Activation of sphingosine-1-phosphate receptor 2 (S1PR2) upregulates dihydropyrimidine dehydrogenase (DPD) expression in colon cancer cells [0.03%]
鞘氨醇-1-磷酸受体2(S1PR2)的激活通过上调结肠癌细胞中二氢嘧啶脱氢酶(DPD)的表达发挥作用
Zhi-Kun Guo,Xin-Feng Wu,Ming-Yong Tan et al.
Zhi-Kun Guo et al.
Introduction: Dihydropyrimidine dehydrogenase (DPD) is a major determinant of cancer 5-fluorouracyl (5-FU) resistance via its direct degradation. However, the mechanisms of tumoral DPD upregulation have not been fully und...
Mycotoxin toxicity and its alleviation strategy on female mammalian reproduction and fertility [0.03%]
霉菌毒素对雌性哺乳动物生殖和生育力毒害及缓解措施研究进展
Ping-Shuang Lu,Shao-Chen Sun
Ping-Shuang Lu
Background: Mycotoxin, a secondary metabolite of fungus, found worldwide and concerning in crops and food, causing multiple acute and chronic toxicities. Its toxic profile includes hepatotoxicity, carcinogenicity, teratog...
Baicalin attenuates the immune escape of oral squamous cell carcinoma by reducing lactate accumulation in tumor microenvironment [0.03%]
柴胡滴定碱通过减少肿瘤微环境中的乳酸积累来抑制口腔鳞状细胞癌的免疫逃逸
Yameng Cui,Jingwen Liu,Xi Wang et al.
Yameng Cui et al.
Introduction: The acidic microenvironment caused by excessive lactate accumulation could inhibit immune lymphocytes antitumor activity and promote the immune escape of tumor cells. Baicalin is an active flavonoid isolated...
Lili Qiu,David M Frazer,Mengxiao Hu et al.
Lili Qiu et al.
Background: Iron plays a crucial role through various life stages of human. Iron homeostasis is primarily regulated by iron absorption which is mediated via divalent metal-ion transporter 1 (DMT1), and iron export protein...
Mechanistic insights into ferroptosis and apoptosis pathways: Synergistic effects of multi-organ toxicity and transgenerational effects induced by co-exposure of epoxiconazole and aflatoxin B1 in zebrafish [0.03%]
基于斑马鱼的丙环唑和黄曲霉毒素B1联合作用协同致多器官毒性及跨代效应的铁死亡与凋亡机制研究
Ruike Wang,Qi Zhang,Gang Chen et al.
Ruike Wang et al.
Introduction: In the environment, mycotoxins and fungicides frequently coexist, potentially causing synergistic risks to organisms. Epoxiconazole (EPO) and aflatoxin B1 (AFB1) are a common fungicide and mycotoxins, respec...
Soil nutrient limitation controls trophic cascade effects of micro-food web-derived ecological functions in degraded agroecosystems [0.03%]
土壤营养限制控制着退化农业生态系统的微食物网衍生生态系统功能的营养级联效应
Haobo Xu,Xinxing He,Juan Chen et al.
Haobo Xu et al.
Introduction: Soil nutrient supply drives the ecological functions of soil micro-food webs through bottom-up and top-down mechanisms in degraded agroecosystems. Nutrient limitation responds sensitively to variations in de...
CDK8 mediated inflammatory microenvironment aggravates osteoarthritis progression [0.03%]
CDK8介导的炎性微环境加重骨关节炎进展
Zhongnan Lin,Yining Xu,Hongyi Jiang et al.
Zhongnan Lin et al.
Introduction: Cyclin-Dependent Kinase 8 (CDK8), a CDK family member, regulates the development of inflammatory processes through transcriptional activation. The involvement of CDK8 in osteoarthritis (OA) progression is no...
Reductive stress: The key pathway in metabolic disorders induced by overnutrition [0.03%]
营养过剩引起的代谢障碍中的关键途径：还原性压力
Shiyi Zhang,Na Wang,Zhichao Gao et al.
Shiyi Zhang et al.
Background: The balance of redox states is crucial for maintaining physiological homeostasis. For decades, the focus has been mainly on the concept of oxidative stress, which is involved in the mechanism of almost all dis...
Hypoxia-induced degradation of FTO promotes apoptosis by unmasking RACK1-mediated activation of MTK1-JNK1/2 pathway [0.03%]
缺氧通过解除RACK1介导的MTK1-JNK1/2通路激活促进FTO降解诱导细胞凋亡
Chengyu Li,Zhaojun Liu,Chen Fu et al.
Chengyu Li et al.
Introduction: Hypoxia, a condition characterized by inadequate oxygen supply to tissues, triggers various cellular responses, including apoptosis. The RNA demethylase FTO has been shown to exert anti-apoptotic effects, bu...
Danil Yu Pimenov,Leonardo Rosa Ribeiro da Silva,Mustafa Kuntoğlu et al.
Danil Yu Pimenov et al.
Background: Today, in a wide variety of industries, grinding operations are an extremely important finishing process for obtaining precise dimensions and meeting strict requirements for roughness and shape accuracy. Howev...