Ginger exosome-like nanoparticle-derived miRNA therapeutics: A strategic inhibitor of intestinal inflammation [0.03%]
姜黄素模拟纳米颗粒递送的miRNA治疗：一种肠道炎症潜在抑制剂
Ling Yan,Yaqi Cao,Linhai Hou et al.
Ling Yan et al.
Introduction: MicroRNAs (miRNAs) involve in destabilising messenger RNA or repressing translation of target molecules. Ginger-derived exosome-like nanoparticles (GELNs) play a crucial role in modulating intestinal inflamm...
Unveiling the regulatory mechanisms of nodules development and quality formation in Panax notoginseng using multi-omics and MALDI-MSI [0.03%]
基于多组学和基质辅助激光解析离子化飞行时间质量监测技术揭示三七主根发育及品质形成的调控机制
Muyao Yu,Chunxia Ma,Badalahu Tai et al.
Muyao Yu et al.
Introduction: Renowned for its role in traditional Chinese medicine, Panax notoginseng exhibits healing properties including bidirectional regulatory effects on hematological system diseases. However, the presence of nodu...
Sedanolide alleviates DSS-induced colitis by modulating the intestinal FXR-SMPD3 pathway in mice [0.03%]
雪松内酯通过调节小鼠肠道FXR-SMPD3通路缓解DS S诱导的结肠炎
Shengjie Li,Aoxiang Zhuge,Hui Chen et al.
Shengjie Li et al.
Introduction: Inflammatory bowel disease (IBD) is a global disease with limited therapy. It is reported that sedanolide exerts anti-oxidative and anti-inflammatory effects as a natural phthalide, but its effects on IBD re...
Advances in molecular mechanisms and therapeutic strategies for central nervous system diseases based on gut microbiota imbalance [0.03%]
基于肠道微生态失衡的中枢神经系统疾病的分子机制及治疗策略研究进展
Wei Tao,Yanren Zhang,Bingbin Wang et al.
Wei Tao et al.
Backgroud: Central nervous system (CNS) diseases pose a serious threat to human health, but the regulatory mechanisms and therapeutic strategies of CNS diseases need to be further explored. It has been demonstrated that t...
Understanding multicomponent low molecular weight gels from gelators to networks [0.03%]
从凝胶剂到网络的多元低分子量凝胶理解
Liangchun Li,Renlin Zheng,Rongqin Sun
Liangchun Li
Background: The construction of gels from low molecular weight gelators (LMWG) has been extensively studied in the fields of bio-nanotechnology and other fields. However, the understanding gaps still prevent the predictio...
Low-frequency magnetic field therapy for glioblastoma: Current advances, mechanisms, challenges and future perspectives [0.03%]
低频磁场治疗胶质母细胞瘤：当前进展、机制、挑战及未来展望
Yinlong Liu,Qisheng Tang,Quan Tao et al.
Yinlong Liu et al.
Background: Glioblastoma (GBM) is the most common malignant tumour of the central nervous system. Despite recent advances in multimodal GBM therapy incorporating surgery, radiotherapy, systemic therapy (chemotherapy, targ...
Comprehensive insights into potential roles of purinergic P2 receptors on diseases: Signaling pathways involved and potential therapeutics [0.03%]
全面了解嘌呤能P2受体在疾病中的潜在作用：涉及的信号通路和潜在治疗手段
Yanshuo Guo,Tianqi Mao,Yafei Fang et al.
Yanshuo Guo et al.
Background: Purinergic P2 receptors, which can be divided into ionotropic P2X receptors and metabotropic P2Y receptors, mediate cellular signal transduction of purine or pyrimidine nucleoside triphosphates and diphosphate...
Exercise-Induced Reduction of IGF1R Sumoylation Attenuates Neuroinflammation in APP/PS1 Transgenic Mice [0.03%]
运动通过减少APP / PS1转基因小鼠中IGF1R的SUMO化来减轻神经炎症
Yisheng Chen,Xiaofeng Chen,Zhiwen Luo et al.
Yisheng Chen et al.
Introduction: Alzheimer's Disease (AD), a progressive neurodegenerative disorder, is marked by cognitive deterioration and heightened neuroinflammation. The influence of Insulin-like Growth Factor 1 Receptor (IGF1R) and i...
Erianin serves as an NFATc1 inhibitor to prevent breast cancer-induced osteoclastogenesis and bone destruction [0.03%]
埃里安因作为NFATc1抑制剂预防乳腺癌诱发的破骨细胞生成及骨破坏作用
Jiehuang Zheng,Weili He,Yan Chen et al.
Jiehuang Zheng et al.
Introduction: Breast cancer-related bone metastasis can lead to skeletal-related events (SREs), which decrease patient quality of life. Inhibition of osteoclastogenesis is a key treatment for SREs; however, the availabili...
PPARs in atherosclerosis: The spatial and temporal features from mechanism to druggable targets [0.03%]
核受体PPARs在动脉粥样硬化中的时空特征从机制到药物靶点
Yi Zheng,Mingyan Shao,Yanfei Zheng et al.
Yi Zheng et al.
Background: Atherosclerosis is a chronic and complex disease caused by lipid disorder, inflammation, and other factors. It is closely related to cardiovascular diseases, the chief cause of death globally. Peroxisome proli...