NAC transcription factor GbNTL9 modifies the accumulation and organization of cellulose microfibrils to enhance cotton fiber strength [0.03%]
NAC转录因子GbNTL9通过改变纤维素微纤丝的积累和排列来提高棉花纤维强度
Mi Wu,Zhiyong Xu,Chao Fu et al.
Mi Wu et al.
Introduction: Fiber strength is a critical determinant of fiber quality, with stronger fibers being highly preferred in the cotton textile industry. However, the genetic basis and the specific regulatory mechanism underly...
Autoimmune responses to myelin-associated proteins as diagnostic and prognostic biomarkers of relapsing-remitting multiple sclerosis: Associations with human herpesvirus-6 and Epstein-Barr virus reactivation [0.03%]
髓鞘相关蛋白的自身免疫反应作为复发缓解型多发性硬化症的诊断和预后生物标志物：与人类玫瑰疹病毒-6和Epstein-Barr病毒再激活的关系
Aristo Vojdani,Abbas F Almulla,Elroy Vojdani et al.
Aristo Vojdani et al.
Background: The pathogenesis of relapsing-remitting multiple sclerosis (RRMS) is linked to autoimmune attacks against myelin proteins, and reactivation of Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV-6). However,...
H4K12 lactylation potentiates mitochondrial oxidative stress via the Foxo1 pathway in diabetes-induced cognitive impairment [0.03%]
H4K12乳酰化通过Foxo1通路促进糖尿病诱导的认知障碍中的线粒体氧化应激
Ying Yang,Lulu Song,Liping Yu et al.
Ying Yang et al.
Aims: To investigate the role and potential mechanisms of H4K12 lactylation modifications in diabetes-related cognitive impairment (DACD). Methods: ...
Specific Macronutrient clusters associated with lower mortality Risk: Evidence from NHANES 1999-2018 [0.03%]
与较低死亡风险相关的特定宏量营养素群：来自NHANES 1999-2018的证据
Jiaying Yu,Yang Chen,Defang Li et al.
Jiaying Yu et al.
Introduction: Accumulating evidence suggest that imbalanced macronutrient composition would increase the risk of chronic diseases. However, previous studies that predominantly focused on individual macronutrients often fa...
Comprehensive single-cell analysis deciphered the immunoregulatory mechanism of TPPU in alleviating sepsis-related acute liver injury [0.03%]
综合单细胞分析阐明了TPPU在缓解脓毒症相关急性肝损伤中的免疫调节机制
Juan Li,Mengjuan Xuan,Li Yang et al.
Juan Li et al.
Introduction: Sepsis-related acute liver injury involves complex immune dysfunctions. Epoxyeicosatrienoic acids (EETs), bioactive molecules derived from arachidonic acid (AA) via cytochrome P450 (CYP450) and rapidly hydro...
A dual absorption pathway of novel oyster-derived peptide-zinc complex enhances zinc bioavailability and restores mitochondrial function [0.03%]
新型的蚝源肽-锌复合物的双重吸收路径提高了锌的生物利用度并恢复了线粒体功能
Ximing Yang,Siyi Wang,Hanxiong Liu et al.
Ximing Yang et al.
Zinc deficiency is a global health issue that impairs immune function, growth, and energy metabolism. Although conventional zinc supplements have been developed, their effectiveness is limited by poor bioavailability and susceptibility to d...
Mebendazole induces ZBP-1 mediated PANoptosis of acute myeloid leukemia cells by targeting TUBA1A and exerts antileukemia effect [0.03%]
甲苯达唑通过靶向TUBA1A诱导急性髓性白血病细胞发生ZBP-1介导的PANoptosis并发挥抗白血病作用
Wei Yang,Ying Xu,Shuai Liu et al.
Wei Yang et al.
Background: Despite notable advancements in AML therapy in recent years, a substantial proportion of patients remain refractory or at high risk of recurrence with limited efficacy. Therefore, it's urgent to develop novel ...
Blocking S1P4 signaling attenuates brain injury in mice with ischemic stroke [0.03%]
阻断S1P4信号可减轻缺血性卒中小鼠的脑损伤
Nikita Basnet,Hyunkyung Cho,Arjun Sapkota et al.
Nikita Basnet et al.
Introduction: The functions of S1P receptors have been revealed using genetic and pharmacological tools, including the potent non-selective modulator FTY720. However, studies on subtype-specific agonists and antagonists a...
Ai-enabled language models (LMs) to large language models (LLMs) and multimodal large language models (MLLMs) in drug discovery and development [0.03%]
人工智能赋能的语言模型（LMs）在药物发现与开发中的应用：从大型语言模型（LLMs）到多模态大型语言模型（MLLMs）
Chiranjib Chakraborty,Manojit Bhattacharya,Soumen Pal et al.
Chiranjib Chakraborty et al.
Background: Due to the recent revolution of artificial intelligence (AI), AI-enabled large language models (LLMs) have flourished and started to be applied in various sectors of science and medicine. Drug discovery and de...
Sequential allogeneic HSCT after CAR-T therapy for relapsed/refractory acute lymphoblastic leukemia patients: A long-term follow-up result [0.03%]
CAR-T治疗后复发/难治急性淋巴细胞白血病患者的序贯异基因HSCT：一项长期随访结果
Tingting Yang,Yetian Dong,Jimin Shi et al.
Tingting Yang et al.
Introduction: CAR-T cell therapy has revolutionized the therapeutic landscape for relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL), and bridging with allogeneic hematopoietic stem cell transplantation...