YAP/TAZ, beta-catenin, and TGFb pathway activation in medical plasma-induced wound healing in diabetic mice [0.03%]
一氧化氮调节的YAP / TAZ，β- catenin和TGF-β途径活化介导糖尿病小鼠伤口愈合中的医疗等离子体治疗作用
Anke Schmidt,Thomas von Woedtke,Klaus-Dieter Weltmann et al.
Anke Schmidt et al.
Introduction: Hippo is a signaling pathway that is evolutionarily conserved and plays critical roles in wound healing and tissue regeneration. Disruption of the transcriptional activity of both Hippo-associated factors, t...
Lijing Zhang,Hengzhen Cui,Wandi Hu et al.
Lijing Zhang et al.
Introduction: Post-stroke cognitive impairment is one of the major causes of disability due to cerebral ischemia. MAD2B is an inhibitor of Cdh1/APC, and loss of Cdh1/APC function in mature neurons increases ROCK2 activity...
Anti-diabetic effect of dicaffeoylquinic acids is associated with the modulation of gut microbiota and bile acid metabolism [0.03%]
二咖啡酸奎宁酸的抗糖尿病作用与肠道菌群和胆汁酸代谢调节有关
Yujie Huang,Weiqi Xu,Wei Dong et al.
Yujie Huang et al.
Introduction: The human gut microbiome plays a pivotal role in health and disease, notably through its interaction with bile acids (BAs). BAs, synthesized in the liver, undergo transformation by the gut microbiota upon ex...
The role of gut microbiota, exosomes, and their interaction in the pathogenesis of ALD [0.03%]
肠道菌群、外泌体及其相互作用在ALD发病机制中的作用
Zilu Cheng,Ling Yang,Huikuan Chu
Zilu Cheng
Background: The liver disorders caused by alcohol abuse are termed alcoholic-related liver disease (ALD), including alcoholic steatosis, alcoholic steatohepatitis alcoholic hepatitis, and alcoholic cirrhosis, posing a sig...
Ginsenoside Rh4 inhibits colorectal cancer via the modulation of gut microbiota-mediated bile acid metabolism [0.03%]
人参皂苷Rh4通过调节肠道菌群介导的胆汁酸代谢抑制结直肠癌
Xue Bai,Zhiguang Duan,Jianjun Deng et al.
Xue Bai et al.
Introduction: Dysbiosis of the gut microbiota is emerging as a pivotal factor in the pathogenesis of colorectal cancer (CRC). Ginsenoside Rh4 (Rh4) is an active compound isolated from ginseng with beneficial effects in mo...
Regenerative endodontic therapy: From laboratory bench to clinical practice [0.03%]
再生性根尖诱导形成术：从实验室到临床
Xin Shi,Xiaohan Hu,Nan Jiang et al.
Xin Shi et al.
Background: Maintaining the vitality and functionality of dental pulp is paramount for tooth integrity, longevity, and homeostasis. Aiming to treat irreversible pulpitis and necrosis, there has been a paradigm shift from ...
E3 ubiquitin ligase RNF128 attenuates colitis and colorectal tumorigenesis by triggering the degradation of IL-6 receptors [0.03%]
E3连接酶RNF128通过促进白细胞介素6受体的降解来抑制结肠炎和结直肠肿瘤发生
Tian-Sheng He,Kuntai Cai,Weiling Lai et al.
Tian-Sheng He et al.
Introduction: Intestinal immune dysregulation is strongly linked to the occurrence and formation of tumors. RING finger protein 128 (RNF128) has been identified to play distinct immunoregulatory functions in innate and ad...
The role of SPI1/VSIG4/THBS1 on glioblastoma progression through modulation of the PI3K/AKT pathway [0.03%]
SPI1/VSIG4/THBS1通过调节PI3K/AKT途径在胶质母细胞瘤进展中的作用
Jie Shen,Lihui Zhou,Ke Ye et al.
Jie Shen et al.
Introduction: Glioblastoma multiforme (GBM) poses a significant challenge in terms of treatment due to its high malignancy, necessitating the identification of additional molecular targets. VSIG4, an oncogenic gene partic...
Macrophage exosomes mediate palmitic acid-induced metainflammation by transferring miR-3064-5p to target IκBα and activate NF-κB signaling [0.03%]
巨噬细胞源外泌体通过递送miR-3064-5p靶向IκBα激活NF-κB信号介导棕榈酸诱导的meta炎症反应
Huiyu Luo,Jiexian Wang,Fengjuan Lin et al.
Huiyu Luo et al.
Introduction: High palmitic acid (PA) levels trigger metainflammation, facilitating the onset and progression of chronic metabolic diseases. Recently, exosomes were identified as new inflammation mediators. However, the m...
Host-virus coevolution drives soil microbial function succession along a millennium land reclamation chronosequence [0.03%]
宿主-病毒的共生进化驱动千年垦荒年代土壤微生物功能演替
Wenbing Li,Yiling Wang,Kankan Zhao et al.
Wenbing Li et al.
Introduction: Gene exchange between viruses and hosts plays an important role in driving virus-host coevolution, enabling adaptation of both viruses and hosts to environmental changes. However, the mechanisms and function...