TRPM2-mediated feed-forward loop promotes chondrocyte damage in osteoarthritis via calcium-cGAS-STING-NF-κB pathway [0.03%]
TRPM2介导的前馈回路通过钙-cGAS-STING-NF-κB通路促进骨关节炎软骨细胞损伤
Kai Sun,Xiong Zhang,Liangcai Hou et al.
Kai Sun et al.
Introductions: Osteoarthritis (OA) is a significant contributor to disability in the elderly population. However, current therapeutic options are limited. The transient receptor potential melastatin 2 (TRPM2) is involved ...
Xuan Tang,Fengjin Zhou,Sicheng Wang et al.
Xuan Tang et al.
The effective regeneration of bone/cartilage defects remains a significant clinical challenge, causing irreversible damage to millions annually.Conventional therapies such as autologous or artificial bone grafting often yield unsatisfactory...
Trichosanthin elicits antitumor activity via MICU3 mediated mitochondria calcium influx [0.03%]
穿心莲内酯诱导的抗肿瘤活性通过MICU3介导的线粒体钙离子流入实现
Yunbin Zhang,Xuping Ding,Qian Zhang et al.
Yunbin Zhang et al.
Introduction: Trichosanthin (TK) is a glycoprotein extracted from the Chinese medicinal herb Trichosanthes kirilowi, which has anti-virus and anti-tumor activity. However, the target and detailed mechanism of TK remains e...
Meiyu Huang,Keshan Wang,Anshu Li et al.
Meiyu Huang et al.
Introduction: The RNA-guided nuclease Cas9 can be used as a programmable transcription activator, but there is still room for improvement in its effectiveness in eukaryotes, and its potential in cancer genetic therapy has...
Chromosome-scale assembly with improved annotation provides insights into breed-wide genomic structure and diversity in domestic cats [0.03%]
染色体水平的基因组组装和改进注释促进了家猫全范围遗传结构和多样性的研究
Yuki Matsumoto,Claire Yik-Lok Chung,Sachiko Isobe et al.
Yuki Matsumoto et al.
Introduction: Comprehensive genomic resources offer insights into biological features, including traits/disease-related genetic loci. The current reference genome assembly for the domestic cat (Felis catus), Felis_Catus_9...
Tailoring obeticholic acid activity by iridium(III) complex conjugation to develop a farnesoid X receptor probe [0.03%]
通过铱(III)配合物偶联调控鹅膏蕈碱衍生物活性以开发法尼醇X受体探针
Dou Niu,Xiaolei Wu,Yuxin Zhang et al.
Dou Niu et al.
Introduction: The farnesoid X receptor (FXR) is a crucial regulator in the intestine, maintaining bile acid homeostasis. Inhibiting intestinal FXR shows promise in managing inflammatory bowel and liver diseases by reducin...
Plasma proteomic profiles reveal proteins and three characteristic patterns associated with osteoporosis: A prospective cohort study [0.03%]
基于血浆蛋白质组特征模式的骨质疏松症生物学标志物筛选及作用机制探究
Yi Zheng,Jincheng Li,Yucan Li et al.
Yi Zheng et al.
Introduction: Exploration of plasma proteins associated with osteoporosis can offer insights into its pathological development, identify novel biomarkers for screening high-risk populations, and facilitate the discovery o...
Small-molecule targeting BCAT1-mediated BCAA metabolism inhibits the activation of SHOC2-RAS-ERK to induce apoptosis of Triple-negative breast cancer cells [0.03%]
小分子靶向BCAT1介导的支链氨基酸代谢抑制SHOC2-RAS-ERK活化诱导三阴性乳腺癌细胞凋亡
Ling Huang,Guanjun Li,Ying Zhang et al.
Ling Huang et al.
Introduction: Triple-negative breast cancer (TNBC) is the most malignant subtype of breast cancer with the worst prognosis. Exploring novel carcinogenic factors and therapeutic drugs for TNBC remains a focus to improve pr...
Impaired stemness in aging periodontal ligament stem cells is mediated by the progerin/endoplasmic reticulum stress/p53 axis [0.03%]
老化牙周韧带干细胞的干细胞特性受损是通过早老素/内质网应激/p53轴介导的
Xige Zhang,Yazheng Wang,Jinjin Wang et al.
Xige Zhang et al.
Introduction: Decreased periodontal ligament stem cells (PDLSCs) stemness is a key factor in age-related alveolar bone loss. Endoplasmic reticulum (ER) stress is closely related to age-related diseases and the mesenchymal...
Multiple roles of p53 in cancer development: Regulation of tumor microenvironment, m6A modification and diverse cell death mechanisms [0.03%]
p53在癌症发生发展中的多重作用：调节肿瘤微环境、m6A修饰及多种细胞死亡方式
Xiangyu Wang,Jianhua Yang,Wanting Yang et al.
Xiangyu Wang et al.
Background: The protein p53, encoded by the most frequently mutated gene TP53 in human cancers, has diverse functions in tumor suppression. As a best known transcription factor, p53 can regulate various fundamental cellul...