Haploinsufficiency of intraflagellar transport protein 172 causes autism-like behavioral phenotypes in mice through BDNF [0.03%]
纤毛动力蛋白复合物基因ITPRIP和IFT172的单倍剂量不足可导致自闭症光谱障碍及相关行为异常小鼠模型
Nanxi Zheng,Shilin Luo,Xin Zhang et al.
Nanxi Zheng et al.
Introduction: Primary cilia are hair-like solitary organelles growing on most mammalian cells that play fundamental roles in embryonic patterning and organogenesis. Defective cilia often cause a suite of inherited disease...
Biomarkers differentiating regression from progression among untreated cervical intraepithelial neoplasia grade 2 lesions [0.03%]
未治疗的宫颈上皮内瘤变Ⅱ级病灶转归与进展的鉴别标志物研究
Xiang Li,Yan Chen,Jing Xiong et al.
Xiang Li et al.
Background: Cervical intraepithelial neoplasia grade 2 (CIN2) is one of the precursor stages before cervical lesions develop into cervical cancer. The spontaneous development of CIN2 is ambiguous. One part of CIN2 lesions...
tsRNA modifications: An emerging layer of biological regulation in disease [0.03%]
疾病中的tsRNA修饰：新兴的生物学调控层
Yaomin Liang,Ding Ji,Xiaoling Ying et al.
Yaomin Liang et al.
Background: Transfer RNA (tRNA)-derived small RNA (tsRNA) represents an important and increasingly valued type of small non-coding RNA (sncRNA). The investigation of tRNA and tsRNA modification crosswalks has not only pro...
Rationally designed BCR-ABL kinase inhibitors for improved leukemia treatment via covalent and pro-/dual-drug targeting strategies [0.03%]
基于理性的BCR-ABL激酶抑制剂设计用于改善白血病治疗的共价和前药/双药策略
Jie Sun,Liang Lou,Chengjun Zhu et al.
Jie Sun et al.
Background: Chronic Myeloid Leukemia (CML) is a blood cancer that remains challenging to cure due to drug resistance and side effects from current BCR-ABL inhibitors. There is an urgent need for novel and more effective B...
Fabrication of nanogels to improve the toxicity and persistence of cycloxaprid against Diaphorina citri, the vector of citrus huanglongbing [0.03%]
制备纳稠胶以提高新烟碱类杀虫剂环丙虫酯对柑橘木虱的毒力和持效性
Li Cui,Guiyun Deng,Jianghong Wu et al.
Li Cui et al.
Introduction: Diaphorina citri is the most serious pest of citrus worldwide because it is the natural insect vector of huanglongbing. Cycloxaprid (Cyc) was highly toxic to D. citri. However, the poor solubility and stabil...
Metabolic phenotyping combined with transcriptomics metadata fortifies the diagnosis of early-stage Hepatocellular carcinoma [0.03%]
结合代谢表型和转录组元数据强化对早期肝细胞癌的诊断
Sun Jo Kim,Cheol Woon Jung,Nguyen Hoang Anh et al.
Sun Jo Kim et al.
Introduction: The low sensitivity of alpha-fetoprotein (AFP) renders it unsuitable as a stand-alone marker for early hepatocellular carcinoma (eHCC) surveillance. Therefore, additional blood-based biomarkers with enhanced...
Brain organoid maturation and implantation integration based on electrical signals input [0.03%]
基于电信号输入的类脑器官成熟和移植后整合研究
Xiao-Hong Li,Nan Hu,Zhe-Han Chang et al.
Xiao-Hong Li et al.
Introduction: Brain organoids are believed to be able to regenerate impaired neural circuits and reinstate brain functionality. The neuronal activity of organoids is considered a crucial factor for restoring host function...
Serum taurine affects lung cancer progression by regulating tumor immune escape mediated by the immune microenvironment [0.03%]
血清牛磺酸通过调节免疫微环境介导的肿瘤免疫逃逸影响肺癌进展
Tu-Liang Liang,Hu-Dan Pan,Pei-Yu Yan et al.
Tu-Liang Liang et al.
Introduction: Taurine is a naturally occurring sulfonic acid involved in various physiological and pathological processes, such as the regulation of calcium signaling, immune function, inflammatory response, and cellular ...
GmBSK1-GmGSK1-GmBES1.5 regulatory module controls heat tolerance in soybean [0.03%]
GmBSK1-GmGSK1-GmBES1.5调控模块控制大豆耐热性
Ze-Hao Hou,Yuan Gao,Jia-Cheng Zheng et al.
Ze-Hao Hou et al.
Introduction: Heat stress poses a severe threat to the growth and production of soybean (Glycine max). Brassinosteroids (BRs) actively participate in plant responses to abiotic stresses, however, the role of BR signaling ...
A wearable conductive hydrogel with triple network reinforcement inspired by bio-fibrous scaffolds for real-time quantitatively sensing compression force exerted on fruit surface [0.03%]
受生物纤维修支架启发的具有三级网络增强功能的可穿戴导电水凝胶用于实时定量感应水果表面承受的压力传感器
Zhichao Yang,Ziqiang Qin,Menglu Wu et al.
Zhichao Yang et al.
Introduction: Mechanical stresses incurred during post-harvest fruit storage and transportation profoundly impact decay and losses. Currently, the monitoring of mechanical forces is primarily focused on vibrational forces...