Genomic insights into the population history of fat-tailed sheep and identification of two mutations that contribute to fat tail adipogenesis [0.03%]
基因组视角下的脂肪尾羊种群历史研究及两个促进脂肪尾形成的突变位点鉴定
Meilin Jin,Gang Liu,Enmin Liu et al.
Meilin Jin et al.
Introduction: Since their domestication, domestic sheep (Ovis aries) have been culturally and economically significant farming animals worldwide. Fat-tailed sheep serve as a unique genetic resource for understanding adipo...
Rab32-based vesicles coordinate mitochondria and actin for spindle migration and organelle rearrangement in oocyte meiosis [0.03%]
Rab32依赖囊泡调控卵母细胞减数分裂纺锤体迁移及线粒体重排的功能及机制研究
Hao-Lin Zhang,Qian Cui,Xiao-Ting Yu et al.
Hao-Lin Zhang et al.
Introduction: Rab32 is part of the Rab GTPase family, which is known as the regulator of vesicle transport for an array of cellular functions including endosomal transport, autophagy, generation of melanosomes, phagocytos...
PEBL, a component-based Chinese medicine, reduces virus-induced acute lung injury by targeting FXR to decrease ACE2 levels [0.03%]
靶向法尼醇受体降低ACE2表达的组分中药PEBL对病毒诱发急性肺损伤的作用研究
Liling Yang,Xiangjun Zhou,Junshan Liu et al.
Liling Yang et al.
Introduction: Despite the growing clinical need, the therapeutic efficacy of drugs for acute lung injury (ALI) remains inadequate. Traditional Chinese Medicine (TCM) holds potential in managing ALI due to its unique thera...
NRXN3 regulates pyroptosis in intrahepatic cholangiocarcinoma via mediating the phospho-dependent ubiquitination and degradation of caspase-3 [0.03%]
NRXN3通过介导磷酸化依赖性泛素化和降解Caspase-3来调节肝内胆管癌的焦亡作用
Tao Zhou,Yaodong Zhang,Tianlin Wang et al.
Tao Zhou et al.
Introduction: Intrahepatic cholangiocarcinoma (ICC) remains one of the most lethal malignancies with an increasing incidence worldwide. Gemcitabine has been considered the standard first-line chemotherapeutic agent for IC...
Regulation of apocarotenoids for quality improvement and biofortification of horticultural crops [0.03%]
利用 apo- 类类胡萝卜素改善园艺作物品质及营养强化的研究进展
Lihong Liu,Yuening Li,Chunxia Jian et al.
Lihong Liu et al.
Background: Agro-food production and consumption impact climate change and human health. Bioactive secondary metabolites in horticulture crops make them an indispensable part of environmentally sustainable and healthy die...
Construction of safer hirudin-derived peptides with enhanced anticoagulant properties based on C-terminal active residue adaptation and modification [0.03%]
基于C端活性残基适应性和改良的更具抗凝血功效的安全的新涎素肽类化合物的构建
Xiaozhe Yi,Xiaoli Wu,Erhuan Zang et al.
Xiaozhe Yi et al.
Introduction: Hirudin exerts anticoagulant effects by inhibiting the binding and catalytic activity of thrombin to fibrinogen. However, its rigid N-terminal region irreversibly occupies the thrombin catalytic center, rais...
Statistical agnostic regression: A machine learning method to validate regression models [0.03%]
统计无偏回归：一种验证回归模型的机器学习方法
J M Gorriz,J Ramirez,F Segovia et al.
J M Gorriz et al.
Introduction: Regression analysis is a central topic in statistical modeling, aimed at estimating the relationships between a dependent variable, commonly referred to as the response variable, and one or more independent ...
AMPCliff: Quantitative definition and benchmarking of activity cliffs in antimicrobial peptides [0.03%]
基于抗菌肽的活性悬崖的定量定义及基准测试
Kewei Li,Yuqian Wu,Yinheng Li et al.
Kewei Li et al.
Introduction: Activity cliff (AC) is a phenomenon that a pair of similar molecules differ by a small structural alternation but exhibit a large difference in their biochemical activities. This phenomenon affects various t...
Dual effects of vaginal Candida albicans on human papillomavirus infection: A large-scale multicenter study in Chinese women [0.03%]
白色念珠菌的阴道感染对人乳头瘤病毒感染的双重影响：中国女性的大规模多中心研究
Muxuan Chen,Rongdan Chen,Yingxuan Zhang et al.
Muxuan Chen et al.
Objectives: Vaginal infections caused by Candida albicans and human papillomavirus (HPV) are common, yet their interactions remain complex and poorly understood. ...
Suppressing wheat sucrose phosphate synthase 1-B protects wheat against stripe rust [0.03%]
抑制小麦蔗糖磷酸合成酶1-B可保护小麦抵御条锈病
Yan Yan,Meng-Lu Wang,Zhen Zhang et al.
Yan Yan et al.
Introduction: Stripe rust caused by Puccinia striiformis Westend. f. sp. tritici (Pst) is a highly destructive wheat disease that threatens global food security. Pst extracts energy from wheat by interfering with photosyn...