A 3R-MYB transcription factor is involved in Methyl Jasmonate-Induced disease resistance in Agaricus bisporus and has implications for disease resistance in Arabidopsis [0.03%]
一种3R-MYB转录因子参与了双孢蘑菇中茉莉酸甲酯诱导的疾病抗性，且对拟南芥中的病害抗性具有影响
Shuai Yuan,Hanyue Jiang,Yating Wang et al.
Shuai Yuan et al.
Introduction: Methyl jasmonate (MeJA) and MYB transcription factors (TFs) play important roles in pathogen resistance in several plants, but MYB TFs in conjunction with MeJA-induced defense against Pseudomonas tolaasii in...
Integrated ultrasensitive metabolomics and single-cell transcriptomics identify crucial regulators of sheep oocyte maturation and early embryo development in vitro [0.03%]
集成超灵敏代谢组学和单细胞转录组学鉴定体内羊卵母细胞成熟和早期胚胎发育的关键调节因子
Bo Pan,JianPeng Qin,KunLin Du et al.
Bo Pan et al.
Introduction: Developmental competence of oocytes matured in vitro is limited due to a lack of complete understanding of metabolism and metabolic gene expression during oocyte maturation and embryo development. Convention...
CDK4/6 inhibitor PD-0332991 suppresses hepatocarcinogenesis by inducing senescence of hepatic tumor-initiating cells [0.03%]
CDK4/6抑制剂PD-0332991通过诱导肝癌起始细胞衰老来抑制肝肿瘤发生
Miaomiao Chen,Wenjian Chen,Shiwen Sun et al.
Miaomiao Chen et al.
Introduction: Owing to the limited treatment options for hepatocellular carcinoma (HCC), interventions targeting pre-HCC stages have attracted increasing attention. In the pre-HCC stage, hepatic tumor-initiating cells (hT...
A new 1,2,3-triazole-indirubin hybrid suppresses tumor growth and pulmonary metastasis by mitigating the HGF/c-MET axis in hepatocellular carcinoma [0.03%]
一种新型的1,2,3-三唑-靛玉红杂化物通过缓解HGF/c-MET轴抑制肝细胞癌的肿瘤生长和肺转移
Shalini V Gowda,Na Young Kim,Kachigere B Harsha et al.
Shalini V Gowda et al.
Introduction: Hepatocellular carcinoma (HCC) is a fatal cancer that is often diagnosed at the advanced stages which limits the available therapeutic options. The interaction of HGF with c-MET (a receptor tyrosine kinase) ...
Novel long noncoding lncARF mediated hyperhomocysteinemia-induced atherosclerosis via autophagy inhibition in foam cells [0.03%]
新型长链非编码RNA lncARF通过抑制泡沫细胞自噬促进高同型半胱氨酸血症诱导的动脉粥样硬化形成
Ning Ding,Shengchao Ma,Qingning Chang et al.
Ning Ding et al.
Introduction: Homocysteine (Hcy) is well recognized to be an independent risk factor for atherosclerosis. Long non-coding RNAs (lncRNAs) are emerging regulators of pathophysiological processes including atherosclerosis, w...
High-resolution 3D spatial distribution of complex microbial colonies revealed by mass spectrometry imaging [0.03%]
基于质谱成像技术揭示复杂的微生物菌落的高空间分辨三维分布
Yuting Shen,Yisu Wang,Jianing Wang et al.
Yuting Shen et al.
Introduction: Bacterial living states and the distribution of microbial colony signaling molecules are widely studied using mass spectrometry imaging (MSI). However, current approaches often treat 3D colonies as flat 2D d...
Simultaneous detection of membrane protein and mRNA at single extracellular vesicle level by droplet microfluidics for cancer diagnosis [0.03%]
基于微滴微流控的单细胞外囊泡膜蛋白和mRNA的同时检测用于癌症诊断
Huixian Lin,Bo Li,Jingyun Guo et al.
Huixian Lin et al.
Introduction: Simultaneous detection of proteins and mRNA within a single extracellular vesicle (EV) enables comprehensive analysis of specific EVs subpopulations, significantly advancing cancer diagnostics. However, deve...
New insights into the function and mechanisms of piRNA PMLCPIR in promoting PM2.5-induced lung cancer [0.03%]
PiRNA PMLCPIR在促进PM2.5诱导的肺癌发生发展中的功能及机制研究新进展
Lin Xu,Wanli Ma,Xiaoyu Huo et al.
Lin Xu et al.
Introduction: Extensive studies have established the correlation between long-term PM2.5 exposure and lung cancer, yet the mechanisms underlying this association remain poorly understood. PIWI-interacting RNAs (piRNAs), a...
Nervonic acid triggered ovarian inflammation by inducing mitochondrial oxidative stress to activate NLRP3/ IL-1β pathway [0.03%]
神经酸通过诱导线粒体氧化应激激活NLRP3/IL-1β信号通路触发卵巢炎症
Xiangzhou Zeng,Xinyin Fan,Haitao Yu et al.
Xiangzhou Zeng et al.
Introduction: Metabolic syndrome is a serious public health concern across the globe. However, the typical metabolites and mechanisms underlying the decreased fertility related to metabolic syndrome is still elusive. ...
Dual nature of type I interferon responses and feedback regulations by SOCS1 dictate malaria mortality [0.03%]
I型干扰素反应的双重性质及其由SOCS1介导的反馈调节决定疟疾死亡率
Jiansen Lu,Zhiqiang Hu,Huaji Jiang et al.
Jiansen Lu et al.
Introduction: Type I interferon (IFN-I, IFN-α/β), precisely controlled by multiple regulators, including suppressor of cytokine signaling 1 (SOCS1), is critical for host defense against pathogens. However, the impact of...