Serum metabolite biomarkers for the early diagnosis and monitoring of age-related macular degeneration [0.03%]
用于年龄相关性黄斑变性的早期诊断和监测的血清代谢标志物
Shengjie Li,Yichao Qiu,Yingzhu Li et al.
Shengjie Li et al.
Introduction: Age-related macular degeneration (AMD) is a leading cause of irreversible blindness worldwide, with significant challenges for early diagnosis and treatment. ...
Zhouhui Yao,Yandan Lu,Pingping Wang et al.
Zhouhui Yao et al.
Background: Fibrosis is a tissue damage repair response caused by multiple pathogenic factors which could occur in almost every apparatus and leading to the tissue structure damage, physiological abnormality, and even org...
Unravelling the role of WRKY transcription factors in leaf senescence: Genetic and molecular insights [0.03%]
WRKY转录因子在叶片衰老中的作用机制：遗传和分子见解
Zishan Ahmad,Muthusamy Ramakrishnan,Chunyue Wang et al.
Zishan Ahmad et al.
Background: Leaf senescence (LS), the final phase in leaf development, is an important and precisely regulated process crucial for plant well-being and the redistribution of nutrients. It is intricately controlled by vari...
Pharmacological upregulation of macrophage-derived itaconic acid by pubescenoside C attenuated myocardial ischemia-reperfusion injury [0.03%]
淫羊藿素C通过上调巨噬细胞源琥珀酸促进心肌缺血再灌注损伤修复
Sixuan Chen,Haojie Yao,Yanmei Lou et al.
Sixuan Chen et al.
Introduction: Myocardial ischemia-reperfusion injury (MIRI) remains a prevalent clinical challenge globally, lacking an ideal therapeutic strategy. Macrophages play a pivotal role in MIRI pathophysiology, exhibiting dynam...
Population genomics analyses reveal the role of hybridization in the rapid invasion of fall armyworm [0.03%]
群体基因组分析揭示杂交在草地贪夜蛾快速入侵中的作用
Xuan Wang,Zhenyong Du,Yuange Duan et al.
Xuan Wang et al.
Introduction: Invasive species pose a major threat to global biodiversity and agricultural productivity, yet the genomic mechanisms driving their rapid expansion into new habitats are not fully understood. The fall armywo...
Salidroside sensitizes Triple-negative breast cancer to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy [0.03%]
山苍子素通过SCD1介导的脂质生成和NCOA4介导的铁死亡相关自噬(铁摄取)增强三阴性乳腺癌细胞对铁死亡的敏感性
Guiqin Huang,Yawen Cai,Menghui Ren et al.
Guiqin Huang et al.
Introduction: Triple-negative breast cancer (TNBC) is the primary cause of breast cancer-induced death in women. Literature has confirmed the benefits of Salidroside (Sal) in treating TNBC. However, the study about potent...
Gastrodin attenuates high fructose-induced sweet taste preference decrease by inhibiting hippocampal neural stem cell ferroptosis [0.03%]
天麻素通过抑制海马神经干细胞铁死亡改善高果糖诱导的甜味偏好降低现象
Chuan-Feng Tang,Hong Ding,Ya-Qian Wu et al.
Chuan-Feng Tang et al.
Introduction: High fructose intake has been implicated as a risk factor for behavioral disorders, potentially through cell ferroptosis induction in the central nervous system. Neural stem cells (NSCs) are crucial for main...
A multi-omics approach reveals that lotus root polysaccharide iron ameliorates iron deficiency-induced testicular damage by activating PPARγ to promote steroid hormone synthesis [0.03%]
多组学分析揭示了铁缺乏导致的睾丸损伤中，莲根多糖铁通过激活PPARγ促进类固醇激素合成来改善缺铁状况
Pei-Yu Dong,Shuai Yuan,Yu-Mei Chen Yan et al.
Pei-Yu Dong et al.
Iron deficiency is a common nutritional issue that seriously affects male reproductive health. Lotus root polysaccharide iron (LRPF), a novel nutritional supplement, may ameliorate the damage caused by iron deficiency, however, the mechanis...
A novel effect of sulforaphane on promoting mouse granulosa cells proliferation via the NRF2-TKT pathway [0.03%]
硫代葡萄糖异硫氰酸盐通过NRF2-TKT信号途径促进小鼠颗粒细胞增殖的新机制研究
Xuan Zhang,Dingding Zhang,Aoyun Fan et al.
Xuan Zhang et al.
Introduction: Granulosa cells (GCs) is essential for maintaining follicular development. Follicle-stimulating Hormone (FSH) has been demonstrated to effectively promote GCs proliferation, driving the establishment of vari...
DeSUMOylation of RBMX regulates exosomal sorting of cargo to promote renal tubulointerstitial fibrosis in diabetic kidney disease [0.03%]
去SUMO化调节RBMX促进糖尿病肾病中肾小管间质纤维化的外泌体分选货物
Yanlin Yang,Shijing Ren,Junyu Xue et al.
Yanlin Yang et al.
Introduction: Diabetic kidney disease (DKD) has become the primary cause of chronic renal failure in China, and renal tubulointerstitial fibrosis plays a central role in DKD progression. Urinary exosomes, which reflect ki...