Hybrid genome and enzyme characterization uncover novel glycosyltransferases associated with benzylisoquinoline alkaloid chemodiversity in lotus [0.03%]
杂交基因组和酶特性鉴定出与莲阿朴吗啡生物碱化学多样性相关的新型糖基转移酶
Hedi Zhao,Xinyi Qi,Yan Liu et al.
Hedi Zhao et al.
Introduction: Hybridization is a key evolutionary force that enriches genetic diversity and is associated with metabolic innovation. Lotus (Nelumbo), comprising Asian lotus (N. nucifera) and American lotus (N. lutea), is ...
A "DUBTAC" targeting GLUL deubiquitination promotes BMSC osteogenic differentiation and implant osseointegration in type 2 diabetes [0.03%]
一种名为"DUBTAC"的GLUL去泛素化促进第2型糖尿病中的骨髓间充质干细胞成骨分化和种植体骨整合
Lingxiao Wang,Zhanqiu Diao,Wanqing Wang et al.
Lingxiao Wang et al.
Introduction: Osseointegration in patients with type 2 diabetes mellitus (T2DM) is poor, and overcoming osseointegration impairment safely and efficiently remains challenging. ...
The moderation and mediation roles of white matter insults in relationship of APOE ε4 genotype with Alzheimer's disease and related phenotypes: two longitudinal studies [0.03%]
APOE ε4基因与阿尔茨海默病及相关表型的关系中白质异常在调节和中介作用：两项纵向研究
Kai-Zheng Liu,Xin Zhou,Yuan-Fei Dong et al.
Kai-Zheng Liu et al.
Introduction: The Apolipoprotein E ε4 (APOE ε4) allele and white matter hyperintensities (WMH) have been implicated in the pathogenesis of Alzheimer's disease (AD). ...
Ca2+ enhances the activity of prodelphinidin B digallate in lowering postprandial hyperglycemia via regulating the mucus layer [0.03%]
钙离子通过调节粘液层增强原棓茋二没食子酸酯降低餐后高血糖的作用力
Yi Wang,Laiming Zhang,Jiaxiong Wu et al.
Yi Wang et al.
Introduction: Phenolic compounds are regarded as promising α-glucosidase inhibitors for regulating postprandial blood glucose, but their α-glucosidase inhibitory activity in vivo is much lower than that in vitro. The sm...
The deficiency of circSLC8A1 fosters tubular partial EMT-induced renal fibrosis through upregulating Annexin A2 signaling [0.03%]
circSLC8A1缺乏通过上调Annexin A2信号促进管状部分上皮间质转化诱导的肾纤维化
Lei Wei,Peng He,Limin Liu et al.
Lei Wei et al.
Background: Chronic kidney disease (CKD) progression to renal fibrosis is primarily driven by maladaptive partial epithelial-mesenchymal transition (pEMT) in tubular epithelial cells (TECs), a process lacking effective th...
Brain Barriers in Normal Pressure Hydrocephalus: Mechanisms and Therapeutic Perspectives [0.03%]
正常压力性脑积水的脑屏障机制及治疗前景
Min Joung Lee,Young Eun Kim,Hee Jin Chang et al.
Min Joung Lee et al.
Background: Normal pressure hydrocephalus (NPH), which is characterized by gait disturbances, cognitive impairment, and urinary incontinence, is a distinct subtype of hydrocephalus that predominantly affects older adults....
Natural flavonoids inhibit plasmid conjugation via iron chelation and zinc-responsive envelope stress [0.03%]
天然黄酮通过铁螯合和锌响应性包膜压力抑制质粒接合转移
Bingqing Yang,Miao Zhang,Shuyao Zhu et al.
Bingqing Yang et al.
Introduction: Plasmid-mediated bacterial conjugation is a major driver of horizontal gene transfer (HGT) via direct cell-to-cell contact, significantly accelerating the dissemination of antimicrobial resistance (AMR). Giv...
HeFS: helper-enhanced feature selection via Pareto-optimized genetic search [0.03%]
基于帕累托优化的遗传算法特征选择方法HeFS
Yusi Fan,Tian Wang,Zhiying Yan et al.
Yusi Fan et al.
Introduction: Feature selection plays a crucial role in improving predictive performance and interpretability in high-dimensional machine learning tasks. However, it is an NP-hard combinatorial optimization problem. Conve...
Muscone promotes remyelination and alleviates Parkinson's disease by targeting FKBP5 in MPTP-induced mouse model [0.03%]
muscone通过靶向FKBP5促进多巴胺能神经元的少突胶质细胞再髓鞘化从而改善1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）诱导的小鼠模型帕金森病症状
Jiatian Zhang,Yulin Xiao,Anyao Li et al.
Jiatian Zhang et al.
Introduction: The side effects and limited efficacy of existing dopaminergic treatments for Parkinson's disease (PD) underscore the urgent need for novel therapeutic strategies. Promoting myelin renewal might be one promi...
High throughput screening identifies sanguinarine chloride as a multi-faceted therapeutic agent for PRCC-TFE3 rRCC by targeting lactylation-driven VEGFB-VEGFR2 signaling and PMN-MDSC infiltration [0.03%]
高效筛选识别血根碱氯化物通过靶向乳酰化驱动的VEGFB-VEGFR2信号传导和PMN-MDSC浸润成为PRCC-TFE3 rRCC多面治疗药物
Xuwentai Liu,Yi Chen,Wujia Liu et al.
Xuwentai Liu et al.
Introduction: PRCC-TFE3 rearranged renal cell carcinoma (PRCC-TFE3 rRCC) is a highly malignant renal malignancy with limited therapeutic options, underscoring the urgent need for novel treatment strategies. ...