Abnormal changes in metabolites caused by m6A methylation modification: The leading factors that induce the formation of immunosuppressive tumor microenvironment and their promising potential for clinical application [0.03%]
m6A甲基化修饰引起的代谢物异常变化：诱导免疫抑制性肿瘤微环境形成的关键因素及其临床应用潜力展望
Liang Zhao,Junchen Guo,Shasha Xu et al.
Liang Zhao et al.
Background: N6-methyladenosine (m6A) RNA methylation modifications have been widely implicated in the metabolic reprogramming of various cell types within the tumor microenvironment (TME) and are essential for meeting the...
Application of atmospheric cold plasma for zearalenone detoxification in cereals: Kinetics, mechanisms, and cytotoxicity analysis [0.03%]
大气冷等离子体净化谷物中玉米赤霉烯酮的研究：动力学、机理及细胞毒性分析
Mengjie Liu,Junxia Feng,Yongqin Fan et al.
Mengjie Liu et al.
Introduction: Zearalenone (ZEN) is one of the most widely contaminated mycotoxins in world, posing a severe threat to human and animal health. Atmospheric cold plasma (ACP) holds great penitential in mycotoxin degradation...
Mitochondrial calcium uniporter as biomarker and therapeutic target for breast cancer: Prognostication, immune microenvironment, epigenetic regulation and precision medicine [0.03%]
线粒体钙单向转运蛋白作为乳腺癌生物标志物和治疗靶点的诊断、免疫微环境、表观遗传调控及精准医疗作用机制研究
Hung-Yu Lin,Pei-Yi Chu
Hung-Yu Lin
Introduction: Mitochondrial calcium uniporter (MCU) is a central subunit of MCU complex that regulate the levels of calcium ions within mitochondria. A comprehensive understanding the implications of MCU in clinical progn...
Nanozyme-based visual diagnosis and therapeutics for myocardial infarction: The application and strategy [0.03%]
基于纳米酶的心肌梗死可视化诊断与治疗：应用和策略
Yuan Zhang,Wanpeng Yu,Lei Zhang et al.
Yuan Zhang et al.
Background: Myocardial infarction (MI) is a heart injury caused by ischemia and low oxygen conditions. The occurrence of MI lead to the activation of a large number of neutrophils and macrophages, inducing severe inflamma...
Maximizing throughput in NOMA-enable industrial IoT networks using digital twin and reinforcement learning [0.03%]
基于数字孪生与强化学习的非正交多址工业物联网调度研究
Sekione Reward Jeremiah,David Camacho,Jong Hyuk Park
Sekione Reward Jeremiah
Introduction: Increased deployment of heterogeneous and complex Industrial Internet of Things (IIoT) applications such as predictive maintenance and asset tracking places a substantial strain on the limited computational ...
Pleiotropic role of GAS6 in cardioprotection against ischemia-reperfusion injury [0.03%]
GAS6在缺血再灌注损伤心脏保护作用中的多效性功能研究
Chenxi Lu,Yanbin Song,Xiaopeng Wu et al.
Chenxi Lu et al.
Introduction: Myocardial ischemia-reperfusion (IR) injury is a common medical issue contributing to the onset and progression of ischemic heart diseases (IHD). Growth arrest-specific gene 6 (GAS6), a vitamin K-dependent s...
Broken but not beaten: Challenge of reducing the amyloids pathogenicity by degradation [0.03%]
破碎但不摧毁：通过降解降低淀粉样蛋白毒性的挑战
Maksim I Sulatsky,Olga V Stepanenko,Olesya V Stepanenko et al.
Maksim I Sulatsky et al.
Background: The accumulation of ordered protein aggregates, amyloid fibrils, accompanies various neurodegenerative diseases (such as Parkinson's, Huntington's, Alzheimer's, etc.) and causes a wide range of systemic and lo...
Co-delivery of fucoxanthin and Twist siRNA using hydroxyethyl starch-cholesterol self-assembled polymer nanoparticles for triple-negative breast cancer synergistic therapy [0.03%]
基于羟乙基淀粉-胆固醇自组装聚合物纳米粒的岩藻黄素和抑制肿瘤 Twist 小干扰 RNA 共递送协同治疗三阴性乳腺癌研究
Zeliang Wu,Yuxiang Tang,Yuanhui Liu et al.
Zeliang Wu et al.
Introduction: Triple-negative breast cancer (TNBC) represents the most aggressive subtype of breast cancer with an extremely dismal prognosis and few treatment options. As a desmoplastic tumor, TNBC tumor cells are girdle...
The circadian rhythm: A new target of natural products that can protect against diseases of the metabolic system, cardiovascular system, and nervous system [0.03%]
生物节律：具有保护代谢系统、心血管系统和神经系统疾病的天然药物的新靶点
Meiling Xin,Fangjie Bi,Chao Wang et al.
Meiling Xin et al.
Background: The treatment of metabolic system, cardiovascular system, and nervous system diseases remains to be explored. In the internal environment of organisms, the metabolism of substances such as carbohydrates, lipid...
Junjie Xu,Yuening Zhao,Randall Tyler Mertens et al.
Junjie Xu et al.
Background: It is widely acknowledged that dietary habits have profound impacts on human health and diseases. As the most important sweeteners and energy sources in human diets, hexoses take part in a broad range of physi...