Inactive-enriched machine-learning models exploiting patent data improve structure-based virtual screening for PDL1 dimerizers [0.03%]
利用专利数据改进PDL1二聚体的基于结构的虚拟筛选的非活性增强机器学习模型
Pablo Gómez-Sacristán,Saw Simeon,Viet-Khoa Tran-Nguyen et al.
Pablo Gómez-Sacristán et al.
Introduction: Small-molecule Programmable Cell Death Protein 1/Programmable Death-Ligand 1 (PD1/PDL1) inhibition via PDL1 dimerization has the potential to lead to inexpensive drugs with better cancer patient outcomes and...
Specifically targeted antimicrobial peptides synergize with bacterial-entrapping peptide against systemic MRSA infections [0.03%]
特异性抗菌肽与细菌捕获肽联用对抗系统性MRSA感染
Bocheng Xu,Lin Wang,Chen Yang et al.
Bocheng Xu et al.
Introduction: The design of precision antimicrobials aims to personalize the treatment of drug-resistant bacterial infections and avoid host microbiota dysbiosis. ...
Alanine metabolism mediates energy allocation of the brown planthopper to adapt to resistant rice [0.03%]
丙氨酸代谢介导了褐飞虱对抗性水稻的能量分配适应性变化
Kai Lin,Lei Yue,Longyu Yuan et al.
Kai Lin et al.
Introduction: During the adaptation to host plant resistance, herbivorous insects faced the challenge of overcoming plant defenses while ensuring their own development and reproductive success. To achieve this, a strategi...
The role of endothelial cell-pericyte interactions in vascularization and diseases [0.03%]
血管内皮细胞-周细胞相互作用在血管生成及疾病中的作用
Gan Li,Junjie Gao,Peng Ding et al.
Gan Li et al.
Background: Endothelial cells (ECs) and pericytes (PCs) are crucial components of the vascular system, with ECs lining the inner layer of blood vessels and PCs surrounding capillaries to regulate blood flow and angiogenes...
The power and the promise of CAR-mediated cell immunotherapy for clinical application in pancreatic cancer [0.03%]
CAR介导的细胞免疫治疗在胰腺癌临床应用中的力量和前景
Hao-Yu Tang,Yi-Zhi Cao,Yi-Wei Zhou et al.
Hao-Yu Tang et al.
Background: Pancreatic cancer, referred to as the "monarch of malignancies," is a neoplastic growth mostly arising from the epithelial cells of the pancreatic duct and acinar cells. This particular neoplasm has a highly u...
Targeting tumor-associated macrophages: Novel insights into immunotherapy of skin cancer [0.03%]
针对肿瘤相关巨噬细胞：皮肤癌免疫治疗的新见解
Jun Liu,Jiaye Lu,Ling Wu et al.
Jun Liu et al.
Background: The incidence of skin cancer is currently increasing, and conventional treatment options inadequately address the demands of disease management. Fortunately, the recent rapid advancement of immunotherapy, part...
Single-cell RNA sequencing combined with proteomics of infected macrophages reveals prothymosin-α as a target for treatment of apical periodontitis [0.03%]
单细胞RNA测序结合感染巨噬细胞的蛋白质组学揭示了プロ胸腺素-α作为治疗牙尖周炎的靶点
Qimei Gong,Xiaomin Lv,Chenxi Liao et al.
Qimei Gong et al.
Introduction: Chronic apical periodontitis (CAP) is a common infectious disease of the oral cavity. Immune responses and osteoclastogenesis of monocytes/macrophages play a crucial role in CAP progression, and this study w...
RvD1 improves resident alveolar macrophage self-renewal via the ALX/MAPK14/S100A8/A9 pathway in acute respiratory distress syndrome [0.03%]
RvD1通过ALX/MAPK14/S100A8/A9通路改善急性呼吸窘迫综合征中驻留肺泡巨噬细胞的自我更新能力
Yang Ye,Qian Yang,Jinling Wei et al.
Yang Ye et al.
Introduction: Acute respiratory distress syndrome (ARDS) is a pulmonary inflammatory process primarily caused by sepsis. The resolution of inflammation is an active process involving the endogenous biosynthesis of special...
A core-shell AuNRs@BUT-16 nanocomposite for enhancement SERS detection and efficient removal of deoxynivalenol [0.03%]
用于脱氧雪腐镰刀菌烯醇增强拉曼检测及高效去除的核壳型AuNRs@BUT-16纳米复合材料
Jing Tao,Yudan Wang,Wenlei Zhai et al.
Jing Tao et al.
Introduction: Deoxynivalenol (DON) is widely found in grains and poses a serious threat to human health, so there is an urgent need to develop methods for its simultaneous removal and detection. The novel metal organic fr...
Advances focusing on the application of decellularization methods in tendon-bone healing [0.03%]
脱细胞方法在肌腱骨骼修复中的应用进展
Sheng Zhong,Yujian Lan,Jinyu Liu et al.
Sheng Zhong et al.
Background: The tendon or ligament is attached to the bone by a triphasic but continuous area of heterogeneous tissue called the tendon-bone interface (TBI). The rapid and functional regeneration of TBI is challenging owi...