Attention over vulnerable brain regions associating cerebral palsy disorder and biological markers [0.03%]
关注易受伤害的脑部区域与脑瘫障碍和生物标志物的关系
Muhammad Hassan,Jieqiong Lin,Ahmed Ameen Fateh et al.
Muhammad Hassan et al.
Introduction: Cerebral palsy (CP) is a neurological disorder caused by cerebral ischemia and hypoxia during fetal brain development.Early intervention in CP favors medications and therapies; however, monitoring early brai...
2'-Fucosyllactose ameliorates aging-related osteoporosis by restoring gut microbial and innate immune homeostasis [0.03%]
2'-岩藻糖基乳糖通过恢复肠道微生物和固有免疫稳态来改善与衰老相关的骨质疏松症
Ang Li,Ruixin Kou,Jin Wang et al.
Ang Li et al.
Introduction: Aging-related osteoporosis is considered as a serious public health concern for middle-aged and elderly people, with an intricated pathogenesis including the recently identified aging-induced immunological d...
Astragaloside IV alleviates septic myocardial injury through DUSP1-Prohibitin 2 mediated mitochondrial quality control and ER-autophagy [0.03%]
Astragaloside IV通过DUSP1-Prohibitin 2介导的线粒体质量控制和内质网-自噬缓解脓毒症心肌损伤
Junyan Wang,Xiangyi Pu,Haowen Zhuang et al.
Junyan Wang et al.
Introduction: Septic cardiomyopathy (SCM) is a complication of myocardial injury in patients with severe sepsis. Objectives: This study...
Oncogenic cholesterol rewires lipid metabolism in hepatocellular carcinoma via the CSNK2A1-IGF2R Ser2484 axis [0.03%]
致癌胆固醇通过CSNK2A1-IGF2R Ser2484轴重新编程肝细胞癌脂质代谢路径
Ren-Yi Su,Chen-Hao Xu,Hai-Jun Guo et al.
Ren-Yi Su et al.
Introduction: Alcohol consumption and hepatitis B virus (HBV) infection are common risk factors for hepatocellular carcinoma (HCC). However, few studies have focused on elucidating the mechanisms of HCC with combined alco...
Deficiency of myeloid NPC1 exacerbates liver injury and fibrosis by impairing macrophage efferocytosis [0.03%]
髓系NPC1缺乏通过损害巨噬细胞的胞葬作用加剧肝损伤和纤维化
Dongwei Guan,Pengju Huang,Xinlei Liu et al.
Dongwei Guan et al.
Introduction: Niemann-Pick C1 (NPC1), a lysosomal cholesterol transport protein, is required for efficient efferocytosis. Patients with Npc1 mutation are frequently accompanied with hepatic symptoms, including hepatomegal...
Transformative applications of oculomics-based AI approaches in the management of systemic diseases: A systematic review [0.03%]
基于眼基因组学的AI在全身性疾病管理中的变革性应用：系统综述
Zhongwen Li,Shiqi Yin,Shihong Wang et al.
Zhongwen Li et al.
Background: Systemic diseases, such as cardiovascular and cerebrovascular conditions, pose significant global health challenges due to their high mortality rates. Early identification and intervention in systemic diseases...
Host genetic regulation of specific functional groups in the rumen microbiome of dairy cows: Implications for lactation trait [0.03%]
宿主基因调控对乳牛瘤胃微生物组中特定功能群的影响及其对泌乳性状的意义
Hao Bai,Zheng Lai,Jiawei Zhang et al.
Hao Bai et al.
Introduction: Ruminants play a pivotal role in our society by transforming non-consumable substances from industrial by-products and plant fibers into valuable resources such as meat and milk. This remarkable conversion a...
Biological functions and pharmacological behaviors of bile acids in metabolic diseases [0.03%]
胆汁酸在代谢性疾病中的生物学功能和药理学行为
Tongxi Zhuang,Xunjiang Wang,Zixuan Wang et al.
Tongxi Zhuang et al.
Background: Bile acids, synthesized endogenously from cholesterol, play a central role in metabolic regulation within the enterohepatic circulatory system. Traditionally known as emulsifying agents that facilitate the int...
Lactate-mediated lactylation in human health and diseases: Progress and remaining challenges [0.03%]
人体健康和疾病中的乳酸介导的乳酸化修饰：进展与挑战
Xue-Ting Hu,Xiao-Feng Wu,Jin-Yi Xu et al.
Xue-Ting Hu et al.
Background: Lactate was once considered as metabolic waste for a long time. In 2019, Professor Zhao Yingming's team from the University of Chicago found that lactate could also be used as a substrate to induce histone lac...
Brain-targeted autoimmunity is strongly associated with Long COVID and its chronic fatigue syndrome as well as its affective symptoms [0.03%]
脑靶向自身免疫与长新冠及其慢性疲劳综合症和情感症状密切相关
Abbas F Almulla,Michael Maes,Bo Zhou et al.
Abbas F Almulla et al.
Introduction: Autoimmune responses contribute to the pathophysiology of Long COVID, affective symptoms and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). ...