Electromagnetic fields regulate iron metabolism: From mechanisms to applications [0.03%]
电磁场调节铁代谢：从机制到应用
Shenghang Wang,Jiancheng Yang,Chenxiao Zhen et al.
Shenghang Wang et al.
Background: Electromagnetic fields (EMFs), as a form of physical therapy, have been widely applied in biomedicine. Iron, the most abundant trace metal in living organisms, plays a critical role in various physiological pr...
Proteomic profiling in cerebrospinal fluid reveal biomarkers for shunt outcome in idiopathic normal-pressure hydrocephalus [0.03%]
脑脊液蛋白质组学揭示了特发性正常压力脑积水分流效果的生物标志物
Yuqi Ying,Jingquan Lin,Wei Gao et al.
Yuqi Ying et al.
Background: The pathophysiology of idiopathic normal pressure hydrocephalus (iNPH) remains unclear, and the treatment strategy remains suboptimal. This study aims to identify biomarkers for shunt prognosis by cerebrospina...
Nutritional and hormonal regulation of mitochondrial biogenesis drives fat body remodeling for reproductive competence [0.03%]
营养和激素调节线粒体生物发生以适应生殖反应脂肪体重塑
Yiying Li,Mengyao Lang,Qiongjie He et al.
Yiying Li et al.
Introduction: Insect fat body serves as a central hub for energy mobilization and protein synthesis. During larval metamorphosis, fat body undergoes programmed cell death and tissue disassembly. Following adult eclosion, ...
OTUD1 delays wound healing by regulating endothelial function and angiogenesis in diabetic mice [0.03%]
OTUD1通过调节糖尿病小鼠内皮细胞功能和血管生成来延缓伤口愈合
Jiajia Zhang,Weiqi Li,Yanan Liu et al.
Jiajia Zhang et al.
Introduction: Diabetic non-healing wounds represent a major complication of diabetes, primarily due to impaired angiogenesis. Ovarian tumor deubiquitinase 1 (OTUD1), a deubiquitinase, has been implicated in vascular patho...
Modulation of Macrophage ferroptosis under the guide of infrared thermography promotes the healing of pressure injuries [0.03%]
红外热图引导巨噬细胞铁死亡调控促进压伤愈合
Xiaoqiong Jiang,Xuanlong Zhang,Huiming Deng et al.
Xiaoqiong Jiang et al.
Background: Accurately recognizing and regulating the transition time of macrophages to a pro- (M1-like) or anti-inflammatory (M2-like) state is essential for improving chronic inflammation in pressure injuries (PIs). ...
Developmentally endothelial locus-1 facilitates intestinal inflammation resolution by suppressing the Cmpk2-cGAS-STING pathway and promoting reparatory macrophage transition [0.03%]
发育内皮定位基因1通过抑制Cmpk2-cGAS-STING通路并促进修复性巨噬细胞转化来促进肠道炎症消退
Meihui Tao,Li Wang,Chaoyue Chen et al.
Meihui Tao et al.
Introduction: Abnormalities in inflammation resolution function are intimately linked to chronic inflammation, and proresolution therapies may offer novel opportunities for IBD treatment. Developmental endothelial locus 1...
Circular RNA circATM binds PARP1 to suppress Wnt/β-catenin signaling and induce cell cycle arrest in gastric cancer cells [0.03%]
CircularRNA circATM通过结合PARP1抑制Wnt/β-catenin信号通路并诱导胃癌细胞周期停滞
Xiaohui Zhu,Xiaojing Zhang,Ying Qin et al.
Xiaohui Zhu et al.
Introduction: Gastric cancer (GC) is a common malignancy, which is associated with high rates of morbidity and mortality. Despite therapeutic advancements, there is an overall lack of effective treatment options for patie...
CircPAFAH1B2 induces chondrocytes mitochondrial dysfunction and promotes cartilage degeneration through binding molecular chaperone ClpB [0.03%]
Circular RNA CircPAFAH1B2通过结合分子伴侣ClpB诱导软骨细胞线粒体功能障碍并促进软骨退变
YuFan Bu,Chang Zhao,Yewen Qian et al.
YuFan Bu et al.
Introduction: This study explores the role of circPAFAH1B2 in osteoarthritis (OA) by investigating its influence on nuclear-mitochondrial communication, a largely unexplored area in OA progression. By uncovering how circP...
Chaperone-mediated autophagy sustains pericyte stemness necessary for brain tissue homeostasis [0.03%]
伴侣介导的自噬维持脑组织稳态所需周细胞干细胞性质
Maria Dolores Salinas,Carlos M Martínez,Francisco J Roca et al.
Maria Dolores Salinas et al.
Introduction: Pericytes (PCs) are mural cells exhibiting some mesenchymal stem cell (MSC) properties and contribute to tissue regeneration after injury. We have previously shown that glioblastoma cancer cells induce in PC...
JAK3-deficient mimi-pigs exhibit impaired lymphoid organogenesis, intestinal structure, and leukocyte/cytokine production [0.03%]
JAK3缺陷型微型猪表现出淋巴器官发生、肠道结构以及白细胞/细胞因子产生的异常
Pil-Soo Jeong,Hae-Jun Yang,Young-Ho Park et al.
Pil-Soo Jeong et al.
Introduction: Severe combined immunodeficiency (SCID) mini-pigs are a highly versatile model for human disease research and regenerative medicine. Objecti...