An essential role of the E3 ubiquitin ligase RNF126 in ensuring meiosis I completion during spermatogenesis [0.03%]
E3泛素连接酶RNF126在精子发生过程中保证第一次减数分裂完成的必要作用
Wenjing Liu,Xiya Sun,Fubing Li et al.
Wenjing Liu et al.
Introduction: Homologous recombination repair during meiosis is essential for the exchange of genetic information between sister chromosomes, underpinning spermatogenesis and, consequently, fertility. The disruption of th...
Impaired microglial glycolysis promotes inflammatory responses after intracerebral haemorrhage via HK2-dependent mitochondrial dysfunction [0.03%]
脑出血后小胶质细胞糖酵解受损通过HK2依赖的线粒体功能障碍促进炎症反应
Yin Li,Hang Zhou,Xuchao He et al.
Yin Li et al.
Introduction: Intracerebral haemorrhage (ICH) is a devastating disease that leads to severe neurological deficits. Microglia are the first line of defence in the brain and play a crucial role in neurological recovery afte...
ARTEMIS: An independently validated prognostic prediction model of breast cancer incorporating epigenetic biomarkers with main effects and gene-gene interactions [0.03%]
基于表观遗传生物标志物的乳腺癌预后预测模型ARTEMIS及其验证
Maojie Xue,Ziang Xu,Xiang Wang et al.
Maojie Xue et al.
Introduction: Breast cancer, a heterogeneous disease, is influenced by multiple genetic and epigenetic factors. The majority of prognostic models for breast cancer focus merely on the main effects of predictors, disregard...
NDRG1 enhances the sensitivity to Cetuximab by promoting Stat1 ubiquitylation in colorectal cancer [0.03%]
NDRG1通过促进Stat1泛素化增强结直肠癌对西妥昔单抗的敏感性
Guang Yang,Chengsheng Ding,Xiao Yang et al.
Guang Yang et al.
Introduction: Cetuximab (CTX) is an effective targeted drug for the treatment of metastatic colorectal cancer, but it is effective only in patients with wild-type KRAS genes. Even in this subset of patients, the sensitivi...
Novel furfural-complexed approach to synthesizing carbon-Doped ZnO with breakthrough photocatalytic efficacy [0.03%]
一种合成碳掺杂ZnO的新糠醛复合法及其优异的光催化性能
Sajid Ali Ansari,Nazish Parveen,Abdullah Aljaafari et al.
Sajid Ali Ansari et al.
Introduction: The efficiency of zinc oxide (ZnO) nanoparticles for environmental decontamination is limited by their reliance on ultraviolet (UV) light and rapid charge carrier recombination. Carbon doping has been propos...
Extracellular vesicle-derived miR-146a as a novel crosstalk mechanism for high-fat induced atherosclerosis by targeting SMAD4 [0.03%]
外源性微囊泡递送miR-146a通过靶向SMAD4参与高脂诱导的动脉粥样硬化新型细胞间通讯机制的研究
Kefeng Zhai,Liangle Deng,Yuxuan Wu et al.
Kefeng Zhai et al.
Introduction: Exosome-miR-146a is significantly increased in patients with Atherosclerosis (AS), but its mechanism and effect on AS have not been fully elucidated. ...
IL-28A/IL-10Rβ axis promotes angiogenesis via eNOS/AKT signaling and AP-1/NF-κB/MMP-2 network by regulating HSP70-1 expression [0.03%]
通过调节HSP70-1表达促进血管生成的IL-28A/IL-10Rβ轴及eNOS/AKT信号和AP-1/NF-κB/MMP-2网络
Jun-Hui Song,Byungdoo Hwang,Sung Lyea Park et al.
Jun-Hui Song et al.
Introduction: Angiogenesis plays a significant role in the development of tumor progression and inflammatory diseases. The role of IL-28A in angiogenesis and its precise regulatory mechanisms remain rarely elucidated. ...
Design and construction of light-regulated gene transcription and protein translation systems in yeast P. Pastoris [0.03%]
毕赤酵母中光调控基因转录和蛋白质翻译系统的构建及应用研究
Siyu Zhang,Jiazhen Zhang,Ru Lin et al.
Siyu Zhang et al.
Introduction: P. pastoris is a common host for effective biosynthesis of heterologous proteins as well as small molecules. Accurate regulation of gene transcription and protein synthesis is necessary to coordinate synthet...
DeepB3P: A transformer-based model for identifying blood-brain barrier penetrating peptides with data augmentation using feedback GAN [0.03%]
基于Transformer的DeepB3P模型：使用反馈GAN数据增强的方法识别穿透血脑屏障的多肽
Qiang Tang,Wei Chen
Qiang Tang
Introduction: The blood-brain barrier (BBB) serves as a critical structural barrier and impedes the entry of most neurotherapeutic drugs into the brain. This poses substantial challenges for central nervous system (CNS) d...
Development of modern Chinese medicine guided by molecular compatibility theory [0.03%]
基于分子配伍理论的现代中药研发新模式
Lifeng Luo,Jieru Zhou,Xiaonan Liu et al.
Lifeng Luo et al.
Background: Traditional Chinese Medicine (TCM) has gained global attention, particularly after Professor Youyou Tu was awarded the Nobel Prize for her discovery of artemisinin as a treatment for malaria. However, the theo...