PIK3R3 regulates differentiation and senescence of periodontal ligament stem cells and mitigates age-related alveolar bone loss by modulating FOXO1 expression [0.03%]
PIK3R3通过调节FOXO1的表达来调控牙周韧带干细胞的分化和衰老并缓解年龄相关的牙槽骨丢失
Xuenan Liu,Donghao Wei,Feilong Wang et al.
Xuenan Liu et al.
Introduction: Periodontal diseases are prevalent among middle-aged and elderly individuals. There's still no satisfactory solution for tooth loss caused by periodontal diseases. Human periodontal ligament stem cells (hPDL...
Astragaloside IV ameliorates autism-like behaviors in BTBR mice by modulating Camk2n2-dependent OXPHOS and neurotransmission in the mPFC [0.03%]
绞股蓝皂苷IV通过调节Camk2n2依赖性OXPHOS和mPFC中的神经传递来改善BTBR小鼠自闭症样行为
Mei Chen,Jiahui Shi,Tianyao Liu et al.
Mei Chen et al.
Introduction: Autism spectrum disorder (ASD) represents a multifaceted set of neurodevelopmental conditions marked by social deficits and repetitive behaviors. Astragaloside IV (ASIV), a natural compound derived from the ...
Integrated multi-omics reveals the Bacillus amyloliquefaciens BA40 against Clostridium perfringens infection in weaned piglets [0.03%]
芽孢杆菌BA40通过整合多组学技术缓解仔猪感染产气荚膜梭菌所致的肠道损伤及屏障功能障碍
Zipeng Jiang,Weifa Su,Mingzhi Yang et al.
Zipeng Jiang et al.
Introduction: Clostridium perfringens (C. perfringens) can cause necrotic enteritis and higher mortality rates in piglets, by impairing the intestinal barrier function. Bacillus amyloliquefaciens 40 (BA40) has showed pote...
Phospholipase C epsilon 1 as a therapeutic target in cardiovascular diseases [0.03%]
磷脂酶Cɛ1作为心血管疾病治疗靶点的研究
Jie Wang,Ting Gao,Dongmei Zhang et al.
Jie Wang et al.
Background: Phospholipase C epsilon 1 (PLCε1) can hydrolyze phosphatidylinositol-4,5-bisphosphate and phosphatidylinositol-4-phosphate at the plasma membrane and perinuclear membrane in the cardiovascular system, produci...
Molecular and cellular morphology of placenta unveils new mechanisms of reproductive immunology [0.03%]
胎盘的分子和细胞形态揭示了生殖免疫学的新机制
Penghao Li,Liting Zeng,Xiaomiao Yan et al.
Penghao Li et al.
Introduction: Despite of numerous studies of the placenta, some molecular and cellular characteristics, particularly the relationship among different cell types, have not been well understood. We aim to investigate the ba...
SCARB1 links cholesterol metabolism-mediated ferroptosis inhibition to radioresistance in tumor cells [0.03%]
SCARB1通过连接胆固醇代谢介导的铁死亡抑制与肿瘤细胞的放射抵抗性将其串联在一起
Xiaojuan Mao,Jingwen Xiong,Mengjiao Cai et al.
Xiaojuan Mao et al.
Introduction: Ferroptosis is an iron-dependent form of cell death triggered by the excessive accumulation of lipid peroxides. Understanding the regulatory mechanisms of ferroptosis and developing strategies to target this...
A novel small molecule NJH-13 induces pyroptosis via the Ca2+ driven AKT-FOXO1-GSDME signaling pathway in NSCLC by targeting TRPV5 [0.03%]
一种新型小分子化合物NJH-13通过靶向TRPV5诱导非小细胞肺癌中Ca2+驱动的AKT-FOXO1-GSDME信号通路介导的细胞焦亡
Xianxiang Dong,Jiahui Nie,Aiying Huang et al.
Xianxiang Dong et al.
Introduction: Pyroptosis represents a mode of programmed necrotic cell death (PCD), mediated by members of gasdermin family (GSDMs), such as GSDME. It is emerging as a promising approach for combating cancer. Notably, GSD...
Development of novel broad-spectrum amphipathic antimicrobial peptides against multidrug-resistant bacteria through a rational combination strategy [0.03%]
通过合理的组合策略开发针对多重耐药细菌的新型广谱两亲性抗菌肽
Jing Zhang,Liang Luan,Youdong Xu et al.
Jing Zhang et al.
Introduction: In recent years, cationic amphipathic antimicrobial peptides (AMPs) have shown great promise in combating antibiotic resistance on account of their distinctive membrane-disruptive mechanism. However, the cli...
LMNA-related cardiomyopathy: From molecular pathology to cardiac gene therapy [0.03%]
LMNA相关的心肌病：从分子病理学到心脏基因治疗
Ze Wang,Jiahao Wu,Zhengyuan Lv et al.
Ze Wang et al.
Background: The genetic variants of LMNA cause an array of diseases that often affect the heart. LMNA-related cardiomyopathy exhibits high-penetrance and early-onset phenotypes that lead to late-stage heart failure or let...
Post-transcriptional and post-translational regulation of anthocyanin biosynthesis in sweetpotato by Ib-miR2111 and IbKFB: Implications for health promotion [0.03%]
Ib-miR2111和IbKFB对甘薯花青素生物合成的转录后和翻译后的调控：促进健康的意义
Ruimin Tang,Cailiang Zhao,Jingjian Dong et al.
Ruimin Tang et al.
Introduction: Sweetpotato (Ipomoea batatas (L.) Lam.) is a genetically intricate hexaploid crop. The purple-fleshed variety, enriched with anthocyanin pigments, is an outstanding source for creating high-value functional ...