Astrocyte-derived LAMC1 protects against intracerebral hemorrhage: A novel genetic mechanism maintaining neurovascular integrity [0.03%]
星形胶质细胞源LAMC1防治脑出血：维持神经血管完整性的新遗传机制
Liang Cao,Yanjun Zhang,Wenjun Pi et al.
Liang Cao et al.
Introduction: Intracerebral hemorrhage (ICH) is a devastating stroke subtype, yet the intrinsic mechanisms conferring genetic protection against it remain poorly understood. While risk-associated loci have been identified...
Time-series transcriptome and metabolome profiling Uncovers WRKY6 and WRKY23 as critical regulators in tobacco response to Pseudomonas syringae infection [0.03%]
时间序列转录组和代谢组分析发现WRKY6和WRKY23是烟草响应丁香假单胞菌侵染的关键调控因子
Xinhua Tian,Peng Lu,Zechao Qu et al.
Xinhua Tian et al.
Introduction: Pseudomonas syringae pv. tabaci, a Gram-negative bacterial pathogen, causes devastating tobacco wildfire disease with global economic impacts. While its pathogenicity is well documented, the dynamic defense ...
Pluripotent stem cell-specific imprinted genes identified using human Uniparental-Induced pluripotent stem cells [0.03%]
利用人类单亲诱导多能干细胞鉴定多功能干细胞特异性印记基因
Na Young Choi,Seokbeom Ham,Dahee Jeong et al.
Na Young Choi et al.
Genomic imprinting is an epigenetic mechanism in which gene expression is determined by the parent of origin. Imprinted genes are crucial for mammalian growth and development, and mutations at imprinting sites can lead to developmental diso...
Oxygen-Vacancy-Regulated Molybdenum oxide nanosheets for a Multi-Phosphate Discriminative colorimetric sensor array [0.03%]
氧空位调控的钼氧化物纳米片多磷酸根鉴别型比色传感器阵列研究
Cheng Cheng,Xingying Li,Zhiwei Chen et al.
Cheng Cheng et al.
The detection and identification of various phosphates are crucial in disease diagnostics. However, traditional detection techniques often require the development of multi-ion systems, and the complexity of sensor unit fabrication has limit...
Podocyte-derived exosomes instruct dendritic cell-dependent CD8+ T cell activation and proliferation in renal inflammation [0.03%]
肾炎症中足细胞源性外泌体诱导树突状细胞依赖的CD8+t细胞活化和增殖
Bin Qian,Shuya Mao,Yang Chen et al.
Bin Qian et al.
Introduction: Minimal Change Disease (MCD) represents a prevalent pathological cause of nephrotic syndrome. While podocyte injury is recognized as the direct cause of proteinuria in MCD, aberrant T-cell activation is a ke...
m6A methylation in ferroptosis regulation: mechanisms, targets, and therapeutic interventions [0.03%]
铁死亡调控中的m6A甲基化修饰：机制、靶点与干预手段
Chaoying Wen,Yi Jiao,Zhaoran Wang et al.
Chaoying Wen et al.
Background: The dynamic crosstalk between N6-methyladenosine (m6A) RNA methylation and ferroptosis is pivotal for understanding disease pathogenesis. As the most abundant form of eukaryotic mRNA modification, m6A methylat...
Rapid profiling of polymyxin B susceptibility in gram-negative bacteria with a novel polymyxin-derived fluorescent probe [0.03%]
一种新型多粘菌素衍生物荧光探针快速检测革兰氏阴性菌多粘菌素B耐药表型的方法研究
Bing Zhang,Wanida Phetsang,Sanjaya Kc et al.
Bing Zhang et al.
Introduction: Polymyxins are considered last-resort antibiotics for treating Gram-negative bacterial infections. The alarming global rise in polymyxin-resistant bacteria coupled with the slowness of conventional antimicro...
METTL4 enhances GLI1 translation through m6Am modification to promote tumor progression as a therapeutic target for hepatocellular carcinoma [0.03%]
METTL4通过m6Am修饰增强GLI1翻译，促进肝细胞癌进展并作为治疗靶点
Weijie Sun,Weiqi Dai,Chaobo Chen et al.
Weijie Sun et al.
Introduction: Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality. Epigenetic dysregulation, particularly through methyltransferase METTL4, plays a critical role in HCC progression. METTL4 is known...
Tetrapeptides derived from black bean enhance osteogenesis and alleviate ovariectomy-induced bone loss via activation of BMP-2/Smad signaling [0.03%]
从黑豆中提取的四肽通过激活BMP-2/Smad信号通路增强成骨作用并缓解卵巢切除术引起的骨质流失
Yan Zhang,Chong Chen,Chibuike C Udenigwe et al.
Yan Zhang et al.
Introduction: Osteoporosis, a "silent killer" among the elderly, is marked by progressive bone loss and microstructural deterioration. Oligopeptides derived from black bean, particularly tetrapeptides, have shown notable ...
Fructooligosaccharides and ellagic acid synergistically enhance muscular endurance via targeting gut microbial urolithin A biosynthesis [0.03%]
益生元低聚果糖和Ellagic酸通过靶向肠道微生物催化产生Urolithin A增强小鼠肌肉耐力的协同作用机制研究
Laiming Zhang,Zengliang Jiang,Donghong Liu et al.
Laiming Zhang et al.
Introduction: Sarcopenia, characterized by the progressive loss of muscle mass and function, may be alleviated by ellagic acid (EA) through its microbial metabolite urolithin A (Uro-A). However, the low in vivo conversion...