Carbon-phosphorus coupling in reddish paddy fields under long-term organic material input: Temporal dynamics and the role of pqqC-harboring bacteria as a driver [0.03%]
长期有机物料投入下水稻土红化过程中的碳磷耦合特征及时间动态：次磷酸酸型土壤活性磷的驱动因素与关键微生物菌群解析
Jian Xiao,Yanhong Lu,Peng Li et al.
Jian Xiao et al.
Introduction: Long-term organic material input has been shown to enhance soil organic carbon (SOC) and potentially improve phosphorus (P) availability. The pqqC gene that encodes pyrroloquinoline quinone synthase can play...
Dual rescue mission: P-G3 dendrimer addresses ovarian and neuroendocrine roots of obesity-linked subfertility [0.03%]
双重救援使命：P-G3树状聚合物针对肥胖相关不孕症的卵巢和神经内分泌根源
Yunhan Nie,Zhe Kuang,Jiqiang Si et al.
Yunhan Nie et al.
Introduction: The dual pathology of obesity-induced infertility, which encompasses both peripheral (ovarian) and central (hypothalamic-pituitary) mechanisms, is well documented. However, existing therapeutic approaches do...
Peroxisomal dysfunction in cardiac adipose tissue is involved in obesity-associated cardiac hypertrophy [0.03%]
线粒体功能障碍参与肥胖相关心脏肥厚
Gahee Song,Se Jin Jung,Wenjun Jiao et al.
Gahee Song et al.
Introduction: Cardiac adipose tissue, which directly interfaces with the myocardium and vasculature, has a pivotal role in obesity-related cardiovascular pathology through its metabolic activity. This tissue contributes t...
Metagenomic characterization of the resistome, bacteriome and mobilome in raw milk from intensive farming systems [0.03%]
集约化奶牛场生乳中抗药基因、细菌和可移动基因组元件的元基因组特征分析
Yiping Xu,Jie Zhao,Ningxin Huang et al.
Yiping Xu et al.
Introduction: Intensive farming, as the dominant paradigm in global dairy production, exacerbates antimicrobial resistance (AMR) risks via concentrated animal operations and routine antimicrobial prophylaxis. Nevertheless...
Dysregulated ITGA3/FAK/YAP axis mediates impaired alveolar type II epithelial cells function in COPD [0.03%]
ITGA3/FAK/YAP轴调节紊乱介导慢性阻塞性肺疾病中II型上皮细胞功能障碍
Li Liu,Suye Zhong,Tengfei Zhou et al.
Li Liu et al.
Introduction: Alveolar regeneration deficiency may lead to persistent emphysematous destruction in chronic obstructive pulmonary disease (COPD), lacking effective treatments to halt disease progression. Dysfunction of alv...
Reactions of N-heterocyclic carbenes with nitrobenzenes: harnessing NHCs as synthetic building blocks [0.03%]
N-杂环卡宾与硝基苯的反应：利用NHC作为合成砌块
Zhiguo Zheng,Youlin Deng,Xiaoqun Yang et al.
Zhiguo Zheng et al.
Introduction: Quinazolin-4-one is a privileged scaffold in drugs with broad clinical applications. Conventionally, an o-amino group was generally needed to be pre-installed on the benzoic acid-derived starting materials f...
Non-traditional lipid-inflammatory parameters estimate the risk of stroke in middle-aged and older Chinese adults: a nationwide prospective cohort study [0.03%]
非传统脂质炎症参数能估算中老年中国人卒中的发病风险——一项全国性前瞻性队列研究
Xiaxuan Huang,Cun Li,Piaorong Zeng et al.
Xiaxuan Huang et al.
Background: Non-traditional lipid parameters demonstrate cardiovascular predictive value, yet their interaction with inflammatory markers in stroke risk assessment remains understudied. This research investigated their in...
Embryo vitrification disturbs the pre-implantation DNA demethylation process and affects hepatic functions to threaten long-term metabolic health in mice [0.03%]
胚胎玻璃化冷冻会干扰小鼠植入前DNA去甲基化过程并影响肝脏功能从而威胁其长期代谢健康
Yue Ying,Yang Yang,Xilin Shen et al.
Yue Ying et al.
Introduction: Embryo vitrification has been linked to an increased incidence of large-for-gestational-age offspring. Investigating how epigenetic regulation transmits vitrification-induced abnormalities to postnatal stage...
IRF1 regulates apoptosis and osteogenic differentiation of bone marrow mesenchymal stem cells and ameliorates osteoporosis by activating the PI3K/AKT signaling pathway [0.03%]
IRF1通过激活PI3K/AKT信号通路调节骨髓间充质干细胞的凋亡及成骨分化从而改善骨质疏松症
Menglong Hu,Erfan Wei,Likun Wu et al.
Menglong Hu et al.
Background: Bone marrow mesenchymal stem cells (BMSCs) are a critical cell type for stem cell-based bone regenerative therapy. Promoting osteogenic differentiation of BMSCs is important for the promotion of bone formation...
Spatial multi-omics guides ASCT2-targeted delivery of glycolysis inhibitor for cervical cancer suppression and chemoresistance reversal [0.03%]
空间多组学引导ASCT2靶向递送糖酵解抑制剂以抑制宫颈癌和逆转耐药性
Xiaojiao Li,Xiangchuan Qin,Xiejun Zhao et al.
Xiaojiao Li et al.
Introduction: Cervical carcinoma (CC) mortality remains high due to chemoresistance. Targeting glycolytic reprogramming is promising since CC cells depend on enhanced glycolysis for proliferation and chemoresistance. Howe...