Deciphering molecular pathways in urological cancers: a gateway to precision therapeutics [0.03%]
解码泌尿系统癌症分子通路：精准治疗的突破口
Kiavash Hushmandi,Najma Farahani,Behzad Einollahi et al.
Kiavash Hushmandi et al.
Background: Urological cancers, including prostate, kidney, bladder, testicular, and penile cancers, pose a significant health challenge, particularly in their metastatic stages. Surgical interventions remain fundamental,...
Cholesterol metabolism-related characteristics predict response and survival in esophageal cancer [0.03%]
胆固醇代谢相关特征预测食管癌的疗效和生存率
Lingyu Tan,Xiaodong Su,Yuanzhen Ma et al.
Lingyu Tan et al.
Introduction: Cholesterol homeostasis has been identified as an essential downstream pathway of mutations in TP53. Esophageal cancer is one of the most prevalent malignancies exhibiting the mutation. ...
Cytoskeletal-related genes function as checkpoints for the maintenance of VSMC contractile phenotype and prevent pathological remodeling in arterial diseases [0.03%]
细胞骨架相关基因可作为血管平滑肌细胞收缩表型维持的检查点并在动脉疾病病理重塑中发挥作用
Yunchang Liu 刘运畅,Liping Zeng 曾利平,Qi Cai 蔡琦 et al.
Yunchang Liu 刘运畅 et al.
Introduction: Arterial pathological remodeling, central to arterial diseases including atherosclerosis and aortic aneurysms, is characterized by vascular smooth muscle cell (VSMC) phenotypic switching with concomitant los...
Integrative multi-omics profiling deciphers tumor microenvironment heterogeneity and immunotherapy vulnerabilities in lung neuroendocrine carcinomas [0.03%]
整合多组学谱分析解码肺神经内分泌癌的肿瘤微环境异质性和免疫治疗弱点
Zicheng Zhang,Modi Zhai,Siqi Bao et al.
Zicheng Zhang et al.
Introduction: Lung neuroendocrine carcinomas (Lu-NECs) are rare, highly aggressive lung tumors with poor prognosis and limited therapeutic options. Understanding the tumor immune microenvironment (TIME) is crucial towards...
SAE1 emerges as a pan-cancer driver and key regulator of HCC metastasis [0.03%]
SAE1作为泛癌症驱动基因和肝细胞癌转移的关键调节因子浮现出来
Hao Zhuang,Yamei Dang,Li Sun et al.
Hao Zhuang et al.
Introduction: Dysregulation of SUMOylation is implicated in cancer progression. While the role of SUMO-activating enzyme (SAE) and its mechanisms in cancer remain unclear. ...
A novel peptide MIB1-223aa encoded by exosomal circMIB1 from cancer-associated fibroblasts drives triple-negative breast cancer metastasis and stemness via stabilizing MIB1 to activate Notch signaling [0.03%]
癌相关成纤维细胞来源的环状circMIB1衍生的小分子多肽MIB1-223aa通过稳定MIB1蛋白激活Notch信号驱动三阴性乳腺癌干细胞特性及转移的功能研究
Fangzhou Ye,Yiran Liang,Jianing Wang et al.
Fangzhou Ye et al.
Introduction: Emerging evidence has indicated that the complex interactions between tumor microenvironment (TME) and cancer cells play a pivotal role in driving tumor initiation and metastasis. Cancer associated fibroblas...
Advancements in bone organoids: perspectives on construction methodologies and application strategies [0.03%]
骨类器官的研究进展：构建方法及应用策略展望
Shuo Huang,Yufei Wu,Hui Zhao et al.
Shuo Huang et al.
Background: In clinical practice and research, bone defects due to tumor growth, trauma, and different pathological conditions are significant challenges. Although bone possesses an intrinsic capacity for regeneration, ex...
Burden of bacterial antimicrobial resistance in China: a systematic analysis from 1990 to 2021 and projections to 2050 [0.03%]
1990至2021年中国细菌耐药负担的系统分析及2050年预测
Jian Xu,Jingyu Liu,Xiaowei Li et al.
Jian Xu et al.
Introduction: Antimicrobial resistance (AMR) has emerged as a critical health challenge; however, there is a paucity of in-depth reports outlining its burden and trends in China. ...
Multi-algorithm consensus classification identifies three distinct acute liver failure subtypes with differential treatment responses: a multi-database cohort study [0.03%]
基于多算法共识分类的急性肝衰竭亚型及其不同的治疗反应：一项多数据库队列研究
Ying Yang,Wei Yang,Bo Tang et al.
Ying Yang et al.
Background: Acute liver failure (ALF) is a heterogeneous syndrome with high mortality. Current prognostic models fail to capture pathophysiological heterogeneity, necessitating refined patient stratification and personali...
Heterojunction configuration-specific photocatalytic degradation of methyl orange and methylene blue dyes using ZnO-based nanocomposites [0.03%]
基于ZnO的纳米复合材料在异质结构配置下对甲基橙和亚甲基蓝染料的光催化降解作用研究
Mengjiao Wu,Chengpu Lv,Yuling Xiong et al.
Mengjiao Wu et al.
Introduction: Heterostructured photocatalysts have shown an enormous potential in photocatalytic degradation of organic pollutants in wastewater. However, the efficacy of such heterojunction on the photocatalytic degradat...