A novel CRISPR-Cas9 nickase-mediated rolling circle amplification (CRIRCA) technique for gene identification and quantitative analysis of extrachromosomal DNA [0.03%]
一种新型的CRISPR-Cas9切口酶介导的滚环扩增技术(CRIRCA)，用于基因鉴定和染色体外DNA的定量分析
Yuchen Song,Chaoyang Guan,Yue Zhang et al.
Yuchen Song et al.
Introduction: Extrachromosomal DNA (ecDNA) plays an important role in the initiation and progression of cancerous tumors. Although Circle-seq and other genetic technologies can be utilized for ecDNA analysis, they fail to...
miR398-SlCSD1 module participates in the SA-H2O2 amplifying feedback loop in Solanum lycopersicum [0.03%]
miR398-SlCSD1模块参与了番茄的水杨酸-H2O2放大反馈环路
Xiujuan Wang,Xinshan Zhang,Yuanyuan Liu et al.
Xiujuan Wang et al.
Introduction: Salicylic acid (SA) is essential for immune response signal transduction in higher plants, with its signaling thought to be enhanced through interactions with reactive oxygen species (ROS). However, the exac...
A novel TGR5 agonist Sauchinone ameliorates IMQ induced murine psoriasis by regulating macrophage polarization [0.03%]
一种新型TGR5激动剂白花前胡素通过调节巨噬细胞极化改善咪喹莫特诱导的小鼠银屑病
Hao-Yu Wang,Su-Ling Huang,Jing Ren et al.
Hao-Yu Wang et al.
Introduction: G-protein-coupled bile acid receptor (TGR5) is a member of G-protein-coupled receptor (GPCR) superfamily that participates in regulating macrophage polarization and resolving inflammatory diseases. Sauchinon...
Niclosamide extends health span and reduces frailty by ameliorating mTORC1 hyperactivation in aging models [0.03%]
尼克地米延长健康寿命并减少衰老模型的衰弱表型通过改善mTORC1过度活化所致的影响
Pyeong Geun Choi,Hee Soo Kim,So-Hyun Park et al.
Pyeong Geun Choi et al.
Introduction: Frailty is characterized by an increased vulnerability to disease and physical debilitation due to a decline in the body's capacity to maintain homeostasis during aging. Therefore, effective management of fr...
From energy metabolism to mood regulation: The rise of lactate as a therapeutic target [0.03%]
从能量代谢到情绪调节：乳酸作为治疗靶点的崛起
Sen Zhang,Jie Xia,Wenke He et al.
Sen Zhang et al.
Background: Disruption of cerebral energy metabolism is increasingly recognized as a key factor in the pathophysiology of mood disorders. Lactate, beyond its role as a metabolic byproduct, is now understood to be a critic...
Prophylactic supplementation with biogenic selenium nanoparticles mitigated intestinal barrier oxidative damage through suppressing epithelial-immune crosstalk with gut-on-a-chip [0.03%]
生物源硒纳米粒子预防性补充通过肠道芯片上皮-免疫互作抑制缓解肠屏障氧化损伤
Lei Qiao,Ge Yang,Tianjing Deng et al.
Lei Qiao et al.
Introduction: Biogenic selenium nanoparticles (SeNPs) have emerged as novel promising modulators of biological reactions such as redox and immune responses due to their multiple bioactivities and unique physicochemical pr...
Astragaloside II, a natural saponin, facilitates remyelination in demyelination neurological diseases via p75NTR receptor mediated β-catenin/Id2/MBP signaling axis in oligodendrocyte precursor cells [0.03%]
Astragaloside Ⅱ通过p75NTR介导的β-catenin/Id2/MBP信号轴促进少突胶质前体细胞在脱髓鞘疾病中的修复作用
Jinfeng Yuan,Yanlin Tao,Mengxue Wang et al.
Jinfeng Yuan et al.
Background: Demyelination is a hallmark of neurological disorders such as multiple sclerosis and neuromyelitis optica, leading to neurological deficits. Existing therapies primarily modulate immune responses but lack effi...
Long read and preliminary pangenome analyses reveal breed-specific structural variations and novel sequences in Holstein and Jersey cattle [0.03%]
长读和初步的泛基因组分析揭示了荷斯坦牛和Jersey牛中特定品种的结构变异及新颖序列
Yahui Gao,Liu Yang,Kristen Kuhn et al.
Yahui Gao et al.
Introduction: Most SV studies in livestock rely on short-read sequencing, posing challenges in accurately characterizing large genomic variants due to their limited read length. ...
Resibufogenin protects against atherosclerosis in ApoE-/- mice through blocking NLRP3 inflammasome assembly [0.03%]
树脂苷素通过阻断NLRP3炎性小体组装保护动脉粥样硬化Apoe基因敲除小鼠模型
Chen Xiaoyang,Chen Yijun,Zhai Chenguang et al.
Chen Xiaoyang et al.
Introduction: Atherosclerosis (AS), a major cause of cardiovascular diseases, is characterized by lipid accumulation and chronic inflammation within arterial walls. Traditional treatments, such as statins, are often ineff...
Urate-lowering effect of delphinidin-3-glucoside in red kidney beans via binding to the FAD site of the XO enzyme [0.03%]
飞燕草素-3-葡萄糖苷通过与黄嘌呤氧化酶的FAD结合位点结合抑制尿酸生成作用机制研究
Yanling Chen,Yingtong Jiang,Lei Huang et al.
Yanling Chen et al.
Background: The incidence of hyperuricemia (HUA) is increasing globally, posing serious health risks. The discovery of natural urate-lowering agents is urgently needed. ...