF11通过保护线粒体功能依赖的NLRP3炎性小体活化来缓解骨关节炎
Pengfei Zhang,Haoxin Zhai,Shuai Zhang et al.
Pengfei Zhang et al.
Introduction: Osteoarthritis (OA) is a highly prevalent degenerative disease worldwide, and tumor necrosis factor (TNF-α) is closely associated with its development. Growth differentiation factor 11 (GDF11) has demonstra...
Inhibition of mitophagy via the EIF2S1-ATF4-PRKN pathway contributes to viral encephalitis [0.03%]
EIF2S1-ATF4-PRKN通路介导的线粒体自噬抑制在病毒性脑炎发生中的作用
Xiaowei Song,Yiliang Wang,Weixiangmin Zou et al.
Xiaowei Song et al.
Introduction: Mitophagy, a selective form of autophagy responsible for maintaining mitochondrial homeostasis, regulates the antiviral immune response and acts as viral replication platforms to facilitate infection with va...
ADAM8 deficiency in macrophages promotes cardiac repair after myocardial infarction via ANXA2-mTOR-autophagy pathway [0.03%]
巨噬细胞中ADAM8缺乏通过ANXA2-mTOR-自噬途径促进心肌梗死后的心脏修复
Zhenjun Ji,Jiaqi Guo,Rui Zhang et al.
Zhenjun Ji et al.
Introduction: A disintegrin and metalloproteinase 8 (ADAM8), a crucial regulator in macrophages, is closely associated with cardiovascular disease progression. ...
IRnet: Immunotherapy response prediction using pathway knowledge-informed graph neural network [0.03%]
基于通路知识告知图神经网络的免疫治疗反应预测模型
Yuexu Jiang,Manish Sridhar Immadi,Duolin Wang et al.
Yuexu Jiang et al.
Introduction: Immune checkpoint inhibitors (ICIs) are potent and precise therapies for various cancer types, significantly improving survival rates in patients who respond positively to them. However, only a minority of p...
Fluoride induces hepatointestinal damage and vitamin B2 mitigation by regulating IL-17A and Bifidobacterium in ileum [0.03%]
氟化物通过调节回肠中IL-17A和双歧杆菌诱导肝肠损伤及核黄素缓解
Chen Liang,Cuicui Zhuang,Chenkai Cheng et al.
Chen Liang et al.
Introduction: Fluorosis is a global public health disease affecting more than 50 countries and 500 million people. Excessive fluoride damages the liver and intestines, yet the mechanisms and therapeutic approaches remain ...
Glutathione hybrid poly (beta-amino ester)-plasmid nanoparticles for enhancing gene delivery and biosafety [0.03%]
半胱氨酸-谷氨酰胺双功能单体与Pluronic F127共混自组装成基因载体纳米材料研究
Songwei Tan,Caiyan Yuan,Yuhe Zhu et al.
Songwei Tan et al.
Introduction: CRISPR/Cas9 gene editing technology has significantly advanced gene therapy, with gene vectors being one of the key factors for its success. Poly (beta-amino ester) (PBAE), a distinguished non-viral cationic...
Insights of immune cell heterogeneity, tumor-initiated subtype transformation, drug resistance, treatment and detecting technologies in glioma microenvironment [0.03%]
关于胶质瘤免疫细胞异质性、肿瘤启动子亚型转化、药物抵抗、治疗及检测技术的新见解
Tongzheng Chen,Wenbin Ma,Xin Wang et al.
Tongzheng Chen et al.
Background: With the gradual understanding of glioma development and the immune microenvironment, many immune cells have been discovered. Despite the growing comprehension of immune cell functions and the clinical applica...
The molecular mechanism of NF-κB dysregulation across different subtypes of renal cell carcinoma [0.03%]
不同亚型肾细胞癌中NF-κB异常调控的分子机制
Nour Abu Jayab,Alaa Abed,Iman M Talaat et al.
Nour Abu Jayab et al.
Background: The nuclear factor kappa B (NF-κB) is a critical pathway that regulates various cellular functions, including immune response, proliferation, growth, and apoptosis. Furthermore, this pathway is tightly regula...
NAT10 promotes osteoclastogenesis in inflammatory bone loss by catalyzing Fos mRNA ac4C modification and upregulating MAPK signaling pathway [0.03%]
NAT10通过催化Fos mRNA的ac4C修饰促进炎性骨丢失过程中的破骨细胞生成及MAPK信号通路的上调
Ruhan Yang,Weijun Yu,Lu Lin et al.
Ruhan Yang et al.
Introduction: Excessive osteoclastogenesis is a key driver of inflammatory bone loss. Suppressing osteoclastogenesis has always been considered essential for the treatment of inflammatory bone loss. N-acetyltransferase 10...