Computational discovery and repurposing of chloramphenicol succinate as a potent P2Y14 receptor antagonist for inflammatory bowel disease therapy [0.03%]
计算发现和再定位氯霉素琥珀酸盐作为炎症性肠病治疗的强效P2Y14受体拮抗剂
Sheng Tian,Kai Wang,Chunxiao Liu et al.
Sheng Tian et al.
Introduction: The P2Y14 receptor (P2Y14R), a Gi-coupled receptor activated by UDP-glucose, plays a critical role in inflammatory responses and immune regulation. Existing P2Y14R antagonists face limitations such as poor b...
Long noncoding RNA Nron and its functional motif modulate macrophage-mediated inflammatory response [0.03%]
长非编码RNA Nron及其功能基序调节巨噬细胞介导的炎症反应
Liuye Yang,Pengchao Wang,Kaiyuan Liu et al.
Liuye Yang et al.
Introduction: Non-resolving macrophage-mediated inflammation is closely linked to the pathogenesis of systemic inflammatory response syndrome. Despite years of clinical trials attempting to mitigate the harmful effects of...
The gut-tumor connection: the role of microbiota in cancer progression and treatment strategies [0.03%]
肠道-肿瘤关联：微生物群在癌症进展与治疗策略中的作用
Ziqing Wei,Guangqi Gao,Qiuwen He et al.
Ziqing Wei et al.
Background: The tumor microenvironment (TME) has become a critical focus in the diagnosis and treatment of cancer. The involvement of the microbiome in tumor initiation and progression underscores its potential as a promi...
Flexible wearable medical devices: from material innovations and data processing to intelligent healthcare applications [0.03%]
灵活的可穿戴医疗设备：从材料创新和数据处理到智能医疗应用
Junxi Zhou,Qingbo Zhang,Ming Zhang et al.
Junxi Zhou et al.
Background: Flexible wearable medical devices drive healthcare transformation via non-invasive, real-time physiological monitoring and personalized management. Traditional rigid devices lack long-term comfort, while chron...
Application of machine learning and deep learning in metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis [0.03%]
机器学习和深度学习在代谢功能异常相关脂肪性肝病中的应用：系统回顾和荟萃分析
Huan Zhang,Xiangyu Wu,Wenjing Ni et al.
Huan Zhang et al.
Introduction: Metabolic dysfunction-associated steatotic liver disease (MASLD) can progress to metabolic dysfunction-associated steatohepatitis (MASH) and liver fibrosis, contributing to a heavier global health burden. No...
Research progress and therapeutic strategies in hepatocellular carcinoma metabolic reprogramming [0.03%]
肝细胞癌代谢重编程的研究进展与治疗策略
Haibo Wang,Yu Lun,Dongdong Xu et al.
Haibo Wang et al.
Background: Hepatocellular carcinoma (HCC) remains a leading cause of cancer-related mortality worldwide, with therapeutic resistance posing a significant clinical challenge. Metabolic reprogramming, a hallmark of cancer,...
The role of induced resistance in mitigating postharvest fungal diseases in fruits and vegetables [0.03%]
诱导抗性在果蔬产后真菌病害防控中的作用研究进展
Yuan Sui,Zhen Li,Xianmei Xiao et al.
Yuan Sui et al.
Background: The process of fruit ripening after harvest renders them susceptible to water loss and disease development by fungal pathogens. Postharvest fungal diseases compromise produce quality and reduce marketable yiel...
Serum uric acid and its metabolism-a vital factor in the inflammatory transformation of cancer [0.03%]
血清尿酸及其代谢-癌症炎性转化的关键因素
Zongping Li,Yingyu Su,Hang Su et al.
Zongping Li et al.
Background: Uric acid (UA) is the terminal product of purine metabolism. Elevated serum uric acid (SUA) levels, resulting from excessive synthesis or impaired excretion, are link to chronic inflammatory stress and increas...
The advent of precision nutrigeroscience in cancer: from clinic towards molecular biology [0.03%]
肿瘤精准营养生殖科学的出现：从临床到分子生物学
Zhijie Gao,Yunqing Liu,Yujie Cui et al.
Zhijie Gao et al.
Nutrimental patterns have been deemed to have an impact on cancer development and the response to cancer therapy. Our growing understanding of cancer and host metabolism has highlighted that nutrient availability in the tumor ecosystem is a...
Compartment-specific archaeal responses to alpine wetland grasslandification reveal distinct taxonomic, functional, and network reorganization across soil-root interfacial continua [0.03%]
阿尔卑山湿地草地化下古菌隔室特异性响应揭示了土壤根界面连续体上不同的分类学、功能和网络重构
Awais Iqbal,Muhammad Maqsood Ur Rehman,Wenyin Wang et al.
Awais Iqbal et al.
Introduction: Alpine wetland ecosystems on the Qinghai-Tibetan Plateau are critical carbon sinks experiencing grasslandification due to anthropogenic activities and climate change. While microbial dynamics underpin ecosys...