Mitochondrial DNA methylation: State-of-the-art in molecular mechanisms and disease implications [0.03%]
线粒体DNA甲基化：分子机制和疾病影响的最新研究进展
Meng-Ting Yin,Liang Guo
Meng-Ting Yin
Background: Mitochondrial DNA (mtDNA), a circular genome essential for cellular energy production, is increasingly recognized to exhibit aberrant methylation under pathological conditions. Dysregulated methylation in regu...
Genome-wide characterization and adaptive evolution of favorable gibberellin 2-oxidase alleles contributing to wheat agronomic traits [0.03%]
有助于小麦农艺性状的有利赤霉素2氧化酶等位基因的全基因组特征及适应性进化
Yingjie Bian,Jiayu Dong,Lingli Li et al.
Yingjie Bian et al.
Introduction: Gibberellins are essential phytohormones that regulate plant growth and development. Gibberellin 2-oxidases (GA2oxs) deactivate bioactive gibberellin isoforms and many GA2ox genes have been validated as key ...
Plasma ceramide mediates the association of peripheral T cells with Alzheimer's disease [0.03%]
血浆丝氨酸介导外周T细胞与阿尔茨海默病的关系
Yunhong Sun,Lili Xia,Xiaofan Xu et al.
Yunhong Sun et al.
Introduction: Neuroinflammation involving peripheral immune cells, particularly T lymphocytes, has been implicated in Alzheimer's disease (AD) progression. Metabolic dysregulation in sphingolipid pathways may influence ne...
Exercise improves hypobaric hypoxia-induced skeletal muscle dysfunction via Sirt1-Mediated myotube and mitochondrial remodeling [0.03%]
运动通过Sirt1介导的肌管和线粒体重塑改善低氧诱导的骨骼肌功能障碍
Caiyun Wang,Wu-Gui Chen,Honghong Chen et al.
Caiyun Wang et al.
Introduction: Skeletal muscle function is profoundly challenged under high-altitude environments, where hypobaric hypoxia disrupts structural integrity and impairs physiological function. However, few animal studies have ...
Multiple organs exhibit exacerbated cachexia in male mice with colon cancer than females [0.03%]
与雌性小鼠相比，结肠癌雄性小鼠的多个器官出现恶病质恶化现象
Mara Barone,Martina Lunardi,Andrea David Re Cecconi et al.
Mara Barone et al.
Introduction: Cachexia is a lethal syndrome with massive muscle wasting that occurs in 60% of colon cancer patients. Several studies in humans and mice show that males are more prone than females to muscle atrophy caused ...
Nuciferine inhibits pressure overload-induced cardiac remodeling by activating the SENP1-ACSL4-ferroptosis axis [0.03%]
荷叶碱通过激活SENP1-ACSL4-铁死亡轴抑制压力超负荷诱导的心脏重构
Yu-Ting Liu,Ya-Jia Ding,Yan Che et al.
Yu-Ting Liu et al.
Introduction: Pressure overload-induced cardiac remodeling and heart failure have received considerable attention owing to their high morbidity and death rates. Nuciferine (NF), an aporphine alkaloid extracted from lotus ...
Cuproptosis in atrazine-induced hepatotoxicity: ATOX1 as a therapeutic target for lycopene-mediated protection [0.03%]
阿特拉津诱导的肝毒性中的杯状凋亡：ATOX1作为番茄红素介导保护的治疗靶点
Nuo-Wa Li,Xin Yao,Wei-Hong Lu et al.
Nuo-Wa Li et al.
Introduction: Atrazine (ATR) is a widely used herbicide in agriculture, and its residues pose a threat to biological organs, with particularly severe damage to the liver. Lycopene (LYC) is a natural pigment that exhibits ...
METTL3 mediates m6A methylation of ADAM17 to Downregulate ACE2-Ang-(1-7) axis and promote progression of hypertension [0.03%]
METTL3介导ADAM17的m６A甲基化以下调ACE２-Ang-(1-7)轴并促进高血压进展
Xuejie Fei,Caiyu Li,Jie Bai et al.
Xuejie Fei et al.
Introduction: Features of hypertension include imbalance between vascular relaxation and constriction along with vascular remodeling caused by endothelial dysfunction, further increasing peripheral resistance and blood pr...
SIRPα extracellular domain shed from neutrophils by ADAM10 aggravates sepsis via initiating nitric oxide release from erythrocyte [0.03%]
中性粒细胞来源的SIRPα通过ADAM10剪切促进脓毒症发展中的作用及机制研究
Hongwei Liang,Geng Lu,Zhen Bian et al.
Hongwei Liang et al.
Introduction: Sepsis is a life-threatening condition with a high mortality rate, yet its underlying mechanisms remain incompletely understood. Objectives:...
Zhibo Wang,Yuye Ning,Peiyang Gao et al.
Zhibo Wang et al.
Introduction: Type 2 diabetes (T2D) significantly increases dementia risk, yet the molecular mechanisms underlying this association remain unclear. Object...