Development of a novel Cas13a/Cas12a-mediated 'one-pot' dual detection assay for genetically modified crops [0.03%]
一种新型Cas13a/Cas12a介导的“一次性”转基因作物检测方法及其应用
Lin Ding,Xiaofu Wang,Xiaoyun Chen et al.
Lin Ding et al.
Introduction: Genetically modified (GM) crops have been widely cultivated across the world and the development of rapid, ultrasensitive, visual multiplex detection platforms that are suitable for field deployment is criti...
Cell-specific Nav1.6 knockdown reduced astrocyte-derived Aβ by reverse Na+-Ca2+ transporter-mediated autophagy in alzheimer-like mice [0.03%]
细胞特异性Nav1.6敲低通过逆转Na+-Ca2+转运蛋白介导的自噬减少类阿尔茨海默病小胶质细胞源Ab生成
Xin Wang,Wei Wu,Guang Yang et al.
Xin Wang et al.
Introduction: Nav1.6 is closely related to the pathology of Alzheimer's Disease (AD), and astrocytes have recently been identified as a significant source of β-amyloid (Aβ). However, little is known about the connection...
Aberrant activation of p53-TRIB3 axis contributes to diabetic myocardial insulin resistance and sulforaphane protection [0.03%]
p53-TRIB3信号轴异常活化参与糖尿病心肌胰岛素抵抗及其硫代萝卜硫烷干预作用机制研究
Guangping Lu,Yufeng Tang,Ou Chen et al.
Guangping Lu et al.
Introduction: Insulin resistance (IR) is associated with multiple pathological features. Although p53- or TRIB3-orchestrated IR is extensively studied in adipose tissue and liver, the role of p53-TRIB3 axis in myocardial ...
A novel drug prejudice scaffold-imidazopyridine-conjugate can promote cell death in a colorectal cancer model by binding to β-catenin and suppressing the Wnt signaling pathway [0.03%]
一种新的抗癌先导结构架-咪唑并吡啶缀合物通过结合β-连环蛋白来抑制Wnt信号通路并促进结直肠癌模型中的细胞死亡
Min Hee Yang,Basappa Basappa,Suresha N Deveshegowda et al.
Min Hee Yang et al.
Introduction: Globally, colorectal cancer (CRC) is the third most common type of cancer, and its treatment frequently includes the utilization of drugs based on antibodies and small molecules. The development of CRC has b...
A mosquito proboscis-inspired cambered microneedle patch for ophthalmic regional anaesthesia [0.03%]
一种用于眼部区域麻醉的仿蚊子弯曲刺针贴片
Xuequan Liu,Xuequan Sun,Hongyu Zhu et al.
Xuequan Liu et al.
Introduction: One of the methods for pain management involves the use of local anesthesia, which numbs sensations in specific body regions while maintaining consciousness. ...
CRISPR/Cas9-mediated neuronal deletion of 5-lipoxygenase alleviates deficits in mouse models of epilepsy [0.03%]
利用CRISPR/Cas9介导的神经元特异性5-脂氧合酶敲除缓解癫痫小鼠模型的病理表型缺陷
Qiwen Guan,Zhaojun Wang,Kai Zhang et al.
Qiwen Guan et al.
Introduction: Our previous work reveals a critical role of activation of neuronal Alox5 in exacerbating brain injury post seizures. However, whether neuronal Alox5 impacts the pathological process of epilepsy remains unkn...
Disturbance of bile acids profile aggravates the diarrhea induced by capecitabine through inhibiting the Wnt/β-catenin pathway [0.03%]
扰乱胆汁酸谱型通过抑制Wnt/β-catenin信号通路加重卡培他滨诱导的腹泻
Zhipeng Wang,Zhijun Liu,Lili Cui et al.
Zhipeng Wang et al.
Introduction: Diarrhea is the primary dose-limiting side effect of capecitabine(Cap) hindering its clinical application, but the mechanism is unclear. Clarifying this mechanism may enhance the patient compliance and impro...
Cadmium targeting transcription factor EB to inhibit autophagy-lysosome function contributes to acute kidney injury [0.03%]
镉通过靶向转录因子EB抑制自噬-溶酶体功能从而导致急性肾损伤
Peng-Fei Dong,Tian-Bin Liu,Kai Chen et al.
Peng-Fei Dong et al.
Introduction: Environmental and occupational exposure to cadmium (Cd) has been shown to cause acute kidney injury (AKI). Previous studies have demonstrated that autophagy inhibition and lysosomal dysfunction are important...
An updated review and recent advancements in carbon-based bioactive coatings for dental implant applications [0.03%]
基于碳的生物活性涂层在牙科种植体应用中的最新进展及综述更新
Nazrah Maher,Anum Mahmood,Muhammad Amber Fareed et al.
Nazrah Maher et al.
Background: Surface coating of dental implants with a bioactive biomaterial is one of the distinguished approaches to improve the osseointegration potential, antibacterial properties, durability, and clinical success rate...
Neopterin mediates sleep deprivation-induced microglial activation resulting in neuronal damage by affecting YY1/HDAC1/TOP1/IL-6 signaling [0.03%]
神经pterin通过影响YY1/HADC1/TOP1/IL-6信号通路介导睡眠剥夺诱导的小胶质细胞活化导致的神经元损伤
Xuan Li,Ziyu Kong,Ke Cai et al.
Xuan Li et al.
Introduction: Sleep deprivation (SD) is a common disorder in modern society. Hippocampus is an important region of the brain for learning, memory, and emotions. Dysfunction of hippocampus can lead to severe learning and m...