Single-cell transcriptomic profiling uncovers cellular complexity and microenvironment in gastric tumorigenesis associated with Helicobacter pylori [0.03%]
单细胞转录组分析揭示幽门螺旋杆菌相关胃肿瘤发生过程中的细胞复杂性和微环境
Nianshuang Li,Sihai Chen,Xinbo Xu et al.
Nianshuang Li et al.
Introduction: Helicobacter pylori (H. pylori) infection is the main risk for gastric cancer (GC). However, the cellular heterogeneity and underlying molecular mechanisms in H. pylori-driven gastric tumorigenesis are poorl...
Ecological consequences of antimicrobial residues and bioactive chemicals on antimicrobial resistance in agroecosystems [0.03%]
抗生素残留及其他生物活性化学物质在农业生态系统中对产生耐药性的生态影响
Muhammad Shafiq,Charles Obinwanne Okoye,Mudasir Nazar et al.
Muhammad Shafiq et al.
Background: The widespread use of antimicrobials in agriculture, coupled with bioactive chemicals like pesticides and growth-promoting agents, has accelerated the global crisis of antimicrobial resistance (AMR). Agroecosy...
Applications of single-cell analysis in immunotherapy for lung cancer: Current progress, new challenges and expectations [0.03%]
单细胞分析在肺癌免疫治疗中应用的最新进展、新挑战与展望
Nan Xiao,Hongyang Liu,Chenxing Zhang et al.
Nan Xiao et al.
Background: Lung cancer is a prevalent form of cancer worldwide, presenting a substantial risk to human well-being. Lung cancer is classified into two main types: non-small cell lung cancer (NSCLC) and small cell lung can...
Food inflammation index reveals the key inflammatory components in foods and heterogeneity within food groups: How do we choose food? [0.03%]
食物炎症指数揭示了食物中关键的炎性成分以及同类食品之间的异质性：我们该如何选择食物？
Zhangtie Wang,Changzheng Yuan,Yansong Zhang et al.
Zhangtie Wang et al.
Introduction: Food is a critical factor of chronic inflammation. Few studies tried to quantize inflammatory effects of food. Moreover, the discrepancies in inflammatory effects among foods within the same food group are f...
Effect of mitochondrial translocator protein TSPO on LPS-induced cardiac dysfunction [0.03%]
外周TSPO调节脂多糖诱导的心肌损伤中的线粒体自噬与心功能障碍
Xingyue Li,Xiao Chen,Feng-Yuan Yang et al.
Xingyue Li et al.
Introduction: Sepsis-induced cardiac dysfunction is one of the most serious complications of sepsis. The mitochondrial translocator protein (TSPO), a mitochondrial outer membrane protein, is widely used as a diagnostic ma...
Activity-based protein profiling guided new target identification of quinazoline derivatives for expediting bactericide discovery: Activity-based protein profiling derived new target discovery of antibacterial quinazolines [0.03%]
基于活性的蛋白质谱学引导喹唑啉衍生物新靶点鉴定以促进杀菌剂发现：基于活性的蛋白质谱学衍生的新靶点发现抗生素喹唑啉
Jiao Meng,Ling Zhang,Xinxin Tuo et al.
Jiao Meng et al.
Introduction: The looming antibiotic-resistance problem has imposed an enormous crisis on global public health and agricultural development. Even worse, the evolution and widespread distribution of antibiotic-resistance e...
Integrated stress response activation induced by usnic acid alleviates BCL-2 inhibitor ABT-199 resistance in acute myeloid leukemia [0.03%]
由落悠悠素诱导的整合应激反应激活可缓解急性髓系白血病中ABT-199耐药性
Dijiong Wu,Man Li,Yaonan Hong et al.
Dijiong Wu et al.
Introduction: ABT-199 (venetoclax) is a BCL-2 suppressor with pronounced effects on acute myeloid leukemia (AML). However, its usefulness as a monotherapy or in combination with hypomethylating medicines like azacitidine ...
Elevated muramyl dipeptide by sialic acid-facilitated postantibiotic pathobiont expansion contributes to gut dysbiosis-induced mastitis in mice [0.03%]
唾液酸促进的抗生素治疗后肠道条件致病菌的增殖导致鸟苷二肽诱导的小鼠乳腺炎
Min Qiu,Cong Ye,Lijuan Bao et al.
Min Qiu et al.
Introduction: In responses to antibiotics exposure, gut dysbiosis is a risk factor not only for pathogen infection but also for facilitating pathobiont expansion, resulting in increased inflammatory responses in the gut a...
Hippocampal dipeptidyl peptidase 9 bidirectionally regulates memory associated with synaptic plasticity [0.03%]
海马二肽基肽酶9通过双向调节与突触可塑性相关的记忆功能
Ya-Bo Zhao,Shi-Zhe Wang,Wen-Ting Guo et al.
Ya-Bo Zhao et al.
Introduction: Subtypes of the dipeptidyl peptidase (DPP) family, such as DPP4, are reportedly associated with memory impairment. DPP9 is widely distributed in cells throughout the body, including the brain. However, wheth...
Columbianadin ameliorates rheumatoid arthritis by attenuating synoviocyte hyperplasia through targeted vimentin to inhibit the VAV2/Rac-1 signaling pathway [0.03%]
宗气通络颗粒通过靶向中间丝蛋白缓解滑膜成纤维细胞增生抑制VAS升高信号通路治疗类风湿性关节炎
Yuli Han,Changqing Liu,Shujing Chen et al.
Yuli Han et al.
Introduction: Rheumatoid arthritis (RA) is an autoimmune disease pathologically characterized by synovial inflammation. The abnormal activation of synoviocytes seems to accompany the progression of RA. The role and exact ...