Targeting APJ drives BNIP3-PINK1-PARKIN induced mitophagy and improves systemic inflammatory bone loss [0.03%]
靶向APJ通过BNIP3-PINK1-PARKIN诱导线粒体自噬并改善全身性炎症骨丢失
Wentao Wang,Qing Wang,Wenming Li et al.
Wentao Wang et al.
Introduction: Inflammatory diseases, such as diabetes mellitus, rheumatoid arthritis, and inflammatory bowel disease, lead to systemic immune microenvironment disturbances, contributing to bone loss, yet the mechanisms by...
Non-destructive detection strategy of maize seed vigor based on seed phenotyping and the potential for accelerating breeding [0.03%]
基于种子表型的玉米种子活力无损检测策略及其在加速育种中的应用潜力
Keling Tu,Shaozhe Wen,Yanan Xu et al.
Keling Tu et al.
Introduction: Seeds are fundamental to agricultural production, and their vigor affects seedling quality, quantity, and crop yield. Accurate vigor assessment methods are crucial for agricultural productivity. ...
Loss of glomerular aldolase B in diabetic nephropathy promotes renal fibrosis via activating Akt/GSK/β-catenin axis [0.03%]
糖尿病肾病中糖酵解关键酶醛缩酶B的丢失促进肾纤维化发生发展
Minghui Liu,Wenwen Yang,Shuang Qu et al.
Minghui Liu et al.
Objective: Diabetic nephropathy (DN), characterized by a complex and multifaceted pathogenesis, stands as the foremost catalyst behind end-stage renal disease (ESRD). This study aims to analyze the level and non-metabolic...
Design of highly leaf-adhesive and anti-UV herbicide nanoformulation for enhanced herbicidal activity [0.03%]
一种设计用于增强除草剂活性的高效粘附叶片且抗紫外线的纳米制剂
Dongdong Li,Jianan Li,Hao Li et al.
Dongdong Li et al.
Introduction: Conventional pesticide formulations have been widely used to boost agricultural productivity, but their weak foliar adhesion and instability under UV light during spraying lead to low utilization rates and p...
Absence of gut microbiota alleviates iron overload-induced colitis by modulating ferroptosis in mice [0.03%]
肠道微生物群的缺失通过调节铁过载小鼠的铁死亡来缓解结肠炎
Ke Gu,Aimin Wu,Chen Liu et al.
Ke Gu et al.
Introduction: Iron overload disrupts gut microbiota and induces ferroptosis, contributing to colitis. However, whether gut microbiota directly drives iron overload-induced colitis and its underlying mechanism remain uncle...
Lina Ding,Ruicheng Zhang,Wenqi Du et al.
Lina Ding et al.
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) signaling pathway has been identified as a crucial mechanism in antiviral defense and innate immunity pathway. Ferroptosis, characterized by iron dependence and lipid...
Tong-Ju Eh,Yaxuan Jiang,Mingquan Jiang et al.
Tong-Ju Eh et al.
Background: Trehalose is a nonreducing disaccharide containing two glucose molecules linked through an α,α-1,1-glycosidic bond. This unique chemical structure causes trehalose levels to fluctuate significantly in plants...
Targeting ATM enhances radiation sensitivity of colorectal cancer by potentiating radiation-induced cell death and antitumor immunity [0.03%]
靶向ATM通过增强放射诱导的细胞凋亡和抗肿瘤免疫来提高结直肠癌对辐射的敏感性
Yuwen Xie,Yang Liu,Mingdao Lin et al.
Yuwen Xie et al.
Introduction: The efficacy of radiotherapy in colorectal cancer (CRC) is often limited by radiation resistance. Ataxia telangiectasia mutated (ATM) is well known for its role in repairing double-strand DNA breaks within t...
Maternal fish oil supplementation enhances nutrient transport in the placenta and milk biosynthesis in the mammary gland via the GPR120 signaling pathway [0.03%]
鱼油补充通过GPR120信号途径增强胎盘营养物质转运和乳腺泌乳作用
Qihui Li,Qianzi Zhang,Senlin Su et al.
Qihui Li et al.
Introduction: Maternal fish oil (FO) supplementation during pregnancy has been shown to improve pregnancy outcomes. FO is recognized as dietary source for n-3 polyunsaturated fatty acids (n-3 PUFAs). While early research ...
FTO activates PD-L1 promotes immunosuppression in breast cancer via the m6A/YTHDF3/PDK1 axis under hypoxic conditions [0.03%]
FTO通过m6A/YTHDF3/PDK1轴在缺氧条件下激活PD-L1促进乳腺癌免疫抑制作用
Siyu Wang,Xingda Zhang,Quanrun Chen et al.
Siyu Wang et al.
Introduction: Altered epigenetic reprogramming enables breast cancer cells to adapt to hypoxic stress. Hypoxic microenvironment can alter immune cell infiltration and function, limiting the effectiveness of immunotherapy....