MTHFR variant links homocysteine metabolism and endothelial cell dysfunction by targeting mitophagy in human thoracic aortic dissection patient induced pluripotent stem cell (iPSC) models [0.03%]
MTHFR变异通过靶向人体胸主动脉瘤诱导多能干细胞(iPSC)模型的线粒体自噬来影响同型半胱氨酸代谢和内皮细胞功能失调
You Yu,Lianbo Shao,Meng Zhang et al.
You Yu et al.
Aims: Genetics and environmental cues boost the development of human diseases. Methylenetetrahydrofolate reductase (MTHFR) is involved in the metabolism of homocysteine, and a common variant rs1801133 of MTHFR has been re...
Digital twin-driven operational CycleGAN-based multiple virtual-physical mappings for remaining useful life prediction under limited life cycle data [0.03%]
基于数字孪生驱动的CycleGAN剩余使用寿命预测方法研究
Quanning Xu,Zihao Lei,Shulong Gu et al.
Quanning Xu et al.
Accurately predicting the remaining useful life (RUL) of complex equipment plays a vital role in maintaining modern manufacturing systems' operational safety and reliability. This challenge has attracted considerable interest within the dom...
Deep-DPC: Deep learning-assisted label-free temporal imaging discovery of anti-fibrotic compounds by controlling cell morphology [0.03%]
Deep-DPC：通过控制细胞形态实现抗纤维化化合物的无标记时序成像发现的深度学习辅助方法
Xu-Dong Xing,Xiang-Yu Yan,Yan-Wei Tan et al.
Xu-Dong Xing et al.
Introduction: Fibrosis can damage the normal function of many organs, such as cardiac function, for which no effective clinical therapies exist. However, traditional approaches to anti-fibrosis drug discovery have primari...
Cuticle thickening mediates insecticide penetration resistance in Spodoptera litura [0.03%]
表皮增厚介导烟芽夜蛾杀虫剂渗透抵抗
Bingjie Wang,Minghui Yi,Mengyu Wang et al.
Bingjie Wang et al.
Introduction: Long-term and extensive use of chemical pesticides has led to the development of resistance in many important agricultural pests. The mechanisms of resistance formation in pests are complex and variable, and...
Enhancing maize resistance to Fusarium verticillioides through modulation of cell wall structure and components by ZmXYXT2 [0.03%]
通过ZmXYXT2调节细胞壁结构和组分提高玉米对Fusarium verticillioides的抗性
Yufang Xu,Yudong Fan,Lujie Liu et al.
Yufang Xu et al.
Introduction: Fusarium verticillioides (F. verticillioides) is a prevalent phytopathogen that incites severe diseases in maize, resulting in substantial reductions in grain yield and quality. Despite its widespread impact...
Lipophagy acts as a nutritional adaptation mechanism for the filamentous entomopathogenic fungus Beauveria bassiana to colonize within the hosts [0.03%]
脂噬作用是链状虫生真菌(Beoerveria bassiana)在宿主内定植的营养适应机制。
Jin-Li Ding,Ming-Guang Feng,Sheng-Hua Ying
Jin-Li Ding
Introduction: Metabolic adaptation to various nutrients is crucial for the pathogenic growth and virulence of filamentous fungal pathogens. Despite its importance, the mechanisms underlying fungal adaptation to nutrient s...
Toxicological mechanisms of carbon polymers in accelerating cognitive decline in Alzheimer's disease [0.03%]
碳聚合物毒理学机制在加速阿尔茨海默病认知衰退中的作用
Zihe Qi,Juanjuan Cao,Jianghua Liu et al.
Zihe Qi et al.
Introduction: Alzheimer's disease (AD) is the primary cause of dementia and is emerging as a global threat to human health. Increased availability of processed food is identified as a crucial environmental risk factor und...
Comprehensive multi-omics analyses exposes a precision therapy strategy that targets replication stress in hepatocellular carcinoma using WEE1 inhibition [0.03%]
综合性多组学分析揭示了针对肝细胞癌复制压力的精准治疗策略——使用WEE1抑制剂
Xing Jia,Xingxin Zhu,Shinuo Chen et al.
Xing Jia et al.
Introduction: Hepatocellular carcinoma (HCC) is an extremely heterogeneous malignancy with a poor prognosis, highlighting the need to target specific vulnerabilities within the tumor during treatment. ...
NAC transcription factor GbNTL9 modifies the accumulation and organization of cellulose microfibrils to enhance cotton fiber strength [0.03%]
NAC转录因子GbNTL9通过改变纤维素微纤丝的积累和排列来提高棉花纤维强度
Mi Wu,Zhiyong Xu,Chao Fu et al.
Mi Wu et al.
Introduction: Fiber strength is a critical determinant of fiber quality, with stronger fibers being highly preferred in the cotton textile industry. However, the genetic basis and the specific regulatory mechanism underly...
Autoimmune responses to myelin-associated proteins as diagnostic and prognostic biomarkers of relapsing-remitting multiple sclerosis: Associations with human herpesvirus-6 and Epstein-Barr virus reactivation [0.03%]
髓鞘相关蛋白的自身免疫反应作为复发缓解型多发性硬化症的诊断和预后生物标志物：与人类玫瑰疹病毒-6和Epstein-Barr病毒再激活的关系
Aristo Vojdani,Abbas F Almulla,Elroy Vojdani et al.
Aristo Vojdani et al.
Background: The pathogenesis of relapsing-remitting multiple sclerosis (RRMS) is linked to autoimmune attacks against myelin proteins, and reactivation of Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV-6). However,...