Ganoderma lucidum spore powder enhances IFN-α-mediated antiviral capacity of COVID-19 vaccine boosters revealed by single-cell multi-omics sequencing [0.03%]
灵芝孢子粉通过单细胞多组学测序揭示可增强新冠肺炎疫苗加强针的干扰素抗病毒能力
Anyao Li,Xiaoyan Lu,Rongfang Guo et al.
Anyao Li et al.
Introduction: Reduced vaccine efficacy may hinder stable herd immunity. Traditional herbal ingredients, such as Ganoderma lucidum products, have shown potential as safe and effective adjuvants to improve vaccine efficacy....
Postmortem energy metabolism and meat quality development: Advances in basic pathways, endogenous regulatory factors, and exogenous management strategies [0.03%]
肉品可食组织死亡后能量代谢及肉品质形成研究进展：基本生化途径、内源调控因子及外源管理策略的研究进展
Chao Ma,Wangang Zhang,Jian Zhang et al.
Chao Ma et al.
Background: A complex series of biochemical processes is involved during the transformation of muscle into meat, among which postmortem energy metabolism that contributes to adenosine triphosphate regeneration remains par...
Breaking the bottleneck of asthma treatment: the future of omni-targeted therapy [0.03%]
突破哮喘治疗瓶颈：全方位靶向治疗的未来方向
Kuan Li,Huimin Xie,Dongshuai Shen et al.
Kuan Li et al.
Background: Bronchial asthma is a complex, highly heterogeneous disease involving multiple pathological mechanisms and inflammatory pathways. Traditional pharmacotherapies, including glucocorticoids, leukotriene modifiers...
A ventral hippocampus-basolateral amygdala circuit regulates the unconditioned stimulus retrieval-induced reconsolidation of remote fear memory [0.03%]
腹侧海马-基底外侧杏仁核环路调节远程恐惧记忆的未条件刺激提取诱导再巩固作用
Dan Guo,Zhong Wang,Fanglin Liu et al.
Dan Guo et al.
Introduction: Memory is retrieved and updated during reconsolidation, which provides a potential target for therapeutic intervention. Reconsolidation blockade following unconditioned stimulus (US) retrieval has shown incr...
Beyond chromosomes: exploring the diverse functions of extrachromosomal circular DNA [0.03%]
染色体之外：探究染色体外环状DNA的多种功能
Yaling Chen,Jian Wang,Xudong Liu et al.
Yaling Chen et al.
Extrachromosomal circular DNA (eccDNA) is defined as a form of circular DNA that is widespread across various biological contexts and exists independently of chromosomal structures. The current distribution of total eccDNA identified in bot...
MK8722 alleviates osteoarthritis by activating Sesn2 and transcriptionally upregulating BNIP3 to promote mitophagy and inhibit chondrocyte ferroptosis [0.03%]
MK8722通过激活Sesn2并转录上调BNIP3促进线粒体自噬和抑制软骨细胞铁死亡从而缓解骨关节炎
Haochen Wang,Ze Zhao,Jianbang Su et al.
Haochen Wang et al.
Introduction: Osteoarthritis (OA) is commonly accompanied by irreversible destruction of articular cartilage and is difficult to effectively relieve, primarily due to the unclear pathogenesis and the lack of effective the...
Bacteroides vulgatus alleviates heart failure via butyric acid-TGF-β1/MAPK pathway [0.03%]
脆弱拟杆菌通过丁酸盐-TGF-β1/MAPK信号通路缓解心力衰竭
Zhiyong Du,Wenxin Zhang,Yu Wang et al.
Zhiyong Du et al.
Introduction: The gut microbiota plays a vital role in the progression of heart failure (HF), making it a potential strategy for treating HF. The Bacteroides genus has shown promising potential for treating HF. However, f...
Rural-urban disparities in cardiovascular and other competing risk of death among cancer patients [0.03%]
癌症患者中心血管疾病及其他总死亡竞争风险的城乡差异
Tianwang Guan,Jiaqi He,Liangjia Zeng et al.
Tianwang Guan et al.
Introduction: Rural-urban disparity of cancer is a major public health problem, with an unclear gap in noncancer death. It is important to evaluate rural-urban disparities in cardiovascular diseases (CVDs) and other compe...
Mitigation of renal tubular injury by SIRT6 may improve individual outcomes in diabetic kidney disease-potential mechanisms involving epigenetic repression of inflammatory responses [0.03%]
SIRT6通过表观遗传抑制炎症反应可能改善糖尿病肾病的肾小管损伤及患者预后-潜在机制研究
Qi Jin,Lanfang Li,Peng Qu et al.
Qi Jin et al.
Introduction: Progressive tubulointerstitial injury plays a critical role in the progression of diabetic kidney disease (DKD), but the epigenetic mechanisms driving this process remain largely unclear. ...
Navel orange postharvest resistance towards Penicillium digitatum - role of histone demethylase CsJMJ12 [0.03%]
CsJMJ12 去甲基酶在调控柠檬组蛋白修饰及提高柠檬对绿霉病抗性中的作用机制研究
Jing Zeng,Ting Li,Mengting Liu et al.
Jing Zeng et al.
Introduction: Histone methylation is essential for plant growth and development, and adaptation to biotic and abiotic stresses. However, its role in postharvest disease resistance in fruits remains poorly understood. The ...