Multi-omics approach reveals TGF-β signaling-driven senescence in periodontium stem cells [0.03%]
多组学方法揭示转化生长因子-β信号驱动的牙周组织干细胞衰老机制
Bo Li,Wei Li,Yueqi Liao et al.
Bo Li et al.
Introduction: The periodontal ligament (PDL), a dynamic connective tissue that anchors teeth to the alveolar bone, enables tooth retention and facilitates continuous turnover. The integrity of the periodontium is maintain...
5-Aminolevulinic acid improves strawberry salt tolerance through a NO-H2O2 signaling circuit regulated by FaWRKY70 and FaWRKY40 [0.03%]
叶绿素酸改善草莓耐盐性通过FaWRKY70和FaWRKY40调控的NO-H2O2信号通路
Hao Yang,Jianting Zhang,Yan Zhong et al.
Hao Yang et al.
Introduction: 5-Aminolevulinic acid (ALA) is an essential biosynthetic precursor of tetrapyrrole compounds, naturally occurring in all living organisms. It has also been suggested as a new plant growth regulator. Treatmen...
Elevated EBF2 in mouse but not pig drives the progressive brown fat lineage specification via chromatin activation [0.03%]
EBF2在小鼠而非猪中上调通过染色质激活驱动渐进的棕色脂肪细胞谱系决定
Yinlong Liao,Zhelun Peng,Shanshan Fu et al.
Yinlong Liao et al.
Brown adipose tissue (BAT) is responsible for non-shivering thermogenesis, but it is absent in some mammals, including pigs. During development, BAT progenitors are derived from paired box 7 (Pax7)-expressing somitic mesodermal stem cells, ...
D-Mannose-Mediated metabolic pathways sustain the molecular signatures of sperm function and fertilization [0.03%]
D-半乳糖介导的代谢通路维持了精子功能和受精的分子标志物
Wenlong Zhao,Nihao Gu,Xueyuan Liu et al.
Wenlong Zhao et al.
Introduction: Mammalian sperm within a single ejaculate exhibit significant heterogeneity, with only a subset possessing the molecular characteristics required for successful fertilization. Identifying the defining traits...
Protein palmitoylation in hepatic diseases: Functional insights and therapeutic strategies [0.03%]
蛋白质棕榈酰化在肝病中的功能作用及治疗策略
Ying Wang,Haoyuan Ma,Bowen Zhang et al.
Ying Wang et al.
Background: Liver pathologies represent a spectrum of conditions ranging from fatty liver to the aggressive hepatocellular carcinoma (HCC), as well as parasitic infections, which collectively pose substantial global healt...
Comprehensive analysis of heterogeneity and cell-cell interactions in Crohn's disease reveals novel location-specific insights [0.03%]
全面分析克罗恩病的异质性和细胞间相互作用揭示了新颖的位置特异性见解
Jing Feng,Li-Na He,Ruchen Yao et al.
Jing Feng et al.
Introduction: In Crohn's disease (CD), lesions are mainly distributed in a segmental manner, with the primary sites of involvement being the ileum and colon. Heterogeneity in colon and ileum results in location-specific c...
Lonicera caerulea genome reveals molecular mechanisms of freezing tolerance and anthocyanin biosynthesis [0.03%]
越橘基因组揭示了抗冻性和花青素生物合成的分子机制
Jing Wang,Xiaotong Wang,Yuwei Ma et al.
Jing Wang et al.
Introduction: Lonicera caerulea L. (blue honeysuckle) is a noteworthy fleshy-fruited tree and a prominent medicinal plant, which possesses notable characteristics such as exceptional resilience to winter conditions and ea...
Tianwang Guan,Yanting Jiang,Peinan Tu et al.
Tianwang Guan et al.
Introduction: Non-cancer events are important causes of competing mortality among cancer patients. However, the risk of non-cancer death and risk classification in middle-aged cancer patients is not clear. To comprehensiv...
Evaluating current status of network pharmacology for herbal medicine focusing on identifying mechanisms and therapeutic effects [0.03%]
聚焦作用机制和药效评价的中药网络药理学现状及挑战
Won-Yung Lee,Kwang-Il Park,Seon-Been Bak et al.
Won-Yung Lee et al.
Introduction: Network pharmacology has gained significant traction as a tool for identifying the mechanisms and therapeutic effects of herbal medicines. However, despite the usefulness of these approaches, their diversity...
Adiponectin deficiency prevents chronic colitis-associated colonic fibrosis via inhibiting CXCL13 production [0.03%]
脂联素缺乏通过抑制CXCL13产生来预防慢性结肠炎相关结肠纤维化
Haitao Xiao,Tianhang Xing,Miao Qiu et al.
Haitao Xiao et al.
Introduction: Colonic fibrosis is a long-term complication of inflammatory bowel disease (IBD), often leading to functional impairment, intestinal obstruction, and surgery. Adiponectin (APN) is an adipokine derived from a...