Linqi Zeng,Xiaokai Zhang,Zihang Huang et al.
Linqi Zeng et al.
Background: Cardiac fibrosis, including reactive fibrosis and replacement fibrosis, is a common pathological process in most cardiovascular diseases. The ubiquitin proteasome system (UPS) plays an important role in the de...
Unlocking biological insights from differentially expressed genes: Concepts, methods, and future perspectives [0.03%]
差异表达基因的生物解读：概念、方法和未来趋势
Huachun Yin,Hongrui Duo,Song Li et al.
Huachun Yin et al.
Background: Identifying differentially expressed genes (DEGs) is a core task of transcriptome analysis, as DEGs can reveal the molecular mechanisms underlying biological processes. However, interpreting the biological sig...
Cancer-associated fibroblasts regulate mitochondrial metabolism and inhibit chemosensitivity via ANGPTL4-IQGAP1 axis in prostate cancer [0.03%]
癌症相关成纤维细胞通过ANGPTL4-IQGAP1轴调节前列腺癌的线粒体代谢并抑制其化疗敏感性
Zhi Xiong,Rui-Lin Zhuang,Shun-Li Yu et al.
Zhi Xiong et al.
Introduction: Cancer-associated fibroblasts (CAFs) are a critical component of the tumor microenvironment, being implicated in enhancing tumor growth and fostering drug resistance. Nonetheless, the mechanisms underlying t...
Asperosaponin VI inhibition of DNMT alleviates GPX4 suppression-mediated osteoblast ferroptosis and diabetic osteoporosis [0.03%]
asperosaponinVI通过抑制DNMT缓解GPX4低表达介导的成骨细胞铁死亡及糖尿病性骨质疏松症
Fanhao Wei,Binjia Ruan,Jian Dong et al.
Fanhao Wei et al.
Introduction: Diabetic osteoporosis (DOP) is an insidious complication of diabetes with limited therapeutic options. DOP is pathologically associated with various types of regulated cell death, but the precise role of fer...
Hypo-osmolarity promotes naive pluripotency by reshaping cytoskeleton and increasing chromatin accessibility [0.03%]
低渗透压通过重塑细胞骨架和增加染色质可及性促进naive多能性
Renhong Lu,Bowen Lin,Zheyi Lin et al.
Renhong Lu et al.
Introduction: Cell fate determination and transition are of paramount importance in biology and medicine. Naive pluripotency could be achieved by reprogramming differentiated cells. However, the mechanism is less clear. O...
Targeting Dlat-Trpv3 pathway by hyperforin elicits non-canonical promotion of adipose thermogenesis as an effective anti-obesity strategy [0.03%]
通过Hyperforin靶向Dlat-Trpv3通路以非经典途径促进脂肪产热作为一种有效的抗肥胖策略
Sijia Lu,Quanxin Jiang,Peihui Zhou et al.
Sijia Lu et al.
Introduction: Promoting adipose thermogenesis is considered as a promising therapeutic intervention in obesity. However, endeavors to develop anti-obesity medications by targeting the canonical thermogenesis regulatory pa...
The potential of circular RNAs as biomarkers and therapeutic targets for gastric cancer: A comprehensive review [0.03%]
循环RNA作为胃癌生物标志物和治疗靶点的潜力：全面综述
Junlin Pu,Xiuli Yan,Hui Zhang
Junlin Pu
Background: Gastric cancer (GC) is a global health concern, contributing significantly to cancer-related mortality rates. Early detection is vital for improving patient outcomes. Recently, circular RNAs (circRNAs) have em...
Full dimensional dynamic 3D convolution and point cloud in pulmonary nodule detection [0.03%]
全维度动态卷积及点云在肺结节检测中的应用研究
Yun Tie,Ying Wang,Dalong Zhang et al.
Yun Tie et al.
Lung cancer is a leading cause of death worldwide, making early and accurate diagnosis essential for improving patient outcomes. Recently, deep learning (DL) has proven to be a powerful tool, significantly enhancing the accuracy of computer...
Exercise-regulated lipolysis: Its role and mechanism in health and diseases [0.03%]
运动调节的脂肪分解作用：其在健康和疾病中的作用和机制
Jie-Ying Zhu,Liang Guo
Jie-Ying Zhu
Exercise has received considerable attention because of its importance not just in regulating physiological function, but also in ameliorating multiple pathological processes. Among these processes, lipolysis may play an important role in e...
Manipulation of artificial light environment improves plant biomass and fruit nutritional quality in tomato [0.03%]
调控人工光环境可以提高番茄的生物量和果实营养品质
Ying Zhang,Kangyou Zhu,Xiujie Wang et al.
Ying Zhang et al.
Introduction: The yield and quality of tomato (Solanum lycopersicum. L) are often decreased when plants suffer from low light intensity and short-photoperiod in winter. Manipulation of the artificial light environment is ...