Spatiotemporal translation of sperm acrosome associated proteins during early capacitation modulates sperm fertilizing ability [0.03%]
精子获能早期与精子顶体相关的蛋白的时空转化调节了精子的受精能力
Yoo-Jin Park,Won-Ki Pang,Do-Yeal Ryu et al.
Yoo-Jin Park et al.
Introduction: Despite the lack of essential cytoplasmic organelles in mature spermatozoa, which creates unfavorable conditions for transcription and translation, the presence of various mRNA and proteins during capacitati...
Evidence for the role of soil C/N ratio in shaping plant responses to root-knot nematode infection [0.03%]
土壤C/N比率在塑造植物对根结线虫感染的反应中的作用的证据
Jiafan Li,Shikai La,Mengyuan Song et al.
Jiafan Li et al.
Introduction: Root-knot nematodes (RKNs) pose a major threat to global crop production. Soil properties influence plant responses to RKN infestation, but the specific soil factors that are most influential in determining ...
Mitochondrial fatty acid oxidation as the target for blocking therapy-resistance and inhibiting tumor recurrence: The proof-of-principle model demonstrated for ovarian cancer cells [0.03%]
线粒体脂肪酸氧化作为阻断治疗抵抗和抑制肿瘤复发的靶点：以卵巢癌细胞为原理证明模型
Hui Lin,Lingfang Wang,Hanwen Chen et al.
Hui Lin et al.
Introduction: Cancer patients treated with current chemotherapeutic and targeted therapies frequently achieve partial remission, which ultimately relapse with more aggressive, drug-resistant tumor phenotypes. To a certain...
Minichromosome maintenance 4 plays a key role in protecting against acute kidney injury by regulating tubular epithelial cells survival and regeneration [0.03%]
微型染色体维持蛋白4通过调节管状上皮细胞的存活和再生在保护急性肾损伤中起关键作用
Jing Huang,Feng Liu,Zhi-Feng Xu et al.
Jing Huang et al.
Introduction: Minichromosome maintenance 4 (MCM4), a constituent of the MCM family, playing a pivotal role in DNA replication. Although MCM4 expression has been widely linked to various malignant tumors, its role in kidne...
Mitigating life-cycle multiple environmental burdens while increasing ecosystem economic benefit and crop productivity with regional universal nitrogen strategy [0.03%]
以区域通用氮策略平衡生态环境效益和作物产量并降低农业活动的环境负荷
Zhi Yao,Xingbang Wang,Wei Zhang et al.
Zhi Yao et al.
Introduction: Nitrogen fertiliser is critical for increasing crop yields worldwide, but excessive use causes significant N losses in various forms and subsequent environmental issues, such as greenhouse gas (GHG) emission...
Adaptive bilirubin nanoscavenger alleviates pulmonary oxidative stress and inflammation for acute lung injury therapy [0.03%]
适应性胆红素纳米清除剂可缓解急性肺损伤治疗中的氧化应激和炎症
Longfa Kou,Yitianhe Xu,Shize Li et al.
Longfa Kou et al.
Introduction: Acute lung injury (ALI) is a life-threatening condition characterized by rapidly progressing respiratory distress and hypoxemia. Oxidative stress-induced inflammation in lung tissue plays a crucial role in t...
MG53 protects against septic cardiac dysfunction by ubiquitinating ATF2 [0.03%]
MG53通过泛素连接酶ATF2保护心脏免受脓毒症损伤
Miao Tian,Yu Shi,Xue Gong et al.
Miao Tian et al.
Introduction: Septic cardiac dysfunction (SCD) is the most common complication of sepsis, which has become the primary cause of death in intensive care units. The muscle-specific protein mitsugumin-53 (MG53) has been iden...
Insights into dill (Anethum graveolens) flavor formation via integrative analysis of chromosomal-scale genome, metabolome and transcriptome [0.03%]
通过整合分析染色体级别的基因组、代谢物和转录组以了解茴香（Anethum graveolens）的风味形成机制
Ya-Hui Wang,Pei-Zhuo Liu,Rong-Rong Zhang et al.
Ya-Hui Wang et al.
Introduction: Dill (Anethum graveolens) is a significant medicinal herb belonging to the Apiaceae family. Owing to its high levels of volatile organic compounds (VOCs), dill is commonly utilized for essential oil extracti...
Intestinal tissue-resident memory T cells: Characteristics, functions under physiological and pathological conditions and spatial specificity [0.03%]
肠道黏膜组织驻留记忆T细胞：生理与病理条件下的特征、功能及其空间特异性
Ruochen Yan,Dingjiacheng Jia,Yadong Qi et al.
Ruochen Yan et al.
Background: Tissue-resident memory T (TRM) cells are a distinct subset of memory T cells that persist in non-lymphoid tissues, providing localized and rapid immune responses to infection and malignancy. Unlike circulating...
Deficit of neuronal EAAT2 impairs hippocampus CA3 neuron's activity and may induce depressive like behaviors [0.03%]
神经元EAAT2的缺陷会损害海马CA3神经元活性并可能诱导类抑郁行为
Ke Cheng,Chong Chen,Qinji Zhou et al.
Ke Cheng et al.
Introduction: Major depressive disorder (MDD) is a severe neuropsychiatric disease that is accompanied by hippocampal dysfunction. Currently, the complex neuronal types and molecules involved in the various hippocampal su...