Hypoxia-induced degradation of FTO promotes apoptosis by unmasking RACK1-mediated activation of MTK1-JNK1/2 pathway [0.03%]
缺氧通过解除RACK1介导的MTK1-JNK1/2通路激活促进FTO降解诱导细胞凋亡
Chengyu Li,Zhaojun Liu,Chen Fu et al.
Chengyu Li et al.
Introduction: Hypoxia, a condition characterized by inadequate oxygen supply to tissues, triggers various cellular responses, including apoptosis. The RNA demethylase FTO has been shown to exert anti-apoptotic effects, bu...
Danil Yu Pimenov,Leonardo Rosa Ribeiro da Silva,Mustafa Kuntoğlu et al.
Danil Yu Pimenov et al.
Background: Today, in a wide variety of industries, grinding operations are an extremely important finishing process for obtaining precise dimensions and meeting strict requirements for roughness and shape accuracy. Howev...
Flavonoids for gastrointestinal tract local and associated systemic effects: A review of clinical trials and future perspectives [0.03%]
flavonoids对胃肠道局部和全身相关作用：临床试验及未来展望综述
Xiaopeng Li,Enjun Xie,Shumin Sun et al.
Xiaopeng Li et al.
Background: Flavonoids are naturally occurring dietary phytochemicals with significant antioxidant effects aside from several health benefits. People often consume them in combination with other food components. Compiling...
Calcium signaling hypothesis: A non-negligible pathogenesis in Alzheimer's disease [0.03%]
钙信号假说在阿尔茨海默病发病机制中的非可忽略作用
Minghui Wang,Hu Zhang,Jiling Liang et al.
Minghui Wang et al.
Background: Alzheimer's disease (AD) presents a significant challenge to global healthcare systems, with an exacerbation by an aging population. Although the plethora of hypotheses are proposed to elucidate the underlying...
LTX-315 is a novel broad-spectrum antimicrobial peptide against clinical multidrug-resistant bacteria [0.03%]
一种针对临床多重耐药细菌的广谱抗菌多肽LTX-315
Yang Tang,Chen Yang,Jiamin Zhao et al.
Yang Tang et al.
Introduction: Infections stemming from multidrug-resistant bacteria present a substantial threat to public health today. Discovering or synthesizing novel compounds is crucial to alleviate this pressing situation. ...
Fangchinoline eliminates intracellular Salmonella by enhancing lysosomal function via the AMPK-mTORC1-TFEB axis [0.03%]
方樟碱通过AMPK-mTORC1-TFEB轴增强溶酶体功能消除胞内沙门氏菌
Mengping He,Huihui Wu,Tianqi Xu et al.
Mengping He et al.
Introduction: Salmonella, a foodborne zoonotic pathogen, is a significant cause of morbidity and mortality in animals and humans globally. With the prevalence of multidrug-resistant strains, Salmonellosis has become a for...
Dimeric guaianolide sesquiterpenoids from the flowers of Chrysanthemum indicum ameliorate hepatic steatosis through mitigating SIRT1-mediated lipid accumulation and ferroptosis [0.03%]
千里光菊花朵中的二聚guaianolide倍半萜类化合物通过减轻SIRT1介导的脂质积累和铁死亡来改善肝脂肪变性
Yu Liu,Fei Zhou,Haoyu Zhao et al.
Yu Liu et al.
Introduction: Non-alcoholic fatty liver disease (NAFLD) acts as the primary contributor to non-alcoholic steatohepatitis, fibrosis, cirrhosis, and potentially hepatocellular carcinoma. The flowers of Chrysanthemum indicum...
Antioxidant taurine inhibits chondrocyte ferroptosis through upregulation of OGT/Gpx4 signaling in osteoarthritis induced by anterior cruciate ligament transection [0.03%]
抗氧化剂牛磺酸通过上调OGT/Gpx4信号通路抑制前交叉韧带切断诱导的骨关节炎软骨细胞铁死亡
Xuchang Zhou,Yajing Yang,Xu Qiu et al.
Xuchang Zhou et al.
Objective: The aim of this study was to investigate the potential molecular mechanisms by which taurine protects against cartilage degeneration. Methods: ...
Yu&#x;e Liu,Huabing Tan,Jingyuan Dai et al.
Yu&#x;e Liu et al.
Background: Cancer immunotherapy has emerged as a groundbreaking approach in cancer treatment, primarily realized through the manipulation of immune cells, notably T cell adoption and immune checkpoint blockade. Neverthel...
Odontogenic exosomes simulating the developmental microenvironment promote complete regeneration of pulp-dentin complex in vivo [0.03%]
模拟发育微环境的牙源性外泌体促进活体牙髓-牙本质复合体的完全再生
Yifan Wang,Jing Mao,Yujie Wang et al.
Yifan Wang et al.
Introduction: Establishing an optimized regenerative microenvironment for pulp-dentin complex engineering has become increasingly critical. Recently, exosomes have emerged as favorable biomimetic nanotherapeutic tools to ...