Nicotinamide riboside alleviates ionizing radiation-induced intestinal senescence by alleviating oxidative damage and regulating intestinal metabolism [0.03%]
烟酰胺核糖通过减轻氧化损伤和调节肠道代谢缓解电离辐射诱导的肠道衰老
Tongpeng Yue,Yinping Dong,Qidong Huo et al.
Tongpeng Yue et al.
Introduction: The intestine, frequently subjected to pelvic or abdominal radiotherapy, is particularly vulnerable to delayed effects of acute radiation exposure (DEARE) owing to its high radiation sensitivity. Radiation-i...
Hyperibone J exerts antidepressant effects by targeting ADK to inhibit microglial P2X7R/TLR4-mediated neuroinflammation [0.03%]
超强骨J通过靶向ADK抑制微胶质细胞P2X7R / TLR4介导的神经炎症发挥抗抑郁作用
Ting Li,Yawei Li,Jinhu Chen et al.
Ting Li et al.
Introduction: The antidepressant properties of Hypericum species are known. Hyperibone J, a principal component found in the flowers of Hypericum bellum, exhibited in vitro anti-inflammatory effects. However, the antidepr...
Elevation of p53 sensitizes obese kidney to adriamycin-induced aberrant lipid homeostasis via repressing HNF4α-mediated FGF21 sensitivity [0.03%]
p53上调通过抑制HNF4α介导的FGF21敏感性使肥胖肾脏易发生阿霉素诱导的脂质稳态异常
Jiahao Li,Yufeng Tang,Guangping Lu et al.
Jiahao Li et al.
Introduction: Lipid metabolism disorders have been confirmed to be closely related to kidney injury caused by adriamycin (ADR) and obesity, respectively. However, it has not been explored whether lipid metabolism disorder...
Tumor necrosis factor-α-treated human adipose-derived stem cells enhance inherent radiation tolerance and alleviate in vivo radiation-induced capsular contracture [0.03%]
肿瘤坏死因子-α处理的人脂肪来源干细胞可提高放射耐受性并减轻体内放射诱导的包囊挛缩病情Severity分级
Chanutchamon Sutthiwanjampa,Seung Hyun Kang,Mi Kyung Kim et al.
Chanutchamon Sutthiwanjampa et al.
Introduction: Post-mastectomy radiotherapy plays a crucial role in breast cancer treatment but can lead to an inflammatory response causing soft tissue damage, particularly radiation-induced capsular contracture (RICC), i...
Auts2 enhances neurogenesis and promotes expansion of the cerebral cortex [0.03%]
Auts2促进神经发生并促进脑皮层的扩张
Cédric Boucherie,Maisa Alkailani,Yves Jossin et al.
Cédric Boucherie et al.
Introduction: The AUTS2 gene is associated with various neurodevelopmental and psychiatric disorders and has been suggested to play a role in acquiring human-specific traits. Functional analyses of Auts2 knockout mice hav...
Charged polystyrene microplastics inhibit uptake and transformation of 14C-triclosan in hydroponics-cabbage system [0.03%]
带电的聚苯乙烯微塑料抑制水培白菜系统的14C-三氯生的吸收和转化
Enguang Nie,Yandao Chen,Shengwei Xu et al.
Enguang Nie et al.
Introduction: Since the outbreak of COVID-19, microplastics (MPs) and triclosan in pharmaceuticals and personal care products (PPCPs) are markedly rising. MPs and triclosan are co-present in the environment, but their int...
Convergent and divergent transcriptional reprogramming of motor and sensory neurons underlying response to peripheral nerve injury [0.03%]
外周神经损伤下运动神经元和感觉神经元的趋同和发散转录重编程
Jian Yang,Shuqiang Zhang,Xiaodi Li et al.
Jian Yang et al.
Introduction: Motor neurons differ from sensory neurons in aspects including origins and surrounding environment. Understanding the similarities and differences in molecular response to peripheral nerve injury (PNI) and r...
Exploitation of enhanced prime editing for blocking aberrant angiogenesis [0.03%]
利用增强型prime编辑抑制异常血管生成
Xionggao Huang,Wenyi Wu,Hui Qi et al.
Xionggao Huang et al.
Introduction: Aberrant angiogenesis plays an important part in the development of a variety of human diseases including proliferative diabetic retinopathy, with which there are still numerous patients remaining a therapeu...
C-reactive protein orchestrates acute allograft rejection in vascularized composite allotransplantation via subset-selective monocyte activation [0.03%]
C反应蛋白通过选择性单核细胞活化在血管化复合组织移植排斥中起主导作用
Jurij Kiefer,Johannes Zeller,Laura Schneider et al.
Jurij Kiefer et al.
Introduction: Despite recent substantial progress in vascularized composite allotransplantation (VCA), such as face transplantations, short- and long-term allograft survival is severely limited by allograft rejection. The...
Reveal the mechanism of hepatic oxidative stress in mice induced by photo-oxidation milk using multi-omics analysis techniques [0.03%]
利用多组学分析技术揭示光氧化奶诱导小鼠肝脏氧化应激的机制
Sijia Tan,Qiangqiang Li,Can Guo et al.
Sijia Tan et al.
Introduction: Photo-oxidation is recognized as a contributor to the deterioration of milk quality, posing potential safety hazards to human health. However, there has been limited investigation into the impact of consumin...