The landscape of genitourinary cancer vaccines: clinical advances and future opportunities [0.03%]
泌尿生殖系肿瘤疫苗的研发进展与未来机遇
Ruoxuan Zheng,Yuxin Cai,Weihong Ding et al.
Ruoxuan Zheng et al.
Background: Cancer vaccines have demonstrated potential as a key immunotherapy strategy based on stimulating immune responses targeting tumor-specific antigens and tumor-associated antigens. Therapeutic cancer vaccines ha...
Deciphering the genetic basis of nodule number through integrative analysis of host genotype and endophytes [0.03%]
整合分析宿主基因型和内生菌解析结瘤数的遗传基础
Ruier Zeng,Peiqi Huang,Yunyi Guo et al.
Ruier Zeng et al.
Introduction: Peanut nodule number is determined by the host genotype and endophytes. However, the genetic mechanisms regulating nodule number and the abundance of endophytes significantly associated with nodule number re...
Vessels encapsulating tumor clusters is associated with impaired efficacy of adjuvant immunotherapy in resected hepatocellular carcinoma [0.03%]
血管包裹肿瘤结节与肝细胞癌切除术后辅助免疫治疗疗效不佳相关性研究
Bin Guo,Guangzhen Cai,Jinghan Zhu et al.
Bin Guo et al.
Introduction: Aggressive pathologic features are closely associated with early recurrence of hepatocellular carcinoma (HCC), and the association between vessels encapsulating tumor clusters (VETC) and poor prognosis has r...
Generation of antifungals to combat drug resistance using language models and diffusion models [0.03%]
使用语言模型和扩散模型生成抗真菌药物以对抗耐药性
Yeji Wang,Yuemei Dong,Yi Zheng et al.
Yeji Wang et al.
Introduction: The growing scarcity of effective antifungal agents, coupled with rising drug‑resistance, creates an urgent demand for novel therapeutics. Recent advances in artificial intelligence (AI) have opened new ave...
Exploring the role of β2-microglobulin in the relationship between physical activity and DNAm-predicted PhenoAge: Evidence from a population-based and mice single-cell RNA-sequencing study [0.03%]
β2微球蛋白在身体活动与DNAm预测的PhenoAge之间的关系中的作用探讨：基于人群和小鼠单细胞RNA测序研究的证据
Yanwei You,Jinwei Li,Yang Zhang et al.
Yanwei You et al.
Introduction: Physical activity (PA) is recognized as a cornerstone of healthy aging, yet the molecular mechanisms linking PA to biological aging remain poorly understood. β2-microglobulin (β2M), an inflammatory and agi...
Tripterygium wilfordii multi-glycoside alleviates ankylosing spondylitis via gut microbiota modulation and metabolite reprogramming [0.03%]
雷公藤多苷通过调控肠道菌群及重塑宿主代谢治疗强直性脊柱炎
Jiaqi Bi,Yanan Yang,Mingxi Li et al.
Jiaqi Bi et al.
Introduction: Ankylosing spondylitis (AS) is a chronic autoimmune inflammatory disorder characterized by severe inflammation in the axial skeleton. Tripterygium wilfordii multi-glycoside (GTW) is widely used in clinical p...
Identification and evaluation of a lipid-lowering small compound as a PCSK9 inhibitor [0.03%]
一种降脂小分子化合物的鉴定及评价及其作为PCSK9抑制剂的作用评估研究
Run Xu,Xutong Wang,Jin Gao et al.
Run Xu et al.
Introduction: Hyperlipidemia is a key contributor to cardiovascular diseases, underscoring the necessity for alternative lipid-lowering treatments beyond statins. ...
ANXA1 improves mitochondrial homeostasis through uncoupling protein 1 in diabetic nephropathy [0.03%]
Annexin A1通过解偶联蛋白1改善糖尿病肾病中的线粒体稳态
Zi-Han Li,Lu Fang,Liang Wu et al.
Zi-Han Li et al.
Introduction: Diabetic nephropathy (DN) is a major public health concern. Our previous study found that annexin A1 (ANXA1) alleviated DN by improving mitochondrial homeostasis. However, the underlying mechanism is not ful...
From theory to practice: DFT-guided Raman spectral analysis and machine learning for high-accuracy pesticide identification [0.03%]
从理论到实践：基于DFT指导的拉曼光谱分析及机器学习的高准确率农药识别方法研究
Yingcheng Xing,Yuan Gao,De Zhang et al.
Yingcheng Xing et al.
Pesticide residues pose threats to the environment and food safety, and accurate and efficient detection technologies are key to addressing the challenges of pesticide residues. Theoretical calculations of Raman spectroscopy can guide molec...
Dietary patterns and testosterone balance: a review of clinical data and perspectives [0.03%]
饮食模式与睾丸激素平衡：临床数据及展望综述
Xinyi Liu,Xusheng Li,Dongbao Cai et al.
Xinyi Liu et al.
Background: Testosterone is a crucial sex hormone that plays an important role in physiology. In recent decades, dietary compounds have demonstrated the ability to modulate testosterone levels in the body. Moreover, clini...