TMEM158 promotes ICC metastasis via inducing lactic acid mediated reduction of actin skeleton stiffness of ICC cells [0.03%]
TMEM158通过诱导乳酸介导的ICC细胞肌动蛋白骨架刚度降低促进ICC转移
Peng Chen,Jing Yang,Shengxi Jin et al.
Peng Chen et al.
Introduction: The survival rate of patients with intrahepatic cholangiocarcinoma (ICC) is extremely low mainly because of its high metastatic characteristic, pushing us to explore effective targets inhibiting the metastas...
ARHGEF3 coordinates adipocyte hypertrophy and differentiation through dual YAP-RhoA and PPARγ activation [0.03%]
ARHGEF3通过双重YAP-RhoA和PPARγ活化协调脂肪细胞肥大和分化
Sana Abdul Khaliq,Shi-Young Park,Syeda Maham et al.
Sana Abdul Khaliq et al.
Introduction: Obesity presents a significant global health burden, necessitating insights into the molecular drivers of adipogenesis and adipose tissue regulation. ...
Hang Xu,Meng Wu,Yujian Wang et al.
Hang Xu et al.
Introduction: Gasdermin (GSDM) is a family of proteins that execute pyroptosis after being activated by caspase (CASP) cleavage. Mammals possess five GSDM members (A - E) with pyroptotic ability. Teleosts possess only one...
Inflammation-driven biomimetic nano-polyphenol drug delivery system alleviates severe acute pancreatitis by inhibiting macrophage PANoptosis and pancreatic enzymes oversecretion [0.03%]
炎症驱动的类生物纳米多酚药物递送系统通过抑制巨噬细胞PANoptosis和胰腺酶过分泌来缓解急性重症胰腺炎
Junyong Wu,Hai Huang,Wenjie Xu et al.
Junyong Wu et al.
Introduction: Severe acute pancreatitis (SAP) is a critical inflammatory disease with high morbidity and mortality. Current treatments focused on symptomatic relief but failed to prevent inflammation progression in cellul...
Blockade of calcium-activated chloride channel ANO1 ameliorates ionizing radiation-induced intestinal injury [0.03%]
氯通道ANO1的阻断改善电离辐射引起的肠损伤
Yuying Guo,Tong Yuan,Yuna Wang et al.
Yuying Guo et al.
Introduction: Radiation enteritis is one of the most frequent clinical complications of radiotherapy (RT), yet few effective strategies currently exist to protect against that. Anoctamin 1 (ANO1) functions both as a chlor...
When glycobiology meets inflammasome activation: Insights and implications [0.03%]
糖生物学与炎性小体活化研究的见解和意义
Hongliang Zhang,Tengchuan Jin,Mengzhou Xue et al.
Hongliang Zhang et al.
Background: Glycobiology focuses mainly on the study of glycan structures and their biological functions. Glycans not only provide a basic energy supply through the tricarboxylic acid cycle and glycolysis but also serve a...
Global, regional, and national burden of neglected tropical diseases and malaria in the general population, 1990-2021: Systematic analysis of the global burden of disease study 2021 [0.03%]
1990年至2021年全球、区域和国家各类热带病和疟疾疾病负担：基于《2021年全球疾病负担研究》的系统分析
Jin-Xin Zheng,Yang Liu,Shi-Yang Guan et al.
Jin-Xin Zheng et al.
Background: Neglected Tropical Diseases (NTDs) and malaria present considerable health obstacles, particularly impacting the socio-economic progress in at-risk areas. We aimed to estimate the burden, trends, and inequalit...
The LoMYB26/LoJAZ4-LoCOMT module regulates anther dehiscence via Jasmonic acid-mediated endothecium lignification in lily [0.03%]
番红花素通过茉莉酸介导的内表皮木质化调节药用百合花粉散发
Qianqian Fang,Xue Pan,Ze Wu et al.
Qianqian Fang et al.
Introduction: Timely anther dehiscence is a key step for successful sexual reproduction in plants. Secondary cell wall thickening of anther endothecium is a vital process during anther dehiscence that provides an indispen...
Development of a fully human glioblastoma-in-brain-spheroid model for accelerated translational research [0.03%]
一种用于加速转化研究的全人胶质母细胞瘤脑类器官模型的发展
Sandra Horschitz,Ammar Jabali,Sophie Heuer et al.
Sandra Horschitz et al.
Introduction: Glioblastoma (GBM) progression and therapeutic resistance are significantly influenced by complex interactions between tumor cells and the brain microenvironment, particularly neurons. However, studying thes...
Screening, identification and detection of the regulated and emerging mycotoxins in edible and medicinal products by integrating diversiform liquid chromatography/mass spectrometry systems and high-throughput sequencing of contaminated fungi [0.03%]
整合多种形式液相色谱/质谱系统和高通量测序真菌技术对食药产品中受控和新出现的霉毒素进行筛选、识别及检测
Xiao-Yan Xu,Yu Wang,Lian-Xing Wang et al.
Xiao-Yan Xu et al.
Introduction: Safety issues pertaining to mycotoxin contamination of the edible and medicinal products (EMPs) have attracted significant attention. EMPs not only have high nutritional values, but also exert valuable medic...