Simultaneous detection of membrane protein and mRNA at single extracellular vesicle level by droplet microfluidics for cancer diagnosis [0.03%]
基于微滴微流控的单细胞外囊泡膜蛋白和mRNA的同时检测用于癌症诊断
Huixian Lin,Bo Li,Jingyun Guo et al.
Huixian Lin et al.
Introduction: Simultaneous detection of proteins and mRNA within a single extracellular vesicle (EV) enables comprehensive analysis of specific EVs subpopulations, significantly advancing cancer diagnostics. However, deve...
New insights into the function and mechanisms of piRNA PMLCPIR in promoting PM2.5-induced lung cancer [0.03%]
PiRNA PMLCPIR在促进PM2.5诱导的肺癌发生发展中的功能及机制研究新进展
Lin Xu,Wanli Ma,Xiaoyu Huo et al.
Lin Xu et al.
Introduction: Extensive studies have established the correlation between long-term PM2.5 exposure and lung cancer, yet the mechanisms underlying this association remain poorly understood. PIWI-interacting RNAs (piRNAs), a...
Nervonic acid triggered ovarian inflammation by inducing mitochondrial oxidative stress to activate NLRP3/ IL-1β pathway [0.03%]
神经酸通过诱导线粒体氧化应激激活NLRP3/IL-1β信号通路触发卵巢炎症
Xiangzhou Zeng,Xinyin Fan,Haitao Yu et al.
Xiangzhou Zeng et al.
Introduction: Metabolic syndrome is a serious public health concern across the globe. However, the typical metabolites and mechanisms underlying the decreased fertility related to metabolic syndrome is still elusive. ...
Dual nature of type I interferon responses and feedback regulations by SOCS1 dictate malaria mortality [0.03%]
I型干扰素反应的双重性质及其由SOCS1介导的反馈调节决定疟疾死亡率
Jiansen Lu,Zhiqiang Hu,Huaji Jiang et al.
Jiansen Lu et al.
Introduction: Type I interferon (IFN-I, IFN-α/β), precisely controlled by multiple regulators, including suppressor of cytokine signaling 1 (SOCS1), is critical for host defense against pathogens. However, the impact of...
An ABC transporter-mediated transport and metabolism of the pesticide bentazone in rice (Oryza sativa L.) [0.03%]
水稻ABC转运蛋白介导的除草剂苯特嗪的转运和代谢研究
Yuxin Qiao,Yujue Wang,Yucheng Gu et al.
Yuxin Qiao et al.
Introduction: Bentazon (BNTZ) is a selective contact herbicide widely used to control field weeds for crop production. Excessive use of BNTZ leads to its accumulation in soils and crops, becoming an environmental contamin...
Polydopamine-assisted smart bacteria-responsive hydrogel: Switchable antimicrobial and antifouling capabilities for accelerated wound healing [0.03%]
聚多巴胺辅助的智能细菌响应性水凝胶：可切换抗菌和防污能力以加速伤口愈合
Zheng Fang,Qingyan He,Yanyu Hu et al.
Zheng Fang et al.
Introduction: Wound infections and formation of biofilms caused by multidrug-resistant bacteria have constituted a series of wound deteriorated and life-threatening problems. The in situ resisting bacterial adhesion, kill...
Dialog between mantle cell lymphoma cells and lymphoma-associated macrophages underlies ibrutinib resistance [0.03%]
耐药性的毛细胞星形细胞瘤与淋巴瘤相关巨噬细胞之间的对话机制研究
Xiaoqing Sun,Caiqin Wang,Jianghua Cao et al.
Xiaoqing Sun et al.
Introduction: Patients with mantle cell lymphoma (MCL) frequently develop resistance to ibrutinib. Lymphoma-associated macrophages (LAMs) may play a causal role in this resistance but remain underexplored in current liter...
Yu&#x;e Liu,Linjun Weng,Yanjin Wang et al.
Yu&#x;e Liu et al.
Background: Immunotherapy has emerged as a novel strategy for cancer treatment following surgery, radiotherapy, and chemotherapy. Immune checkpoint blockade and Chimeric antigen receptor (CAR)-T cell therapies have been s...
CRISPR/Cas genome editing in soybean: challenges and new insights to overcome existing bottlenecks [0.03%]
大豆基因组编辑面临的挑战及克服现有瓶颈的新见解
Nayara Sabrina Freitas-Alves,Clidia E Moreira-Pinto,Fabiano T P K Távora et al.
Nayara Sabrina Freitas-Alves et al.
Background: Soybean is a worldwide-cultivated crop due to its applications in the food, feed, and biodiesel industries. Genome editing in soybean began with ZFN and TALEN technologies; however, CRISPR/Cas has emerged and ...
Matrix stiffness-dependent PD-L2 deficiency improves SMYD3/xCT-mediated ferroptosis and the efficacy of anti-PD-1 in HCC [0.03%]
基质硬度依赖的PD-L2缺乏通过改善SMYD3/xCT介导的铁死亡和抗PD-1的效果来提高肝癌免疫治疗效果
Shunxi Wang,Xiaoxue Yuan,Zetao Yang et al.
Shunxi Wang et al.
Introduction: Heterogeneous tissue stiffening promotes tumor progression and resistance, and predicts a poor clinical outcome in patients with hepatocellular carcinoma (HCC). Ferroptosis, a congenital tumor suppressive me...