Activation of Sirt6 by icariside Ⅱ alleviates depressive behaviors in mice with poststroke depression by modulating microbiota-gut-brain axis [0.03%]
黄酮类化合物icariside Ⅱ通过调节微生物-肠-脑轴激活Sirt6减轻中风后抑郁小鼠的抑郁行为
Jianmei Gao,Yifan He,Fuguo Shi et al.
Jianmei Gao et al.
Background: Sirt6-mediated gut microbiota plays a vital role in poststroke depression (PSD). Icariside Ⅱ (ICS Ⅱ) is a naturally-occurring neuroprotectant with Sirt6 induction potency. However, it is unknown whether ICS ...
The causal links between long-term exposure to major chemical components of PM2.5 and overall outpatient visits in mainland China: A nationwide study in the difference-in-differences framework [0.03%]
长期暴露于PM2.5主要化学成分与中国大陆总体门诊就诊之间的因果联系：差异中的差异框架下的全国性研究
Shuaiqi Zhang,Zhibing Chen,Zhicheng Du et al.
Shuaiqi Zhang et al.
Introduction: Although the adverse health effects of PM2.5 exposure has been well documented, evidence of its adverse effect on overall outpatient visits was still limited. Besides, the adverse health effects of PM2.5 exp...
Reinforcement learning-based generative artificial intelligence for novel pesticide design [0.03%]
基于强化学习的生成式人工智能在新型农药设计中的应用
Ruoqi Yang,Biao Li,Jin Dong et al.
Ruoqi Yang et al.
Introduction: Pesticides play a pivotal role in ensuring food security, and the development of green pesticides is an inevitable trend in global agricultural progress. Although deep learning-based generative models have r...
Factors affecting the intracytoplasmic sperm cell injection outcomes: A meta-analysis of porcine studies [0.03%]
影响胞浆内精子注射结果的因素：猪研究的meta分析
Muhammad Ameen Jamal,Ali Husnain,Kaixiang Xu et al.
Muhammad Ameen Jamal et al.
Background: Intracytoplasmic sperm cell injection (ICSI) has the potential to produce gene-edited (GE) pigs for biomedical research, but its success is limited. The factors impeding ICSI in pigs are impractical in-vivo oo...
Corrigendum to Exopolysaccharide from the yeast Papiliotrema terrestris PT22AV for skin wound healing [Journal of Advanced Research,Volume 46, April 2023, Pages 61-74] [0.03%]
关于酵母Papiliotrema terrestris PT22AV的外聚糖在皮肤伤口愈合中的应用[《高级研究杂志》，第46卷，2023年4月，第61-74页]的勘误表
Masoud Hamidi,Oseweuba Valentine Okoro,Giuseppe Ianiri et al.
Masoud Hamidi et al.
Dual function of MrgprB2 receptor-dependent neural immune axis in chronic pain [0.03%]
MrgprB2受体依赖性神经免疫轴在慢性疼痛中的双重功能
Yucui Jiang,Fan Ye,Jian Zhang et al.
Yucui Jiang et al.
Introduction: Neuro-immune interactions have been recognized to be involved in the development of neuropathic pain induced by chemotherapeutic drugs (CINP). However, its role in pain resolution remains largely unknown, pa...
Four distinct pathways involved in a "tug-of-war" lead to the non-linear nature of phenolic chemistry during lactic acid fermentation of fruits and vegetables [0.03%]
水果和蔬菜乳酸发酵过程中，“拔河”所涉及的四条独特途径导致酚类化学的非线性特性
Yuqing Duan,Fanqiang Meng,Sivakumar Manickam et al.
Yuqing Duan et al.
Introduction Lactic acid fermentation of fruits and vegetables (F&V) is endowed with new nutrients and flavors. "Phenolics" is a hot spot in this area, which evolve irregularly during fermentation. However, the mechanism about this non-line...
Long non-coding RNA LINC01532 sustains redox homeostasis and accelerates lenvatinib resistance in hepatocellular carcinoma [0.03%]
长链非编码RNA LINC01532维持氧化还原稳态并加速肝细胞癌中对乐伐替尼的耐药性形成
Yang Hu,Muhua Chen,Shiqi Sun et al.
Yang Hu et al.
Introduction: Lenvatinib is the first-line therapy of hepatocellular carcinoma (HCC) and the high frequency of lenvatinib resistance hinders the improvement of HCC treatment. Since NADPH plays vital roles in antioxidant d...
NRIR promotes immune escape in hepatocellular cancer by regulating IFNγ-induced PD-L1 expression [0.03%]
NRIR通过调节IFNγ诱导的PD-L1表达促进肝细胞癌免疫逃逸
Yan Zhou,Jing Wang,Yuanhang Chen et al.
Yan Zhou et al.
Introduction: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide, with insensitive treatment and poor prognosis; in recent years, breakthroughs in IFN signaling pathway and PDL1/PD1 signal...
Tubular epithelial cell-derived Flt3L is required for type 1 conventional dendritic cell (cDC1) activation and expansion in promoting the recovery in acute kidney injury [0.03%]
管状上皮细胞衍生的Flt3L对于急性肾损伤中促进恢复的类型1常规树突细胞(cDC1)激活和扩增是必需的
Na Li,Stefanie Steiger,Yao Guo et al.
Na Li et al.
Introduction: Dendritic cells (DCs) play a crucial role in the recovery following acute kidney injury (AKI). Fms-related tyrosine kinase 3 ligand (Flt3L) is essential for the generation and maintenance of DCs. However, th...