Nanoparticle-mediated celastrol ER targeting delivery amplify immunogenic cell death in melanoma [0.03%]
纳米颗粒介导的雷斯坦醇ER靶向递送可增强黑色素瘤的免疫原性细胞死亡
Fengling Wang,Wenjing Lai,Dandan Xie et al.
Fengling Wang et al.
Introduction: Chemoimmunotherapy, which benefits from the combination of chemotherapy and immunotherapy, has emerged as a promising strategy in cancer treatment. However, effectively inducing a robust immune response rema...
Associations between specific dietary patterns, gut microbiome composition, and incident subthreshold depression in Chinese young adults [0.03%]
特定饮食模式、肠道菌群构成与中国年轻人亚临床抑郁的发病之间的关联
Xiumin Jiang,Xiaotong Wang,Meng Zhang et al.
Xiumin Jiang et al.
Introduction: The interplay between influential factors and the incidence of subthreshold depression (SD) in young adults remains poorly understood. Objec...
Hippo-YAP/TAZ-ROS signaling axis regulates metaflammation induced by SelenoM deficiency in high-fat diet-derived obesity [0.03%]
硒缺乏通过 hippo-YAP/TAZ-ROS 信号轴诱发高脂饮食引起的代谢性炎症
Jingzeng Cai,Jiaqiang Huang,Di Li et al.
Jingzeng Cai et al.
Introduction: Metabolic inflammation (metaflammation) in obesity is primarily initiated by proinflammatory macrophage infiltration into adipose tissue. SelenoM contributes to the modulation of antioxidative stress and inf...
Muhammad Mahtab Aslam Khan Khakwani,Xin-Ying Ji,Saadullah Khattak et al.
Muhammad Mahtab Aslam Khan Khakwani et al.
Background: Nuclear pore complexes (NPCs) are the architectures entrenched in nuclear envelop of a cell that regulate the nucleo-cytoplasmic transportation of materials, such as proteins and RNAs for proper functioning of...
Pyroptosis: A spoiler of peaceful coexistence between cells in degenerative bone and joint diseases [0.03%]
焦亡：退变性骨关节疾病细胞和平共存的破坏者
Zhichao Li,Wenxiang Cheng,Kuanhui Gao et al.
Zhichao Li et al.
Background: As people age, degenerative bone and joint diseases (DBJDs) become more prevalent. When middle-aged and elderly people are diagnosed with one or more disorders such as osteoporosis (OP), osteoarthritis (OA), a...
Tumor microenvironment as niche constructed by cancer stem cells: Breaking the ecosystem to combat cancer [0.03%]
肿瘤微环境作为由癌症干细胞构建的生态位：打破生态系统以对抗癌症
Hao Zhong,Shiyue Zhou,Shuangshuang Yin et al.
Hao Zhong et al.
Background: Cancer stem cells (CSCs) are a distinct subpopulation of cancer cells with the capacity to constantly self-renew and differentiate, and they are the main driver in the progression of cancer resistance and rela...
Genetic and phenotypic associations of frailty with cardiovascular indicators and behavioral characteristics [0.03%]
脆弱性与心血管指标和行为特征的遗传和表型关联
Yihan Chen,Siying Lin,Shuangyu Yang et al.
Yihan Chen et al.
Introduction: Frailty Index (FI) is a common measure of frailty, which has been advocated as a routine clinical test by many guidelines. The genetic and phenotypic relationships of FI with cardiovascular indicators (CIs) ...
A trans-acting sRNA SaaS targeting hilD, cheA and csgA to inhibit biofilm formation of S. Enteritidis [0.03%]
副黏附基因座sRNA SaaS通过靶向hilD、cheA和csgA抑制肠炎沙门氏菌生物被膜形成
Chongyang Lyu,Haijing Hu,Linlin Cai et al.
Chongyang Lyu et al.
Introduction: Salmonella Enteritidis has brought great harm to public health, animal production and food safety worldwide. The biofilm formed by Salmonella Enteritidis plays a critical role in microbial cross-contaminatio...
Synergistic effects of laser powder bed fusion and annealing on the texture-selective recrystallization of magnetostrictive Fe-Ga-NbC alloys for biomedical applications [0.03%]
激光粉末床熔合和退火对铁磁致伸缩Fe-Ga-NbC合金生物医学应用择优再结晶的协同效应研究
Chengde Gao,Qi Zeng,Youwen Deng et al.
Chengde Gao et al.
Introduction: Magnetostrictive Fe-Ga alloys have garnered extensive attention owing to their excellent magnetic properties and acceptable biocompatibility. Nevertheless, the polycrystalline Fe-Ga alloys currently availabl...
Estrogen receptor β activation alleviates inflammatory bowel disease by suppressing NLRP3-dependent IL-1β production in macrophages via downregulation of intracellular calcium level [0.03%]
雌激素受体β通过下调细胞内钙离子水平抑制巨噬细胞中NLRP3依赖的白介素-1β生成从而缓解炎症性肠病
Yanrong Zhu,Yilei Guo,Pengxiang Guo et al.
Yanrong Zhu et al.
Introduction: Although several estrogen receptor β (ERβ) agonists have been reported to alleviate IBD, the pivotal mechanism remains obscure. Objectives...