Three-dimensional multimodal imaging for predicting early recurrence of hepatocellular carcinoma after surgical resection [0.03%]
三维多模态影像预测肝癌手术切除后早期复发的研究
Jie Peng,Jiaren Wang,Hongbo Zhu et al.
Jie Peng et al.
Background: High tumor recurrence after surgery remains a significant challenge in managing hepatocellular carcinoma (HCC). We aimed to construct a multimodal model to forecast the early recurrence of HCC after surgical r...
Root-derived low molecular weight organic acids modulate keystone microbial taxa impacting plant phosphorus acquisition [0.03%]
根系来源的低分子量有机酸调节关键微生物类群以影响植物磷素吸收
Jie Zheng,Guangping Shi,Francisco Dini-Andreote et al.
Jie Zheng et al.
Introduction: Low-molecular-weight organic acids (LMWOAs) present in root exudates modulate the assembly and function of phosphorus (P)-mobilizing bacteria in the rhizosphere. Nonetheless, relatively little is known about...
Probiotics and triglyceride manipulation: potential implications for alleviating hypertriglyceridemia [0.03%]
益生菌与甘油三酯调节：对缓解高甘油三酯血症的潜在影响
Mingliang Zhang,Weimin Jiang,Jie Yin et al.
Mingliang Zhang et al.
Background: Hypertriglyceridemia is one of the most prevalent lipid abnormalities encountered in clinical practice. Although many monogenic disorders causing severe hypertriglyceridemia have been identified, in most patie...
Age-dependent elevation of Nr4a1 attenuates PI3K/AKT/GSK3β pathway and mediates tau hyperphosphorylation and cognitive impairments [0.03%]
Nr4a1年龄依赖性升高通过抑制PI3K / AKT / GSK3β通路介导tau过度磷酸化和认知障碍
Ling Lei,Qian Guo,Yilei Cheng et al.
Ling Lei et al.
Introduction: Tau hyperphosphorylation exhibited in Alzheimer's brains is also commonly observed in aging process, however, the molecular mechanism underlying tau hyperphosphorylation in aging is largely unknown. The nucl...
GhGLDH35A gene-mediated ROS homeostasis and stomatal movement via the ascorbic acid pathway confers alkaline stress tolerance [0.03%]
通过抗坏血酸途径介导的GhGLDH35A基因ROS稳态和气孔运动以提高耐碱性
Yapeng Fan,Ning Wang,Shuai Wang et al.
Yapeng Fan et al.
Introduction: Ascorbic acid (AsA) is involved in plant responses to various abiotic stresses. However, its specific function in alkaline stress tolerance remains poorly understood. The L-galactono-1,4-lactone dehydrogenas...
Mesenchymal stem cell transplantation alleviated TBI-induced lung injury by inhibiting PAD4-dependent NET formation [0.03%]
间充质干细胞移植通过抑制PAD4依赖性的NET形成缓解创伤性脑损伤引起的肺损伤
Jing Peng,Fengming Pan,Yu Xu et al.
Jing Peng et al.
Introduction: Traumatic brain injury (TBI) affects millions of people worldwide and often results in significant extracranial complications, particularly acute respiratory distress syndrome (ARDS). The mechanisms underlyi...
FGFs/FGFRs and neuroinflammatory diseases: mechanism, drug therapies and delivery systems [0.03%]
FGFs/FGFRs与神经炎症性疾病：机制、药物治疗及递送系统
Juan Wang,Lijuan Xing,Song Yang et al.
Juan Wang et al.
Background: Fibroblast Growth Factors and Fibroblast Growth Factor Receptors (FGFs/FGFRs) constitute a complex and diverse signaling system crucial in various biological processes, such as cell proliferation, differentiat...
Targeting post-translational modifications: novel insights into bone metabolic diseases [0.03%]
骨代谢疾病的蛋白质修饰调控新机制研究进展
Hui Kong,Juan-Juan Han,Guo Liang et al.
Hui Kong et al.
Background: Bone metabolic diseases constitute a group of disorders characterized by abnormal alterations in bone mass and skeletal metabolism, often resulting from oxidative stress, nutritional deficiencies, and various ...
Ion interference induced by Ca-Mn nanoplatform enhances ferroptosis and promotes immune response for osteosarcoma treatment [0.03%]
锰钙纳米平台诱导的离子干扰增强铁死亡并促进免疫反应以治疗骨肉瘤
Minyi Zhang,Qi Wang,Chen Li et al.
Minyi Zhang et al.
Introduction: Ion interference therapy has emerged as a promising new treatment for Osteosarcoma (OS). However, its efficacy is significantly restricted by inadequate hydrogen peroxide (H2O2) under the complex tumor micro...
The purinergic receptor P2rx7 mediated ATP sensing is required to prevent bone aging by directing mitochondrial fitness of MSCs [0.03%]
ATP感应的嘌呤受体P2rx7介导的骨衰老预防机制通过调节MSC中的线粒体活性起作用
Zimeng Zhuang,Chunshan Han,Meilian Cai et al.
Zimeng Zhuang et al.
Background: Bone aging, displays osteoporosis and impaired bone formation, intricately linked to the metabolic alteration of mesenchymal stem cells (MSCs). However, the precise mechanisms underlying this relationship rema...