Resveratrol and p53: How are they involved in CRC plasticity and apoptosis? [0.03%]
白藜芦醇和p53：它们如何参与CRC的可塑性和凋亡？
Aranka Brockmueller,Constanze Buhrmann,Amir Reza Moravejolahkami et al.
Aranka Brockmueller et al.
Background: Colorectal cancer (CRC), which is mainly caused by epigenetic and lifestyle factors, is very often associated with functional plasticity during its development. In addition, the malignant plasticity of CRC cel...
The transcription factor PbbHLH164 is destabilized by PbRAD23C/D.1 and mediates ethylene biosynthesis during pear fruit ripening [0.03%]
转录因子PbbHLH164在梨果成熟过程中被PbRAD23C/D.1失稳并介导乙烯生物合成
ZhiHua Guo,Hong Liu,SiQi Zheng et al.
ZhiHua Guo et al.
The phytohormone ethylene plays an important role in climacteric fruit ripening. However, the knowledge on molecular regulation of ethylene biosynthesis remains limited in pear fruit. Herein, a new basic helix-loop-helix transcription facto...
Lamei Yuan,Xiangyu Chen,Joseph Jankovic et al.
Lamei Yuan et al.
Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common hereditary cerebral small vessel disease (CSVD), pathologically characterized by a non-at...
Tiantian Shan,Xi Chen,Xinxuan Zhou et al.
Tiantian Shan et al.
Background: Helicobacter pylori (H. pylori), the only bacterium classified as a type I (definite) carcinogen, is strongly associated with the development of gastric inflammation and adenocarcinoma. It infects the stomach ...
Complete genomic profiles of 1496 Taiwanese reveal curated medical insights [0.03%]
1496名台湾人的完整基因组谱揭示了整理后的医疗见解
Jacob Shujui Hsu,Dung-Chi Wu,Shang-Hung Shih et al.
Jacob Shujui Hsu et al.
Introduction: The population of Taiwan has a long history of ethno-cultural evolution. The Taiwanese population was isolated from other large populations such as the European, Han Chinese, and Japanese population. The Tai...
HMGB1 promotes chemoresistance in small cell lung cancer by inducing PARP1-related nucleophagy [0.03%]
HMGB1通过诱导PARP1相关的核自噬来促进小细胞肺癌的化学抗性
Weitao Shen,Qiong Lyu,Ruibin Yi et al.
Weitao Shen et al.
Introduction: Small cell lung cancer (SCLC) is prone to chemoresistance, which is closely related to genome homeostasis-related processes, such as DNA damage and repair. Nucleophagy is the elimination of specific nuclear ...
The light-harvesting chlorophyll a/b-binding proteins of photosystem II family members are responsible for temperature sensitivity and leaf color phenotype in albino tea plant [0.03%]
光系统II捕光色素蛋白家族成员对白化茶树的温度敏感性和叶片颜色表现型负责
Jing-Jing Ye,Xin-Yi Lin,Zi-Xian Yang et al.
Jing-Jing Ye et al.
Introduction: Light-harvesting chlorophyll a/b-binding (LHCB) protein complexes of photosystem II are integral to the formation of thylakoid structure and the photosynthetic process. They play an important role in photopr...
Targeting acid ceramidase enhances antitumor immune response in colorectal cancer [0.03%]
靶向酸性神经酰胺酶可增强结肠癌的抗肿瘤免疫反应
Yadu Vijayan,Shirley James,Arun Viswanathan et al.
Yadu Vijayan et al.
Introduction: Acid ceramidase (hereafter referred as ASAH1) is an enzyme in sphingolipid metabolism that converts pro-survival ceramide into sphingosine. ASAH1 has been shown to be overexpressed in certain cancers. Howeve...
Early concentrate starter introduction induces rumen epithelial parakeratosis by blocking keratinocyte differentiation with excessive ruminal butyrate accumulation [0.03%]
早期精料启动通过在瘤胃上皮中积聚过多的丁酸来阻止角质细胞分化从而诱导过度角化
Kai Zhang,Yali Zhang,Jing Qin et al.
Kai Zhang et al.
Introduction: Rumen epithelial parakeratosis, a common disease in ruminants caused by abnormalities in the ruminal stratified squamous epithelial keratinization process, negatively impacts ruminant health and performance....
Zhaobo Zhang,Yuanming Zou,Chunyu Song et al.
Zhaobo Zhang et al.
Background: Cardiovascular disease (CVD) has been the leading cause of death worldwide for many years. In recent years, exosomes have gained extensive attention in the cardiovascular system due to their excellent biocompa...