Developing chemical reprogramming strategies of non-hepatocytes for liver regeneration [0.03%]
开发非肝细胞化学重编程策略以实现肝脏再生
Dongxue Ge,Wanqi Yang,Haozhen Ren et al.
Dongxue Ge et al.
Background: Liver injury and the ensuing regenerative processes exert a profound impact on treatment outcomes. Conventional pharmacotherapy, nutritional adjuncts, and invasive interventions, despite their frequent utiliza...
Plant-derived bioactives in early-life complementary foods: a nutritional blueprint for lifelong health [0.03%]
生命早期辅食中植物来源的生物活性物质：终生健康的营养蓝图
Feng Lu,Chengfeng Yang,Hao Yang et al.
Feng Lu et al.
Background: The initial 1,000 days of life represent a critical window for determining long-term health. Nutrition in early life has a significant impact on developmental programming of metabolism, immunity, and gut micro...
The immune regulation and signaling transduction of FAM134B-mediated endoplasmic reticulum-phagy in ferroptosis of dendritic cells after sepsis [0.03%]
脓毒症后树突状细胞铁死亡过程中FAM134B介导的内质网自噬的免疫调控和信号转导机制研究
Jing-Yan Li,Peng-Yue Zhao,Yi-Qing Shi et al.
Jing-Yan Li et al.
Introduction: Fam134B-mediated endoplasmic reticulum (ER)-phagy is one of the key mechanisms for maintaining functional homeostasis of ER and cell survival. In fact, Fam134B-mediated ER-phagy has been proved to exert a do...
Refining antibiotic cocktail regimens for pseudo-germ-free mice and their impact on gut microbiome and pancreatic tumor proteomics [0.03%]
优化伪无菌小鼠抗生素鸡尾酒方案及其对肠道微生物组和胰腺肿瘤蛋白质组学的影响
Suraphan Panyod,Wei-Kai Wu,Yen-Peng Lee et al.
Suraphan Panyod et al.
Introduction: The gut microbiome critically influences health, disease, and therapeutic responses. However, creating robust pseudo-germ-free (PGF) mouse models for microbiota-host interaction studies remains challenging d...
Microbiome-metabolome generated bile acids gatekeep infliximab efficacy in Crohn's disease by licensing M1 suppression and Treg dominance [0.03%]
肠道菌群-代谢产物产生的胆酸通过许可M1抑制和Treg优势调控英夫利昔单抗在克罗恩病中的疗效
Le Liu,Liping Liang,Huifeng Liang et al.
Le Liu et al.
Introduction: Despite the effectiveness of infliximab in treating Crohn's disease (CD), up to 40 % of patients fail to respond adequately. Objectives: ...
ALKBH5 modulates COL5A1 mRNA stability via m6A demethylation to promote tobacco carcinogen NNK-induced lung cancer occurrence and progression [0.03%]
ALKBH5通过去甲基化调控COL5A1 mRNA稳定性以促进烟草致癌物NNK诱导的肺癌发生发展
Yiheng Du,Lirong Tu,Jiaxin Zhou et al.
Yiheng Du et al.
Introduction: The tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), has been extensively studied for its carcinogenic role in lung cancer. However, the involvement of N6-methyladenosine (m6...
Airway basal stem cell-derived extracellular vesicles drive ECM remodeling and suppress fibroblasts activation via the miR-30a-5p/FAP axis in benign tracheal stenosis [0.03%]
良性气管狭窄中支气管基底干细胞来源的细胞外囊泡通过miR-30a-5p/FAP轴重塑ECM并抑制成纤维细胞活化
Lisi Luo,Junfeng Huang,Difei Chen et al.
Lisi Luo et al.
Introduction: Benign tracheal stenosis (BTS) is characterized by granulation tissue hyperplasia, driven by abnormal fibroblast activation and excessive extracellular matrix deposition. Targeting these mechanisms with nove...
Gut microbiota and metabolite signatures predict severe immune-related adverse events in advanced hepatobiliary cancers [0.03%]
肠道微生物群和代谢物标志物可预测晚期肝胆癌症患者发生严重免疫相关不良事件的风险
Chengpei Zhu,Dongya Zhang,Yunchao Wang et al.
Chengpei Zhu et al.
Introduction: Immune checkpoint inhibition (ICI) has proven to be a major breakthrough in hepatobiliary cancers treatment. However, immune-related adverse events (irAEs) remain a major concern. The gut microbiome has been...
Quercetin attenuates tendon stem/progenitor cell senescence and promotes aged tendon repair via AKT/NF-κB/NLRP3-mediated mitophagy activation [0.03%]
槲皮素通过AKT/NF-κB/NLRP3介导的线粒体自噬激活来缓解肌腱干细胞衰老并促进老年肌腱修复
Hao Wang,Yu-Cheng Gao,Ming-Zhang et al.
Hao Wang et al.
Introduction: Aged tendon exhibits impaired regenerative capacity due to the accumulation of senescent tendon stem/progenitor cells (TSPCs), which secrete senescence-associated secretory phenotype (SASP) factors and displ...
RNA-m5C regulatory atlas of human fetal tissues uncover the activities of Nsun2/Jarid2/Alyref axis [0.03%]
人类胎儿组织中的RNA-m5C调控图谱揭示Nsun2/Jarid2/Alyref轴的活性
Xiujuan Hu,Chenyue Ding,Jiafeng Lu et al.
Xiujuan Hu et al.
Introduction: Cytosine methylation (m5C) is a pivotal RNA modification essential for human fetal development, yet its tissue-specific distribution and regulatory mechanisms remain largely undefined. ...