Activated hepatic stellate cell-derived exosomal miR-23a-3p promotes hepatocellular carcinogenesis by regulating DUSP5/ERK signaling [0.03%]
活化的肝星状细胞来源的外泌体miR-23a-3p通过调节DUSP5/ERK信号促进肝细胞癌发生
Xiaona Lu,Jia Shi,Wenlan Zheng et al.
Xiaona Lu et al.
Introduction: Activation of hepatic stellate cells (HSCs) is a core driver of liver fibrosis and may contribute to the evolution to hepatocellular carcinoma (HCC). Exosomes mediate intercellular signaling by transporting ...
scPlantAnnotate: an accurate and robust transformer-based model for plant cell type annotation [0.03%]
scPlantAnnotate：一种精确而稳健的基于变压器的植物细胞类型注释模型
Chunyang Lu,Manish Sridhar Immadi,Yen On Chan et al.
Chunyang Lu et al.
Introduction: Accurate cell type annotation remains a major bottleneck in plant single-cell RNA sequencing (scRNA-seq), where existing tools are often adapted from animal studies and perform sub-optimally on plant data. T...
TNFSF10 drives hyperactive immune responses via NLRP3 inflammasome and endoplasmic reticulum stress in autoimmune and inflammatory diseases [0.03%]
TNFSF10通过NLRP3炎症小体和内质网应激驱动自身免疫和炎症性疾病中的过度免疫反应
Huilin Zhang,Yaoyao Chen,Yingmei Li et al.
Huilin Zhang et al.
Introduction: Autoimmune and inflammatory diseases are characterized by multifaceted pathogenesis, demanding effective therapeutic strategies. Objectives:...
Apple phenolic compounds enhance dental remineralization in human: a multifactorial in situ study [0.03%]
苹果酚类化合物可促进人体牙齿再矿化：一项多因素的体内研究
Niklas Roeder,Antje Geiken,Vivian Schaarschmidt et al.
Niklas Roeder et al.
Introduction: Excessive consumption of sugar-sweetened beverages is a major contributor to dental caries and a global public health concern due to its negative effects on oral health. Phenolic compounds found in edible pl...
Modeling and analyzing glucose-insulin interactions during diabetes through fractional dynamics in presence of glucagon [0.03%]
基于胰高血糖素分数动力学的糖尿病过程中葡萄糖-胰岛素相互作用的建模与分析
Parvaiz Ahmad Naik,Bijal M Yeolekar,Kolade M Owolabi et al.
Parvaiz Ahmad Naik et al.
Introduction and objective: Diabetes is a chronic metabolic disorder characterized by higher blood glucose levels due to insufficient insulin production, weakened insulin action, or both. This study aims to construct and ...
Study on the formation mechanism of the key fresh aroma component (Z)-3-hexen-1-ol during the spreading process of lu'an Guapian green tea [0.03%]
六安瓜片绿茶摊放过程中关键鲜爽香气组分(Z)-3-己烯-1-醇的形成机制研究
Yuchuan Li,Hong Zhang,Mingle Wang et al.
Yuchuan Li et al.
Introduction: The regulation of aroma quality during the postharvest processing of fresh tea leaves is a critical yet underexplored area. Green tea spreading, a key step that induces dehydration stress, significantly infl...
Phocaeicola vulgatus promote growth rate via tryptophan metabolism pathway mediated gut sIgA production in Taihe Silky fowl [0.03%]
Taihe丝羽乌骨鸡生长速度受肠道sIgA介导的色氨酸代谢途径调控及相关微生物研究
Wentao Li,Haoneng Guo,Qi Wang et al.
Wentao Li et al.
Introduction: Taihe Silky Fowl (TSF) has a long growth cycle and slow growth rate, how to effectively improve the growth rate of TSF has become the primary concern for breeders. Currently, extensive research has establish...
Synthesis and bioactivity evaluation of isoxazoline scaffolds using heterogeneous photocatalytic (3 + 2) cycloaddition [0.03%]
基于手性固体酸光催化剂的异噁唑啉类化合物合成及生物活性研究
Shaochen Li,Bingrui Liu,Xinran Chen et al.
Shaochen Li et al.
Introduction: The (3 + 2) cycloaddition is a classic method for synthesizing bioactive isoxazoline and isoxazole heterocycles. However, its utility is hampered by a reliance on stoichiometric halogenating oxidants, bases,...
Multi-organ metabolic dysregulation and cecal microbiota alterations following black carbon exposure [0.03%]
暴露于黑碳后的多器官代谢失调及结肠微生物群改变
Shengtao Wei,Wenxue Li,Shanshan Ran et al.
Shengtao Wei et al.
Background: Black carbon (BC) has been linked to adverse health outcomes, yet underlying mechanisms remain unclear. Integrating metabolomic and metagenomic data across tissues may clarify BC-induced biological pathways. ...
Bio-inspired supramolecular hydrogel inhibits ferroptosis to accelerate diabetic wound healing [0.03%]
仿生超分子水凝胶抑制糖尿病伤口铁死亡以加速创面修复
Haiting Zou,Jingyi Chen,Yumeng Huang et al.
Haiting Zou et al.
Introduction: Ferroptosis significantly compromises diabetic wound healing and represents a promising therapeutic target for clinical intervention. Baicalein (Bai), a natural flavonoid, has been considered to own ferropto...