L-ornithine-L-aspartate enhances protein anabolism and growth performance in broilers by modulating the liver-NH3/Gln-muscle axis [0.03%]
L-鸟氨酸-L天冬氨酸通过调节肝-NH3/Gln-肌肉轴增强肉鸡蛋白同化及生长性能
Xiaodan Zhang,Guangzhi Ma,Bin Wang et al.
Xiaodan Zhang et al.
Introduction: Dysregulation of hepatic nitrogen metabolism precipitates ammonia (NH3) accumulation, severely compromising broiler growth performance and muscle protein homeostasis via the liver-muscle axis. While L-ornith...
Targeting myofibroblast copper vulnerability reverses pulmonary fibrosis via METTL3-directed STAT6 m6A driving cuproptosis [0.03%]
靶向肌纤维母细胞铜脆弱性通过METTL3定向STAT6 mRNA m6A修饰驱动铜死亡逆转肺纤维化
Youjing Yang,Jianzhong Li,Ting Jiang et al.
Youjing Yang et al.
Introduction: Idiopathic pulmonary fibrosis (IPF) remains a fatal disease due to apoptosis-resistant myofibroblasts driving pathological extracellular matrix deposition. Current therapies fail to directly eliminate these ...
A triple-functional sandwich-like nanofibrous matrix for accelerated gingival augmentation [0.03%]
一种用于加速牙龈增强的三功能夹心状纳米纤维素基质
Lizhi Zeng,Shanghui Huang,Tim Forouzanfar et al.
Lizhi Zeng et al.
Introduction: Keratinized gingival defect repair and soft tissue augmentation are crucial in oral and maxillofacial surgery, but current treatment strategies often face limitations such as insufficient antimicrobial prope...
Spatial transcriptomics links hippocampal synaptic remodeling to microglial phagocytosis in synucleinopathy [0.03%]
空间转录组学将突触核蛋白病海马区的突触重塑与小胶质细胞吞噬作用联系起来
Min-Tae Jeon,Jisu Jeong,Moonseok Choi et al.
Min-Tae Jeon et al.
Introduction: Synucleinopathies, including Parkinson's disease (PD) and Lewy body dementia (LBD), are characterized by misfolding and aggregation of α-synuclein (α-syn) into Lewy bodies, a key pathological hallmark. The...
Artificial intelligence-based vascular pattern profiling predicts prognosis and therapeutic response in hepatocellular carcinoma [0.03%]
基于人工智能的血管模式谱分析预测肝癌预后及治疗反应
Jun-Guang Chen,Xiao-Yu Zhang,Chen Xie et al.
Jun-Guang Chen et al.
Background: Hepatocellular carcinoma (HCC) is characterized by active angiogenesis and heterogeneous vascular patterns. However, vascular pattern profiling in tumors and its clinical significance remain unexplored. ...
A multi-bioactive pesticide delivery nanosystem for precise and efficient management of pest stresses in rice [0.03%]
一种用于精准高效管理水稻害虫压力的多生物活性农药递送纳米系统
Hui Zhang,Jiao Liu,Chengshuai He et al.
Hui Zhang et al.
Introduction: Rice production is increasingly threatened by simultaneous insect and fungal stresses, yet conventional pesticide applications suffer from low utilization, poor systemic mobility, and limited ability to mana...
PERK drives aflatoxin B1-induced cellular senescence by promoting NLRP3-mediated PANoptosis [0.03%]
泛依赖蛋白激酶PERK通过促进NLRP3介导的泛细胞程序性死亡调控黄曲霉毒素B1致衰老作用
Yue Cheng,Zi-Yan Hu,Hong-Li Si et al.
Yue Cheng et al.
Introduction: Mycotoxins are ubiquitous pollutants that can pose a serious threat to public health. Aflatoxin B1 (AFB1), one of the most toxic mycotoxins, is potentially hazardous to humans and animals. Poultry is more se...
PRR33 protects against cardiac hypertrophy by regulating myocyte cytoskeleton remodeling [0.03%]
PRR33通过调节心肌细胞细胞骨架重塑保护心脏肥大
Xuyang Fu,Feng Zhang,Linbin Pu et al.
Xuyang Fu et al.
Introduction: Cardiac hypertrophy is tightly governed by cytoskeletal and Z-disc-associated protein networks that integrate structural stability with hypertrophic signaling. Although disruption of this structural signalin...
Synthesis of scarless circular RNAs expressing long-acting GLP-1RAs for type 2 diabetes therapy [0.03%]
用于治疗2型糖尿病的无痕闭合环形RNA合成表达长效GLP-1受体激动剂疗法
Yude Lin,Zhibo Huang,Zhiwei Xiao et al.
Yude Lin et al.
Introduction: Glucagon-like peptide-1 (GLP-1) is a prominent therapeutic agent capable of normalizing fasting blood glucose levels in diabetic patients. While GLP-1-expressing mRNA encapsulated in lipid nanoparticles (LNP...
Nuclear factor erythroid 2-related factor 2 (Nrf2) inhibition revisited: advances and unmet challenges [0.03%]
核因子E2相关因子2(Nrf2)抑制再思考：进展与未竟挑战
Mengchen Lu,Ziyu Yang,Yabing Xin et al.
Mengchen Lu et al.
Background: Over the past decades, NRF2 has evolved from a redox/detox regulator to a central orchestrator of cellular stability, governing protein integrity, metabolism, immunity, and iron homeostasis, with roles in canc...