Chronic arsenic exposure-provoked biotoxicity involved in liver-microbiota-gut axis disruption in chickens based on multi-omics technologies [0.03%]
基于多组学技术的慢性砷暴露引起的鸡肝脏-微生物群-肠道轴紊乱的生物毒性研究
Jiayi Li,Changming Guo,Yan Liu et al.
Jiayi Li et al.
Introduction: Arsenic has been ranked as the most hazardous substance by the U.S. Agency for Toxic Substances and Disease Registry. Environmental arsenic exposure-evoked health risks have become a vital public health conc...
The circUbqln1, regulated by XBP1s, interplays with 14-3-3ζ to inhibit collagen synthesis and promote osteoarthritis by controlling PRODH activity and proline metabolism [0.03%]
由XBP1s调控的circUbqln1通过控制PRODH活性和脯氨酸代谢与14-3-3ζ相互作用抑制胶原蛋白合成并促进骨关节炎的发展
Naibo Feng,Yuanlan Ye,Yiming Pan et al.
Naibo Feng et al.
Introduction: Osteoarthritis (OA) is a degenerative bone disease associated with ageing, characterized by joint pain, stiffness, swelling and deformation. Currently, pharmaceutical options for the clinical treatment of OA...
HSPA12A acts as a scaffolding protein to inhibit cardiac fibroblast activation and cardiac fibrosis [0.03%]
HSPA12A充当分子支架蛋白抑制心脏成纤维细胞的激活和心肌纤维化
Qian Mao,Xiaojin Zhang,Jinna Yang et al.
Qian Mao et al.
Introduction: Cardiac fibrosis is the main driver for adverse remodeling and progressive functional decline in nearly all types of heart disease including myocardial infarction (MI). The activation of cardiac fibroblasts ...
Hierarchical double-layer microneedles accomplish multicenter skin regeneration in diabetic full-thickness wounds [0.03%]
分层双层微针实现糖尿病全厚皮伤口的多中心皮肤再生
Xiaoqi Huang,Xingtang Niu,Yuan Ma et al.
Xiaoqi Huang et al.
Introduction: Managing large chronic wounds presents significant challenges because of inadequate donor sites, infection, and lack of structural support from dermal substitutes. Hydrogels are extensively used in various f...
Yan Wu,Peiran Song,Miaomiao Wang et al.
Yan Wu et al.
Background: Bone metabolism can maintain the normal homeostasis and function of bone tissue. Once the bone metabolism balance is broken, it will cause osteoporosis, osteoarthritis, bone defects, bone tumors, or other bone...
Therapeutic effect of phycocyanin on chronic obstructive pulmonary disease in mice [0.03%]
藻红蛋白对小鼠慢性阻塞性肺疾病的作用效果研究
Wenjun Li,Yuanyuan Li,Qi Wang et al.
Wenjun Li et al.
Introduction: The prevention and treatment of chronic obstructive pulmonary disease (COPD) is closely tied to antioxidation and anti-inflammation. Phycocyanin (PC) has numerous pharmacological effects, such as antioxidati...
Multiomics analyses of the effects of LED white light on the ripening of apricot fruits [0.03%]
LED白光对油桃果实成熟的影响的多组学分析
Chunmei Bai,Yanyan Zheng,Christopher Brian Watkins et al.
Chunmei Bai et al.
Introduction: Apricot (Prunus armeniaca L.) fruits are highly perishable and prone to quality deterioration during storage and transportation. Objectives:...
Diversity of Gibberellin 2-oxidase genes in the barley genome offers opportunities for genetic improvement [0.03%]
大麦基因组中赤霉素2-氧化酶基因的多样性为遗传改良提供了机会
Jingye Cheng,Yong Jia,Camilla Hill et al.
Jingye Cheng et al.
Introduction: Gibberellin (GA) is a vital phytohormone in regulating plant growth and development. During the "Green Revolution", modification of GA-related genes created semi-dwarfing phenotype in cereal crops but advers...
Wenxiang Fan,Linhong Fan,Ziying Wang et al.
Wenxiang Fan et al.
Background: Rare ginsenosides (Rg3, Rh2, C-K, etc.) refer to a group of dammarane triterpenoids that exist in low natural abundance, mostly produced by deglycosylation or side chain modification via physicochemical proces...
Current perspectives on microglia-neuron communication in the central nervous system: Direct and indirect modes of interaction [0.03%]
中枢神经系统中巨噬细胞-神经元交流的当前观点：直接和间接相互作用模式
Yue Hu,Weiwei Tao
Yue Hu
Background: The incessant communication that takes place between microglia and neurons is essential the development, maintenance, and pathogenesis of the central nervous system (CNS). As mobile phagocytic cells, microglia...