Zn-doped CaP coating equips Ti implants with corrosion resistance, biomineralization, antibacterial and immunotolerant activities [0.03%]
掺锌CaP涂层使钛植入物具备耐蚀、生物矿化、抗菌和免疫调控性能
Anca C Parau,Senem Büyüksungur,Guanhao Li et al.
Anca C Parau et al.
Introduction: Chronic inflammation leading to implant failure present major challenges in orthopedics, dentistry, and reconstructive surgery. Titanium alloys, while widely used, often provoke inflammatory complications. Z...
Autophagy activation within inflammatory microenvironment improved the therapeutic effect of MSC-Derived extracellular Vesicle in SLE [0.03%]
炎症微环境中自噬激活可增强间充质干细胞来源的外泌体治疗SLE效果
Shuzhen Liao,Fengbiao Guo,Zengzhi Xiao et al.
Shuzhen Liao et al.
Introduction: Developing strategies to improve the therapeutic efficacy of mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) in autoimmune diseases have garnered increased attention. ...
Actl6a regulates autophagy via Sox2-dependent Atg5 and Atg7 expression to inhibit apoptosis in spinal cord injury [0.03%]
ACTL6A通过Sox2依赖性Atg5和Atg7表达调节自噬抑制脊髓损伤中的细胞凋亡
Jian Hao,Yubiao Yang,Li Xie et al.
Jian Hao et al.
Introduction: Spinal cord injury (SCI) is a severe central nervous system disorder with limited treatment options. While autophagy plays a protective role in neural repair, its regulatory mechanisms in SCI remain unclear....
The urinary eccDNA landscape in prostate cancer reveals associations with genome instability and vital roles in cancer progression [0.03%]
前列腺癌尿液eccDNA景观揭示其与基因组不稳定的相关性及其在癌症进展中的重要作用
Shengcai Chen,Zhimin Zhou,Yangchen Ye et al.
Shengcai Chen et al.
Introduction: Extrachromosomal circular DNA (eccDNA) plays significant roles in cancer progression and prognosis. However, it remains unclear whether cell-free eccDNA, considered more stable than linear DNA, possesses can...
Hypericin photoactivation induces triple-negative breast cancer cells pyroptosis by targeting the ROS/CALR/Caspase-3/GSDME pathway [0.03%]
光活化诱导虎皮蓝激活ROS/CALR/ caspase-3/GSDME途径介导的三阴性乳腺癌细胞焦亡
Chen Liang,Xiao Liu,Jie Yu et al.
Chen Liang et al.
Introduction: Hypericin (HP), a natural photosensitizer, has demonstrated great efficacy in photodynamic therapy (PDT) for cancer treatment. In addition to the induction of apoptosis and necrosis through reactive oxygen s...
Integrative multi-omics analysis of autism spectrum disorder reveals unique microbial macromolecules interactions [0.03%]
自闭症谱系障碍的集成多组学分析揭示了独特的微生物大分子互作
Aya Osama,Ali Mostafa Anwar,Shahd Ezzeldin et al.
Aya Osama et al.
Introduction: Gut microbiota alterations have been implicated in Autism Spectrum Disorder (ASD), yet the mechanisms linking these changes to ASD pathophysiology remain unclear. ...
CHMP4C promotes pancreatic cancer progression by inhibiting necroptosis via the RIPK1/RIPK3/MLKL pathway [0.03%]
CHMP4C通过RIPK1/RIPK3/MLKL途径抑制坏死性凋亡从而促进胰腺癌进展
Longchen Yu,Qining Guo,Yaping Li et al.
Longchen Yu et al.
Introduction: Pancreatic cancer (PC) cannot currently be completely cured and has a poor prognosis. Necroptosis is a distinct form of regulated cell death that differs from both necrosis and apoptosis. Understanding the r...
Cardiac ATP production and contractility are favorably regulated by short-term S100A9 blockade after myocardial infarction [0.03%]
短期阻断心肌梗死后S100A9对心脏ATP生成和收缩功能的调节作用的影响
Raluca M Boteanu,Viorel I Suica,Elena Uyy et al.
Raluca M Boteanu et al.
Introduction: The infarcted heart is energetically compromised exhibiting a deficient production of adenosine triphosphate (ATP) and the ensuing impaired contractile function. Short-term blockade of the protein S100A9 imp...
FOXS1, frequently inactivated by promoter methylation, inhibited colorectal cancer cell growth by promoting TGFBI degradation through autophagy-lysosome pathway [0.03%]
FOXS1通过自噬-溶酶体途径促进TGFBI降解来抑制结直肠癌细胞的增殖，且其启动子区经常发生高甲基化失活
Yeye Kuang,Yijian Yu,Chan Wang et al.
Yeye Kuang et al.
Introduction: Tumor suppressor gene (TSG) inactivation by epigenetic modifications contributes to the carcinogenesis and progression of colorectal cancer (CRC). Expression profiling and CpG methylomics revealed that a for...
Ailanthone induces triple-negative breast cancer cells death involving the inhibition of OTUB1-mediated ERRα deubiquitylation [0.03%]
黄檀茋通过抑制OTUB1介导的ERRα去泛素化诱导三阴性乳腺癌细胞死亡
Ziyue Zhang,Wei Huang,Li Wang et al.
Ziyue Zhang et al.
Introduction: Triple-negative breast cancer (TNBC) remains the most aggressive subtype of breast cancer, and effective therapeutic strategies are needed. Estrogen-related receptor alpha (ERRα) is considered a promising t...