Design of a targeted dual drug delivery system for boosting the efficacy of photoimmunotherapy against melanoma proliferation and metastasis [0.03%]
一种针对黑色素瘤增殖和转移的光免疫治疗递药系统的设计
Yi Chen,Shan Xu,Shuang Ren et al.
Yi Chen et al.
Introduction: The combination of a photosensitizer and indoleamine-2,3 dioxygenase (IDO) inhibitor provides a promising photoimmunotherapy (PIT) strategy for melanoma treatment. A dual drug delivery system offers a potent...
Mesenteric adipose-derived exosomal TINAGL1 enhances intestinal fibrosis in Crohn's Disease via SMAD4 [0.03%]
肠系膜脂肪源性外泌体TINAGL1通过SMAD4增强克罗恩病肠道纤维化
Yidong Chen,Junrong Li,Xiaopeng Zhang et al.
Yidong Chen et al.
Introduction: Crohn's Disease (CD) is a chronic inflammatory condition characterized by intestinal fibrosis, severely impacting patient quality of life. The molecular mechanisms driving this fibrosis remain inadequately u...
Targeting selective autophagy and beyond: From underlying mechanisms to potential therapies [0.03%]
选择性自噬的靶向及展望：从潜在机制到未来疗法
Wei Ma,Yingying Lu,Xin Jin et al.
Wei Ma et al.
Background: Autophagy is an evolutionarily conserved turnover process for intracellular substances in eukaryotes, relying on lysosomal (in animals) or vacuolar (in yeast and plants) mechanisms. In the past two decades, em...
Sodium-glucose exchanger 2 inhibitor canagliflozin promotes mitochondrial metabolism and alleviates salt-induced cardiac hypertrophy via preserving SIRT3 expression [0.03%]
钠-葡萄糖协同转运蛋白2抑制剂卡格列净通过维持SIRT3表达促进线粒体代谢并缓解盐诱导的心脏肥厚
Yu Zhao,Zongshi Lu,Hexuan Zhang et al.
Yu Zhao et al.
Introduction: Excess salt intake is not only an independent risk factor for heart failure, but also one of the most important dietary factors associated with cardiovascular disease worldwide. Metabolic reprogramming in ca...
High-fat diet induces sarcopenic obesity in natural aging rats through the gut-trimethylamine N-oxide-muscle axis [0.03%]
高脂饮食通过肠道-TMAO-肌肉轴诱导自然衰老大鼠发生肌少症性肥胖
Xiaoxing Mo,Ruijie Cheng,Lihui Shen et al.
Xiaoxing Mo et al.
Introduction: The lack of suitable animal models for sarcopenic obesity (SO) limits in-depth research into the disease. Emerging studies have demonstrated that gut dysbiosis is involved in the development of SO. As the im...
L-lysine dietary supplementation for childhood and adolescent growth: Promises and precautions [0.03%]
L-赖氨酸饮食补充与儿童及青少年生长：前景和预防措施
Rasika Gunarathne,Xiao Guan,Tao Feng et al.
Rasika Gunarathne et al.
Background: L-lysine (lysine) is an essential amino acid that plays a vital role in human nutrition. It serves as a key component in protein synthesis and fulfills critical roles in various physiological activities. For d...
ANGPTL3 accelerates atherosclerotic progression via direct regulation of M1 macrophage activation in plaque [0.03%]
血管生成素样蛋白3通过直接调控斑块内M1型巨噬细胞活化促进动脉粥样硬化进展
Yuejie Zhang,Cen Yan,Yuan Dong et al.
Yuejie Zhang et al.
Introduction: The N-terminal domain of angiopoietin-like protein 3 (ANGPTL3) inhibits lipoprotein lipase activity. Its C-terminal fibrinogen-like (FBN) domain is a ligand of macrophage integrin αvβ3. ...
Organellophagy regulates cell death:A potential therapeutic target for inflammatory diseases [0.03%]
细胞器自噬调控细胞死亡：炎症疾病潜在的治疗靶点
Yu Duan,Ren-Qi Yao,Hua Ling et al.
Yu Duan et al.
Background: Dysregulated alterations in organelle structure and function have a significant connection with cell death, as well as the occurrence and development of inflammatory diseases. Maintaining cell viability and in...
Biogeography of intestinal mucus-associated microbiome: Depletion of genus Pseudomonas is associated with depressive-like behaviors in female cynomolgus macaques [0.03%]
肠道粘液相关微生物群的生物地理学：肠道假单胞菌属耗竭与雌性猕猴类似抑郁行为有关
Xunmin Tan,Jing Wu,Hanping Zhang et al.
Xunmin Tan et al.
Introduction: Depression is a debilitating and poorly understood mental disorder. There is an urgency to explore new potential biological mechanisms of depression and the gut microbiota is a promising research area. ...
Quercetin, a natural flavonoid, protects against hepatic ischemia-reperfusion injury via inhibiting Caspase-8/ASC dependent macrophage pyroptosis [0.03%]
天然黄酮类化合物檞皮素通过抑制巨噬细胞caspase-8/ASC依赖性焦亡保护肝脏缺血再灌注损伤
Jiacheng Lin,Fuyang Li,Junzhe Jiao et al.
Jiacheng Lin et al.
Introduction: Hepatic ischemia-reperfusion injury (IRI) is an inevitable adverse event following liver surgery, leading to liver damage and potential organ failure. Despite advancements, effective interventions for hepati...