Metabolic module exchange in plant-endophyte coevolution: mechanisms and implications [0.03%]
植物-内生菌共生进化中的代谢模块互换：机制与启示
Xuejing Zhong,Hanping Bao,Shen Zhang et al.
Xuejing Zhong et al.
Background: Endophytes establish intimate symbioses with their hosts through long-term coevolution. They are known to promote plant growth, enhance stress resistance, and contribute to the biosynthesis of bioactive compou...
Bone marrow mesenchymal stem cells have tissue-specific characteristic in promoting the potential of periodontal ligament stem cells for periodontal regeneration [0.03%]
牙髓间充质干细胞促进牙周膜干细胞潜能的组织特异性分化特征研究
Fen Liu,Zhifei Zhou,Xiao Sun et al.
Fen Liu et al.
Introduction: Periodontal ligament stem cells (PDLSCs) are commonly used in regenerating damaged periodontal tissues. The regeneration of complex periodontal tissues relies on stem cell crosstalk. Typically, bone marrow m...
Dietary EGCG reshapes metabolic-epigenetic interplay to induce transgenerational host defense [0.03%]
饮食EGCG重塑代谢-表观遗传相互作用以诱导跨世代宿主防御反应
Wenqi Huang,Shiye Lin,Xuanyu Zheng et al.
Wenqi Huang et al.
Introduction: Parental diet is a key determinant of offspring health and immune function, in part through epigenetic regulation. Metabolic and epigenetic networks integrate nutrient sensing with chromatin dynamics to main...
Nanoplastics exposure accelerates the progression of osteoarthritis via lysosomal destabilization-mediated pyroptosis [0.03%]
纳米塑料通过溶酶体破坏介导的炎性细胞焦亡加速骨关节炎进展
Tanxin Yu,Hanwen Zhang,Weiqian Sun et al.
Tanxin Yu et al.
Introduction: Nanoplastics (NPs), as emerging environmental pollutants, are increasingly detected in human musculoskeletal tissues, but their impact on osteoarthritis (OA) pathogenesis remains unclear. ...
UHRF1-mediated DNA 5-mC modification drives super-enhancer redistribution and impedes osteogenesis via TGM2-regulated autophagic flux in senile osteoporosis [0.03%]
DNA 5-甲基化修饰驱动超级增强子重分布并通过TGM2调节的自噬流抑制衰老性骨质疏松症中的成骨作用
Peizhuo Pang,Junhua Chen,Qibo Li et al.
Peizhuo Pang et al.
Introduction: Senile osteoporosis (SOP) is an age-related skeletal disorder characterized by progressive bone mineral density loss and deteriorated bone microarchitecture, imposing significant burdens on aging populations...
Time-series single-cell transcriptomics and spatial metabolomics reveal spatiotemporal tobacco leaf response to herbivory [0.03%]
时间序列单细胞转录组学和空间代谢组学揭示了叶片对取食的时空响应
Huan Su,Xiaoxiang Hu,Lijun Meng et al.
Huan Su et al.
Introduction: Plants have evolved complex defense systems to cope with herbivore attack, yet how these defense responses are coordinated across distinct cell types and time scales remains unclear. Understanding the cellul...
MXene-based biomaterial nanoarchitectonics for chronic wound healing [0.03%]
用于慢性伤口愈合的MXene基生物材料纳米结构设计
Lufeng Yao,Guodun Zheng,Jin Cao et al.
Lufeng Yao et al.
Background: Chronic wounds impose a severe global clinical burden, affecting millions of patients yearly and causing substantial healthcare costs. Commercial dressings are limited by single-functionality. They cannot addr...
Molecular adaptation of sweet potato to Martian soil simulant: insights from mRNA and long non-coding RNA analyses [0.03%]
基于甜薯模拟火星土壤培养的mRNA和长链非编码RNA分子适应性分析
Subramanyam Reddy Chinreddy,Karthik Chinnannan,Purushothaman Natarajan et al.
Subramanyam Reddy Chinreddy et al.
Introduction: Understanding how crops adapt to extraterrestrial environments is essential for sustainable space agriculture. Sweet potato (Ipomoea batatas), a nutritionally rich and stress-resilient crop, is a promising c...
Integrated multi-omics analysis to elucidate the genetic basis of seed traits in cotton [0.03%]
集成多组学分析阐明棉花种子性状的遗传基础
Rumeng Zhao,Le Liu,Yuling Guo et al.
Rumeng Zhao et al.
Introduction: Seed size is a complex agronomic trait influencing seed germination, seedling vitality, and yield. The traditional single-omics strategy for identifying seed size-related genes has the disadvantage of low ac...
Nafamostat mesilate improves sepsis outcomes by modulating complement and coagulation pathways [0.03%]
纳法莫司酯通过调节补体和凝血途径改善脓毒症预后
Qiaolan He,Yuanjun Yang,Zhuxin Xie et al.
Qiaolan He et al.
Introduction: Sepsis is a leading cause of mortality in critically ill patients, characterized by dysregulation of multiple biological systems, including the complement, coagulation and contact pathways Nafamostat (NM), a...