Genetic associations of metabolic factors and therapeutic drug targets with polycystic ovary syndrome [0.03%]
与多囊卵巢综合征具有遗传关联的代谢因素和治疗药物作用靶点
Changlong Zhang,Yuxuan Li,Yang Wang et al.
Changlong Zhang et al.
Introduction: Polycystic ovary syndrome (PCOS) is frequently accompanied with metabolic dysfunctions, yet the causal relationships between metabolic factors and PCOS remain to be conclusively established and etiology-base...
scPerb: Predict single-cell perturbation via style transfer-based variational autoencoder [0.03%]
基于风格转换的变分自编码器预测单细胞扰动：scPerb
Zijia Tang,Minghao Zhou,Kai Zhang et al.
Zijia Tang et al.
Introduction: Traditional methods for obtaining cellular responses after perturbation are usually labor-intensive and costly, especially when working with multiple different experimental conditions. Therefore, accurate pr...
Linxuan Li,Tingting Zhu,Lina Wen et al.
Linxuan Li et al.
Background: Potato (Solanum tuberosum L.) is the fourth most important food crop after rice, wheat and maize in the world with the potential to feed the world's population, and potato is a major staple food in many countr...
Exerkine irisin mitigates cognitive impairment by suppressing gut-brain axis-mediated inflammation [0.03%]
exercise诱导的irisin通过抑制肠-脑轴介导的炎症来缓解认知障碍
Hu Zhang,Jiling Liang,Jielun Huang et al.
Hu Zhang et al.
Introduction: Exercise has been recognized to improve cognitive performance by optimizing gut flora and up-regulating exerkine irisin. Objective: ...
Synergistic potentiation of the anti-metastatic effect of a Ginseng-Salvia miltiorrhiza herbal pair and its biological ingredients via the suppression of CD62E-dependent neutrophil infiltration and NETformation [0.03%]
通过抑制CD62E依赖的中性粒细胞浸润和NET形成协同增强人参-丹参药对及其生物活性成分的抗转移效果
Keqin Lu,Yawen Xia,Peng Cheng et al.
Keqin Lu et al.
Introduction: The combination of the roots of ginseng and Salvia miltiorrhiza is an effective approach for treating metastatic cancer in patients with Qi stagnation and blood stasis patterns. However, the molecular mechan...
Dihydrokoumine, a dual-target analgesic with reduced side effects isolated from a traditional Chinese medicine [0.03%]
来源于传统中药的低副作用双靶标镇痛活性成分二氢厚朴酚
Dian Liu,Jixia Wang,Tao Hou et al.
Dian Liu et al.
Introduction: Opioids are the most common antinociceptive drugs, but long-term administration causes serious adverse side effects. Gelsemium elegans Benth. is traditionally used as an analgesic agent and mainly contains i...
Regulatory balance between ear rot resistance and grain yield and their breeding applications in maize and other crops [0.03%]
抗茎腐病和产量的平衡及其在玉米等作物育种中的应用
Zechao Yin,Xun Wei,Yanyong Cao et al.
Zechao Yin et al.
Background: Fungi are prevalent pathogens that cause substantial yield losses of major crops. Ear rot (ER), which is primarily induced by Fusarium or Aspergillus species, poses a significant challenge to maize production ...
Yu-Lin Li,Bo-Yan Chen,Ze-Hao Feng et al.
Yu-Lin Li et al.
Introduction: The significance of oral/gut microbiota in acute myocardial infarction (AMI) has been increasingly appreciated. However, correlations between oral/gut microbiota and AMI parameter, as well as the key microbi...
Neural and molecular investigation into the paraventricular thalamus for chronic restraint stress induced depressive-like behaviors [0.03%]
与慢性束缚应激诱发的抑郁样行为相关的底丘脑核的神经和分子学研究
Yong He,Yikun Ren,Xiangyu Chen et al.
Yong He et al.
Introduction: Disturbance of neural circuits and chronic stress contribute to depression onset. Given the crucial role of paraventricular nucleus of thalamus (PVT) in emotional behaviors, however, the specific neural and ...
Pleiotropic role of CCR9/CCL25 signaling in adriamycin-induced cardiomyopathy [0.03%]
趋化因子受体CCR9/CCL25信号通路在阿霉素诱导的心肌病变中的多效性作用研究
Xue Wu,Zheng Wang,Zhenxing Liang et al.
Xue Wu et al.
Introduction: Adriamycin (ADR)-induced cardiomyopathy is a common problem in many cancer survivors. Recently, specific chemokine receptors have garnered interest as therapeutic targets in cardiovascular diseases. ...