Stattic engineering M2 macrophage-derived exosomes mediate autophagy and immune reprogramming for secondary hyperparathyroidism [0.03%]
工程化M2型巨噬细胞源性外泌体通过介导自噬和免疫重编程治疗继发性甲状旁腺功能亢进症
Peiting Li,Runzhi Liao,Jingyi Li et al.
Peiting Li et al.
Introduction: Secondary hyperparathyroidism (SHPT) remains a major complication of chronic kidney disease (CKD), characterized by parathyroid hyperplasia, inflammation, and parathyroid hormone (PTH) excessive secretion, a...
Preclinical evidence of adenosine for early intervention in Bungarus multicinctus envenomation [0.03%]
五步蛇毒液的临床前证据表明腺苷可作为早期干预手段
Jing Huang,Yue Qin,Haiyu Chen et al.
Jing Huang et al.
Introduction: Snakebites, one of the world's deadliest neglected tropical diseases, predominantly affect impoverished rural communities in tropical and subtropical regions. The clinical management of snakebite envenomatio...
Construction of mitochondrial-targeted ferritin carrier: subunit-terminal fused mitochondrial presequences facilitate efficient delivery [0.03%]
线粒体靶向铁蛋白载体的构建：亚基C末端融合线粒体导向序列促进有效递送
Jia Zeng,Yitong Li,Xinning Fang et al.
Jia Zeng et al.
Introduction: Protein sorting within mitochondria is intricately linked to the amino acid sequence facilitating the transmembrane transport of proteins into this organelle. Leveraging the Mitochondrial Targeting Signal (M...
Development and characterization of endolysosomal trafficking targeting chimera degraders of α1A-adrenergic receptor [0.03%]
靶向内溶酶体转运的嵌合降解剂的研发及α1A肾上腺素受体降解机制研究
Jiwei Chen,Shuo Wang,Tong Li et al.
Jiwei Chen et al.
Introduction: Despite the booming targeted protein degradation technologies, degrading cell membrane proteins remains an enormous challenge. In particular, only a limited approach is appropriate for the degradation of the...
Adaptation of plateau frog peptide: From antimicrobial to angiogenic and proliferative functions [0.03%]
高原蛙肽的适应性进化：从抗菌到促血管生成和增殖功能
Kaixun Cao,Liting Zhang,Min Yang et al.
Kaixun Cao et al.
Introduction: Amphibian skin peptides, particularly defensins, play important roles in environmental adaptation, but often exhibit functional redundancy. SC17-2, a novel peptide from the high altitude frog Nanorana parker...
Kinetic modeling study of autoignition, laminar burning velocity, and emission characteristics of n-heptane/ammonia mixtures [0.03%]
正庚烷/氨混合物的自燃、层流燃烧速度和排放特性的动力学模型研究
Zhenhua Ji,Zhongqiang Bao,Hao Chen et al.
Zhenhua Ji et al.
Introduction: The mixed combustion of ammonia (NH3) and high activity fuel in internal combustion engines is an effective way to achieve global decarbonization. However, there remains a lack of detailed high-precision num...
A novel fuzzy system-based genetic algorithm for trajectory segment generation in urban global positioning system [0.03%]
一种基于模糊系统的遗传算法在城市GPS路段生成中的应用研究
Xiaojuan Ran,Naret Suyaroj,Worawit Tepsan et al.
Xiaojuan Ran et al.
Introduction: The widespread adoption of Global Positioning System (GPS) technology has rendered trajectory data pivotal for urban traffic planning and travel pattern analysis. However, the traditional trajectory generati...
Acidic tumor microenvironment-modulated nanoparticle potentiates gastric cancer photoimmunotherapy [0.03%]
酸性肿瘤微环境修饰的纳米颗粒可增强胃癌光免疫疗法
Menglin Zhu,Zhixiong Wang,Yiren He et al.
Menglin Zhu et al.
Introduction: Immunotherapy, especially anti-PD-1 antibodies (α-PD-1), has revolutionized the landscape of cancer treatment. However, the response rate of α-PD-1 for Gastric Cancer (GC) remains relatively low. The acidi...
A comprehensive examination of the impact of environmental pollution on lung cancer: A review [0.03%]
环境污染对肺癌影响的综合评估：综述文章
Hongyan Zhang,Hongyi Wei,Sijia Han et al.
Hongyan Zhang et al.
Background: Lung cancer is a leading cause of death worldwide, with environmental factors playing critical roles in its development and progression. Respirable and food-borne contaminants are major contributors to lung ca...
OsCPK9-mediated Thr105 phosphorylation activates OsCATC to enhance drought tolerance in rice [0.03%]
OsCPK9介导的Thr105磷酸化激活OsCATC以增强水稻耐旱性
Fu Shi,Li Li,Yaqiong Wang et al.
Fu Shi et al.
Introduction: Drought poses a significant environmental challenge, disrupting plant growth and reducing crop productivity. As sensors and effectors in calcium signaling, calcium-dependent protein kinases (CPKs) regulate p...