Novel dual-targeting biofilm inhibitors for potentiating antibiotic efficacy against multidrug-resistant Pseudomonas aeruginosa infections [0.03%]
用于增强抗生素对多重耐药铜绿假单胞菌感染疗效的新型双重作用生物被膜抑制剂
Weijin Chen,Hanxiao Shang,Wenlong Zhang et al.
Weijin Chen et al.
Introduction: With the increasing global challenge posed by multidrug-resistant Pseudomonas aeruginosa, which utilizes biofilm formation and virulence mechanisms to exacerbate infections, there is an urgent need for novel...
Organic fertilizer regulates multispecies biofilm formation and structure to enhance Cd removal efficiency [0.03%]
有机肥通过调控多菌株生物被膜的形成及结构提高其Cd富集效率
Yu Jiang,Yujia Li,Sheng Zhao et al.
Yu Jiang et al.
Introduction: Cadmium (Cd) contamination of soil poses a risk to both environmental and agricultural safety. Although microbial biofilms have the potential to immobilize heavy metals, there is a lack of strategies to enha...
Adipose Serpina3c is induced by exercise to alleviate diabetic nephropathy in mice [0.03%]
运动通过诱导白色脂肪组织中Serpina3c的表达来缓解小鼠糖尿病肾病
Ruo-Ying Li,Jie-Ying Zhu,Lin-Jing Yan et al.
Ruo-Ying Li et al.
Exercise is an effective approach to slow down the progression of diabetic nephropathy (DN), but the underlying mediators remain incompletely understood. Here we demonstrate that exercise induces the expression of the adipokine Serpina3c in...
Single-cell multi-omics analysis reveals two molecular subtypes of human male breast cancer with distinct neuroendocrine and immune characteristics [0.03%]
单细胞多组学分析揭示了具有不同神经内分泌和免疫特征的人类男性乳腺癌的两个分子亚型
Handong Sun,Ruilin Wang,Zhonglin Wang et al.
Handong Sun et al.
Introduction: Male breast cancer (MBC) is a rare and malignant disease with limited molecular understanding. There is still no specific therapeutic strategy for patients with MBC in the clinic, the current treatment optio...
Andrographolide attenuates pulmonary fibrosis by covalently targeting Ptges3 and disrupting the Ptges3-Hsp90-NF-κB axis [0.03%]
andrographolide通过共价靶向Ptges3并破坏Ptges3-Hsp90-NF-κB轴来缓解肺纤维化
Qianyu Zhang,Ying Zhang,Chen Wang et al.
Qianyu Zhang et al.
Introduction: Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease characterized by chronic inflammation and fibroblast activation, with limited treatment options. The bioactive diterpenoid androgra...
Primary cilia protect against intervertebral disc degeneration and spine scoliosis by regulating Hedgehog-P53-mediated cell apoptosis signaling [0.03%]
原纤毛通过调节Hedgehog-P53介导的细胞凋亡信号保护椎间盘免于退变及脊柱侧弯
Xinhua Li,Kai Guo,Yang Yang et al.
Xinhua Li et al.
Introduction: Spinal disorders such as intervertebral disc degeneration (IVDD) and scoliosis cause significant disability and socioeconomic burden. Current treatments are palliative, which reflects a limited understanding...
Insig1 deficiency protects against acute kidney injury via targeting Dapk3 [0.03%]
INSIG1通过靶向DAPK3抵抗急性肾损伤
Shihan Cao,Qian Wang,Mengyu Zhou et al.
Shihan Cao et al.
Introduction: Acute kidney injury (AKI) is characterized by a rapid decline in renal function, often associated with tubular cell death. Insulin-induced gene 1 (Insig1), a key regulator of cholesterol metabolism, has not ...
Monoterpenoid-ciprofloxacin hybrids as a strategy to disrupt Staphylococcus aureus biofilms and overcome associated resistance [0.03%]
单萜类-环丙沙星杂合物作为破坏金黄色葡萄球菌生物被膜并克服相关耐药性的策略
Miguel M Leitão,Fernando Cagide,Ariana S C Gonçalves et al.
Miguel M Leitão et al.
Introduction: Staphylococcus aureus is an important opportunistic pathogen whose ability to form biofilms and acquire multidrug resistance limits the effectiveness of conventional antibiotics. Although some antibiotic com...
IFITM3 knockout alleviates neuronal parthanatos by restoring astrocytic glutamate uptake in intracerebral hemorrhage mice [0.03%]
Ifitml3敲除通过恢复星形胶质细胞谷氨酸摄取缓解脑内血肿小鼠神经元parthanatos现象
Miaoxian Yang,Qian Xie,Xiya Long et al.
Miaoxian Yang et al.
Introduction: Intracerebral hemorrhage (ICH) causes severe neurological deficits mainly attributable to secondary brain injury. Parthanatos is a subtype of regulated cell death triggered by glutamate excitotoxicity. Inter...
Nematode gut microbiota confers cadmium tolerance through microbial-dependent activation of detoxification and innate immune pathways [0.03%]
肠道微生物通过依赖微生物的解毒和先天免疫通路的活化赋予线虫镉耐受性
Fei Zheng,Jingwei Gao,Xun Han et al.
Fei Zheng et al.
Introduction: Soil heavy metal pollution, especially cadmium (Cd) contamination, represents a serious threat to ecosystem health and agricultural sustainability. Understanding how soil organisms and their associated micro...