Arabidopsis Nuclear Architecture related 1 facilitates the floral transition in a process involving molecular hydrogen [0.03%]
分子氢通过新的组蛋白甲基化 Readers CHROMOMETHYLASE 2和Nuclear Architecture Related 1促进拟南芥成花转变
Pengfei Cheng,Yueqiao Wang,Ke Jiang et al.
Pengfei Cheng et al.
Introduction: Although emerging evidence revealed that molecular hydrogen (H2) positively regulates numerous physiological responses, understanding the synthesis of H2 and its functions is a challenge for biology. ...
The commensal microbiome in respiratory tract tumors: From oncogenic mechanisms to clinical translation [0.03%]
呼吸道肿瘤中的共生微生物组：从致癌机制到临床转化
Jiale Yu,Ciliang Guo,Yan Liu et al.
Jiale Yu et al.
Background: The human commensal microbiome, commonly recognized as a "second genome", exerts a crucial regulatory role in host metabolism, immune homeostasis maintenance, and the progression of various diseases. Respirato...
Platelet factors 4 produces an antidepressant effect in mice via inhibition of neuroinflammation [0.03%]
血小板因子4通过抑制神经炎症在小鼠中产生抗抑郁作用
Yi-Heng Li,Jin-Qiong Zhan,Ying Zhao et al.
Yi-Heng Li et al.
Introduction: Platelet factor 4 (PF4) is secreted by platelets and can cross blood-brain barrier (BBB) to affect brain function, including regulations of neuroinflammation and synaptic plasticity, which are involved in th...
SFRP2 aggravates diabetic kidney disease by repressing the renal protective CH25H/25-hydroxycholesterol axis in mesangial cells [0.03%]
SFRP2通过抑制系膜细胞中的肾保护性CH25H/25-羟基胆固醇轴加重糖尿病肾脏疾病
Dan Lv,Ziyue Lin,Jiakun Yang et al.
Dan Lv et al.
Introduction: Diabetic kidney disease (DKD) is characterized by renal lipid accumulation, but the molecular mechanisms underlying this lipotoxic phenotype remain unclear. Secreted frizzled-related protein 2 (SFRP2) has be...
Peroxisome-derived and liver-specific hydroxyacid oxidase 1-mediated hydrogen peroxide promotes ferroptosis by augmenting peroxisomal ROS [0.03%]
过氧化物酶体衍生的和肝脏特异性的羟基酸氧化酶1介导的过氧化氢通过增加过氧化物酶体ROS促进铁死亡
Xintong Peng,Yanling Zhou,Jielin Chen et al.
Xintong Peng et al.
Introduction: While peroxisome-associated molecules have been implicated in ferroptosis, the mechanistic relationship between peroxisomes and ferroptosis remains poorly understood. Key unresolved questions include whether...
Mechanistic insights into hexavalent chromium-induced ferroptosis in mRTECs: a novel MTF1-IREB2-FTH1/DMT1 axis-mediated iron homeostasis dysregulation [0.03%]
六价铬通过新的金属调节转录因子1-铁反应元件结合蛋白2-富含半胱氨酸的衔接蛋白1/ div金属转运体1轴介导的铁死亡的机制：mRTECs中铁稳态失调的新机制见解
Changxi Qi,Muzi Li,Yue Yu et al.
Changxi Qi et al.
Introduction: Hexavalent Chromium [Cr(VI)], a Group 1 carcinogen designated by the International Agency for Research on Cancer (IARC), is a pervasive environmental pollutant. The kidneys are particularly vulnerable to Cr(...
Oligofructose alleviates hyperandrogenism in polycystic ovary syndrome through gut microbiota-derived bile acids [0.03%]
寡果糖通过肠道菌群衍生的胆汁酸缓解多囊卵巢综合征患者的高雄素血症
Yuhui Wang,Xitong Liu,Zhi Li et al.
Yuhui Wang et al.
Introduction: Polycystic ovary syndrome (PCOS) is a common endocrine disorder in reproductive-age women, characterized by hyperandrogenism and metabolic dysfunction. Dietary interventions are recommended as one of the fir...
Sirtuin 7-mediated deacetylation of hypoxia-inducible factor 1-alpha facilitates glycolytic reprogramming and inflammation of keratinocytes in psoriasis [0.03%]
组蛋白去乙酰化酶Sirtuin 7介导的表皮角质形成细胞HIF-1α去乙酰化在银屑病病理发生中的作用及机制研究
Yixin Luo,Xiaolei Su,Chen Zhang et al.
Yixin Luo et al.
Introduction: Psoriasis is a chronic inflammatory disease characterized by epidermal hyperplasia and dermal T cell infiltration. Epidermal keratinocytes function not only as the primary targets of the inflammatory respons...
Portulaca oleracea L. polysaccharide alleviates colitis-associated bone loss through Muribaculaceae-enriched gut microbiota and elevated colonic melatonin [0.03%]
Portulaca oleracea L.多糖通过富含Muribaculaceae的肠道菌群和升高的结肠褪黑素缓解炎性肠病相关骨丢失
Kun Li,Ruiqing Zhu,Yabo Chen et al.
Kun Li et al.
Aims: Colitis and its associated bone loss are major global health concerns with limited therapeutic options. Portulaca oleracea L. polysaccharide (POP) has been suggested to ameliorate both conditions via microbiota modu...
Sleep deprivation accelerates Parkinson's disease pathology by upregulating LAG3 in astrocytes and disrupting glymphatic system function [0.03%]
睡眠剥夺通过上调星形胶质细胞LAG3并破坏glymphatic系统功能而加速帕金森病病理变化
Yan-Rui Sun,Qian-Kun Lv,Xin-Yu Xue et al.
Yan-Rui Sun et al.
Introduction: Parkinson's disease (PD) progression is strongly associated with sleep disturbances, but the molecular mechanisms linking sleep loss to PD pathology remain poorly understood. Emerging evidence implicates imp...