Synthetic tunable promoters for flexible control of multi-gene expression in mammalian cells [0.03%]
合成可调式启动子在哺乳动物细胞多重基因表达中的灵活调控作用
Zong-Heng Fu,Si Cheng,Jia-Wei Li et al.
Zong-Heng Fu et al.
Introduction: Synthetic biology revolutionizes our ability to decode and recode genetic systems. The capability to reconstruct and flexibly manipulate multi-gene systems is critical for understanding cellular behaviors an...
Qian Sun,Hua Chang,Huan Wang et al.
Qian Sun et al.
Background: Extracellular vesicles (EVs) are heterogeneous membranous structures released by various cell types, including large vesicles, microvesicles (MVs), and exosomes. These vesicles play crucial roles in intercellu...
Long non-coding RNAs: Emerging regulators of invasion and metastasis in pancreatic cancer [0.03%]
长非编码RNA：在胰腺癌中调控侵袭和转移的新因子
Mengmeng Shi,Rui Zhang,Hao Lyu et al.
Mengmeng Shi et al.
Background: The invasion and metastasis of pancreatic cancer (PC) are key factors contributing to disease progression and poor prognosis. This process is primarily driven by EMT, which has been the focus of recent studies...
Neonatal sevoflurane exposures inhibits DHHC5-mediated palmitoylation of TfR1 in oligodendrocytes, leading to hypomyelination and neurological impairments [0.03%]
新生儿暴露于地氟醚中抑制少突胶质细胞中TfR1的DHHC5介导棕榈酰化作用，导致脱髓鞘和神经损伤
Huiqing Liu,Binxiao Su,Zhihao Zhang et al.
Huiqing Liu et al.
Introduction: Neonatal anesthesia-related neurological impairments are of significant concern, closely linked to oligodendrocyte dysfunction. However, there is a notable temporal discrepancy between the sustained developm...
Lactation duration and the risk of type 2 diabetes mellitus in parous women: A perspective on socioeconomic status disparity [0.03%]
哺乳持续时间与经产妇2型糖尿病风险的关系：从社会经济地位差异的角度分析
Qian Yi,Weidi Sun,Leying Hou et al.
Qian Yi et al.
Background & aims: Whether and how socioeconomic status (SES) influences the associations between type 2 diabetes mellitus (T2DM) and lactation remains unknown. We aimed to evaluate the associations between lactation dura...
PA2G4 in health and disease: An underestimated multifunctional regulator [0.03%]
PA2G4在健康和疾病中的作用：一个被低估的多功能调节因子
Wenlong Jia,Gaocheng Wang,Sheng Sun et al.
Wenlong Jia et al.
Background: Proliferation-associated protein 2G4 (PA2G4), also known as ErbB3-binding protein 1 (EBP1), is an evolutionarily conserved, ubiquitously expressed, multifunctional factor in health and disease. In recent decad...
LncRNA CRCMSL interferes in phospholipid unsaturation to suppress colorectal cancer progression via reducing membrane fluidity [0.03%]
长链非编码RNA CRCMSL通过降低膜流动性干扰磷脂不饱和度从而抑制结直肠癌进展
Muhong Jiang,Lijun Xu,Wandie Lin et al.
Muhong Jiang et al.
Introduction: Reprogrammed metabolism is an important basis of colorectal cancer (CRC) progression; however, its mechanisms remain unclear. This study illustrated a novel mechanism for long noncoding RNA (lncRNA) CRCMSL i...
A functional cascading of lignin modification via repression of caffeic acid O-methyltransferase for bioproduction and anti-oxidation in rice [0.03%]
通过抑制咖啡酸O甲基转移酶功能改进水稻木质素的生物生产及抗氧化研究
Hua Yu,Guifen Zhang,Jingyuan Liu et al.
Hua Yu et al.
Introduction: Crop straws provide substantial biomass resources that are transformable for sustainable biofuels and valuable bioproducts. However, the natural lignocellulose recalcitrance results in an expensive biomass p...
A novel navigation assistant method for substation inspection robot based on multisensory information fusion [0.03%]
基于多传感器信息融合的变电站巡检机器人导航助理方法研究
Qiang Yang,Jingze Dong,Minyao Tan et al.
Qiang Yang et al.
Introduction: Due to the complex environment of the substation, the inspection work of the substation becomes time-consuming and laborious. As a result, the substation inspection robot has gradually become a hot research ...
Developing pangenomes for large and complex plant genomes and their representation formats [0.03%]
大型复杂植物基因组泛基因组的开发及其表示格式
Pradeep Ruperao,Parimalan Rangan,Trushar Shah et al.
Pradeep Ruperao et al.
Background: The development of pangenomes has revolutionized genomic studies by capturing the complete genetic diversity within a species. Pangenome assembly integrates data from multiple individuals to construct a compre...