Loss of glomerular aldolase B in diabetic nephropathy promotes renal fibrosis via activating Akt/GSK/β-catenin axis [0.03%]
糖尿病肾病中糖酵解关键酶醛缩酶B的丢失促进肾纤维化发生发展
Minghui Liu,Wenwen Yang,Shuang Qu et al.
Minghui Liu et al.
Objective: Diabetic nephropathy (DN), characterized by a complex and multifaceted pathogenesis, stands as the foremost catalyst behind end-stage renal disease (ESRD). This study aims to analyze the level and non-metabolic...
Design of highly leaf-adhesive and anti-UV herbicide nanoformulation for enhanced herbicidal activity [0.03%]
一种设计用于增强除草剂活性的高效粘附叶片且抗紫外线的纳米制剂
Dongdong Li,Jianan Li,Hao Li et al.
Dongdong Li et al.
Introduction: Conventional pesticide formulations have been widely used to boost agricultural productivity, but their weak foliar adhesion and instability under UV light during spraying lead to low utilization rates and p...
Absence of gut microbiota alleviates iron overload-induced colitis by modulating ferroptosis in mice [0.03%]
肠道微生物群的缺失通过调节铁过载小鼠的铁死亡来缓解结肠炎
Ke Gu,Aimin Wu,Chen Liu et al.
Ke Gu et al.
Introduction: Iron overload disrupts gut microbiota and induces ferroptosis, contributing to colitis. However, whether gut microbiota directly drives iron overload-induced colitis and its underlying mechanism remain uncle...
Lina Ding,Ruicheng Zhang,Wenqi Du et al.
Lina Ding et al.
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway has been identified as a crucial mechanism in antiviral defense and innate immunity pathway. Ferroptosis, characterized by iron dependence and lipid...
Tong-Ju Eh,Yaxuan Jiang,Mingquan Jiang et al.
Tong-Ju Eh et al.
Background: Trehalose is a nonreducing disaccharide containing two glucose molecules linked through an α,α-1,1-glycosidic bond. This unique chemical structure causes trehalose levels to fluctuate significantly in plants...
Targeting ATM enhances radiation sensitivity of colorectal cancer by potentiating radiation-induced cell death and antitumor immunity [0.03%]
靶向ATM通过增强放射诱导的细胞凋亡和抗肿瘤免疫来提高结直肠癌对辐射的敏感性
Yuwen Xie,Yang Liu,Mingdao Lin et al.
Yuwen Xie et al.
Introduction: The efficacy of radiotherapy in colorectal cancer (CRC) is often limited by radiation resistance. Ataxia telangiectasia mutated (ATM) is well known for its role in repairing double-strand DNA breaks within t...
Maternal fish oil supplementation enhances nutrient transport in the placenta and milk biosynthesis in the mammary gland via the GPR120 signaling pathway [0.03%]
鱼油补充通过GPR120信号途径增强胎盘营养物质转运和乳腺泌乳作用
Qihui Li,Qianzi Zhang,Senlin Su et al.
Qihui Li et al.
Introduction: Maternal fish oil (FO) supplementation during pregnancy has been shown to improve pregnancy outcomes. FO is recognized as dietary source for n-3 polyunsaturated fatty acids (n-3 PUFAs). While early research ...
FTO activates PD-L1 promotes immunosuppression in breast cancer via the m6A/YTHDF3/PDK1 axis under hypoxic conditions [0.03%]
FTO通过m6A/YTHDF3/PDK1轴在缺氧条件下激活PD-L1促进乳腺癌免疫抑制作用
Siyu Wang,Xingda Zhang,Quanrun Chen et al.
Siyu Wang et al.
Introduction: Altered epigenetic reprogramming enables breast cancer cells to adapt to hypoxic stress. Hypoxic microenvironment can alter immune cell infiltration and function, limiting the effectiveness of immunotherapy....
Biomechanical research using advanced micro-nano devices: In-Vitro cell Characterization focus [0.03%]
利用高级微纳米设备进行生物力学研究：以体外细胞表征为重点
Shiqiang Yan,Yan Lu,Changming An et al.
Shiqiang Yan et al.
Background: Cells in the body reside in a dynamic microenvironment subjected to various physical stimuli, where mechanical stimulation plays a crucial role in regulating cellular physiological behaviors and functions. ...
An AP2/ERF transcription factor controls generation of the twin-seedling rice [0.03%]
一个AP2/ERF型转录因子调控水稻分蘖稻的形成
Kaichong Teng,Neng Zhao,Yonghong Xie et al.
Kaichong Teng et al.
Introduction: The floret of rice is a main component of the spikelet, and the ovule of pistil is a critical organ for successful reproduction and determines the number of seeds. However, the molecular mechanisms underlyin...