Development of a bacterial gene transcription activating strategy based on transcriptional activator positive feedback [0.03%]
基于转录激活子正反馈的细菌基因转录激活策略开发
Guangle Yu,Qiuyue Duan,Tianqi Cui et al.
Guangle Yu et al.
Introduction: Transcription of biological nitrogen fixation (nif) genes is activated by the NifA protein which recognizes specific activating sequences upstream of σ54-dependent nif promoters. The large quantities of nit...
Lipidomics identified novel cholesterol-independent predictors for risk of incident coronary heart disease: Mediation of risk from diabetes and aggravation of risk by ambient air pollution [0.03%]
脂质组学识别出胆固醇非依赖性的心脏病独立发病危险因素：糖尿病的危险中介及大气污染的风险恶化作用
Yingmei Li,Hao Wang,Yang Xiao et al.
Yingmei Li et al.
Introduction: Previous lipidomics studies have identified various lipid predictors for cardiovascular risk, however, with limited predictive increment, sometimes using too many predictor variables at the expense of practi...
Ginsenoside Rb2 inhibits p300-mediated SF3A2 acetylation at lysine 10 to promote Fscn1 alternative splicing against myocardial ischemic/reperfusion injury [0.03%]
Ginsenoside Rb2通过抑制p300介导的SF3A2赖氨酸10乙酰化促进Fscn1可变剪接以对抗心肌缺血再灌注损伤
Qingxia Huang,Yao Yao,Yisa Wang et al.
Qingxia Huang et al.
Introduction: Ginsenosides (GS) derived from Panax ginseng can regulate protein acetylation to promote mitochondrial function for protecting cardiomyocytes. However, the potential mechanisms of GS for regulating acetylati...
Understanding the mechanobiology of phytoacoustics through molecular Lens: Mechanisms and future perspectives [0.03%]
植物声学力学生物学的分子机制及未来展望
Sajad Ali,Anshika Tyagi,Suvin Park et al.
Sajad Ali et al.
Background: How plants emit, perceive, and respond to sound vibrations (SVs) is a long-standing question in the field of plant sensory biology. In recent years, there have been numerous studies on how SVs affect plant mor...
Slow gut transit increases the risk of Alzheimer's disease: An integrated study of the bi-national cohort in South Korea and Japan and Alzheimer's disease model mice [0.03%]
肠蠕动缓慢增加阿尔茨海默病的风险：韩国和日本跨国队列研究及阿尔茨海默病模型小鼠的综合分析
Jiseung Kang,Myeongcheol Lee,Mincheol Park et al.
Jiseung Kang et al.
Introduction: Although the association between Alzheimer's disease (AD) and constipation is controversial, its causality and underlying mechanisms remain unknown. ...
New insights into the roles of fungi and bacteria in the development of medicinal plant [0.03%]
药用植物发育过程中细菌和真菌作用的新见解
Jingsheng Yu,Yixuan Zheng,Chi Song et al.
Jingsheng Yu et al.
Background: The interaction between microorganisms and medicinal plants is a popular topic. Previous studies consistently reported that microorganisms were mainly considered pathogens or contaminants. However, with the de...
Loss of Sc5d results in micrognathia due to a failure in osteoblast differentiation [0.03%]
Sc5d基因缺失通过抑制成骨细胞分化导致小颌畸形
Chihiro Iwaya,Akiko Suzuki,Junichi Iwata
Chihiro Iwaya
Introduction: Mutations in genes related to cholesterol metabolism, or maternal diet and health status, affect craniofacial bone formation. However, the precise role of intracellular cholesterol metabolism in craniofacial...
Rapid visualization of PD-L1 expression level in glioblastoma immune microenvironment via machine learning cascade-based Raman histopathology [0.03%]
基于机器学习的拉曼组病理学技术快速可视化胶质母细胞瘤免疫微环境中的PD-L1表达水平
Qing-Qing Zhou,Jingxing Guo,Ziyang Wang et al.
Qing-Qing Zhou et al.
Introduction: Combination immunotherapy holds promise for improving survival in responsive glioblastoma (GBM) patients. Programmed death-ligand 1 (PD-L1) expression in immune microenvironment (IME) is the most important p...
The NLRP3 molecule influences the therapeutic effects of mesenchymal stem cells through Glut1-mediated energy metabolic reprogramming [0.03%]
NLRP3分子通过Glut1介导的代谢重组影响间充质干细胞的治疗效果
Jingrou Chen,Shujuan Xie,Dongbo Qiu et al.
Jingrou Chen et al.
Introduction: Numerous studies demonstrated that NLRP3 has been implicated in the pathogenesis of inflammatory bowel disease (IBD). Mesenchymal stem cells (MSCs) regulated the NLRP3 inflammasome, which has emerged as a no...
Genomic insights into the contribution of de novo lipogenesis to intramuscular fat deposition in chicken [0.03%]
基因组学视角下鸡肌肉内新脂肪合成的贡献分析
Huanxian Cui,Yongli Wang,Yuting Zhu et al.
Huanxian Cui et al.
Introduction: The proportion of animal based foods in daily diet of consumers is constantly increasing, with chicken being highly favored due to its high protein and low fat characteristics. The consumption of chicken aro...