RNA modification gene WDR4 facilitates tumor progression and immunotherapy resistance in breast cancer [0.03%]
乳腺癌中RNA修饰基因WDR4促进肿瘤进展和免疫治疗抵抗
Yongzhou Luo,Wenwen Tian,Da Kang et al.
Yongzhou Luo et al.
Introduction: Growing interest toward RNA modification in cancer has inspired the exploration of gene sets related to multiple RNA modifications. However, a comprehensive elucidation of the clinical value of various RNA m...
The mechanism by which oriented polypropylene packaging alleviates postharvest 'Black Spot' in radish root (Raphanus sativus) [0.03%]
定向聚丙烯包装袋对减轻萝卜肉质根贮藏后黑斑病的影响机制
Zixin Lin,Bihong Feng,Shibei Fang et al.
Zixin Lin et al.
Introduction: The postharvest physiological disorder known as 'black spot' in radish roots (Raphanus sativus) poses a significant challenge to quality maintenance during storage, particularly under summer conditions. The ...
WTAP/YTHDF1-mediated m6A modification amplifies IFN-γ-induced immunosuppressive properties of human MSCs [0.03%]
WTAP/YTHDF1介导的mRNA m6A修饰增强人脐带间充质干细胞免疫抑制功能
Quan Chen,Luoquan Ao,Qing Zhao et al.
Quan Chen et al.
Introduction: The immunosuppressive capacity of mesenchymal stem cells (MSCs) is dependent on the "license" of several pro-inflammatory factors to express immunosuppressive molecular profiles, which determines the therape...
Developing a multi-modular assembled prime editing (mPE) system improved precise multi-base insertion efficiency in dicots [0.03%]
一种用于双子叶植物多碱基精准插入的多模块组装式prime编辑系统(mPE)的研究与发展
Pengjun Lu,Erwei Zuo,Jianbin Yan
Pengjun Lu
Introduction: The Prime Editing (PE) system is a precise and versatile genome editing tool with great potential in plant breeding and plant synthetic biology. However, low PE efficiency severely restricts its application,...
Transcriptomic profiling of gastrointestinal tracts in dairy cattle during lactation reveals molecular adaptations for milk synthesis [0.03%]
泌乳期间对奶牛胃肠 tract的转录组分析揭示了牛奶合成的分子适应性
Yahui Gao,George E Liu,Li Ma et al.
Yahui Gao et al.
During lactation, dairy cattle's digestive tract requires significant adaptations to meet the increased nutrient demands for milk production. As we attempt to improve milk-related traits through selective pressure, it is crucial to understa...
WWP2 deletion aggravates acute kidney injury by targeting CDC20/autophagy axis [0.03%]
WWP2缺失通过靶向CDC20/自噬轴加重急性肾损伤
Ran You,Yanwei Li,Yuteng Jiang et al.
Ran You et al.
Introduction: Acute kidney injury (AKI) is associated with high morbidity and mortality rates. The molecular mechanisms underlying AKI are currently being extensively investigated. WWP2 is an E3 ligase that regulates cell...
Challenges and advances in the management of inflammation in atherosclerosis [0.03%]
动脉粥样硬化炎症管理面临的挑战与进展
Yiming Xing,Xianhe Lin
Yiming Xing
Introduction: Atherosclerosis, traditionally considered a lipid-related disease, is now understood as a chronic inflammatory condition with significant global health implications. ...
Targeting the STAT3/IL-36G signaling pathway can be a promising approach to treat rosacea [0.03%]
靶向STAT3/IL-36G信号通路有望成为治疗玫瑰痤疮的新方法
Xin Meng,Yun Zhong,Xuyuan Kuang et al.
Xin Meng et al.
Background: Rosacea is an inflammatory skin disorder characterized by the release of inflammatory mediators from keratinocytes, which are thought to play a crucial role in its pathogenesis. Despite an incidence of approxi...
Zipan Lyu,Yau-Tuen Chan,Yuanjun Lu et al.
Zipan Lyu et al.
Introduction: Adipogenesis, the process of white adipose tissue expansion, plays a critical role in the development of obesity. Osteoprotegerin (OPG), known for its role in bone metabolism regulation, emerges as a potenti...
Kynurenine acts as a signaling molecule to attenuate pulmonary fibrosis by enhancing the AHR-PTEN axis [0.03%]
犬尿酸通过增强AHR-PTEN轴作为信号分子来缓解肺纤维化
Yi Wang,Guo-Rao Wu,Huihui Yue et al.
Yi Wang et al.
Introduction: Pulmonary fibrosis (PF) is a fatal fibrotic lung disease without any options to halt disease progression. Feasible evidence suggests that aberrant metabolism of amino acids may play a role in the pathoetiolo...