Transforming destructive mechanical cues into therapeutic power: Activation of PIEZO1 and TRPV4 counteracts mechano-induced damage of cellular junctions in Hailey-Hailey disease [0.03%]
将破坏性机械刺激转化为治疗力量：PIEZO1和TRPV4的激活可对抗Hailey-Hailey病中的细胞连接损伤效应
Jiahui Hu,Yuanbo Jia,Fan Feng et al.
Jiahui Hu et al.
Introduction: Hailey-Hailey disease (HHD) is characterized by impaired intracellular calcium transport due to ATP2C1 mutations, leading to defective interkeratinocyte adhesion and acantholysis, especially under mechanical...
Novel protein acylations in Alzheimer's disease: molecular, mechanisms, biological significance, and diagnostic and therapeutic potentials [0.03%]
阿尔茨海默病中的新型蛋白质脂化：分子机制、生物学意义及诊断和治疗潜力
Yue Yang,Zhihua Yu,Rui Gao et al.
Yue Yang et al.
Background: Alzheimer's disease (AD) is a prevalent neurodegenerative disorder characterized by complex pathogenesis including amyloid-β (Aβ), hyperphosphorylated tau mediated neurofibrillary tangles (NFTs), energy meta...
Spop-binding bifunctional degraders: a novel approach for cancer immunotherapy [0.03%]
靶向SPOP的双功能降解剂：癌症免疫治疗的新策略
Binbin Cheng,Zhihua Kong,Yaru Shi et al.
Binbin Cheng et al.
Introduction: Current PD-L1 degraders, whether antibody-based or small-molecule-mediated, are hindered by limitations in pharmacokinetics (e.g., poor tissue penetration) or pharmacodynamics (e.g., suboptimal degradation e...
Rhein alleviates acute pancreatitis by inhibiting TMAO-mediated inflammatory signaling pathways and reducing acinar cell injury [0.03%]
莱根通过抑制三甲胺-N-氧化物介导的炎症信号通路和减少腺泡细胞损伤来缓解急性胰腺炎
Yunshu Zhang,Jifeng Liu,Xiaonan Zhang et al.
Yunshu Zhang et al.
Introduction: Acute pancreatitis (AP) represents a significant global health challenge. Despite recent advances in medical treatment, the development of novel therapeutic strategies remains crucial. ...
A rapidly fabricated bone marrow enrichment material with a controllable pore size promotes osteogenesis close to autogenous bone graft in clinic [0.03%]
一种可调控孔径的快速制备的骨髓富集材料促进临床异体骨移植近似自体骨移植成骨修复
Qiandong Yang,Bo Yu,Chunyu Liu et al.
Qiandong Yang et al.
Introduction: The shortage of highly osteogenic grafts significantly impacts clinical bone repair and reconstruction in clinic. Selective cell retention technology increases the number of bone marrow (BM)-derived osteogen...
Cinnamic acid derivatives in agrochemicals: current use and future perspective [0.03%]
香豆酸衍生物在农药中的应用：现状与未来展望
Qiong Lei,Wei Zhang,Wang Geng et al.
Qiong Lei et al.
Cinnamic acid (CA) and its derivatives are usual phenylpropanoids including natural products and synthetic compounds, which are widely used in various fields due to their robust and broad-spectrum biological activities, and eco-friendly pro...
Diosgenin activates ERα-dependent PI3K/AKT/GSK3β signaling to enhance brain-derived serotonin and alleviate postmenopausal bone loss [0.03%]
薯蓣皂苷通过激活ERα依赖的PI3K / AKT / GSK3β信号通路增强脑源性血清素的生成并缓解绝经后骨质流失
Xi Chen,MengXue Zhang,Lihui Qian et al.
Xi Chen et al.
Introduction: Postmenopausal osteoporosis (PMOP) stems from estrogen deficiency, which leads to reduced central serotonin (5-HT) levels, induces depressive-like behaviors, enhances sympathetic nervous system (SNS) activit...
A lightweight fully convolutional neural network for efficient and accurate tunnel crack detection [0.03%]
一种用于隧道裂缝高效精准检测的轻量级全卷积网络
Hao Huang,G T S Ho,V Tang et al.
Hao Huang et al.
Introduction: Crack damage is a significant issue in tunnel environments, requiring efficient and reliable detection to ensure structural integrity. Many existing solutions are computationally expensive, making them unsui...
Burden profiles and mortality-attributable risk factors for gastrointestinal cancers: A comprehensive analysis, 1990-2021 [0.03%]
1990-2021年全球胃肠肿瘤疾病负担及归因危险因素的综合分析
Ahui Fan,Chunbaixue Yang,Yangyan Fan et al.
Ahui Fan et al.
Background: Gastrointestinal (GI) cancers accounted for 23.6% of new cancer cases and 34.2% of cancer-related deaths globally. A comprehensive understanding of GI cancer burden and mortality-attributable risk factors is u...
Eravacycline and omadacycline Rescue multidrug-resistant Elizabethkingia anophelis: Triple-Model evaluation across in Vitro, Galleria mellonella, and murine bacteremia systems [0.03%]
依托伐青霉素和奥马潘南治疗耐多药的伊丽莎白菌：在体外、大蜡螟和小鼠菌血症模型中的三重评估
Shaohua Hu,Li Jiang,Hao Xu et al.
Shaohua Hu et al.
Introduction: Elizabethkingia anophelis has emerged as a formidable pathogen causing severe, life-threatening human infections. Treatment remains challenging due to its intrinsic multidrug resistance. ...