Engineering a multifunctional nanoplatform with cascade catalytic and bidirectional immunomodulatory capacities for integrating sepsis therapy [0.03%]
工程化多功能纳米平台用于整合脓毒症治疗，其具有级联通用和双向免疫调节功能
Yao Xiao,Xiaoyong Zhang,Dandan Che et al.
Yao Xiao et al.
Introduction: Sepsis is a life-threatening condition characterized by organ dysfunction due to a dysregulated immune response to infection. Despite extensive research into its complex pathogenesis, effective clinical trea...
Metabolic vulnerabilities in ovarian cancer decoding the nexus between nutrient adaptation and therapy resistance [0.03%]
卵巢癌中的代谢弱点及其营养适应和治疗耐药之间的关系解析
Xiaoyu Guo,Zongang Liu,Xiaoman Li et al.
Xiaoyu Guo et al.
Background: Ovarian cancer (OC) is a leading cause of gynecologic cancer-related mortality, primarily due to frequent therapy resistance and disease recurrence. Growing evidence indicates that metabolic reprogramming serv...
Treatment of clonal hematopoiesis associated atherosclerosis via vaccine-based clearance of the mutant cells [0.03%]
通过疫苗清除突变细胞治疗克隆性血液疾病相关的动脉粥样硬化
Shuang Liang,Wenxin Tao,Di Qu et al.
Shuang Liang et al.
Clonal hematopoiesis of indeterminate potential (CHIP), driven by somatic mutations (e.g., TET2), is an independent risk factor for atherosclerosis (AS). CHIP-mutant macrophages promote plaque inflammation, but targeted therapies are lackin...
Snapin mediates neuronal PANoptosis after mild traumatic brain injury via H2S-dependent S-sulfhydration of CTSD [0.03%]
轻度脑损伤后Snapin介导的神经元PANoptosis发生及其机制研究：H2S依赖性的CTSD翻译后修饰(S-硫化)在其中的作用
Xueshi Chen,Xinqi Huang,Yumei An et al.
Xueshi Chen et al.
Introduction: Traumatic brain injury (TBI) induces complex secondary neuronal death, yet no specific therapeutic strategies are available to ameliorate post-traumatic neurological dysfunction. PANoptosis is a coordinated ...
Multi-targeted synergy of Bacillus sp. TC5 fermentation products for transdermal drug delivery and hair regeneration [0.03%]
芽孢杆菌TC5发酵产物的多靶点协同作用促进经皮药物递送及毛发再生
Dan Liu,YiDan Chen,WenZhao Li et al.
Dan Liu et al.
Introduction: The stratum corneum represents a major barrier to transdermal drug delivery, while limited follicular activity contributes to hair loss disorders. Bacillus species, generally recognized as safe microorganism...
Decoding intervertebral disc degeneration pathomechanics: from mechanisms to therapeutic horizons [0.03%]
椎间盘退变发病机制的解析：从机制到治疗前景
HanLin Qiao,TongLei Chen,Jing Yu et al.
HanLin Qiao et al.
Background: Intervertebral disc degeneration (IVDD) is widely recognized as a key factor in various lumbar spine disorders. Biomechanical factors play a crucial role in maintaining homeostasis and influencing the degenera...
Pan-cancer epigenetic landscape of human tumor-associated macrophages reveals crucial enhancers governing their heterogenous formation by Pol II pausing modulation [0.03%]
泛癌症人类肿瘤相关巨噬细胞表观遗传景观的绘制揭示了Pol II暂停调控异质形成的关键增强子
Chenchen Xiong,Hanhan Ning,Xiaoqiang Wang et al.
Chenchen Xiong et al.
Introduction: Tumor-associated macrophages (TAMs) are a functionally heterogeneous population within the tumor microenvironments, exhibiting both anti-tumor and pro-tumor functions. Pro-tumorigenic TAMs can derive from pe...
A DNA triangular prism scaffold-guided directionally-controlled derailment-free DNAzyme walker [0.03%]
一种DNA三角棱柱支架导向的定向无脱轨DNAzyme行走器
Limei Xiao,Yaqin Wang,Hong Huang et al.
Limei Xiao et al.
Introduction: Deoxyribozyme (DNAzyme) with RNA cleavage activity, including a DNAzyme walker, has been extensively explored as the tool for cancer diagnosis and therapy due to its excellent programmability, stability, and...
Distinct effector functions and synergy of CAR mRNA-engineered T cells and macrophages in the clearance of CD19+ leukemia cells [0.03%]
针对CD19+白血病细胞清除的CAR mRNA工程T细胞和巨噬细胞的特异性效应功能及协同作用
Liangliang Liao,Cheng Lin,Adrian Kuzmanović et al.
Liangliang Liao et al.
Introduction: Chimeric antigen receptor (CAR) technology represents a groundbreaking advancement in gene therapy. While CAR-T cells are approved for specific types of leukemia, the therapeutic potential of CAR-macrophages...
Construction of musculoskeletal quantitative model based on deep learning and study of musculoskeletal relationship in patients with osteoporosis [0.03%]
基于深度学习的骨代谢性疾病定量模型构建及骨质疏松症患者肌肉骨骼关系研究
Zhenzhen Guan,Yijin Wang,Shiyu Zhang et al.
Zhenzhen Guan et al.
Introduction: Lumbar CT and MRI scans are helpful for osteoporosis (OP) screening. Deep learning enhances the efficiency and accuracy of musculoskeletal quantification for OP screening. ...