Macrophage P2Y12 regulates iron transport and its inhibition protects against atherosclerosis [0.03%]
巨噬细胞P2Y12调节铁的运输及其抑制作用可防止动脉粥样硬化
Yang-Xi Hu,Hong-Min You,Mei-Rong Bai et al.
Yang-Xi Hu et al.
Introduction: Iron retention is commonly observed in atherosclerotic plaques and is believed to be detrimental to atherosclerosis. Platelet P2Y12 is a target of antiplatelet therapy in preventing thrombotic complications ...
Predictive value of remnant cholesterol inflammatory index for stroke risk: Evidence from the China health and Retirement Longitudinal study [0.03%]
中国健康与退休纵向研究中残余胆固醇炎症指数对卒中风险的预测价值
Jiaying Chen,Qiheng Wu,Haotian Liu et al.
Jiaying Chen et al.
Introduction: Remnant cholesterol (RC) and high-sensitivity C-reactive protein (hs-CRP) are established stroke risk factors, but their joint impact remains unclear. ...
KBTBD8/RRP15 as a potential novel therapeutic target associates with lenvatinib-inhibited progression in hepatocellular carcinoma both in vitro and in vivo [0.03%]
KBTBD8/RRP15作为潜在的新型治疗靶点与LEN在肝癌中抑制肿瘤进展的作用密切相关：体内与体外研究
Saili Zhao,Xuran Wang,Rui Wu et al.
Saili Zhao et al.
Introduction: We have previously demonstrated that RRP15 (Ribosomal RNA Processing 15 Homolog) was significantly elevated in hepatocellular carcinoma (HCC) and correlated directly with poor prognosis. RRP15 suppression cu...
Genome-wide profiling and functional study of short N-terminal H2B variants in Arabidopsis [0.03%]
拟南芥H2B变体的全基因组分析及其功能研究
Peng Yao,Qin He,Ying Wang et al.
Peng Yao et al.
Introduction: Nucleosomes harboring specific histone variants show distinct chromatin localization patterns and regulatory functions, thereby playing crucial roles in epigenetic regulation. Compared to the well-understood...
Bio-friendly multi-stimuli responsive α-CD polymer-gated mesoporous carbon nanoherbicides for enhanced paraquat delivery [0.03%]
生物友好型多刺激响应α-环糊精聚合物 gate 涂层介孔碳纳米除草剂用于增强百草枯输送
Jiangtao Dong,Guoquan Wang,Xiaona Li et al.
Jiangtao Dong et al.
Introduction: Weeds seriously affect crop yield in global agricultural production. Paraquat (PQ), as one of low cost and highly effective herbicide, is forbidden or severely restricted in production and sales owing to its...
Dissecting the anti-obesity components of ginseng: How ginseng polysaccharides and ginsenosides target gut microbiota to suppress high-fat diet-induced obesity [0.03%]
解析人参的抗肥胖成分：人参多糖和人参皂苷如何靶向肠道微生物以抑制高脂饮食引起的肥胖症状
Han-Yan Luo,Jing Fang,Wei-Hao Zhang et al.
Han-Yan Luo et al.
Introduction: Ginseng demonstrates therapeutic potential in treating obesity, with both experimental and clinical studies suggesting its anti-obesity effects are mediated by gut microbiota. Nonetheless, the specific chemi...
ORP5 promotes cardiac hypertrophy by regulating the activation of mTORC1 on lysosome [0.03%]
ORP5通过调节溶酶体上mTORC1的活化促进心室肥厚
Di Zhao,Ran Xu,Yufei Zhou et al.
Di Zhao et al.
Introduction: Oxysterol binding protein (OSBP)-related protein 5 (ORP5) mainly functions as a lipid transfer protein at membrane contact sites (MCS). ORP5 facilitates cell proliferation through the activation of mTORC1 si...
Key β1-4 galactosylated glycan receptors of SARS-CoV-2 and its inhibitor from the galactosylated glycoproteins of bovine milk [0.03%]
牛乳中半乳糖化糖蛋白的SARS-CoV-2关键β1-4半乳糖基甘露糖受体及其抑制剂
Hanjie Yu,Wentian Chen,Jian Shu et al.
Hanjie Yu et al.
Introduction: The binding of the spike (S) protein of SARS-CoV-2 to angiotensin-converting enzyme 2 (ACE2) is a critical stage in the process of infection. While previous studies indicated that the S protein and ACE2 are ...
Not only the top: Type I topoisomerases function in multiple tissues and organs development in plants [0.03%]
不止于顶端：植物I型拓扑异构酶在多种组织和器官发育中的功能
Hao Zhang,Lirong Tian,Yuru Ma et al.
Hao Zhang et al.
Background: DNA topoisomerases (TOPs) are essential components in a diverse range of biological processes including DNA replication, transcription and genome integrity. Although the functions and mechanisms of TOPs, parti...
Dual regulation of phaseol on osteoclast formation and osteoblast differentiation by targeting TAK1 kinase for osteoporosis treatment [0.03%]
Phaseolon通过靶向TAK1激酶调控破骨细胞形成及成骨细胞分化治疗骨质疏松
Lihua Tan,Zhimin Miao,Yuxin Zhao et al.
Lihua Tan et al.
Introduction: Osteoporosis is an osteolytic disorder resulting from an inequilibrium between osteoblast-mediated osteogenesis and osteoclast-driven bone absorption. Safe and effective approaches for osteoporosis managemen...