MCU complex: Exploring emerging targets and mechanisms of mitochondrial physiology and pathology [0.03%]
MCU 复合体：探索线粒体生理和病理学的新兴靶点和机制
Jin Wang,Jinyong Jiang,Haoliang Hu et al.
Jin Wang et al.
Background: Globally, the onset and progression of multiple human diseases are associated with mitochondrial dysfunction and dysregulation of Ca2+ uptake dynamics mediated by the mitochondrial calcium uniporter (MCU) comp...
HnRNPR-mediated UPF3B mRNA splicing drives hepatocellular carcinoma metastasis [0.03%]
HnRNPR介导的UPF3B mRNA剪接驱动肝细胞癌转移
Hong Wang,Dong Qian,Jiabei Wang et al.
Hong Wang et al.
Introduction: Abnormal alternative splicing (AS) contributes to aggressive intrahepatic invasion and metastatic spread, leading to the high lethality of hepatocellular carcinoma (HCC). ...
Metal-free production of natural blue colorants through anthocyanin-protein interactions [0.03%]
通过花青素-蛋白质相互作用无金属生产天然蓝色素
Wenxin Wang,Peiqing Yang,Fuqing Gao et al.
Wenxin Wang et al.
Introduction: The scarcity of naturally available sources for blue colorants has driven reliance on synthetic alternatives. Nevertheless, growing health concerns have prompted the development of naturally derived blue col...
Exploring the impacts of senescence on implantation and early embryonic development using totipotent cell-derived blastoids [0.03%]
使用全能细胞衍生的胚泡探讨衰老对着床和早期胚胎发育的影响
Yuxin Luo,Chenrui An,Ke Zhong et al.
Yuxin Luo et al.
Introduction: Advanced maternal age is associated with reduced implantation and pregnancy rates, yet the underlying mechanisms remain poorly understood, and research models are limited. ...
Melatonin alleviates high temperature exposure induced fetal growth restriction via the gut-placenta-fetus axis in pregnant mice [0.03%]
褪黑素通过怀孕小鼠的肠道-胎盘-胎儿轴缓解高温暴露引起的胎儿生长受限问题
Jia-Jin Wu,Xiaoyu Zheng,Caichi Wu et al.
Jia-Jin Wu et al.
Introduction: Global warming augments the risk of adverse pregnancy outcomes in vulnerable expectant mothers. Pioneering investigations into heat stress (HS) have predominantly centered on its direct impact on reproductiv...
AdipoRon ameliorates the progression of heart failure with preserved ejection fraction via mitigating lipid accumulation and fibrosis [0.03%]
AdipoRon通过减轻脂质积累和纤维化来改善射血分数保留型心力衰竭的进展
Wuping Tan,Yijun Wang,Siyi Cheng et al.
Wuping Tan et al.
Introduction: Obesity and imbalance in lipid homeostasis contribute greatly to heart failure with preserved ejection fraction (HFpEF), the dominant form of heart failure. Few effective therapies exist to control metabolic...
Valerenic acid attenuates pathological myocardial hypertrophy by promoting the utilization of multiple substrates in the mitochondrial energy metabolism [0.03%]
伐伦酸通过促进线粒体能量代谢中多种底物的利用来减轻病理性心肌肥大
Tiantian Liu,Xu Chen,Qianbin Sun et al.
Tiantian Liu et al.
Introduction: Valerenic acid (VA) is a unique and biologically active component in Valeriana officinalis L., which has been reported to have a regulatory effect on the cardiovascular system. However, its therapeutic effec...
Targeting lipid metabolism of macrophages: A new strategy for tumor therapy [0.03%]
针对巨噬细胞的脂质代谢：肿瘤治疗的新策略
Nan Shao,Hui Qiu,Jing Liu et al.
Nan Shao et al.
Background: Lipid metabolism has been implicated in a variety of normal cellular processes and strongly related to the development of multiple diseases, including tumor. Tumor-associated macrophage (TAM) has emerged as a ...
A narrative review about cognitive impairment in metabolic Dysfunction-Associated liver disease (MASLD): Another matter to face through a holistic approach [0.03%]
代谢功能障碍相关性肝病(MASLD)中的认知障碍的叙述综述:通过整体方法面对的另一个问题
Marica Meroni,Miriam Longo,Erika Paolini et al.
Marica Meroni et al.
Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic hepatic disorder worldwide in both adults and children. It is well established that MASLD represents the hepatic mani...
Claudia Fornelli,Alessia Sofia Cento,Lorenzo Nevi et al.
Claudia Fornelli et al.
Introduction: Obesity, one of the most frequent health problems in the adult population, is a condition characterized by excessive white adipose tissue accumulation and accompanied by the increased risk to develop other d...