IRnet: Immunotherapy response prediction using pathway knowledge-informed graph neural network [0.03%]
基于通路知识告知图神经网络的免疫治疗反应预测模型
Yuexu Jiang,Manish Sridhar Immadi,Duolin Wang et al.
Yuexu Jiang et al.
Introduction: Immune checkpoint inhibitors (ICIs) are potent and precise therapies for various cancer types, significantly improving survival rates in patients who respond positively to them. However, only a minority of p...
Fluoride induces hepatointestinal damage and vitamin B2 mitigation by regulating IL-17A and Bifidobacterium in ileum [0.03%]
氟化物通过调节回肠中IL-17A和双歧杆菌诱导肝肠损伤及核黄素缓解
Chen Liang,Cuicui Zhuang,Chenkai Cheng et al.
Chen Liang et al.
Introduction: Fluorosis is a global public health disease affecting more than 50 countries and 500 million people. Excessive fluoride damages the liver and intestines, yet the mechanisms and therapeutic approaches remain ...
Glutathione hybrid poly (beta-amino ester)-plasmid nanoparticles for enhancing gene delivery and biosafety [0.03%]
半胱氨酸-谷氨酰胺双功能单体与Pluronic F127共混自组装成基因载体纳米材料研究
Songwei Tan,Caiyan Yuan,Yuhe Zhu et al.
Songwei Tan et al.
Introduction: CRISPR/Cas9 gene editing technology has significantly advanced gene therapy, with gene vectors being one of the key factors for its success. Poly (beta-amino ester) (PBAE), a distinguished non-viral cationic...
Insights of immune cell heterogeneity, tumor-initiated subtype transformation, drug resistance, treatment and detecting technologies in glioma microenvironment [0.03%]
关于胶质瘤免疫细胞异质性、肿瘤启动子亚型转化、药物抵抗、治疗及检测技术的新见解
Tongzheng Chen,Wenbin Ma,Xin Wang et al.
Tongzheng Chen et al.
Background: With the gradual understanding of glioma development and the immune microenvironment, many immune cells have been discovered. Despite the growing comprehension of immune cell functions and the clinical applica...
The molecular mechanism of NF-κB dysregulation across different subtypes of renal cell carcinoma [0.03%]
不同亚型肾细胞癌中NF-κB异常调控的分子机制
Nour Abu Jayab,Alaa Abed,Iman M Talaat et al.
Nour Abu Jayab et al.
Background: The nuclear factor kappa B (NF-κB) is a critical pathway that regulates various cellular functions, including immune response, proliferation, growth, and apoptosis. Furthermore, this pathway is tightly regula...
NAT10 promotes osteoclastogenesis in inflammatory bone loss by catalyzing Fos mRNA ac4C modification and upregulating MAPK signaling pathway [0.03%]
NAT10通过催化Fos mRNA的ac4C修饰促进炎性骨丢失过程中的破骨细胞生成及MAPK信号通路的上调
Ruhan Yang,Weijun Yu,Lu Lin et al.
Ruhan Yang et al.
Introduction: Excessive osteoclastogenesis is a key driver of inflammatory bone loss. Suppressing osteoclastogenesis has always been considered essential for the treatment of inflammatory bone loss. N-acetyltransferase 10...
Metarhizium spp. encode an ochratoxin cluster and a high efficiency ochratoxin-degrading amidohydrolase revealed by genomic analysis [0.03%]
基因组分析揭示绿僵菌属既能编码生产黄曲伏毒素的基因簇又能高效降解黄曲伏毒素的酰胺酶
Gang Wang,Wenqing Wu,Nancy P Keller et al.
Gang Wang et al.
Introduction: Ochratoxins (OTs) are worldwide regulated mycotoxins contaminating a variety of food-environment and agro-environment. Several Aspergillus and Pencillium species synthesize OTs from a six-gene biosynthetic g...
Drug repurposing of cyclin-dependent kinase inhibitors for neutrophilic acute respiratory distress syndrome and psoriasis [0.03%]
寻找用于中性粒细胞急性呼吸窘迫综合征和银屑病的细胞周期依赖性激酶抑制剂的新用途
Shun-Hua Chen,Chun-Hong Chen,Hsin-Chieh Lin et al.
Shun-Hua Chen et al.
Background: Neutrophilic inflammation, characterized by dysregulated neutrophil activation, triggers a variety of inflammatory responses such as chemotactic infiltration, oxidative bursts, degranulation, neutrophil extrac...
Ultra-high static magnetic fields altered the embryonic division and development in Caenorhabditis elegans via multipolar spindles [0.03%]
超强静态磁场可通过多极纺锤体改变秀丽隐杆线虫的胚胎分裂与发育
Lei Cheng,Mudi Wang,Baolin Yang et al.
Lei Cheng et al.
Introduction: Ultra-high static magnetic fields (SMFs) have unique advantages in improving medical and academic research. However, the research on the early embryo exposure of ultra-high SMFs is minimal, extensive explora...
Single-cell atlas of human gingiva unveils a NETs-related neutrophil subpopulation regulating periodontal immunity [0.03%]
人龈单细胞图谱揭示了一种与NETs相关的调节牙周免疫的中性粒细胞亚群
Wei Qiu,Ruiming Guo,Hongwen Yu et al.
Wei Qiu et al.
Introduction: Exaggerated neutrophil recruitment and activation are the major features of pathological alterations in periodontitis, in which neutrophil extracellular traps (NETs) are considered to be responsible for infl...